Modulation of thrombomodulin-dependent activation of human protein C through differential expression of endothelial Smads

Protein C is a plasma protease that in its active form plays a central role in the regulation of vascular function by modulating thrombosis, inflammation, and apoptosis. A central player in this pathway is the cytokine-regulated receptor thrombomodulin (TM), which functions as a co-factor for the th...

Full description

Saved in:

Bibliographic Details
Published in:	The Journal of biological chemistry Vol. 277; no. 51; p. 49815
Main Authors:	Sandusky, George, Berg, David T, Richardson, Mark A, Myers, Laura, Grinnell, Brian W
Format:	Journal Article
Language:	English
Published:	United States 20.12.2002
Subjects:	Animals Arteriosclerosis - pathology Cell Survival Chloramphenicol O-Acetyltransferase - metabolism DNA-Binding Proteins - metabolism Dose-Response Relationship, Drug Down-Regulation Endothelium, Vascular - cytology Endothelium, Vascular - metabolism Enzyme-Linked Immunosorbent Assay Genes, Reporter Humans Immunohistochemistry Lymphotoxin-alpha - metabolism Oligonucleotides, Antisense - pharmacology Protein C - metabolism Signal Transduction Smad6 Protein Smad7 Protein Thrombomodulin - metabolism Time Factors Trans-Activators - metabolism Transcriptional Activation Transfection Transforming Growth Factor beta - metabolism Up-Regulation Xenopus Xenopus Proteins
ISSN:	0021-9258
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!