In vivo single-cell CRISPR uncovers distinct TNF programmes in tumour evolution

The tumour evolution model posits that malignant transformation is preceded by randomly distributed driver mutations in cancer genes, which cause clonal expansions in phenotypically normal tissues. Although clonal expansions can remodel entire tissues 1 – 3 , the mechanisms that result in only a sma...

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Veröffentlicht in:	Nature (London) Jg. 632; H. 8024; S. 419 - 428
Hauptverfasser:	Renz, Peter F., Ghoshdastider, Umesh, Baghai Sain, Simona, Valdivia-Francia, Fabiola, Khandekar, Ameya, Ormiston, Mark, Bernasconi, Martino, Duré, Clara, Kretz, Jonas A., Lee, Minkyoung, Hyams, Katie, Forny, Merima, Pohly, Marcel, Ficht, Xenia, Ellis, Stephanie J., Moor, Andreas E., Sendoel, Ataman
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 08.08.2024 Nature Publishing Group
Schlagworte:	38 38/39 38/91 45 45/100 631/1647/2017 631/208/191/2018 631/67/1244 631/67/70 64 64/60 Animals Autocrine signalling Cancer Carcinogenesis - genetics Carcinogenesis - pathology Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - pathology Cell Transformation, Neoplastic - genetics Clonal Evolution - genetics Clone Cells - metabolism Cloning Clustered Regularly Interspaced Short Palindromic Repeats - genetics CRISPR CRISPR-Cas Systems - genetics Down-regulation Epithelial-Mesenchymal Transition - genetics Evolution Evolutionary genetics Female Gene Expression Regulation, Neoplastic Gene sequencing Genes Humanities and Social Sciences Humans In vivo methods and tests Invasiveness Libraries Macrophages Macrophages - metabolism Male Mice Modules multidisciplinary Mutation Neoplasm Invasiveness - genetics Receptors, Tumor Necrosis Factor, Type I - genetics Receptors, Tumor Necrosis Factor, Type I - metabolism Science Science (multidisciplinary) Signal Transduction - genetics Single-Cell Analysis Squamous cell carcinoma Stem cells Tissues Transcriptome - genetics Transcriptomics Tumor necrosis factor Tumor necrosis factor receptors Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-TNF Tumor Necrosis Factors - genetics Tumor Necrosis Factors - metabolism Tumorigenesis Tumors Ultrasonic imaging
ISSN:	0028-0836, 1476-4687, 1476-4687
Online-Zugang:	Volltext
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