Obesity-induced extracellular vesicles proteins drive the endometrial cancer pathogenesis: therapeutic potential of HO-3867 and Metformin

Endometrial cancer (EC) is the leading gynecologic malignancy in the United States with obesity implicated in 57% of cases. This research investigates the molecular complexities of extracellular vesicles (EV) secretion as carriers of oncogenic protein and their involvement in obesity-mediated EC. An...

Full description

Saved in:

Bibliographic Details
Published in:	Oncogene Vol. 43; no. 49; pp. 3586 - 3597
Main Authors:	Sakaue, Takahiko, Dorayappan, Kalpana Deepa Priya, Zingarelli, Roman, Khadraoui, Wafa, Anbalagan, Muralidharan, Wallbillich, John, Bognar, Balazs, Wanner, Ross, Cosgrove, Casey, Suarez, Adrian, Koga, Hironori, Maxwell, G. Larry, O’Malley, David M., Cohn, David E., Selvendiran, Karuppaiyah
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 27.11.2024 Nature Publishing Group
Subjects:	631/67 631/67/1517/1709 Adipocytes Adipose tissue Animals Antidiabetics Apoptosis Body fat Body weight Cell Biology Cell growth Cell Line, Tumor Cell migration Cell proliferation Cell Proliferation - drug effects Diet, High-Fat - adverse effects Endometrial cancer Endometrial Neoplasms - drug therapy Endometrial Neoplasms - metabolism Endometrial Neoplasms - pathology Endometrium Extracellular vesicles Extracellular Vesicles - metabolism Female High fat diet Human Genetics Humans Hyperplasia Internal Medicine Malignancy Medicine Medicine & Public Health Metformin Metformin - pharmacology Metformin - therapeutic use Mice Obesity Obesity - drug therapy Obesity - metabolism Oncology Pathogenesis Patients Protein expression Proteins Secretion Stat5 protein Tumor suppressor genes Tumors Uterine cancer Uterus
ISSN:	0950-9232, 1476-5594, 1476-5594
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Abstract	Endometrial cancer (EC) is the leading gynecologic malignancy in the United States with obesity implicated in 57% of cases. This research investigates the molecular complexities of extracellular vesicles (EV) secretion as carriers of oncogenic protein and their involvement in obesity-mediated EC. An understanding of these mechanisms is pivotal for unraveling pathways relevant to obesity-associated EC, thereby guiding the development of innovative prevention and treatment strategies. Our exploration revealed a significant increase in EV secretion carrying oncogenic proteins (TMEM205, STAT5, and FAS) in adipose and uterine tissues/serum samples from obese EC patients compared to control (without cancer). We identified alterations in EV-regulating proteins (Rab7, Rab11, and Rab27a) in obesity-mediated EC patients, adipose/uterine tissues, and serum samples. Through a 24-week analysis of the effects of a 45% kcal high-fat diet (HFD) on mice, we observed increased body weight, increased adipose tissue, enlarged uterine horns, and increased inflammation in the HFD group. This correlated with elevated levels of EV secretion and increased expression of oncogenic proteins TMEM205, FAS, and STAT5 and downregulation of the tumor suppressor gene PIAS3 in adipose and uterine tissues. Furthermore, our study confirmed that adipocyte derived EV increased EC cell proliferation, migration and xenograft tumor growth. Additionally, we identified that the small molecule inhibitors (HO-3867) or Metformin inhibited EV secretion in vitro and in vivo, demonstrating significant inhibition of high glucose or adipocyte-mediated EC cell proliferation and a reduction in body weight and adipose tissue accumulation when administered to HFD mice. Moreover, HO-3867 or Metformin treatment inhibited HFD induced hyperplasia (precursor of EC) by altering the expression of EV-regulated proteins and decreasing oncogenic protein expression levels. This study provides critical insights into the mechanisms underpinning obesity-mediated EV secretion with oncogenic protein expression, shedding light on their role in EC pathogenesis. Additionally, it offers pre-clinical evidence supporting the initiation of novel studies for EV-targeted therapies aimed at preventing obesity-mediated EC.
AbstractList	Endometrial cancer (EC) is the leading gynecologic malignancy in the United States with obesity implicated in 57% of cases. This research investigates the molecular complexities of extracellular vesicles (EV) secretion as carriers of oncogenic protein and their involvement in obesity-mediated EC. An understanding of these mechanisms is pivotal for unraveling pathways relevant to obesity-associated EC, thereby guiding the development of innovative prevention and treatment strategies. Our exploration revealed a significant increase in EV secretion carrying oncogenic proteins (TMEM205, STAT5, and FAS) in adipose and uterine tissues/serum samples from obese EC patients compared to control (without cancer). We identified alterations in EV-regulating proteins (Rab7, Rab11, and Rab27a) in obesity-mediated EC patients, adipose/uterine tissues, and serum samples. Through a 24-week analysis of the effects of a 45% kcal high-fat diet (HFD) on mice, we observed increased body weight, increased adipose tissue, enlarged uterine horns, and increased inflammation in the HFD group. This correlated with elevated levels of EV secretion and increased expression of oncogenic proteins TMEM205, FAS, and STAT5 and downregulation of the tumor suppressor gene PIAS3 in adipose and uterine tissues. Furthermore, our study confirmed that adipocyte derived EV increased EC cell proliferation, migration and xenograft tumor growth. Additionally, we identified that the small molecule inhibitors (HO-3867) or Metformin inhibited EV secretion in vitro and in vivo, demonstrating significant inhibition of high glucose or adipocyte-mediated EC cell proliferation and a reduction in body weight and adipose tissue accumulation when administered to HFD mice. Moreover, HO-3867 or Metformin treatment inhibited HFD induced hyperplasia (precursor of EC) by altering the expression of EV-regulated proteins and decreasing oncogenic protein expression levels. This study provides critical insights into the mechanisms underpinning obesity-mediated EV secretion with oncogenic protein expression, shedding light on their role in EC pathogenesis. Additionally, it offers pre-clinical evidence supporting the initiation of novel studies for EV-targeted therapies aimed at preventing obesity-mediated EC. Endometrial cancer (EC) is the leading gynecologic malignancy in the United States with obesity implicated in 57% of cases. This research investigates the molecular complexities of extracellular vesicles (EV) secretion as carriers of oncogenic protein and their involvement in obesity-mediated EC. An understanding of these mechanisms is pivotal for unraveling pathways relevant to obesity-associated EC, thereby guiding the development of innovative prevention and treatment strategies. Our exploration revealed a significant increase in EV secretion carrying oncogenic proteins (TMEM205, STAT5, and FAS) in adipose and uterine tissues/serum samples from obese EC patients compared to control (without cancer). We identified alterations in EV-regulating proteins (Rab7, Rab11, and Rab27a) in obesity-mediated EC patients, adipose/uterine tissues, and serum samples. Through a 24-week analysis of the effects of a 45% kcal high-fat diet (HFD) on mice, we observed increased body weight, increased adipose tissue, enlarged uterine horns, and increased inflammation in the HFD group. This correlated with elevated levels of EV secretion and increased expression of oncogenic proteins TMEM205, FAS, and STAT5 and downregulation of the tumor suppressor gene PIAS3 in adipose and uterine tissues. Furthermore, our study confirmed that adipocyte derived EV increased EC cell proliferation, migration and xenograft tumor growth. Additionally, we identified that the small molecule inhibitors (HO-3867) or Metformin inhibited EV secretion in vitro and in vivo, demonstrating significant inhibition of high glucose or adipocyte-mediated EC cell proliferation and a reduction in body weight and adipose tissue accumulation when administered to HFD mice. Moreover, HO-3867 or Metformin treatment inhibited HFD induced hyperplasia (precursor of EC) by altering the expression of EV-regulated proteins and decreasing oncogenic protein expression levels. This study provides critical insights into the mechanisms underpinning obesity-mediated EV secretion with oncogenic protein expression, shedding light on their role in EC pathogenesis. Additionally, it offers pre-clinical evidence supporting the initiation of novel studies for EV-targeted therapies aimed at preventing obesity-mediated EC.Endometrial cancer (EC) is the leading gynecologic malignancy in the United States with obesity implicated in 57% of cases. This research investigates the molecular complexities of extracellular vesicles (EV) secretion as carriers of oncogenic protein and their involvement in obesity-mediated EC. An understanding of these mechanisms is pivotal for unraveling pathways relevant to obesity-associated EC, thereby guiding the development of innovative prevention and treatment strategies. Our exploration revealed a significant increase in EV secretion carrying oncogenic proteins (TMEM205, STAT5, and FAS) in adipose and uterine tissues/serum samples from obese EC patients compared to control (without cancer). We identified alterations in EV-regulating proteins (Rab7, Rab11, and Rab27a) in obesity-mediated EC patients, adipose/uterine tissues, and serum samples. Through a 24-week analysis of the effects of a 45% kcal high-fat diet (HFD) on mice, we observed increased body weight, increased adipose tissue, enlarged uterine horns, and increased inflammation in the HFD group. This correlated with elevated levels of EV secretion and increased expression of oncogenic proteins TMEM205, FAS, and STAT5 and downregulation of the tumor suppressor gene PIAS3 in adipose and uterine tissues. Furthermore, our study confirmed that adipocyte derived EV increased EC cell proliferation, migration and xenograft tumor growth. Additionally, we identified that the small molecule inhibitors (HO-3867) or Metformin inhibited EV secretion in vitro and in vivo, demonstrating significant inhibition of high glucose or adipocyte-mediated EC cell proliferation and a reduction in body weight and adipose tissue accumulation when administered to HFD mice. Moreover, HO-3867 or Metformin treatment inhibited HFD induced hyperplasia (precursor of EC) by altering the expression of EV-regulated proteins and decreasing oncogenic protein expression levels. This study provides critical insights into the mechanisms underpinning obesity-mediated EV secretion with oncogenic protein expression, shedding light on their role in EC pathogenesis. Additionally, it offers pre-clinical evidence supporting the initiation of novel studies for EV-targeted therapies aimed at preventing obesity-mediated EC.
Author	Cosgrove, Casey O’Malley, David M. Suarez, Adrian Zingarelli, Roman Bognar, Balazs Sakaue, Takahiko Cohn, David E. Khadraoui, Wafa Wanner, Ross Maxwell, G. Larry Anbalagan, Muralidharan Dorayappan, Kalpana Deepa Priya Wallbillich, John Koga, Hironori Selvendiran, Karuppaiyah
Author_xml	– sequence: 1 givenname: Takahiko surname: Sakaue fullname: Sakaue, Takahiko organization: Division of GYN/ONC, The James Comprehensive Cancer Center, Ohio State University, Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine – sequence: 2 givenname: Kalpana Deepa Priya surname: Dorayappan fullname: Dorayappan, Kalpana Deepa Priya organization: Division of GYN/ONC, The James Comprehensive Cancer Center, Ohio State University – sequence: 3 givenname: Roman surname: Zingarelli fullname: Zingarelli, Roman organization: Division of GYN/ONC, The James Comprehensive Cancer Center, Ohio State University – sequence: 4 givenname: Wafa surname: Khadraoui fullname: Khadraoui, Wafa organization: Division of GYN/ONC, The James Comprehensive Cancer Center, Ohio State University – sequence: 5 givenname: Muralidharan surname: Anbalagan fullname: Anbalagan, Muralidharan organization: Tulane University – sequence: 6 givenname: John surname: Wallbillich fullname: Wallbillich, John organization: Division of GYN/ONC, The James Comprehensive Cancer Center, Ohio State University – sequence: 7 givenname: Balazs surname: Bognar fullname: Bognar, Balazs organization: Institute of Organic and Medicinal Chemistry, Medical School, University of Pécs – sequence: 8 givenname: Ross surname: Wanner fullname: Wanner, Ross organization: Division of GYN/ONC, The James Comprehensive Cancer Center, Ohio State University – sequence: 9 givenname: Casey surname: Cosgrove fullname: Cosgrove, Casey organization: Division of GYN/ONC, The James Comprehensive Cancer Center, Ohio State University – sequence: 10 givenname: Adrian surname: Suarez fullname: Suarez, Adrian organization: Department of Pathology, The Ohio State University – sequence: 11 givenname: Hironori surname: Koga fullname: Koga, Hironori organization: Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine – sequence: 12 givenname: G. Larry surname: Maxwell fullname: Maxwell, G. Larry organization: Inova Women’s Service Line and the Inova Schar Cancer Institute – sequence: 13 givenname: David M. surname: O’Malley fullname: O’Malley, David M. organization: Division of GYN/ONC, The James Comprehensive Cancer Center, Ohio State University – sequence: 14 givenname: David E. surname: Cohn fullname: Cohn, David E. organization: Division of GYN/ONC, The James Comprehensive Cancer Center, Ohio State University – sequence: 15 givenname: Karuppaiyah surname: Selvendiran fullname: Selvendiran, Karuppaiyah email: selvendiran.karuppaiyah@osumc.edu organization: Division of GYN/ONC, The James Comprehensive Cancer Center, Ohio State University
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/39414985$$D View this record in MEDLINE/PubMed
BookMark	eNp9kl1vFCEYhYmpsdvqH_DCkHjjzShfM4A3xjRqTWr2Rq8Jy7yzSzMLIzAb-xP81zJu60cvmpBA8j7n5ADnDJ2EGACh55S8poSrN1lQrlRDmGgIp4o17BFaUSG7pm21OEErolvSaMbZKTrL-ZoQIjVhT9Ap14IKrdoV-rneQPblpvGhnx30GH6UZB2M4zzahA916EbIeEqxgA8Z98kfAJcdYAh93ENJ3o7Y2eAg4cmWXdxCqKr8doGSnWAu3uGpykNZ0Djgy3XDVSexDT3-AmWIae_DU_R4sGOGZ7f7Ofr28cPXi8vmav3p88X7q8YJ2ZbGisFuWAe6a2U3AIeupdK1VtczlbST0PNWKT6IQUjNBg2Ua2s5FZ3rmbL8HL07-k7zZg-9q7GSHc2U_N6mGxOtN_9Pgt-ZbTwYSjvCJFHV4dWtQ4rfZ8jF7H1enswGiHM2nFLZ1SV1RV_eQ6_jnEK9X6V4Dcq5XqgX_0b6k-XumyqgjoBLMecEg3G-2OLjktCPhhKzNMIcG2FqI8zvRhhWpeye9M79QRE_inKFwxbS39gPqH4B_-nLDg
CitedBy_id	crossref_primary_10_1016_j_jacc_2025_06_055
Cites_doi	10.1007/s10555-021-10002-6 10.1016/j.cell.2017.08.035 10.1016/j.bbrc.2018.06.138 10.1038/s41388-018-0189-0 10.1038/nature10166 10.1038/s41467-020-20500-w 10.1002/jex2.92 10.15252/embj.2019102525 10.3389/fgene.2020.575776 10.1038/srep25689 10.1007/s11095-011-0562-y 10.1038/ijo.2017.280 10.3389/fonc.2019.01440 10.1111/cas.13310 10.1007/s00018-021-03973-w 10.1152/physrev.00059.2009 10.1371/journal.pone.0170318 10.1124/jpet.111.183681 10.1007/s12672-023-00704-4 10.1242/jcs.030544 10.1002/jcp.22287 10.1038/aps.2015.4 10.1038/nature21365 10.1152/physrev.00017.2012 10.1158/0008-5472.CAN-13-2433 10.1002/ijc.23213 10.3389/fphys.2022.837001 10.1186/s12964-018-0255-9 10.1111/1471-0528.13731 10.1038/s41467-023-36148-1 10.1210/er.2017-00229 10.1002/jev2.12307 10.1016/j.jsbmb.2021.105849 10.1016/S0140-6736(08)60269-X 10.1038/sj.onc.1203480 10.1093/aje/kwn168 10.1200/JCO.2016.67.4283 10.1158/1541-7786.MCR-10-0201 10.21873/cdp.10143 10.1073/pnas.1808855115 10.1158/0008-5472.CAN-16-0651 10.1371/journal.pone.0266339 10.1016/j.canlet.2021.08.021 10.1016/j.febslet.2015.08.040 10.1038/nrc.2016.89 10.3322/caac.21763 10.1172/jci.insight.128846 10.1016/j.ygyno.2021.10.076 10.1172/jci.insight.141962
ContentType	Journal Article
Copyright	The Author(s) 2024 2024. The Author(s). The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. The Author(s) 2024 2024
Copyright_xml	– notice: The Author(s) 2024 – notice: 2024. The Author(s). – notice: The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: The Author(s) 2024 2024
DBID	C6C AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7TM 7TO 7U9 7X7 7XB 88A 88E 8AO 8C1 8FD 8FE 8FH 8FI 8FJ 8FK 8G5 ABUWG AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO FR3 FYUFA GHDGH GNUQQ GUQSH H94 HCIFZ K9. LK8 M0S M1P M2O M7P MBDVC P64 PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS Q9U RC3 7X8 5PM
DOI	10.1038/s41388-024-03182-2
DatabaseName	Springer Nature OA Free Journals CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Nucleic Acids Abstracts Oncogenes and Growth Factors Abstracts Virology and AIDS Abstracts ProQuest Health & Medical Collection (NC LIVE) ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) ProQuest Pharma Collection ProQuest Public Health Database (NC LIVE) Technology Research Database ProQuest SciTech Collection ProQuest Natural Science Collection ProQuest Hospital Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Research Library (Alumni) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials - QC ProQuest Biological Science Collection ProQuest Central ProQuest Natural Science Collection ProQuest One Community College ProQuest Central Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student ProQuest Research Library AIDS and Cancer Research Abstracts ProQuest SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Biological Sciences ProQuest Health & Medical Collection PML(ProQuest Medical Library) ProQuest Research Library (NC LIVE) ProQuest Biological Science Database (NC LIVE) Research Library (Corporate) Biotechnology and BioEngineering Abstracts Proquest Central Premium ProQuest One Academic ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China ProQuest Central Basic Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles)
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Research Library Prep ProQuest Central Student Oncogenes and Growth Factors Abstracts ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection ProQuest Central China ProQuest One Applied & Life Sciences Health Research Premium Collection Natural Science Collection Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Engineering Research Database ProQuest One Academic ProQuest One Academic (New) Technology Research Database ProQuest One Academic Middle East (New) ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing Research Library (Alumni Edition) ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Biology Journals (Alumni Edition) ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea AIDS and Cancer Research Abstracts ProQuest Research Library ProQuest Public Health ProQuest Central Basic ProQuest SciTech Collection ProQuest Medical Library ProQuest Central (Alumni) MEDLINE - Academic
DatabaseTitleList	Research Library Prep CrossRef MEDLINE MEDLINE - Academic
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Medicine Chemistry Biology
EISSN	1476-5594
EndPage	3597
ExternalDocumentID	PMC11602708 39414985 10_1038_s41388_024_03182_2
Genre	Journal Article
GrantInformation_xml	– fundername: United States Department of Defense \| United States Army \| Army Medical Command \| Congressionally Directed Medical Research Programs (CDMRP) grantid: W81XWH-22-1-0656 funderid: https://doi.org/10.13039/100000090 – fundername: United States Department of Defense \| United States Army \| Army Medical Command \| Congressionally Directed Medical Research Programs (CDMRP) grantid: W81XWH-22-1-0656
GroupedDBID	--- 0R~ 123 29N 36B 39C 4.4 406 53G 5RE 70F AACDK AANZL AASML AATNV AAYZH AAZLF ABAKF ABJNI ABLJU ABZZP ACAOD ACGFO ACGFS ACKTT ACMJI ACPRK ACRQY ACZOJ ADBBV ADFRT ADHDB AEFQL AEJRE AEMSY AENEX AEVLU AEXYK AFBBN AFSHS AGHAI AGQEE AHMBA AHSBF AIGIU AILAN AJRNO ALFFA ALIPV ALMA_UNASSIGNED_HOLDINGS AMYLF ASPBG AVWKF AXYYD AZFZN BENPR BHPHI BKKNO C6C CS3 DNIVK DPUIP DU5 E3Z EAP EBLON EBS EE. EIOEI F5P FDQFY FEDTE FERAY FIGPU FSGXE HCIFZ HVGLF HZ~ IAO IHR INH IWAJR JSO JZLTJ KQ8 L7B LGEZI LOTEE M2O M7P N9A NADUK NQJWS NXXTH O9- OK1 P2P RNT RNTTT ROL SNX SNYQT SOHCF SOJ SRMVM SWTZT TAOOD TBHMF TDRGL TSG WH7 AAYXX ABBRH ABDBE ABFSG ABRTQ ACSTC AEZWR AFDZB AFHIU AHWEU AIXLP ATHPR AYFIA CITATION TUS -Q- .55 .GJ 2WC 3O- 7X7 88E 8AO 8C1 8FE 8FH 8FI 8FJ 8G5 8R4 8R5 ABAWZ ABDBF ABEFU ABUWG ACUHS AFFNX AFKRA AZQEC B0M BAWUL BBNVY BPHCQ BVXVI CAG CCPQU CGR COF CUY CVF DIK DWQXO EAD EBC EBD ECM EIF EJD EMB EMK EMOBN EPL ESX FIZPM FYUFA GNUQQ GUQSH HMCUK INR ITC LK8 M1P NPM OVD PHGZT PQQKQ PROAC PSQYO Q2X RNS SV3 TEORI TR2 UDS UKHRP X7M ZXP ~8M 3V. 7TM 7TO 7U9 7XB 88A 8FD 8FK FR3 H94 K9. MBDVC P64 PHGZM PJZUB PKEHL PPXIY PQEST PQGLB PQUKI PRINS Q9U RC3 7X8 5PM AFFHD
ID	FETCH-LOGICAL-c475t-a4fab26e96576fe3e6517c5a9fe317167ed35883f4f4792f9e139aa3146cd28a3
IEDL.DBID	8C1
ISICitedReferencesCount	3
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=001333461000002&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	0950-9232 1476-5594
IngestDate	Tue Nov 04 02:04:43 EST 2025 Sun Nov 09 13:33:16 EST 2025 Sun Nov 02 05:44:08 EST 2025 Thu Apr 03 07:27:25 EDT 2025 Tue Nov 18 20:37:42 EST 2025 Sat Nov 29 04:02:59 EST 2025 Fri Feb 21 02:38:10 EST 2025
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	49
Language	English
License	2024. The Author(s). Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c475t-a4fab26e96576fe3e6517c5a9fe317167ed35883f4f4792f9e139aa3146cd28a3
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
OpenAccessLink	https://pubmed.ncbi.nlm.nih.gov/PMC11602708
PMID	39414985
PQID	3133583399
PQPubID	36330
PageCount	12
ParticipantIDs	pubmedcentral_primary_oai_pubmedcentral_nih_gov_11602708 proquest_miscellaneous_3117617679 proquest_journals_3133583399 pubmed_primary_39414985 crossref_citationtrail_10_1038_s41388_024_03182_2 crossref_primary_10_1038_s41388_024_03182_2 springer_journals_10_1038_s41388_024_03182_2
PublicationCentury	2000
PublicationDate	2024-11-27
PublicationDateYYYYMMDD	2024-11-27
PublicationDate_xml	– month: 11 year: 2024 text: 2024-11-27 day: 27
PublicationDecade	2020
PublicationPlace	London
PublicationPlace_xml	– name: London – name: England – name: New York
PublicationTitle	Oncogene
PublicationTitleAbbrev	Oncogene
PublicationTitleAlternate	Oncogene
PublicationYear	2024
Publisher	Nature Publishing Group UK Nature Publishing Group
Publisher_xml	– name: Nature Publishing Group UK – name: Nature Publishing Group
References	Dorayappan, Wagner, Park, Newcomer, Lightfoot, Kalaiyarasan (CR20) 2024; 3 Li, Fang, Fang, He, Liu (CR46) 2018; 16 Epplein, Reed, Voigt, Newton, Holt, Weiss (CR27) 2008; 168 Barakat, Ismail, Chattopadhyay, Davies (CR29) 2022; 2 Bond, Calkin, Drew (CR33) 2022; 13 Ray, Meira, Michael, Ellis (CR30) 2022; 41 Selvendiran, Ahmed, Dayton, Ravi, Kuppusamy, Bratasz (CR17) 2010; 8 Prip, Stentebjerg, Bennetsen, Petersen, Bor (CR28) 2022; 17 Renehan, Tyson, Egger, Heller, Zwahlen (CR3) 2008; 371 Trayhurn (CR12) 2013; 93 Hetemaki, Mikkola, Tikkanen, Wang, Hamalainen, Turpeinen (CR5) 2021; 209 Kumar, Sundaram, Mu, Dryden, Sriwastva, Lei (CR32) 2021; 12 Ying, Riopel, Bandyopadhyay, Dong, Birmingham, Seo (CR34) 2017; 171 (CR13) 2011; 474 Siegel, Miller, Wagle, Jemal (CR1) 2023; 73 Levy, Gilliland (CR38) 2000; 19 CR8 Hutagalung, Novick (CR44) 2011; 91 Dayton, Selvendiran, Meduru, Khan, Kuppusamy, Naidu (CR15) 2011; 339 Kulaj, Harger, Bauer, Caliskan, Gupta, Chiang (CR22) 2023; 14 Renehan, MacKintosh, Crosbie (CR4) 2016; 123 Simon, Greening, Bolumar, Balaguer, Salamonsen, Vilella (CR37) 2018; 39 Iyengar, Gucalp, Dannenberg, Hudis (CR7) 2016; 34 Lazar, Clement, Dauvillier, Milhas, Ducoux-Petit, LeGonidec (CR19) 2016; 76 Rao, Wu, Zhou, Deng, Ma (CR40) 2020; 11 Chaudhry, Srinivasan, Patel, Gopalan, Majumdar (CR14) 2008; 122 Thomou, Mori, Dreyfuss, Konishi, Sakaguchi, Wolfrum (CR10) 2017; 542 Shen, Ma, Okabe, Zhang, Xia, Gottesman (CR41) 2010; 225 Matsumoto, Takahashi, Nishikawa, Sano, Morishita, Charoenviriyakul (CR49) 2017; 108 Clement, Lazar, Attane, Carrie, Dauvillier, Ducoux-Petit (CR11) 2020; 39 Kwan, Chen, Xu, Chen (CR23) 2021; 78 Wallbillich, Josyula, Saini, Zingarelli, Dorayappan, Riley (CR9) 2017; 12 Shen, Gottesman (CR42) 2012; 29 Zhang, Peng, Huang, Lai, Hu, Li (CR48) 2018; 504 Rohrig, Schulze (CR39) 2016; 16 Kimura, Kaneko, Yamada, Ishihara, Senda, Iwamatsu (CR45) 2008; 121 Rath, Naidu, Lata, Bid, Rivera, McCann (CR16) 2014; 74 La Camera, Gelsomino, Malivindi, Barone, Panza, De Rose (CR36) 2021; 521 Sriwastva, Teng, Mu, Xu, Kumar, Sundaram (CR35) 2023; 12 Zhou, Huang, Da, Jin, Zhou (CR24) 2023; 14 Castano, Kalko, Novials, Parrizas (CR6) 2018; 115 Zhang, Gong, Liu, Jiang, Sun, Ma (CR2) 2019; 9 CR25 CR21 Zheng, Yang, Li, Zhao, Shao, Xiang (CR47) 2015; 36 Jae, McEwan, Manavski, Boon, Dimmeler (CR43) 2015; 589 Lombardo, Dentelli, Togliatto, Rosso, Gili, Gallo (CR26) 2016; 6 Poret, Souza-Smith, Marcell, Gaudet, Tzeng, Braymer (CR31) 2018; 42 Dorayappan, Wanner, Wallbillich, Saini, Zingarelli, Suarez (CR18) 2018; 37 MK Sriwastva (3182_CR35) 2023; 12 G La Camera (3182_CR36) 2021; 521 C Simon (3182_CR37) 2018; 39 AG Renehan (3182_CR4) 2016; 123 J Rao (3182_CR40) 2020; 11 C Zhou (3182_CR24) 2023; 14 F Rohrig (3182_CR39) 2016; 16 A Matsumoto (3182_CR49) 2017; 108 N Hetemaki (3182_CR5) 2021; 209 DW Shen (3182_CR42) 2012; 29 P Trayhurn (3182_CR12) 2013; 93 KS Rath (3182_CR16) 2014; 74 I Lazar (3182_CR19) 2016; 76 G Lombardo (3182_CR26) 2016; 6 Z Li (3182_CR46) 2018; 16 3182_CR8 DE Levy (3182_CR38) 2000; 19 A Dayton (3182_CR15) 2011; 339 3182_CR21 HY Kwan (3182_CR23) 2021; 78 AG Renehan (3182_CR3) 2008; 371 3182_CR25 JM Poret (3182_CR31) 2018; 42 E Clement (3182_CR11) 2020; 39 KDP Dorayappan (3182_CR18) 2018; 37 A Kumar (3182_CR32) 2021; 12 DW Shen (3182_CR41) 2010; 225 I Ray (3182_CR30) 2022; 41 YT Zheng (3182_CR47) 2015; 36 NM Iyengar (3182_CR7) 2016; 34 CM Prip (3182_CR28) 2022; 17 S Zhang (3182_CR2) 2019; 9 P Chaudhry (3182_CR14) 2008; 122 RL Siegel (3182_CR1) 2023; 73 W Ying (3182_CR34) 2017; 171 C Castano (3182_CR6) 2018; 115 T Thomou (3182_CR10) 2017; 542 AH Hutagalung (3182_CR44) 2011; 91 K Selvendiran (3182_CR17) 2010; 8 T Kimura (3182_CR45) 2008; 121 M Epplein (3182_CR27) 2008; 168 N Jae (3182_CR43) 2015; 589 Cancer Genome Atlas Research N. (3182_CR13) 2011; 474 H Zhang (3182_CR48) 2018; 504 ST Bond (3182_CR33) 2022; 13 K Kulaj (3182_CR22) 2023; 14 JJ Wallbillich (3182_CR9) 2017; 12 A Barakat (3182_CR29) 2022; 2 KDP Dorayappan (3182_CR20) 2024; 3
References_xml	– volume: 41 start-page: 211 year: 2022 end-page: 42 ident: CR30 article-title: Adipocytokines and disease progression in endometrial cancer: a systematic review publication-title: Cancer Metastasis Rev doi: 10.1007/s10555-021-10002-6 – volume: 171 start-page: 372 year: 2017 end-page: 84.e312 ident: CR34 article-title: Adipose Tissue Macrophage-Derived Exosomal miRNAs Can Modulate In Vivo and In Vitro Insulin Sensitivity publication-title: Cell doi: 10.1016/j.cell.2017.08.035 – volume: 504 start-page: 1 year: 2018 end-page: 5 ident: CR48 article-title: Effects of amiloride on physiological activity of stem cells of human lung cancer and possible mechanism publication-title: Biochemical Biophys Res Commun doi: 10.1016/j.bbrc.2018.06.138 – volume: 37 start-page: 3806 year: 2018 end-page: 21 ident: CR18 article-title: Hypoxia-induced exosomes contribute to a more aggressive and chemoresistant ovarian cancer phenotype: a novel mechanism linking STAT3/Rab proteins publication-title: Oncogene doi: 10.1038/s41388-018-0189-0 – volume: 474 start-page: 609 year: 2011 end-page: 15 ident: CR13 article-title: Integrated genomic analyses of ovarian carcinoma publication-title: Nature doi: 10.1038/nature10166 – volume: 12 year: 2021 ident: CR32 article-title: High-fat diet-induced upregulation of exosomal phosphatidylcholine contributes to insulin resistance publication-title: Nat Commun doi: 10.1038/s41467-020-20500-w – volume: 3 year: 2024 ident: CR20 article-title: ISG15 mediates the function of extracellular vesicles in promoting ovarian cancer progression and metastasis publication-title: J Extracell Biol doi: 10.1002/jex2.92 – volume: 39 year: 2020 ident: CR11 article-title: Adipocyte extracellular vesicles carry enzymes and fatty acids that stimulate mitochondrial metabolism and remodeling in tumor cells publication-title: EMBO J doi: 10.15252/embj.2019102525 – volume: 11 year: 2020 ident: CR40 article-title: TMEM205 Is an Independent Prognostic Factor and Is Associated With Immune Cell Infiltrates in Hepatocellular Carcinoma publication-title: Front Genet doi: 10.3389/fgene.2020.575776 – volume: 6 year: 2016 ident: CR26 article-title: Activated Stat5 trafficking Via Endothelial Cell-derived Extracellular Vesicles Controls IL-3 Pro-angiogenic Paracrine Action publication-title: Sci Rep doi: 10.1038/srep25689 – volume: 29 start-page: 643 year: 2012 end-page: 50 ident: CR42 article-title: RAB8 enhances TMEM205-mediated cisplatin resistance publication-title: Pharm Res doi: 10.1007/s11095-011-0562-y – ident: CR8 – volume: 42 start-page: 535 year: 2018 end-page: 41 ident: CR31 article-title: High fat diet consumption differentially affects adipose tissue inflammation and adipocyte size in obesity-prone and obesity-resistant rats publication-title: Int J Obes doi: 10.1038/ijo.2017.280 – ident: CR25 – volume: 9 start-page: 1440 year: 2019 ident: CR2 article-title: Global, Regional, and National Burden of Endometrial Cancer, 1990-2017: Results From the Global Burden of Disease Study, 2017 publication-title: Front Oncol doi: 10.3389/fonc.2019.01440 – ident: CR21 – volume: 108 start-page: 1803 year: 2017 end-page: 10 ident: CR49 article-title: Accelerated growth of B16BL6 tumor in mice through efficient uptake of their own exosomes by B16BL6 cells publication-title: Cancer Sci doi: 10.1111/cas.13310 – volume: 78 start-page: 7275 year: 2021 end-page: 88 ident: CR23 article-title: The impact of obesity on adipocyte-derived extracellular vesicles publication-title: Cell Mol Life Sci doi: 10.1007/s00018-021-03973-w – volume: 91 start-page: 119 year: 2011 end-page: 49 ident: CR44 article-title: Role of Rab GTPases in membrane traffic and cell physiology publication-title: Physiological Rev doi: 10.1152/physrev.00059.2009 – volume: 12 start-page: e0170318 year: 2017 ident: CR9 article-title: High Glucose-Mediated STAT3 Activation in Endometrial Cancer Is Inhibited by Metformin: Therapeutic Implications for Endometrial Cancer publication-title: PloS One doi: 10.1371/journal.pone.0170318 – volume: 339 start-page: 350 year: 2011 end-page: 7 ident: CR15 article-title: Amelioration of doxorubicin-induced cardiotoxicity by an anticancer-antioxidant dual-function compound, HO-3867 publication-title: J Pharm Exp Ther doi: 10.1124/jpet.111.183681 – volume: 14 start-page: 92 year: 2023 ident: CR24 article-title: Adipocyte-derived extracellular vesicles: bridging the communications between obesity and tumor microenvironment publication-title: Discov Oncol doi: 10.1007/s12672-023-00704-4 – volume: 121 start-page: 3092 year: 2008 end-page: 8 ident: CR45 article-title: The GDP-dependent Rab27a effector coronin 3 controls endocytosis of secretory membrane in insulin-secreting cell lines publication-title: J Cell Sci doi: 10.1242/jcs.030544 – volume: 225 start-page: 822 year: 2010 end-page: 8 ident: CR41 article-title: Elevated expression of TMEM205, a hypothetical membrane protein, is associated with cisplatin resistance publication-title: J Cell Physiol doi: 10.1002/jcp.22287 – volume: 36 start-page: 614 year: 2015 end-page: 26 ident: CR47 article-title: Amiloride sensitizes human pancreatic cancer cells to erlotinib in vitro through inhibition of the PI3K/AKT signaling pathway publication-title: Acta Pharmacologica Sin doi: 10.1038/aps.2015.4 – volume: 542 start-page: 450 year: 2017 end-page: 5 ident: CR10 article-title: Adipose-derived circulating miRNAs regulate gene expression in other tissues publication-title: Nature doi: 10.1038/nature21365 – volume: 93 start-page: 1 year: 2013 end-page: 21 ident: CR12 article-title: Hypoxia and adipose tissue function and dysfunction in obesity publication-title: Physiological Rev doi: 10.1152/physrev.00017.2012 – volume: 74 start-page: 2316 year: 2014 end-page: 27 ident: CR16 article-title: HO-3867, a safe STAT3 inhibitor, is selectively cytotoxic to ovarian cancer publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-13-2433 – volume: 122 start-page: 1716 year: 2008 end-page: 21 ident: CR14 article-title: Serum soluble Fas levels and prediction of response to platinum-based chemotherapy in epithelial ovarian cancer publication-title: Int J Cancer doi: 10.1002/ijc.23213 – volume: 13 year: 2022 ident: CR33 article-title: Adipose-Derived Extracellular Vesicles: Systemic Messengers and Metabolic Regulators in Health and Disease publication-title: Front Physiol doi: 10.3389/fphys.2022.837001 – volume: 16 start-page: 44 year: 2018 ident: CR46 article-title: Functional implications of Rab27 GTPases in Cancer publication-title: Cell Commun Signal doi: 10.1186/s12964-018-0255-9 – volume: 123 start-page: 175 year: 2016 end-page: 8 ident: CR4 article-title: Obesity and endometrial cancer: unanswered epidemiological questions publication-title: BJOG doi: 10.1111/1471-0528.13731 – volume: 14 year: 2023 ident: CR22 article-title: Adipocyte-derived extracellular vesicles increase insulin secretion through transport of insulinotropic protein cargo publication-title: Nat Commun doi: 10.1038/s41467-023-36148-1 – volume: 39 start-page: 292 year: 2018 end-page: 332 ident: CR37 article-title: Extracellular Vesicles in Human Reproduction in Health and Disease publication-title: Endocr Rev doi: 10.1210/er.2017-00229 – volume: 12 year: 2023 ident: CR35 article-title: An extracellular vesicular mutant KRAS-associated protein complex promotes lung inflammation and tumor growth publication-title: J Extracell Vesicles doi: 10.1002/jev2.12307 – volume: 209 year: 2021 ident: CR5 article-title: Adipose tissue estrogen production and metabolism in premenopausal women publication-title: J Steroid Biochem Mol Biol doi: 10.1016/j.jsbmb.2021.105849 – volume: 371 start-page: 569 year: 2008 end-page: 78 ident: CR3 article-title: Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies publication-title: Lancet doi: 10.1016/S0140-6736(08)60269-X – volume: 19 start-page: 2505 year: 2000 end-page: 10 ident: CR38 article-title: Divergent roles of STAT1 and STAT5 in malignancy as revealed by gene disruptions in mice publication-title: Oncogene doi: 10.1038/sj.onc.1203480 – volume: 168 start-page: 563 year: 2008 end-page: 70 ident: CR27 article-title: Risk of complex and atypical endometrial hyperplasia in relation to anthropometric measures and reproductive history publication-title: Am J Epidemiol doi: 10.1093/aje/kwn168 – volume: 34 start-page: 4270 year: 2016 end-page: 6 ident: CR7 article-title: Obesity and Cancer Mechanisms: Tumor Microenvironment and Inflammation publication-title: J Clin Oncol doi: 10.1200/JCO.2016.67.4283 – volume: 8 start-page: 1188 year: 2010 end-page: 97 ident: CR17 article-title: HO-3867, a synthetic compound, inhibits the migration and invasion of ovarian carcinoma cells through downregulation of fatty acid synthase and focal adhesion kinase publication-title: Mol cancer Res MCR doi: 10.1158/1541-7786.MCR-10-0201 – volume: 2 start-page: 564 year: 2022 end-page: 8 ident: CR29 article-title: Endometrial Cancer Incidence in Patients With Atypical Endometrial Hyperplasia According to Mode of Management publication-title: Cancer Diagn Progn doi: 10.21873/cdp.10143 – volume: 115 start-page: 12158 year: 2018 end-page: 63 ident: CR6 article-title: Obesity-associated exosomal miRNAs modulate glucose and lipid metabolism in mice publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.1808855115 – volume: 76 start-page: 4051 year: 2016 end-page: 7 ident: CR19 article-title: Adipocyte Exosomes Promote Melanoma Aggressiveness through Fatty Acid Oxidation: A Novel Mechanism Linking Obesity and Cancer publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-16-0651 – volume: 17 start-page: e0266339 year: 2022 ident: CR28 article-title: Risk of atypical hyperplasia and endometrial carcinoma after initial diagnosis of non-atypical endometrial hyperplasia: A long-term follow-up study publication-title: PLoS One doi: 10.1371/journal.pone.0266339 – volume: 521 start-page: 155 year: 2021 end-page: 68 ident: CR36 article-title: Adipocyte-derived extracellular vesicles promote breast cancer cell malignancy through HIF-1alpha activity publication-title: Cancer Lett doi: 10.1016/j.canlet.2021.08.021 – volume: 589 start-page: 3182 year: 2015 end-page: 8 ident: CR43 article-title: Rab7a and Rab27b control secretion of endothelial microRNA through extracellular vesicles publication-title: FEBS Lett doi: 10.1016/j.febslet.2015.08.040 – volume: 16 start-page: 732 year: 2016 end-page: 49 ident: CR39 article-title: The multifaceted roles of fatty acid synthesis in cancer publication-title: Nat Rev Cancer doi: 10.1038/nrc.2016.89 – volume: 73 start-page: 17 year: 2023 end-page: 48 ident: CR1 article-title: Cancer statistics, 2023 publication-title: CA Cancer J Clin doi: 10.3322/caac.21763 – volume: 37 start-page: 3806 year: 2018 ident: 3182_CR18 publication-title: Oncogene doi: 10.1038/s41388-018-0189-0 – volume: 3 year: 2024 ident: 3182_CR20 publication-title: J Extracell Biol doi: 10.1002/jex2.92 – volume: 39 start-page: 292 year: 2018 ident: 3182_CR37 publication-title: Endocr Rev doi: 10.1210/er.2017-00229 – volume: 91 start-page: 119 year: 2011 ident: 3182_CR44 publication-title: Physiological Rev doi: 10.1152/physrev.00059.2009 – volume: 12 start-page: e0170318 year: 2017 ident: 3182_CR9 publication-title: PloS One doi: 10.1371/journal.pone.0170318 – volume: 42 start-page: 535 year: 2018 ident: 3182_CR31 publication-title: Int J Obes doi: 10.1038/ijo.2017.280 – volume: 108 start-page: 1803 year: 2017 ident: 3182_CR49 publication-title: Cancer Sci doi: 10.1111/cas.13310 – volume: 73 start-page: 17 year: 2023 ident: 3182_CR1 publication-title: CA Cancer J Clin doi: 10.3322/caac.21763 – volume: 371 start-page: 569 year: 2008 ident: 3182_CR3 publication-title: Lancet doi: 10.1016/S0140-6736(08)60269-X – volume: 76 start-page: 4051 year: 2016 ident: 3182_CR19 publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-16-0651 – volume: 17 start-page: e0266339 year: 2022 ident: 3182_CR28 publication-title: PLoS One doi: 10.1371/journal.pone.0266339 – volume: 16 start-page: 732 year: 2016 ident: 3182_CR39 publication-title: Nat Rev Cancer doi: 10.1038/nrc.2016.89 – volume: 121 start-page: 3092 year: 2008 ident: 3182_CR45 publication-title: J Cell Sci doi: 10.1242/jcs.030544 – volume: 12 year: 2021 ident: 3182_CR32 publication-title: Nat Commun doi: 10.1038/s41467-020-20500-w – ident: 3182_CR8 doi: 10.1172/jci.insight.128846 – volume: 39 year: 2020 ident: 3182_CR11 publication-title: EMBO J doi: 10.15252/embj.2019102525 – volume: 589 start-page: 3182 year: 2015 ident: 3182_CR43 publication-title: FEBS Lett doi: 10.1016/j.febslet.2015.08.040 – volume: 14 year: 2023 ident: 3182_CR22 publication-title: Nat Commun doi: 10.1038/s41467-023-36148-1 – volume: 474 start-page: 609 year: 2011 ident: 3182_CR13 publication-title: Nature doi: 10.1038/nature10166 – volume: 74 start-page: 2316 year: 2014 ident: 3182_CR16 publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-13-2433 – volume: 78 start-page: 7275 year: 2021 ident: 3182_CR23 publication-title: Cell Mol Life Sci doi: 10.1007/s00018-021-03973-w – volume: 123 start-page: 175 year: 2016 ident: 3182_CR4 publication-title: BJOG doi: 10.1111/1471-0528.13731 – volume: 171 start-page: 372 year: 2017 ident: 3182_CR34 publication-title: Cell doi: 10.1016/j.cell.2017.08.035 – volume: 93 start-page: 1 year: 2013 ident: 3182_CR12 publication-title: Physiological Rev doi: 10.1152/physrev.00017.2012 – volume: 225 start-page: 822 year: 2010 ident: 3182_CR41 publication-title: J Cell Physiol doi: 10.1002/jcp.22287 – volume: 2 start-page: 564 year: 2022 ident: 3182_CR29 publication-title: Cancer Diagn Progn doi: 10.21873/cdp.10143 – volume: 11 year: 2020 ident: 3182_CR40 publication-title: Front Genet doi: 10.3389/fgene.2020.575776 – volume: 122 start-page: 1716 year: 2008 ident: 3182_CR14 publication-title: Int J Cancer doi: 10.1002/ijc.23213 – volume: 8 start-page: 1188 year: 2010 ident: 3182_CR17 publication-title: Mol cancer Res MCR doi: 10.1158/1541-7786.MCR-10-0201 – volume: 36 start-page: 614 year: 2015 ident: 3182_CR47 publication-title: Acta Pharmacologica Sin doi: 10.1038/aps.2015.4 – volume: 542 start-page: 450 year: 2017 ident: 3182_CR10 publication-title: Nature doi: 10.1038/nature21365 – volume: 19 start-page: 2505 year: 2000 ident: 3182_CR38 publication-title: Oncogene doi: 10.1038/sj.onc.1203480 – volume: 34 start-page: 4270 year: 2016 ident: 3182_CR7 publication-title: J Clin Oncol doi: 10.1200/JCO.2016.67.4283 – ident: 3182_CR25 doi: 10.1016/j.ygyno.2021.10.076 – volume: 115 start-page: 12158 year: 2018 ident: 3182_CR6 publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.1808855115 – volume: 14 start-page: 92 year: 2023 ident: 3182_CR24 publication-title: Discov Oncol doi: 10.1007/s12672-023-00704-4 – volume: 521 start-page: 155 year: 2021 ident: 3182_CR36 publication-title: Cancer Lett doi: 10.1016/j.canlet.2021.08.021 – volume: 41 start-page: 211 year: 2022 ident: 3182_CR30 publication-title: Cancer Metastasis Rev doi: 10.1007/s10555-021-10002-6 – volume: 168 start-page: 563 year: 2008 ident: 3182_CR27 publication-title: Am J Epidemiol doi: 10.1093/aje/kwn168 – volume: 16 start-page: 44 year: 2018 ident: 3182_CR46 publication-title: Cell Commun Signal doi: 10.1186/s12964-018-0255-9 – ident: 3182_CR21 doi: 10.1172/jci.insight.141962 – volume: 29 start-page: 643 year: 2012 ident: 3182_CR42 publication-title: Pharm Res doi: 10.1007/s11095-011-0562-y – volume: 339 start-page: 350 year: 2011 ident: 3182_CR15 publication-title: J Pharm Exp Ther doi: 10.1124/jpet.111.183681 – volume: 9 start-page: 1440 year: 2019 ident: 3182_CR2 publication-title: Front Oncol doi: 10.3389/fonc.2019.01440 – volume: 6 year: 2016 ident: 3182_CR26 publication-title: Sci Rep doi: 10.1038/srep25689 – volume: 504 start-page: 1 year: 2018 ident: 3182_CR48 publication-title: Biochemical Biophys Res Commun doi: 10.1016/j.bbrc.2018.06.138 – volume: 12 year: 2023 ident: 3182_CR35 publication-title: J Extracell Vesicles doi: 10.1002/jev2.12307 – volume: 13 year: 2022 ident: 3182_CR33 publication-title: Front Physiol doi: 10.3389/fphys.2022.837001 – volume: 209 year: 2021 ident: 3182_CR5 publication-title: J Steroid Biochem Mol Biol doi: 10.1016/j.jsbmb.2021.105849
SSID	ssj0007902
Score	2.4840217
Snippet	Endometrial cancer (EC) is the leading gynecologic malignancy in the United States with obesity implicated in 57% of cases. This research investigates the...
SourceID	pubmedcentral proquest pubmed crossref springer
SourceType	Open Access Repository Aggregation Database Index Database Enrichment Source Publisher
StartPage	3586
SubjectTerms	631/67 631/67/1517/1709 Adipocytes Adipose tissue Animals Antidiabetics Apoptosis Body fat Body weight Cell Biology Cell growth Cell Line, Tumor Cell migration Cell proliferation Cell Proliferation - drug effects Diet, High-Fat - adverse effects Endometrial cancer Endometrial Neoplasms - drug therapy Endometrial Neoplasms - metabolism Endometrial Neoplasms - pathology Endometrium Extracellular vesicles Extracellular Vesicles - metabolism Female High fat diet Human Genetics Humans Hyperplasia Internal Medicine Malignancy Medicine Medicine & Public Health Metformin Metformin - pharmacology Metformin - therapeutic use Mice Obesity Obesity - drug therapy Obesity - metabolism Oncology Pathogenesis Patients Protein expression Proteins Secretion Stat5 protein Tumor suppressor genes Tumors Uterine cancer Uterus
Title	Obesity-induced extracellular vesicles proteins drive the endometrial cancer pathogenesis: therapeutic potential of HO-3867 and Metformin
URI	https://link.springer.com/article/10.1038/s41388-024-03182-2 https://www.ncbi.nlm.nih.gov/pubmed/39414985 https://www.proquest.com/docview/3133583399 https://www.proquest.com/docview/3117617679 https://pubmed.ncbi.nlm.nih.gov/PMC11602708
Volume	43
WOSCitedRecordID	wos001333461000002&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 1476-5594 dateEnd: 20241207 omitProxy: false ssIdentifier: ssj0007902 issn: 0950-9232 databaseCode: M7P dateStart: 20210101 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1476-5594 dateEnd: 20241207 omitProxy: false ssIdentifier: ssj0007902 issn: 0950-9232 databaseCode: 7X7 dateStart: 20210101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1476-5594 dateEnd: 20241207 omitProxy: false ssIdentifier: ssj0007902 issn: 0950-9232 databaseCode: BENPR dateStart: 20210101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Public Health Database (NC LIVE) customDbUrl: eissn: 1476-5594 dateEnd: 20241207 omitProxy: false ssIdentifier: ssj0007902 issn: 0950-9232 databaseCode: 8C1 dateStart: 20210101 isFulltext: true titleUrlDefault: https://search.proquest.com/publichealth providerName: ProQuest – providerCode: PRVPQU databaseName: Research Library customDbUrl: eissn: 1476-5594 dateEnd: 20241207 omitProxy: false ssIdentifier: ssj0007902 issn: 0950-9232 databaseCode: M2O dateStart: 20210101 isFulltext: true titleUrlDefault: https://search.proquest.com/pqrl providerName: ProQuest
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3db9MwED-xDQYvfHQDCqMyEm9grbYT2-EFQbVpD7SrEKC-RW5iQyVIStNN4k_gv-YuSVvKxF54iRL58uHcz-ezfb4fwIuQGS_QT8ZhiU5o6sbxqTYRF8LFKmgdh5qm8_N7MxrZySQZtxNuVRtWubKJtaHOy4zmyI8VDqZoh1CSvJn_4MQaRaurLYXGDuwJ2Y-oYdrBJsTDNDGH6EX0OToyst0001f2uELjjRjBHooTrCWX2x3TFW_zatDkXyundYd0eu9_q3If7rauKHvbYOcB3PBFB2415JQ_O3B7sOKC68D-sF2CP4BfLZUAx8E8wiJnaN0Xjub_KaCVXWIhBdqxOgHErKhYvkCDytDPZL7Iy---5glhGaFtwYgQufxC9nZWvWZ_bAZjc7y9WJJoGdjZOVdWG-aKnA39khztWXEIn05PPg7OeMvnwLPIxEvuouCmUvtE4yAneOV1LEwWuwTPKWuP8Tn-F6tCFBA0MiQe3VPnFBrzLJfWqYewW5SFfwws6Ng7l2UyGBfhY12cRCrYqYsE9cq-C2KlzDRrk50T58a3tF50VzZtAJAiANIaAKnswsv1PfMm1ce10kcr5aZts6_SjWa78HxdjLoiLbjClxckIwy6jdqgzKMGUuvXqQS_P7FxF-wW2NYClAx8u6SYfa2Tgguh-9L0bRderXC5-a5_V-PJ9dV4CncktREhuDRHsLtcXPhncDO7XM6qRQ92zMTUR9urW14P9t6djMYf8Gooz-loxr8Bebc2EQ
linkProvider	ProQuest
linkToHtml	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwEB6V8igXHstroYCR4ARWEzuJEySEUKHaqrsLh1LtLXgTGyKBs2y2Rf0J_Bl-IzN5bFkqeuuBWyQ7iRN_M_ONPZ4BeGozZXzkyeiWRAkt3Wg-jVTAfV-H0kZRaOsynQdDNR7Hk0nyYQ1-dWdhKKyy04m1os7LjNbItyQ6U3RCKElez75zqhpFu6tdCY0GFnvm-Ae6bNWr3bc4v8-E2Hm3vz3gbVUBngUqXHAdWD0VkUkipNrWSBOFvspCneA15Y5RJscXxdIGFocubGKQJGktUaVkuYi1xOdegIuoxxWFkKnJ0sHzVBPjiKzF40icRHtIx5PxVoXGAjGJFpGTGAkuVg3hKXZ7Okjzr53a2gDuXP_fft0NuNZSbfamkY2bsGZcDy43xTePe7Cx3dW668GVURticAt-tqUSeOFyhH3O0HrNNe1vUMAuO8JGCiRkdYKLwlUsn6PBYMijmXF5-c3UdVBYRtI0Z1TwufxM9qSoXrI_DruxGd7uFtS1tGzwnss4Uky7nI3MghyJwt2Gj-fye-7AuiuduQfMRqHROsuEVTrAx-owCaSNpzrwiXWYPvgdeNKsTeZONUW-pnVQgYzTBnApAi6tAZeKPjxf3jNrUpmc2XuzA1PaqrUqPUFSH54sm3GuaBa0M-Uh9fEV0uJIYZ-7DYSXr5MJjj-Jwz7EK-BedqBk56strvhSJz33_cgTyov78KKTg5Nx_fsz7p_9GY9hY7A_GqbD3fHeA7gqSD59nwu1CeuL-aF5CJeyo0VRzR_Vks7g03nLx2-lRo2D
linkToPdf	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1bb9MwFD4aGwxeuJQBhQFGgiewWtuJnSAhBNuqTdtKhQDtLXMTGyKBU5puaD-Bv8Sv4ziXjjKxtz3wFsnOxfF3fD7bx-cDeGpTZRjyZJyWyNgv3Wg6liqgjOlQWClDW8l0ftpTw2F0cBCPluBXexbGh1W2Y2I1UGdF6tfIewInU_6EUBz3bBMWMdocvJ58p15Byu-0tnIaNUR2zckPnL6Vr3Y2sa-fcT7Y-rCxTRuFAZoGKpxRHVg95tLEEmm3NcLIkKk01DFe-zwyymT40kjYwGIzuI0NEiatBQ4vacYjLfC5l2BFIclA61p5uzUcvZ_7AVVHPCKH6VOkUbw5stMXUa9E14EIRf9IvVFxyhfd4hmuezZk869928odDm78zz_yJlxvSDh5U1vNLVgyrgNXalnOkw5c3WhV8Dqwut8EH9yGn42IAs1dhgaREWzTVPudDx_KS46x0IcYkir1Re5Kkk3RlRBk2MS4rPhmKoUUkno7mxIvBV189p4mL1-SP47BkQne7ma-amHJ9jsqIqmIdhnZNzM_xcjdGny8kN9zB5Zd4cw9IFaGRus05VbpAB-rwzgQNhrrgHk-YrrAWiAlaZPm3auNfE2qcAMRJTX4EgRfUoEv4V14Pr9nUic5Obf2eguspBnwyuQUVV14Mi_GvvK9oJ0pjnwdppAwS4V17tZwnr9OxPj9cRR2IVoA-ryCT4O-WOLyL1U6dMZkn6t-1IUXrU2cfte_m3H__GY8hlU0i2RvZ7j7AK5xb6qMUa7WYXk2PTIP4XJ6PMvL6aPG7AkcXrSB_AaOrJek
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Obesity-induced+extracellular+vesicles+proteins+drive+the+endometrial+cancer+pathogenesis%3A+therapeutic+potential+of+HO-3867+and+Metformin&rft.jtitle=Oncogene&rft.au=Sakaue%2C+Takahiko&rft.au=Dorayappan%2C+Kalpana+Deepa+Priya&rft.au=Zingarelli%2C+Roman&rft.au=Khadraoui%2C+Wafa&rft.date=2024-11-27&rft.pub=Nature+Publishing+Group&rft.issn=0950-9232&rft.eissn=1476-5594&rft.volume=43&rft.issue=49&rft.spage=3586&rft.epage=3597&rft_id=info:doi/10.1038%2Fs41388-024-03182-2&rft.externalDBID=HAS_PDF_LINK
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0950-9232&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0950-9232&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0950-9232&client=summon