Cuproptosis: p53-regulated metabolic cell death?

Cuproptosis is a novel type of copper-induced cell death that primarily occurs in cells that utilize oxidative phosphorylation as the main metabolic pathway to produce energy. Copper directly associates with the lipoylated proteins of the tricarboxylic acid cycle, leading to the disulfide-bond-depen...

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Bibliographic Details
Published in:	Cell death and differentiation Vol. 30; no. 4; pp. 876 - 884
Main Authors:	Xiong, Chen, Ling, Hong, Hao, Qian, Zhou, Xiang
Format:	Journal Article
Language:	English
Published:	England Nature Publishing Group 01.04.2023
Subjects:	Apoptosis Cell death Copper Copper - metabolism Glutathione Glycolysis Iron Iron - metabolism Metabolic pathways Metabolism Metabolites Mutants Oxidative Phosphorylation p53 Protein Phosphorylation Proteins Sulfur Tricarboxylic acid cycle Tumor suppressor genes Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumors
ISSN:	1350-9047, 1476-5403, 1476-5403
Online Access:	Get full text
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