Rationale and Design for the BLOCK-SAH Study (Pterygopalatine Fossa Block as an Opioid-Sparing Treatment for Acute Headache in Aneurysmal Subarachnoid Hemorrhage): A Phase II, Multicenter, Randomized, Double-Blinded, Placebo-Controlled Clinical Trial with a Sequential Parallel Comparison Design

Background Acute post-subarachnoid hemorrhage (SAH) headaches are common and severe. Management strategies for post-SAH headaches are limited, with heavy reliance on opioids, and pain control is overall poor. Pterygopalatine fossa (PPF) nerve blocks have shown promising results in treatment of acute...

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Bibliographic Details
Published in:	Neurocritical care Vol. 42; no. 1; pp. 290 - 300
Main Authors:	Busl, Katharina M., Smith, Cameron R., Troxel, Andrea B., Fava, Maurizio, Illenberger, Nicholas, Pop, Ralisa, Yang, Wenqing, Frota, Luciola Martins, Gao, Hanzhi, Shan, Guogen, Hoh, Brian L., Maciel, Carolina B.
Format:	Journal Article
Language:	English
Published:	New York Springer US 01.02.2025 Springer Nature B.V
Subjects:	Adult Analgesics Analgesics, Opioid Anesthetics, Local - administration & dosage Aneurysms Clinical trials Clinical Trials, Phase II as Topic Critical Care Medicine Double-Blind Method Drug use Female Headache - drug therapy Headache - etiology Headache - therapy Headaches Hemorrhage Hospitalization Humans Hypotheses Intensive Internal Medicine Male Medical imaging Medicine Medicine & Public Health Middle Aged Morphine Multicenter Studies as Topic Narcotics Nerve Block - methods Neurology Neurosurgery Pain Pterygopalatine Fossa Randomized Controlled Trials as Topic Subarachnoid Hemorrhage - complications Substance abuse treatment Take a Closer Look at Trials Ultrasonic imaging Headache Intensive care Nerve block Subarachnoid hemorrhage Opioid analgesics
ISSN:	1541-6933, 1556-0961, 1556-0961
Online Access:	Get full text
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