CTGF/VEGFA-activated Fibroblasts Promote Tumor Migration Through Micro-environmental Modulation

Fibroblast activation is associated with tumor progression and implicated in metastasis, but the initial triggering signals required to kick-start this process remain largely unknown. Because small cancerous lesions share limited physical contact with neighboring fibroblasts, we reasoned the first t...

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Veröffentlicht in:	Molecular & cellular proteomics Jg. 17; H. 8; S. 1502
Hauptverfasser:	Wu, Wei, Zaal, Esther A, Berkers, Celia R, Lemeer, Simone, Heck, Albert J R
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.08.2018
Schlagworte:	Breast Neoplasms - metabolism Breast Neoplasms - pathology Carcinoma, Ductal, Breast - metabolism Carcinoma, Ductal, Breast - pathology Cell Adhesion Cell Line, Tumor Cell Movement Connective Tissue Growth Factor - metabolism Female Fibroblasts - metabolism Fibroblasts - pathology Humans Models, Biological Oxidative Stress rho-Associated Kinases - metabolism Signal Transduction Transcription Factors - metabolism Tumor Microenvironment Vascular Endothelial Growth Factor A - metabolism Tumor microenvironment Mass Spectrometry Secretome Click chemistry Metastasis reciprocal signaling fibroblast activation
ISSN:	1535-9484, 1535-9484
Online-Zugang:	Weitere Angaben
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