Molecular Design of Highly Efficient Heavy‐Atom‐Free Triplet BODIPY Derivatives for Photodynamic Therapy and Bioimaging

Novel BODIPY photosensitizers were developed for imaging‐guided photodynamic therapy. The introduction of a strong electron donor to the BODIPY core through a phenyl linker combined with the twisted arrangement between the donor and the BODIPY acceptor is essential for reducing the energy gap betwee...

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Bibliographic Details
Published in:	Angewandte Chemie International Edition Vol. 59; no. 23; pp. 8957 - 8962
Main Authors:	Nguyen, Van‐Nghia, Yim, Yubin, Kim, Sangin, Ryu, Bokyeong, Swamy, K. M. K., Kim, Gyoungmi, Kwon, Nahyun, Kim, C‐Yoon, Park, Sungnam, Yoon, Juyoung
Format:	Journal Article
Language:	English
Published:	WEINHEIM Wiley 02.06.2020 Wiley Subscription Services, Inc
Edition:	International ed. in English
Subjects:	aggregation-induced emission Aqueous solutions Atomic energy levels BODIPY Boron Compounds - chemistry Boron Compounds - pharmacology Boron Compounds - therapeutic use Cell Line, Tumor Chemistry Chemistry, Multidisciplinary Drug Design Energy gap heavy-atom-free photosensitizers Humans In vivo methods and tests Medical imaging Molecular Imaging - methods Photochemotherapy - methods Photodynamic therapy Photosensitizing Agents - chemistry Photosensitizing Agents - pharmacology Photosensitizing Agents - therapeutic use Physical Sciences reactive oxygen species Science & Technology Singlet oxygen Triplet state BODIPY ELECTRON-TRANSFER DYES photodynamic therapy reactive oxygen species PHOTOSENSITIZERS aggregation-induced emission heavy-atom-free photosensitizers GENERATION DYADS EXCITED-STATES
ISSN:	1433-7851, 1521-3773, 1521-3773
Online Access:	Get full text
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