Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint

The ATR-dependent DNA damage response pathway can respond to a diverse group of lesions as well as inhibitors of DNA replication. Using the Xenopus egg extract system, we show that lesions induced by UV irradiation and cis-platinum cause the functional uncoupling of MCM helicase and DNA polymerase a...

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Bibliographic Details
Published in:	Genes & development Vol. 19; no. 9; p. 1040
Main Authors:	Byun, Tony S, Pacek, Marcin, Yee, Muh-ching, Walter, Johannes C, Cimprich, Karlene A
Format:	Journal Article
Language:	English
Published:	United States 01.05.2005
Subjects:	Adaptor Proteins, Signal Transducing - metabolism Animals Aphidicolin - metabolism Aphidicolin - pharmacology Ataxia Telangiectasia Mutated Proteins Cell Cycle Proteins - metabolism Cell-Free System Checkpoint Kinase 1 Chromatin - metabolism DNA Damage DNA Helicases - metabolism DNA Primers DNA Replication - physiology DNA, Single-Stranded - drug effects DNA, Single-Stranded - metabolism DNA-Directed DNA Polymerase - metabolism Phosphorylation Plasmids - genetics Protein Kinases - metabolism Protein-Serine-Threonine Kinases - metabolism Xenopus Xenopus Proteins - metabolism
ISSN:	0890-9369
Online Access:	Get more information
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