Integrative analyses highlight functional regulatory variants associated with neuropsychiatric diseases

Noncoding variants of presumed regulatory function contribute to the heritability of neuropsychiatric disease. A total of 2,221 noncoding variants connected to risk for ten neuropsychiatric disorders, including autism spectrum disorder, attention deficit hyperactivity disorder, bipolar disorder, bor...

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Veröffentlicht in:	Nature genetics Jg. 55; H. 11; S. 1876 - 1891
Hauptverfasser:	Guo, Margaret G., Reynolds, David L., Ang, Cheen E., Liu, Yingfei, Zhao, Yang, Donohue, Laura K. H., Siprashvili, Zurab, Yang, Xue, Yoo, Yongjin, Mondal, Smarajit, Hong, Audrey, Kain, Jessica, Meservey, Lindsey, Fabo, Tania, Elfaki, Ibtihal, Kellman, Laura N., Abell, Nathan S., Pershad, Yash, Bayat, Vafa, Etminani, Payam, Holodniy, Mark, Geschwind, Daniel H., Montgomery, Stephen B., Duncan, Laramie E., Urban, Alexander E., Altman, Russ B., Wernig, Marius, Khavari, Paul A.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	New York Nature Publishing Group US 01.11.2023 Nature Publishing Group
Schlagworte:	38/91 42/70 631/208/191 692/699/476 Agriculture Animal Genetics and Genomics Anxiety Anxiety disorders Attention Deficit Disorder with Hyperactivity - genetics Attention deficit hyperactivity disorder Autism Autism Spectrum Disorder - genetics Binomial distribution Biomedical and Life Sciences Biomedicine Bipolar disorder Bipolar Disorder - genetics Borderline personality disorder Cancer Research Chromatin Depressive Disorder, Major - genetics Disease Gene expression Gene Function Gene mapping Generalized anxiety disorder Genes Genetic modification Genome editing Health risks Heritability Human Genetics Humans Magnesium Mental disorders Network analysis Neuroses Nucleotides Obsessive compulsive disorder Obsessive-Compulsive Disorder - genetics Obsessive-Compulsive Disorder - psychology Panic attacks Post traumatic stress disorder Psychological stress Schizophrenia Schizophrenia - genetics Signs and symptoms Transcriptomics
ISSN:	1061-4036, 1546-1718, 1546-1718
Online-Zugang:	Volltext
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