Clinical implications of T cell exhaustion for cancer immunotherapy

Immunotherapy has been a remarkable clinical advancement in the treatment of cancer. T cells are pivotal to the efficacy of current cancer immunotherapies, including immune-checkpoint inhibitors and adoptive cell therapies. However, cancer is associated with T cell exhaustion, a hypofunctional state...

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Veröffentlicht in:	Nature reviews. Clinical oncology Jg. 19; H. 12; S. 775 - 790
Hauptverfasser:	Chow, Andrew, Perica, Karlo, Klebanoff, Christopher A, Wolchok, Jedd D
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Nature Publishing Group 01.12.2022
Schlagworte:	Antigens Cancer Cancer immunotherapy Chronic exposure Clinical outcomes Epigenetics Humans Immune Checkpoint Inhibitors Immunotherapy Immunotherapy, Adoptive Lymphocytes Lymphocytes T Microenvironments Neoplasms Reviews T-Lymphocytes Tumor Microenvironment Tumors
ISSN:	1759-4774, 1759-4782, 1759-4782
Online-Zugang:	Volltext
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