Template-assisted covalent modification underlies activity of covalent molecular glues

Molecular glues are proximity-inducing small molecules that have emerged as an attractive therapeutic approach. However, developing molecular glues remains challenging, requiring innovative mechanistic strategies to stabilize neoprotein interfaces and expedite discovery. Here we unveil a trans -labe...

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Veröffentlicht in:	Nature chemical biology Jg. 20; H. 12; S. 1640 - 1649
Hauptverfasser:	Li, Yen-Der, Ma, Michelle W., Hassan, Muhammad Murtaza, Hunkeler, Moritz, Teng, Mingxing, Puvar, Kedar, Rutter, Justine C., Lumpkin, Ryan J., Sandoval, Brittany, Jin, Cyrus Y., Schmoker, Anna M., Ficarro, Scott B., Cheong, Hakyung, Metivier, Rebecca J., Wang, Michelle Y., Xu, Shawn, Byun, Woong Sub, Groendyke, Brian J., You, Inchul, Sigua, Logan H., Tavares, Isidoro, Zou, Charles, Tsai, Jonathan M., Park, Paul M. C., Yoon, Hojong, Majewski, Felix C., Sperling, Haniya T., Marto, Jarrod A., Qi, Jun, Nowak, Radosław P., Donovan, Katherine A., Słabicki, Mikołaj, Gray, Nathanael S., Fischer, Eric S., Ebert, Benjamin L.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	New York Nature Publishing Group US 01.12.2024 Nature Publishing Group
Schlagworte:	631/154/309 631/45/535 631/92/609 631/92/613 Adhesives Biochemical Engineering Biochemistry Bioorganic Chemistry Bromodomain Containing Proteins Cell Biology Cell Cycle Proteins - chemistry Cell Cycle Proteins - metabolism Chemistry Chemistry and Materials Science Chemistry/Food Science Complementarity Covalence Glues HEK293 Cells Humans Labeling Medical innovations Models, Molecular Mutagenesis Pharmacology Protein Binding Proteolysis Transcription Factors - chemistry Transcription Factors - metabolism
ISSN:	1552-4450, 1552-4469, 1552-4469
Online-Zugang:	Volltext
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