Biosafety, Functionalities, and Applications of Biomedical Micro/nanomotors

Due to their unique ability to actively move, micro/nanomotors offer the possibility of breaking through the limitations of traditional passive drug delivery systems for the treatment of many diseases, and have attracted the increasing attention of researchers. However, at present, the realization o...

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Bibliographic Details
Published in:Angewandte Chemie International Edition Vol. 60; no. 24; pp. 13158 - 13176
Main Authors: Wan, Mimi, Li, Ting, Chen, Huan, Mao, Chun, Shen, Jian
Format: Journal Article
Language:English
Published: Germany Wiley Subscription Services, Inc 07.06.2021
Edition:International ed. in English
Subjects:
antitumor agents
biomedical applications
Biomedical materials
Biosafety
Cardiovascular diseases
Disease
Drug delivery
Drug delivery systems
Gastrointestinal diseases
Health services
imaging agents
Medical treatment
micro/nanomotors
Micromotors
Nanotechnology devices
Orthopedics
micro/nanomotors
imaging agents
biomedical applications
antitumor agents
biosafety
ISSN:1433-7851, 1521-3773, 1521-3773
Online Access:Get full text
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Summary:Due to their unique ability to actively move, micro/nanomotors offer the possibility of breaking through the limitations of traditional passive drug delivery systems for the treatment of many diseases, and have attracted the increasing attention of researchers. However, at present, the realization of many advantages of micro/nanomotors in disease treatment in vivo is still in its infancy, because of the complexity and particularity of diseases in different parts of human body. In this Minireview, we first focus on the biosafety and functionality of micro/nanomotors as a biomedical treatment system. Then, we address the treatment difficulties of various diseases in vivo (such as ophthalmic disease, orthopedic disease, gastrointestinal disease, cardiovascular disease, and cancer), and then review the research progress of biomedical micro/nanomotors in the past 20 years, Finally, we propose the challenges in this field and possible future development directions Research on micro/nanomotors has been booming in the past two decades, and their applications in the biomedical field have also received increasing attention. This Minireview summarizes research progress in the biosafety, functionality, and therapeutic effect of micro/nanomotors that can be used to treat different diseases. The direction of future developments is also discussed.
Bibliography:These authors contributed equally to this work.
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ISSN:1433-7851
1521-3773
1521-3773
DOI:10.1002/anie.202013689