Formin-2 drives polymerisation of actin filaments enabling segregation of apicoplasts and cytokinesis in Plasmodium falciparum

In addition to its role in erythrocyte invasion, Plasmodium falciparum actin is implicated in endocytosis, cytokinesis and inheritance of the chloroplast-like organelle called the apicoplast. Previously, the inability to visualise filamentous actin (F-actin) dynamics had restricted the characterisat...

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Veröffentlicht in:	eLife Jg. 8
Hauptverfasser:	Stortz, Johannes Felix, Del Rosario, Mario, Singer, Mirko, Wilkes, Jonathan M, Meissner, Markus, Das, Sujaan
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England eLife Sciences Publications Ltd 19.07.2019 eLife Sciences Publications, Ltd
Schlagworte:	Actin Actin Cytoskeleton - chemistry Actin Cytoskeleton - metabolism Actins - genetics Actins - metabolism apicoplast Apicoplasts Apicoplasts - chemistry Apicoplasts - metabolism Cell Biology Chloroplasts Conditional mutant CRISPR Cytokinesis Cytokinesis - genetics Endocytosis Endocytosis - genetics Erythrocytes Erythrocytes - chemistry Erythrocytes - parasitology Filaments formin Formins - chemistry Formins - genetics Gene Expression Regulation - genetics Heredity Humans malaria Malaria, Falciparum - genetics Malaria, Falciparum - metabolism Malaria, Falciparum - parasitology Microbiology and Infectious Disease Microscopy Motility Parasites Parasitology Plasmodium Plasmodium falciparum Plasmodium falciparum - chemistry Plasmodium falciparum - metabolism Polymerization Protein Binding Regulatory proteins Research Advance Toxoplasma Toxoplasma - metabolism Toxoplasma - pathogenicity Toxoplasma gondii toxoplasmosis Netherlands actin Toxoplasma gondii cell biology infectious disease toxoplasmosis P. falciparum formin microbiology malaria apicoplast
ISSN:	2050-084X, 2050-084X
Online-Zugang:	Volltext
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