Shared and distinct biological circuits in effector, memory and exhausted CD8 + T cells revealed by temporal single-cell transcriptomics and epigenetics

Naïve CD8 T cells can differentiate into effector (T ), memory (T ) or exhausted (T ) T cells. These developmental pathways are associated with distinct transcriptional and epigenetic changes that endow cells with different functional capacities and therefore therapeutic potential. The molecular cir...

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Bibliographic Details
Published in:	Nature immunology Vol. 23; no. 11; pp. 1600 - 1613
Main Authors:	Giles, Josephine R, Ngiow, Shin Foong, Manne, Sasikanth, Baxter, Amy E, Khan, Omar, Wang, Ping, Staupe, Ryan, Abdel-Hakeem, Mohamed S, Huang, Hua, Mathew, Divij, Painter, Mark M, Wu, Jennifer E, Huang, Yinghui Jane, Goel, Rishi R, Yan, Patrick K, Karakousis, Giorgos C, Xu, Xiaowei, Mitchell, Tara C, Huang, Alexander C, Wherry, E John
Format:	Journal Article
Language:	English
Published:	United States Nature Publishing Group 01.11.2022
Subjects:	Apoptosis CD8 antigen CD8-Positive T-Lymphocytes - metabolism Cell differentiation Cellular stress response Chromatin Chromatin - genetics Chromatin - metabolism Chronic infection Circuits Comparative analysis Cytotoxicity Effector cells Epigenesis, Genetic Epigenetics Hepatocyte nuclear factor 1 Heterogeneity Humans Immunological memory Infections Lymphocytes Lymphocytes T Lymphocytic Choriomeningitis - metabolism Lymphocytic choriomeningitis virus Memory cells Natural killer cells PD-1 protein Transcriptome Transcriptomics Transposase
ISSN:	1529-2908, 1529-2916, 1529-2916
Online Access:	Get full text
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