A vertebral skeletal stem cell lineage driving metastasis

Vertebral bone is subject to a distinct set of disease processes from long bones, including a much higher rate of solid tumour metastases 1 – 4 . The basis for this distinct biology of vertebral bone has so far remained unknown. Here we identify a vertebral skeletal stem cell (vSSC) that co-expresse...

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Veröffentlicht in:	Nature (London) Jg. 621; H. 7979; S. 602 - 609
Hauptverfasser:	Sun, Jun, Hu, Lingling, Bok, Seoyeon, Yallowitz, Alisha R., Cung, Michelle, McCormick, Jason, Zheng, Ling J., Debnath, Shawon, Niu, Yuzhe, Tan, Adrian Y., Lalani, Sarfaraz, Morse, Kyle W., Shinn, Daniel, Pajak, Anthony, Hammad, Mohammed, Suhardi, Vincentius Jeremy, Li, Zan, Li, Na, Wang, Lijun, Zou, Weiguo, Mittal, Vivek, Bostrom, Mathias P. G., Xu, Ren, Iyer, Sravisht, Greenblatt, Matthew B.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 21.09.2023 Nature Publishing Group
Schlagworte:	13/100 14/1 631/532 631/67/322/803 Adipocytes Biomarkers Bone growth Bones Breast cancer Breast Neoplasms - pathology Cartilage Cell Differentiation Cell Lineage Cell Self Renewal Cell surface Differentiation Humanities and Social Sciences Humans Labeling Long bone Metastases Metastasis multidisciplinary Neoplasm Metastasis - pathology Osteoblasts - cytology Osteoblasts - pathology Osteogenesis Physiology Science Science (multidisciplinary) Solid tumors Spine - cytology Spine - pathology Stem cells Stem Cells - cytology Stem Cells - metabolism Stem Cells - pathology Surface markers Transcription factors Tropism Vertebrae
ISSN:	0028-0836, 1476-4687, 1476-4687
Online-Zugang:	Volltext
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