Automated Quantification of Hydroxyl Reactivities: Prediction of Glycosylation Reactions

The stereoselectivity and yield in glycosylation reactions are paramount but unpredictable. We have developed a database of acceptor nucleophilic constants (Aka) to quantify the nucleophilicity of hydroxyl groups in glycosylation influenced by the steric, electronic and structural effects, providing...

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Bibliographic Details
Published in:	Angewandte Chemie International Edition Vol. 60; no. 22; pp. 12413 - 12423
Main Authors:	Chang, Chun‐Wei, Lin, Mei‐Huei, Chan, Chieh‐Kai, Su, Kuan‐Yu, Wu, Chia‐Hui, Lo, Wei‐Chih, Lam, Sarah, Cheng, Yu‐Ting, Liao, Pin‐Hsuan, Wong, Chi‐Huey, Wang, Cheng‐Chung
Format:	Journal Article
Language:	English
Published:	Germany Wiley Subscription Services, Inc 25.05.2021
Edition:	International ed. in English
Subjects:	Algorithms Automation Carbohydrates Computer applications diastereoselectivity Donors (electronic) Glycosylation hydroxyl Hydroxyl groups predictive algorithms Reactivity Software Stereoselectivity carbohydrates hydroxyl glycosylation diastereoselectivity predictive algorithms
ISSN:	1433-7851, 1521-3773, 1521-3773
Online Access:	Get full text
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