Therapeutic induction of antigen-specific immune tolerance

The development of therapeutic approaches for the induction of robust, long-lasting and antigen-specific immune tolerance remains an important unmet clinical need for the management of autoimmunity, allergy, organ transplantation and gene therapy. Recent breakthroughs in our understanding of immune...

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Veröffentlicht in:Nature reviews. Immunology Jg. 24; H. 5; S. 338 - 357
Hauptverfasser: Kenison, Jessica E, Stevens, Nikolas A, Quintana, Francisco J
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England Nature Publishing Group 01.05.2024
Schlagworte:
Allergies
Animals
Antigens
Antigens - immunology
Apoptosis
Autoimmune diseases
Autoimmune Diseases - immunology
Autoimmune Diseases - therapy
Autoimmunity
Autoimmunity - immunology
Bone marrow
Cell death
Cloning
Cytokines
Gene therapy
Humans
Immune Tolerance - immunology
Immunological tolerance
Immunology
Lymphocytes
Organ Transplantation
Peptides
Thymus gland
Transcription factors
Transplantation
Transplants & implants
Tumor necrosis factor-TNF
ISSN:1474-1733, 1474-1741, 1474-1741
Online-Zugang:Volltext
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Beschreibung
Zusammenfassung:The development of therapeutic approaches for the induction of robust, long-lasting and antigen-specific immune tolerance remains an important unmet clinical need for the management of autoimmunity, allergy, organ transplantation and gene therapy. Recent breakthroughs in our understanding of immune tolerance mechanisms have opened new research avenues and therapeutic opportunities in this area. Here, we review mechanisms of immune tolerance and novel methods for its therapeutic induction.
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ISSN:1474-1733
1474-1741
1474-1741
DOI:10.1038/s41577-023-00970-x