Clinical significance of CTNNB1 mutation and Wnt pathway activation in endometrioid endometrial carcinoma

Endometrioid endometrial carcinoma (EEC) is the most common form of endometrial carcinoma. The heterogeneous clinical course of EEC is an obstacle to individualized patient care. We performed an integrated analysis on the multiple-dimensional data types including whole-exome and RNA sequencing, RPPA...

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Veröffentlicht in:	JNCI : Journal of the National Cancer Institute Jg. 106; H. 9
Hauptverfasser:	Liu, Yuexin, Patel, Lalit, Mills, Gordon B, Lu, Karen H, Sood, Anil K, Ding, Li, Kucherlapati, Raju, Mardis, Elaine R, Levine, Douglas A, Shmulevich, Ilya, Broaddus, Russell R, Zhang, Wei
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.09.2014
Schlagworte:	Adult beta Catenin - genetics Biomarkers, Tumor - genetics Carcinoma, Endometrioid - genetics Carcinoma, Endometrioid - metabolism Carcinoma, Endometrioid - mortality Carcinoma, Endometrioid - pathology Endometrial Neoplasms - genetics Endometrial Neoplasms - metabolism Endometrial Neoplasms - mortality Endometrial Neoplasms - pathology Female Gene Expression Profiling Gene Expression Regulation, Neoplastic Humans Kaplan-Meier Estimate Mutation Neoplasm Grading Neoplasm Staging Tissue Array Analysis Transcriptome Wnt Signaling Pathway
ISSN:	1460-2105, 1460-2105
Online-Zugang:	Weitere Angaben
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