Implications of obesity and insulin resistance for the treatment of oestrogen receptor-positive breast cancer

Breast cancer is the most common cancer in women, and incidence rates are rising, it is thought in part, due to increasing levels of obesity. Endocrine therapy (ET) remains the cornerstone of systemic therapy for early and advanced oestrogen receptor-positive (ER + ) breast cancer, but despite treat...

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Published in:British journal of cancer Vol. 131; no. 11; pp. 1724 - 1736
Main Authors: Javed, Sohail Rooman, Skolariki, Aglaia, Zameer, Mohammed Zeeshan, Lord, Simon R
Format: Journal Article
Language:English
Published: England Nature Publishing Group 14.12.2024
Subjects:
Antineoplastic Agents, Hormonal - adverse effects
Antineoplastic Agents, Hormonal - therapeutic use
Body mass index
Breast cancer
Breast Neoplasms - drug therapy
Breast Neoplasms - metabolism
Cancer therapies
Clinical outcomes
Diabetes mellitus
Drug Resistance, Neoplasm
Endocrine therapy
Estrogen receptors
Female
Humans
Insulin Resistance
Obesity
Obesity - complications
Obesity - metabolism
Receptors, Estrogen - metabolism
Toxicity
Womens health
ISSN:0007-0920, 1532-1827, 1532-1827
Online Access:Get full text
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Summary:Breast cancer is the most common cancer in women, and incidence rates are rising, it is thought in part, due to increasing levels of obesity. Endocrine therapy (ET) remains the cornerstone of systemic therapy for early and advanced oestrogen receptor-positive (ER + ) breast cancer, but despite treatment advances, it is becoming more evident that obesity and insulin resistance are associated with worse outcomes. Here, we describe the current understanding of the relationship between both obesity and diabetes and the prevalence and outcomes for ER+ breast cancer. We also discuss the mechanisms associated with resistance to ET and the relationship to treatment toxicity.
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ISSN:0007-0920
1532-1827
1532-1827
DOI:10.1038/s41416-024-02833-1