A promoter interaction map for cardiovascular disease genetics

Over 500 genetic loci have been associated with risk of cardiovascular diseases (CVDs); however, most loci are located in gene-distal non-coding regions and their target genes are not known. Here, we generated high-resolution promoter capture Hi-C (PCHi-C) maps in human induced pluripotent stem cell...

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Veröffentlicht in:	eLife Jg. 7
Hauptverfasser:	Montefiori, Lindsey E, Sobreira, Debora R, Sakabe, Noboru J, Aneas, Ivy, Joslin, Amelia C, Hansen, Grace T, Bozek, Grazyna, Moskowitz, Ivan P, McNally, Elizabeth M, Nóbrega, Marcelo A
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England eLife Sciences Publications Ltd 10.07.2018 eLife Sciences Publications, Ltd
Schlagworte:	capture Hi-C Cardiomyocytes Cardiovascular disease Cardiovascular diseases Cardiovascular Diseases - genetics Chromatin Chromosomes and Gene Expression Epigenetics Gene expression Gene Expression Regulation Gene mapping gene regulation Gene Regulatory Networks Genetic Loci Genetics Genome, Human Genome-Wide Association Study Genomes Genomics GWAS Human Biology and Medicine Humans Induced Pluripotent Stem Cells - cytology Induced Pluripotent Stem Cells - metabolism Myocytes, Cardiac - cytology Myocytes, Cardiac - metabolism Pluripotency Polymorphism, Single Nucleotide Promoter Regions, Genetic Regulatory Elements, Transcriptional Single-nucleotide polymorphism Stem cells Tools and Resources United States > US Chicago Illinois cardiomyocytes human biology cardiovascular disease GWAS gene regulation chromosomes medicine capture Hi-C human gene expression
ISSN:	2050-084X, 2050-084X
Online-Zugang:	Volltext
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