Identification of patient-specific CD4+ and CD8+ T cell neoantigens through HLA-unbiased genetic screens

Cancer neoantigens that arise from tumor mutations are drivers of tumor-specific T cell responses, but identification of T cell-recognized neoantigens in individual patients is challenging. Previous methods have restricted antigen discovery to selected HLA alleles, thereby limiting the breadth of ne...

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Veröffentlicht in:	Nature biotechnology Jg. 41; H. 6; S. 783 - 787
Hauptverfasser:	Cattaneo, Chiara M., Battaglia, Thomas, Urbanus, Jos, Moravec, Ziva, Voogd, Rhianne, de Groot, Rosa, Hartemink, Koen J., Haanen, John B. A. G., Voest, Emile E., Schumacher, Ton N., Scheper, Wouter
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	New York Nature Publishing Group US 01.06.2023 Nature Publishing Group
Schlagworte:	631/250/251 631/61/191 631/67/580 Agriculture Antigens Antigens, Neoplasm Bioinformatics Biomedical and Life Sciences Biomedical Engineering/Biotechnology Biomedicine Biotechnology Brief Communication Cancer CD4 antigen CD4-Positive T-Lymphocytes CD8 antigen CD8-Positive T-Lymphocytes Communication Genetic screening Genotypes Histocompatibility antigen HLA Humans Identification Life Sciences Lymphocytes Lymphocytes T Mutation Neoantigens Neoplasms Oncology Patients T cell receptors Tumors
ISSN:	1087-0156, 1546-1696, 1546-1696
Online-Zugang:	Volltext
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