CTGF/VEGFA-activated Fibroblasts Promote Tumor Migration Through Micro-environmental Modulation

Fibroblast activation is associated with tumor progression and implicated in metastasis, but the initial triggering signals required to kick-start this process remain largely unknown. Because small cancerous lesions share limited physical contact with neighboring fibroblasts, we reasoned the first t...

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Vydáno v:	Molecular & cellular proteomics Ročník 17; číslo 8; s. 1502
Hlavní autoři:	Wu, Wei, Zaal, Esther A, Berkers, Celia R, Lemeer, Simone, Heck, Albert J R
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 01.08.2018
Témata:	Breast Neoplasms - metabolism Breast Neoplasms - pathology Carcinoma, Ductal, Breast - metabolism Carcinoma, Ductal, Breast - pathology Cell Adhesion Cell Line, Tumor Cell Movement Connective Tissue Growth Factor - metabolism Female Fibroblasts - metabolism Fibroblasts - pathology Humans Models, Biological Oxidative Stress rho-Associated Kinases - metabolism Signal Transduction Transcription Factors - metabolism Tumor Microenvironment Vascular Endothelial Growth Factor A - metabolism Tumor microenvironment Mass Spectrometry Secretome Click chemistry Metastasis reciprocal signaling fibroblast activation
ISSN:	1535-9484, 1535-9484
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