Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) is lethal in 88% of patients 1 , yet harbours mutation-derived T cell neoantigens that are suitable for vaccines 2 , 3 . Here in a phase I trial of adjuvant autogene cevumeran, an individualized neoantigen vaccine based on uridine mRNA–lipoplex nanoparticles,...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	Nature (London) Ročník 618; číslo 7963; s. 144 - 150
Hlavní autoři:	Rojas, Luis A., Sethna, Zachary, Soares, Kevin C., Olcese, Cristina, Pang, Nan, Patterson, Erin, Lihm, Jayon, Ceglia, Nicholas, Guasp, Pablo, Chu, Alexander, Yu, Rebecca, Chandra, Adrienne Kaya, Waters, Theresa, Ruan, Jennifer, Amisaki, Masataka, Zebboudj, Abderezak, Odgerel, Zagaa, Payne, George, Derhovanessian, Evelyna, Müller, Felicitas, Rhee, Ina, Yadav, Mahesh, Dobrin, Anton, Sadelain, Michel, Łuksza, Marta, Cohen, Noah, Tang, Laura, Basturk, Olca, Gönen, Mithat, Katz, Seth, Do, Richard Kinh, Epstein, Andrew S., Momtaz, Parisa, Park, Wungki, Sugarman, Ryan, Varghese, Anna M., Won, Elizabeth, Desai, Avni, Wei, Alice C., D’Angelica, Michael I., Kingham, T. Peter, Mellman, Ira, Merghoub, Taha, Wolchok, Jedd D., Sahin, Ugur, Türeci, Özlem, Greenbaum, Benjamin D., Jarnagin, William R., Drebin, Jeffrey, O’Reilly, Eileen M., Balachandran, Vinod P.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 01.06.2023 Nature Publishing Group
Témata:	13/31 14/63 38/39 38/91 45/23 5-Fluorouracil 631/67/1059/2325 631/67/1504/1713 Adenocarcinoma Adjuvants, Immunologic - therapeutic use Antigens Antigens, Neoplasm - immunology Cancer therapies Cancer Vaccines - immunology Carcinoma, Pancreatic Ductal - genetics Carcinoma, Pancreatic Ductal - immunology Carcinoma, Pancreatic Ductal - therapy CD8 antigen CD8-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - immunology Chemotherapy Effector cells Folinic acid Humanities and Social Sciences Humans Immunotherapy Irinotecan Lymphocyte Activation - immunology Lymphocytes Lymphocytes T Monoclonal antibodies mRNA mRNA Vaccines multidisciplinary Mutation Nanoparticles Neoantigens Oxaliplatin Pancreatic cancer Pancreatic Neoplasms - genetics Pancreatic Neoplasms - immunology Pancreatic Neoplasms - therapy Patients Science Science (multidisciplinary) Severe acute respiratory syndrome coronavirus 2 Surgery Survival T cell receptors T-Lymphocytes - cytology T-Lymphocytes - immunology Targeted cancer therapy Tumors Uridine Vaccines
ISSN:	0028-0836, 1476-4687, 1476-4687
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Buďte první, kdo okomentuje tento záznam!