Semi‐Mechanistic Population Pharmacokinetic/Pharmacodynamic (PK/PD) Modeling of Dupilumab on Pre‐Bronchodilator Forced Expiratory Volume in 1 Second (FEV1) in Uncontrolled Moderate‐To‐Severe Asthma

ABSTRACT In this study, we investigated the pharmacokinetic/pharmacodynamic (PK/PD) relationship of dupilumab as an add‐on therapy in the intent‐to‐treat (ITT) uncontrolled moderate‐to‐severe asthma population and identified the factors significantly contributing to variability in forced expiratory...

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Bibliographic Details
Published in:	CPT: pharmacometrics and systems pharmacology Vol. 14; no. 8; pp. 1370 - 1380
Main Authors:	Zhang, Li, Davis, John D., Kanamaluru, Vanaja, Xu, Christine
Format:	Journal Article
Language:	English
Published:	United States John Wiley & Sons, Inc 01.08.2025 John Wiley and Sons Inc Wiley
Subjects:	Adolescent Adult Aged Airway management Anti-Asthmatic Agents - administration & dosage Anti-Asthmatic Agents - pharmacokinetics Anti-Asthmatic Agents - pharmacology Antibodies, Monoclonal, Humanized - administration & dosage Antibodies, Monoclonal, Humanized - pharmacokinetics Antibodies, Monoclonal, Humanized - pharmacology Asthma Asthma - drug therapy Asthma - physiopathology Biomarkers Bronchodilators Dose-Response Relationship, Drug Double-Blind Method Drug dosages dupilumab Female Forced Expiratory Volume - drug effects forced expiratory volume in 1 s Humans Inflammation Male Middle Aged Missing data Models, Biological Monoclonal antibodies Patients Pediatrics Pharmacodynamics Pharmacokinetics Placebo effect Population population pharmacokinetic/pharmacodynamic Severity of Illness Index Software Spirometry Steroids Young Adult United States > US asthma forced expiratory volume in 1 s population pharmacokinetic/pharmacodynamic dupilumab monoclonal antibodies
ISSN:	2163-8306, 2163-8306
Online Access:	Get full text
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