Structural basis for the assembly of the mitotic motor Kinesin-5 into bipolar tetramers

Chromosome segregation during mitosis depends upon Kinesin-5 motors, which display a conserved, bipolar homotetrameric organization consisting of two motor dimers at opposite ends of a central rod. Kinesin-5 motors crosslink adjacent microtubules to drive or constrain their sliding apart, but the st...

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Vydáno v:	eLife Ročník 3; s. e02217
Hlavní autoři:	Scholey, Jessica E, Nithianantham, Stanley, Scholey, Jonathan M, Al-Bassam, Jawdat
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England eLife Sciences Publications Ltd 08.04.2014 eLife Sciences Publications, Ltd
Témata:	Amino Acid Sequence Animals Biophysics and Structural Biology Biopolymers - chemistry Cell Biology Cell division coiled-coil Crystallography Crystallography, X-Ray Drosophila Hydrophobicity Interfaces Kinesin Kinesin - chemistry Kinesin-5 microtubule Microtubules Mitosis Models, Molecular Molecular Sequence Data motor protein Mutagenesis Protein Conformation Sequence Homology, Amino Acid X-ray structure microtubule coiled-coil mitosis motor protein X-ray structure Kinesin-5
ISSN:	2050-084X, 2050-084X
On-line přístup:	Získat plný text
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