Glycyrrhizin mitigates radiation‐induced acute lung injury by inhibiting the HMGB1/TLR4 signalling pathway

Radiation‐induced lung injury (RILI) is the major complication of thoracic radiation therapy, and no effective treatment is available. This study explored the role of high‐mobility group box 1 (HMGB1) in acute RILI and the therapeutic effect of glycyrrhizin, an inhibitor of HMGB1, on RILI. C57BL/6 m...

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Bibliographic Details
Published in:	Journal of cellular and molecular medicine Vol. 24; no. 1; pp. 214 - 226
Main Authors:	Zheng, Lei, Zhu, Qian, Xu, Cheng, Li, Min, Li, Huan, Yi, Pei‐Qiang, Xu, Fei‐Fei, Cao, Lu, Chen, Jia‐Yi
Format:	Journal Article
Language:	English
Published:	England John Wiley & Sons, Inc 01.01.2020 John Wiley and Sons Inc
Subjects:	Acute Lung Injury - drug therapy Acute Lung Injury - etiology Acute Lung Injury - metabolism Acute Lung Injury - pathology Advanced glycosylation end products Alveoli Animals Anti-Inflammatory Agents - pharmacology Bronchus Cell adhesion & migration Cell culture Cytokines FDA approval Female Gamma Rays - adverse effects Gene Expression Regulation - drug effects Glycyrrhizic Acid - pharmacology Glycyrrhizin HMGB1 HMGB1 protein HMGB1 Protein - antagonists & inhibitors Inflammation Laboratory animals Lungs Mice Mice, Inbred C57BL Original Pneumonia - drug therapy Pneumonia - etiology Pneumonia - metabolism Pneumonia - pathology Proteins Radiation therapy radiation‐induced lung injury (RILI) RAGE Sepsis Signal transduction Statistical analysis Thorax TLR4 TLR4 protein Toll-Like Receptor 4 - antagonists & inhibitors Toll-like receptors Transcription factors Tumor necrosis factor X-rays China Japan HMGB1 RAGE TLR4 radiation-induced lung injury (RILI) glycyrrhizin
ISSN:	1582-1838, 1582-4934, 1582-4934
Online Access:	Get full text
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