Extra-abdominal and intra-abdominal FET::CREM fusion mesenchymal neoplasms: comparative clinicopathological study of 9 new cases further supporting a distinct potentially aggressive sarcoma and report of novel sites

With the wide use of RNA sequencing technologies, the family of FET::CREB fusion mesenchymal neoplasms has expanded rapidly to include potentially aggressive neoplasms, not fitting any well established WHO entity. Recently, a group of intra-abdominal FET ( EWSR1/FUS ) ::CREB ( CREM/ATF1 ) fused uncl...

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Bibliographic Details
Published in:	Virchows Archiv : an international journal of pathology Vol. 485; no. 6; pp. 1007 - 1019
Main Authors:	Agaimy, Abbas, Blakely, Morgan, Breimer, Gerben E., Hölsken, Annett, Koppes, Sjors A., Meidenbauer, Norbert, Rijken, Johannes A., Schad, Arno, Simon, Adrian G., Stoehr, Robert, Bishop, Justin A., Din, Nasir Ud
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer Berlin Heidelberg 01.12.2024 Springer Nature B.V
Subjects:	Abdomen Abdominal diseases Abdominal Neoplasms - genetics Abdominal Neoplasms - pathology Adolescent Adult Aged Biomarkers, Tumor - analysis Biomarkers, Tumor - genetics CD30 antigen CD34 antigen CD99 antigen Chemotherapy Child Cyclic AMP Response Element Modulator - genetics Cyclic AMP response element-binding protein Desmin Fatalities Female FLI-1 protein Gene sequencing Genotypes Head and Neck Neoplasms - genetics Head and Neck Neoplasms - pathology Histiocytoma Humans Inhibin Keratin Male Medicine Medicine & Public Health Mesentery Metastases Middle Aged Neoplasms Nervous system diseases Oncogene Proteins, Fusion - genetics Original Original Article Pathology Patients Pax8 protein Phenotypes RNA-Binding Protein EWS - genetics RNA-Binding Protein FUS - genetics Sarcoma Sarcoma - genetics Sarcoma - pathology Soft Tissue Neoplasms - genetics Soft Tissue Neoplasms - pathology Soft tissues Sox10 protein Synaptophysin Tumors Young Adult Constitutional symptoms Ewing sarcoma Profiling Precision medicine Next generation sequencing Genetic landscape
ISSN:	0945-6317, 1432-2307, 1432-2307
Online Access:	Get full text
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