Transcriptomic classes of BCR-ABL1 lymphoblastic leukemia

In BCR-ABL1 lymphoblastic leukemia, treatment heterogeneity to tyrosine kinase inhibitors (TKIs), especially in the absence of kinase domain mutations in BCR-ABL1 , is poorly understood. Through deep molecular profiling, we uncovered three transcriptomic subtypes of BCR-ABL1 lymphoblastic leukemia,...

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Veröffentlicht in:	Nature genetics Jg. 55; H. 7; S. 1186 - 1197
Hauptverfasser:	Kim, Jaeseung C., Chan-Seng-Yue, Michelle, Ge, Sabrina, Zeng, Andy G. X., Ng, Karen, Gan, Olga I., Garcia-Prat, Laura, Flores-Figueroa, Eugenia, Woo, Tristan, Zhang, Amy Xin Wei, Arruda, Andrea, Chithambaram, Shivapriya, Dobson, Stephanie M., Khoo, Amanda, Khan, Shahbaz, Ibrahimova, Narmin, George, Ann, Tierens, Anne, Hitzler, Johann, Kislinger, Thomas, Dick, John E., McPherson, John D., Minden, Mark D., Notta, Faiyaz
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	New York Nature Publishing Group US 01.07.2023 Nature Publishing Group
Schlagworte:	38/91 45 45/23 631/208/199 631/67/1990/283/2125 Agriculture Animal Genetics and Genomics Antigens BCR-ABL protein Biomedical and Life Sciences Biomedicine Blood Cancer Research Cell cycle Cell differentiation Cell Differentiation - genetics Clinical outcomes Cloning Depth profiling Disease Flow cytometry Fusion Proteins, bcr-abl - genetics Fusion Proteins, bcr-abl - metabolism Gene expression Gene Expression Profiling Gene Function Genomics Genotype & phenotype Heterogeneity Human Genetics Humans Kinases Kruskal-Wallis test Leukemia Lymphatic leukemia Lymphocytes B Maturation Mutation Patients Phenotypes Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Progenitor cells Protein Kinase Inhibitors - pharmacology Protein Kinase Inhibitors - therapeutic use Protein-tyrosine kinase Stem cells Thermal resistance Transcriptome - genetics Transcriptomics Tyrosine
ISSN:	1061-4036, 1546-1718, 1546-1718
Online-Zugang:	Volltext
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