Multi-level analysis of the gut–brain axis shows autism spectrum disorder-associated molecular and microbial profiles

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by heterogeneous cognitive, behavioral and communication impairments. Disruption of the gut–brain axis (GBA) has been implicated in ASD although with limited reproducibility across studies. In this study, we developed a Ba...

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Vydáno v:	Nature neuroscience Ročník 26; číslo 7; s. 1208 - 1217
Hlavní autoři:	Morton, James T., Jin, Dong-Min, Mills, Robert H., Shao, Yan, Rahman, Gibraan, McDonald, Daniel, Zhu, Qiyun, Balaban, Metin, Jiang, Yueyu, Cantrell, Kalen, Gonzalez, Antonio, Carmel, Julie, Frankiensztajn, Linoy Mia, Martin-Brevet, Sandra, Berding, Kirsten, Needham, Brittany D., Zurita, María Fernanda, David, Maude, Averina, Olga V., Kovtun, Alexey S., Noto, Antonio, Mussap, Michele, Wang, Mingbang, Frank, Daniel N., Li, Ellen, Zhou, Wenhao, Fanos, Vassilios, Danilenko, Valery N., Wall, Dennis P., Cárdenas, Paúl, Baldeón, Manuel E., Jacquemont, Sébastien, Koren, Omry, Elliott, Evan, Xavier, Ramnik J., Mazmanian, Sarkis K., Knight, Rob, Gilbert, Jack A., Donovan, Sharon M., Lawley, Trevor D., Carpenter, Bob, Bonneau, Richard, Taroncher-Oldenburg, Gaspar
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	New York Nature Publishing Group US 01.07.2023 Nature Publishing Group
Témata:	631/114/2401 631/208/212 631/326 631/378/1689/1373 Algorithms Amino acids Animal Genetics and Genomics Autism Autism Spectrum Disorder - genetics Autism Spectrum Disorder - metabolism Bayes Theorem Bayesian analysis Behavioral Sciences Biological Techniques Biomedical and Life Sciences Biomedicine Brain Brain architecture Brain-Gut Axis Carbohydrates Cognitive ability Cross-Sectional Studies Cytokines Datasets Diet Disruption Gastrointestinal Microbiome - genetics Gene expression Gut-brain axis Heterogeneity Humans Inflammation Lipids Metabolomics Microbiomes Microorganisms Neurobiology Neurodevelopmental disorders Neurosciences Phenotypes Reproducibility Reproducibility of Results
ISSN:	1097-6256, 1546-1726, 1546-1726
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