Structural basis for the assembly of the mitotic motor Kinesin-5 into bipolar tetramers

Chromosome segregation during mitosis depends upon Kinesin-5 motors, which display a conserved, bipolar homotetrameric organization consisting of two motor dimers at opposite ends of a central rod. Kinesin-5 motors crosslink adjacent microtubules to drive or constrain their sliding apart, but the st...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	eLife Jg. 3; S. e02217
Hauptverfasser:	Scholey, Jessica E, Nithianantham, Stanley, Scholey, Jonathan M, Al-Bassam, Jawdat
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England eLife Sciences Publications Ltd 08.04.2014 eLife Sciences Publications, Ltd
Schlagworte:	Amino Acid Sequence Animals Biophysics and Structural Biology Biopolymers - chemistry Cell Biology Cell division coiled-coil Crystallography Crystallography, X-Ray Drosophila Hydrophobicity Interfaces Kinesin Kinesin - chemistry Kinesin-5 microtubule Microtubules Mitosis Models, Molecular Molecular Sequence Data motor protein Mutagenesis Protein Conformation Sequence Homology, Amino Acid X-ray structure microtubule coiled-coil mitosis motor protein X-ray structure Kinesin-5
ISSN:	2050-084X, 2050-084X
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!