Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) is lethal in 88% of patients 1 , yet harbours mutation-derived T cell neoantigens that are suitable for vaccines 2 , 3 . Here in a phase I trial of adjuvant autogene cevumeran, an individualized neoantigen vaccine based on uridine mRNA–lipoplex nanoparticles,...

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Bibliographic Details
Published in:	Nature (London) Vol. 618; no. 7963; pp. 144 - 150
Main Authors:	Rojas, Luis A., Sethna, Zachary, Soares, Kevin C., Olcese, Cristina, Pang, Nan, Patterson, Erin, Lihm, Jayon, Ceglia, Nicholas, Guasp, Pablo, Chu, Alexander, Yu, Rebecca, Chandra, Adrienne Kaya, Waters, Theresa, Ruan, Jennifer, Amisaki, Masataka, Zebboudj, Abderezak, Odgerel, Zagaa, Payne, George, Derhovanessian, Evelyna, Müller, Felicitas, Rhee, Ina, Yadav, Mahesh, Dobrin, Anton, Sadelain, Michel, Łuksza, Marta, Cohen, Noah, Tang, Laura, Basturk, Olca, Gönen, Mithat, Katz, Seth, Do, Richard Kinh, Epstein, Andrew S., Momtaz, Parisa, Park, Wungki, Sugarman, Ryan, Varghese, Anna M., Won, Elizabeth, Desai, Avni, Wei, Alice C., D’Angelica, Michael I., Kingham, T. Peter, Mellman, Ira, Merghoub, Taha, Wolchok, Jedd D., Sahin, Ugur, Türeci, Özlem, Greenbaum, Benjamin D., Jarnagin, William R., Drebin, Jeffrey, O’Reilly, Eileen M., Balachandran, Vinod P.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.06.2023 Nature Publishing Group
Subjects:	13/31 14/63 38/39 38/91 45/23 5-Fluorouracil 631/67/1059/2325 631/67/1504/1713 Adenocarcinoma Adjuvants, Immunologic - therapeutic use Antigens Antigens, Neoplasm - immunology Cancer therapies Cancer Vaccines - immunology Carcinoma, Pancreatic Ductal - genetics Carcinoma, Pancreatic Ductal - immunology Carcinoma, Pancreatic Ductal - therapy CD8 antigen CD8-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - immunology Chemotherapy Effector cells Folinic acid Humanities and Social Sciences Humans Immunotherapy Irinotecan Lymphocyte Activation - immunology Lymphocytes Lymphocytes T Monoclonal antibodies mRNA mRNA Vaccines multidisciplinary Mutation Nanoparticles Neoantigens Oxaliplatin Pancreatic cancer Pancreatic Neoplasms - genetics Pancreatic Neoplasms - immunology Pancreatic Neoplasms - therapy Patients Science Science (multidisciplinary) Severe acute respiratory syndrome coronavirus 2 Surgery Survival T cell receptors T-Lymphocytes - cytology T-Lymphocytes - immunology Targeted cancer therapy Tumors Uridine Vaccines
ISSN:	0028-0836, 1476-4687, 1476-4687
Online Access:	Get full text
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