Are Alzheimer’s disease, hypertension, and cerebrocapillary damage related?
Alzheimer’s disease (AD) patients are often subject to vascular dysfunction besides their specific CNS pathology, which warrants further examination of the interaction between vascular factors and the development of dementia. The association of decreased cerebral blood flow (CBF) or hypertension wit...
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| Vydáno v: | Neurobiology of aging Ročník 21; číslo 2; s. 235 - 243 |
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| Hlavní autoři: | , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
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London
Elsevier Inc
01.03.2000
Elsevier Science |
| Témata: | |
| ISSN: | 0197-4580, 1558-1497 |
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| Abstract | Alzheimer’s disease (AD) patients are often subject to vascular dysfunction besides their specific CNS pathology, which warrants further examination of the interaction between vascular factors and the development of dementia. The association of decreased cerebral blood flow (CBF) or hypertension with AD has been a target of growing interest. Parallel with physiological changes, the cerebral capillaries in AD are also prone to degenerative processes. The microvascular abnormalities that are the result of such degeneration may be the morphological correlates of the vascular pathophysiology pointing to a compromised nutrient transport through the capillaries. Animal models have been developed to study the consequences of hypertension and reduced CBF. Spontaneously hypertensive rats are widely used in hypertension research whereas ligation of the carotid arteries has become a method to produce cerebral hypoperfusion. Based on these models, we propose a relationship between hypertension, cerebral hypoperfusion, cerebral capillary malformation and cognitive decline as it occurs in AD. We suggest that the above conditions are functionally related and can contribute to the progression of AD. |
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| AbstractList | Alzheimer's disease (AD) patients are often subject to vascular dysfunction besides their specific CNS pathology, which warrants further examination of the interaction between vascular factors and the development of dementia. The association of decreased cerebral blood flow (CBF) or hypertension with AD has been a target of growing interest. Parallel with physiological changes, the cerebral capillaries in AD are also prone to degenerative processes. The microvascular abnormalities that are the result of such degeneration may be the morphological correlates of the vascular pathophysiology pointing to a compromised nutrient transport through the capillaries. Animal models have been developed to study the consequences of hypertension and reduced CBF. Spontaneously hypertensive rats are widely used in hypertension research whereas ligation of the carotid arteries has become a method to produce cerebral hypoperfusion. Based on these models, we propose a relationship between hypertension, cerebral hypoperfusion, cerebral capillary malformation and cognitive decline as it occurs in AD. We suggest that the above conditions are functionally related and can contribute to the progression of AD. Alzheimer's disease (AD) patients are often subject to vascular dysfunction besides their specific CNS pathology, which warrants further examination of the interaction between vascular factors and the development of dementia. The association of decreased cerebral blood flow (CBF) or hypertension with AD has been a target of growing interest. Parallel with physiological changes, the cerebral capillaries in AD are also prone to degenerative processes. The microvascular abnormalities that are the result of such degeneration may be the morphological correlates of the vascular pathophysiology pointing to a compromised nutrient transport through the capillaries. Animal models have been developed to study the consequences of hypertension and reduced CBF. Spontaneously hypertensive rats are widely used in hypertension research whereas ligation of the carotid arteries has become a method to produce cerebral hypoperfusion. Based on these models, we propose a relationship between hypertension, cerebral hypoperfusion, cerebral capillary malformation and cognitive decline as it occurs in AD. We suggest that the above conditions are functionally related and can contribute to the progression of AD.Alzheimer's disease (AD) patients are often subject to vascular dysfunction besides their specific CNS pathology, which warrants further examination of the interaction between vascular factors and the development of dementia. The association of decreased cerebral blood flow (CBF) or hypertension with AD has been a target of growing interest. Parallel with physiological changes, the cerebral capillaries in AD are also prone to degenerative processes. The microvascular abnormalities that are the result of such degeneration may be the morphological correlates of the vascular pathophysiology pointing to a compromised nutrient transport through the capillaries. Animal models have been developed to study the consequences of hypertension and reduced CBF. Spontaneously hypertensive rats are widely used in hypertension research whereas ligation of the carotid arteries has become a method to produce cerebral hypoperfusion. Based on these models, we propose a relationship between hypertension, cerebral hypoperfusion, cerebral capillary malformation and cognitive decline as it occurs in AD. We suggest that the above conditions are functionally related and can contribute to the progression of AD. |
| Author | De Vos, Rob A.I. Luiten, Paul G.M. Farkas, Eszter Steur, Ernst N.H.Jansen |
| Author_xml | – sequence: 1 givenname: Eszter surname: Farkas fullname: Farkas, Eszter email: E.FARKAS@biol.rug.nl organization: Department of Animal Physiology, Graduate School of Behavioral and Cognitive Neurosciences, University of Groningen, Groningen, The Netherlands – sequence: 2 givenname: Rob A.I. surname: De Vos fullname: De Vos, Rob A.I. organization: The East-Netherlands Laboratorium of Pathology, Medisch Spectrum Twente, Enschede, The Netherlands – sequence: 3 givenname: Ernst N.H.Jansen surname: Steur fullname: Steur, Ernst N.H.Jansen organization: Department of Neurology, Medisch Spectrum Twente, Enschede, The Netherlands – sequence: 4 givenname: Paul G.M. surname: Luiten fullname: Luiten, Paul G.M. organization: Department of Animal Physiology, Graduate School of Behavioral and Cognitive Neurosciences, University of Groningen, Groningen, The Netherlands |
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| Cites_doi | 10.3109/10641969909061021 10.1007/s002340050553 10.1007/s004010050386 10.1016/0006-8993(92)90132-S 10.1038/380168a0 10.1111/j.1749-6632.1997.tb48457.x 10.1177/000331979504600906 10.1111/j.1749-6632.1994.tb44427.x 10.1016/S0306-4522(98)00659-9 10.1016/S0140-6736(98)03086-4 10.1111/j.1749-6632.1997.tb48512.x 10.1161/01.STR.21.2.283 10.1007/s002590050383 10.1097/00002093-199040100-00002 10.1136/jnnp.66.2.228 10.1016/S0304-3940(97)13421-8 10.1136/jnnp.55.12.1182 10.1291/hypres.18.111 10.1093/oxfordjournals.aje.a116868 10.1016/S0163-7258(96)00116-7 10.1080/01616412.1993.11740127 10.1016/S1053-0770(96)80186-8 10.1042/cs0910539 10.1159/000109800 10.1016/0197-4580(92)90076-A 10.1016/S0733-8619(18)30238-X 10.1016/0300-2977(95)00066-V 10.1007/BF00229004 10.1016/0003-4975(94)91666-7 10.1016/0022-510X(95)00105-B 10.1007/s004150050171 10.1080/01616412.1997.11740844 10.1007/s002590050387 10.1007/BF00193951 10.1111/j.1749-6632.2000.tb06352.x 10.1016/S0140-6736(96)90608-X 10.1111/j.1749-6632.1997.tb48479.x 10.1007/s004010051044 10.1016/S0304-3940(99)00239-6 10.1161/01.STR.24.8.1148 10.1016/0361-9230(90)90007-M 10.1139/y92-252 10.1016/S0753-3322(97)89428-0 10.1016/0006-8993(95)01267-2 10.1007/s004010000195 10.1016/S0197-4580(97)00111-5 10.1016/S0306-4522(97)00037-7 10.1016/0006-8993(92)91668-5 10.1016/0006-8993(94)90394-8 |
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| Keywords | Cerebral hypoperfusion Alzheimer’s disease Carotid occlusion Chronic hypertension Cerebral capillaries Human Hypertension Vascular disease Regional blood flow Microcirculation Nervous system diseases Alzheimer disease Central nervous system disease Cardiovascular disease Degenerative disease Hemodynamics Cerebral disorder |
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| References | Furlan, Sila, Chimowitz, Jones (BIB24) 1992; 10 de la Torre, Fortin, Park (BIB7) 1992; 582 Fujishima, Ibayashi, Fujii, Mori (BIB22) 1995; 18 O’Brien, Eagger, Syed, Sahakian, Levy (BIB40) 1992; 55 Ohta, Nishikawa, Kimura, Anayama, Miyamoto (BIB42) 1997; 79 Forette, Seux, Staessen (BIB19) 1998; 352 Dickinson (BIB12) 1996; 91 Fujii, Sadoshima, Okada, Yao, Kuwabara, Ichiya, Fujishima (BIB21) 1990; 21 Ohnishi, Hoshi, Nagamachi, Jinnouchi, Flores, Futami, Watanabe (BIB41) 1995; 36 Croughwell, Newman, Blumenthal (BIB5) 1994; 58 Launer, Masaki, Petrovitch, Foley, Havlik (BIB32) 1995; 274 Kalaria (BIB30) 1996; 72 Sparks, Scheff, Liu, Landers, Coyne, Hunsaker (BIB50) 1995; 131 Nagata, Buchan, Yokoyama (BIB36) 1997; 826 Eberling, Jagust, Reed, Baker (BIB13) 1992; 13 Forette, Rigaud, Morin, Gisselbrecht, Bert (BIB18) 1995; 47 DeKosky, Shih, Schmitt, Coupal, Kirkpatrick (BIB11) 1990; 4 Nobili, Rodriguez, Marenco (BIB39) 1993; 24 Stump DA, Rogers AT, Hammon JW, Newman SP. Cerebral emboli and cognitive outcome after cardiac surgery. J Cardiothorac Vasc Anesth 1996;10(1):113–8; quiz 118–9. Imran, Kawashima, Awata (BIB29) 1999; 66 Pappas, Davidson, Bennett, de la Torre, Fortin, Tenniswood (BIB45) 1997; 826 Thomas, Thomas, McLendon, Sutton, Mullan (BIB52) 1996; 380 de la Torre (BIB10) 1999; 98 Herbert, Brayne (BIB26) 1995; 14 Harik (BIB27) 1992; 70 Pavics, Grunwald, Reichmann (BIB46) 1999; 26 Lis, Gaviria (BIB33) 1997; 19 Arendash, Su, Crawford, Bjugstad, Mullan (BIB1) 1999; 268 Van Kooten, Bots, Breteler (BIB55) 1998; 245 Farkas, De Jong, De Vos, Jansen Steur, Luiten (BIB15) 1999 Horwood, Davies (BIB28) 1994; 425 Fujishima, Tsuchihashi (BIB23) 1999; 21 Fukuyama, Ogawa, Yamaguchi (BIB20) 1994; 35 Gunaydin, Babacan (BIB25) 1998; 4 de la Torre, Mussivand (BIB8) 1993; 15 Luiten, De Jong, Schuurman (BIB34) 1994; 747 Claus, Walstra, Hijdra, Van Royen, Verbeeten, van Gool (BIB4) 1999; 26 Farkas E, De Jong GI, Apró E, De Vos RAI, Jansen Steur ENH, Luiten PGM. Similar ultrastructural breakdown of cerebrocortical capillaries in Alzheimer’s disease, Parkinson’s disease and experimental hypertension. What is the functional link? Ann NY Acad Sci, in press, 2000. Perlmutter, Chui (BIB47) 1990; 24 Pappas, de la Torre, Davidson, Keyes, Fortin (BIB44) 1996; 708 Skoog (BIB49) 1997; 51 Skoog, Lernfelt, Landahl (BIB48) 1996; 347 Wyss, Fisk, van Groen (BIB56) 1992; 592 Tsuchiya, Sako, Yura, Yonemasu (BIB54) 1992; 89 Farkas E, De Jong GI, De Vos RAI, Jansen Steur ENH, Luiten PGM. Pathological features of cerebral cortical capillaries are doubled in Alzheimer’s disease and Parkinson’s disease. Submitted to Acta Neuropathol. In press, 2000. Claudio (BIB3) 1996; 91 Buée, Hof, Delacourte (BIB2) 1997; 826 Nakane, Ibayashi, Fujii, Irie, Sadoshima, Fujishima (BIB37) 1995; 46 Tohgi, Yonezawa, Takahasi (BIB53) 1998; 40 De Jong, Farkas, Stienstra (BIB6) 1999; 91 Mooradian, Chung, Shah (BIB35) 1997; 18 Ni, Ohta, Matsumoto, Wanatabe (BIB38) 1994; 653 Katsuta (BIB31) 1997; 88 de la Torre, C̆ada, Nelson, Davis, Sutherland, Gonzalez–Lima (BIB9) 1997; 233 Elias, Wolf, D’Agostino, Cobb, White (BIB14) 1993; 138 Pantoni L, Garcia JH. Cerebral ischemia and cognitive impairment in the elderly. Facts and research in gerontology. Stroke 1996;(suppl.):171–82. Farkas (10.1016/S0197-4580(00)00122-6_BIB15) 1999 Nagata (10.1016/S0197-4580(00)00122-6_BIB36) 1997; 826 Skoog (10.1016/S0197-4580(00)00122-6_BIB49) 1997; 51 Forette (10.1016/S0197-4580(00)00122-6_BIB18) 1995; 47 Fukuyama (10.1016/S0197-4580(00)00122-6_BIB20) 1994; 35 10.1016/S0197-4580(00)00122-6_BIB43 DeKosky (10.1016/S0197-4580(00)00122-6_BIB11) 1990; 4 Fujii (10.1016/S0197-4580(00)00122-6_BIB21) 1990; 21 Luiten (10.1016/S0197-4580(00)00122-6_BIB34) 1994; 747 Ohnishi (10.1016/S0197-4580(00)00122-6_BIB41) 1995; 36 10.1016/S0197-4580(00)00122-6_BIB16 10.1016/S0197-4580(00)00122-6_BIB17 De Jong (10.1016/S0197-4580(00)00122-6_BIB6) 1999; 91 Kalaria (10.1016/S0197-4580(00)00122-6_BIB30) 1996; 72 de la Torre (10.1016/S0197-4580(00)00122-6_BIB9) 1997; 233 Launer (10.1016/S0197-4580(00)00122-6_BIB32) 1995; 274 Pappas (10.1016/S0197-4580(00)00122-6_BIB45) 1997; 826 Tohgi (10.1016/S0197-4580(00)00122-6_BIB53) 1998; 40 de la Torre (10.1016/S0197-4580(00)00122-6_BIB8) 1993; 15 10.1016/S0197-4580(00)00122-6_BIB51 Wyss (10.1016/S0197-4580(00)00122-6_BIB56) 1992; 592 Croughwell (10.1016/S0197-4580(00)00122-6_BIB5) 1994; 58 Eberling (10.1016/S0197-4580(00)00122-6_BIB13) 1992; 13 Ohta (10.1016/S0197-4580(00)00122-6_BIB42) 1997; 79 Dickinson (10.1016/S0197-4580(00)00122-6_BIB12) 1996; 91 Claus (10.1016/S0197-4580(00)00122-6_BIB4) 1999; 26 Skoog (10.1016/S0197-4580(00)00122-6_BIB48) 1996; 347 Mooradian (10.1016/S0197-4580(00)00122-6_BIB35) 1997; 18 Imran (10.1016/S0197-4580(00)00122-6_BIB29) 1999; 66 Van Kooten (10.1016/S0197-4580(00)00122-6_BIB55) 1998; 245 Lis (10.1016/S0197-4580(00)00122-6_BIB33) 1997; 19 Thomas (10.1016/S0197-4580(00)00122-6_BIB52) 1996; 380 Pavics (10.1016/S0197-4580(00)00122-6_BIB46) 1999; 26 Sparks (10.1016/S0197-4580(00)00122-6_BIB50) 1995; 131 Arendash (10.1016/S0197-4580(00)00122-6_BIB1) 1999; 268 de la Torre (10.1016/S0197-4580(00)00122-6_BIB7) 1992; 582 de la Torre (10.1016/S0197-4580(00)00122-6_BIB10) 1999; 98 Horwood (10.1016/S0197-4580(00)00122-6_BIB28) 1994; 425 Gunaydin (10.1016/S0197-4580(00)00122-6_BIB25) 1998; 4 Nobili (10.1016/S0197-4580(00)00122-6_BIB39) 1993; 24 Katsuta (10.1016/S0197-4580(00)00122-6_BIB31) 1997; 88 Buée (10.1016/S0197-4580(00)00122-6_BIB2) 1997; 826 Claudio (10.1016/S0197-4580(00)00122-6_BIB3) 1996; 91 Tsuchiya (10.1016/S0197-4580(00)00122-6_BIB54) 1992; 89 Harik (10.1016/S0197-4580(00)00122-6_BIB27) 1992; 70 Herbert (10.1016/S0197-4580(00)00122-6_BIB26) 1995; 14 Ni (10.1016/S0197-4580(00)00122-6_BIB38) 1994; 653 Nakane (10.1016/S0197-4580(00)00122-6_BIB37) 1995; 46 Forette (10.1016/S0197-4580(00)00122-6_BIB19) 1998; 352 Pappas (10.1016/S0197-4580(00)00122-6_BIB44) 1996; 708 Perlmutter (10.1016/S0197-4580(00)00122-6_BIB47) 1990; 24 Fujishima (10.1016/S0197-4580(00)00122-6_BIB23) 1999; 21 O’Brien (10.1016/S0197-4580(00)00122-6_BIB40) 1992; 55 Elias (10.1016/S0197-4580(00)00122-6_BIB14) 1993; 138 Furlan (10.1016/S0197-4580(00)00122-6_BIB24) 1992; 10 Fujishima (10.1016/S0197-4580(00)00122-6_BIB22) 1995; 18 |
| References_xml | – volume: 91 start-page: 203 year: 1999 end-page: 210 ident: BIB6 article-title: Cerebral hypoperfusion yields capillary damage in hippocampus CA1 that correlated to spatial memory impairment publication-title: Neurosci – volume: 18 start-page: 111 year: 1995 end-page: 117 ident: BIB22 article-title: Cerebral blood flow and brain function in hypertension publication-title: Hypertens Res – volume: 88 start-page: 65 year: 1997 end-page: 74 ident: BIB31 article-title: Decreased local cerebral blood flow in young and aged spontaneously hypertensive rats publication-title: Fukuoka Igaku Zasshi – reference: Stump DA, Rogers AT, Hammon JW, Newman SP. Cerebral emboli and cognitive outcome after cardiac surgery. J Cardiothorac Vasc Anesth 1996;10(1):113–8; quiz 118–9. – volume: 79 start-page: 1039 year: 1997 end-page: 1050 ident: BIB42 article-title: Chronic cerebral hypoperfusion by permanent internal carotid ligation produces learning impairment without brain damage in rats publication-title: Neuroscience – volume: 138 start-page: 353 year: 1993 end-page: 364 ident: BIB14 article-title: Untreated blood pressure level is inversely related to cognitive functioning publication-title: Am J Epidemiol – volume: 24 start-page: 677 year: 1990 end-page: 686 ident: BIB47 article-title: Microangiopathy, the vascular basement membrane and Alzheimer’s Disease publication-title: Brain Res Bull – volume: 274 start-page: 1846 year: 1995 end-page: 1851 ident: BIB32 article-title: The association between midlife blood pressure levels and late-life cognitive function publication-title: The Honolulu-Asia Aging Study JAMA – reference: Farkas E, De Jong GI, De Vos RAI, Jansen Steur ENH, Luiten PGM. Pathological features of cerebral cortical capillaries are doubled in Alzheimer’s disease and Parkinson’s disease. Submitted to Acta Neuropathol. In press, 2000. – volume: 89 start-page: 87 year: 1992 end-page: 92 ident: BIB54 article-title: Cerebral blood flow and histopathological changes after permanent bilateral carotid artery ligation in Wistar rats publication-title: Exp Brain Res – volume: 24 start-page: 1148 year: 1993 end-page: 1153 ident: BIB39 article-title: Regional cerebral blood flow in chronic hypertension. A correlative study publication-title: Stroke – volume: 425 start-page: 69 year: 1994 end-page: 72 ident: BIB28 article-title: Immunolabeling of hippocampal microvessel glucose transporter protein is reduced in Alzheimer’s disease publication-title: Virchows Arch – volume: 747 start-page: 431 year: 1994 end-page: 451 ident: BIB34 article-title: Cerebrovascular, neuronal, and behavioral effects of long-term Ca publication-title: Ann NY Acad Sci – volume: 55 start-page: 1182 year: 1992 end-page: 1187 ident: BIB40 article-title: A study of regional cerebral blood flow and cognitive performance in Alzheimer’s disease publication-title: J Neuro Neurosur Psych – volume: 131 start-page: 162 year: 1995 end-page: 169 ident: BIB50 article-title: Increased incidence of neurofibrillary tangles (NFT) in non-demented individuals with hypertension publication-title: J Neurol Sci – volume: 4 start-page: 12 year: 1998 end-page: 17 ident: BIB25 article-title: Cerebral hypoperfusion after cardiac surgery and anesthetic strategies publication-title: Ann Thorac Cardiovasc Surg – volume: 233 start-page: 165 year: 1997 end-page: 168 ident: BIB9 article-title: Reduced cytochrome oxidase and memory dysfunction after chronic brain ischemia in aged rats publication-title: Neurosci Lett – volume: 18 start-page: 469 year: 1997 end-page: 474 ident: BIB35 article-title: GLUT-1 expression in the cerebra of patients with Alzheimer’s disease publication-title: Neurobiol Aging – volume: 98 start-page: 1 year: 1999 end-page: 8 ident: BIB10 article-title: Critical threshold cerebral hypoperfusion causes Alzheimer’s disease? publication-title: Acta Neuropathol – reference: Farkas E, De Jong GI, Apró E, De Vos RAI, Jansen Steur ENH, Luiten PGM. Similar ultrastructural breakdown of cerebrocortical capillaries in Alzheimer’s disease, Parkinson’s disease and experimental hypertension. What is the functional link? Ann NY Acad Sci, in press, 2000. – volume: 72 start-page: 193 year: 1996 end-page: 214 ident: BIB30 article-title: Cerebral vessels in aging and Alzheimer’s disease publication-title: Pharmacol Ther – volume: 35 start-page: 1 year: 1994 end-page: 6 ident: BIB20 article-title: Altered cerebral energy metabolism in Alzheimer’s disease publication-title: J Nucl Med – volume: 13 start-page: 483 year: 1992 end-page: 491 ident: BIB13 article-title: Reduced temporal lobe blood flow in Alzheimer’s disease publication-title: Neurobiol Aging – volume: 268 start-page: 17 year: 1999 end-page: 20 ident: BIB1 article-title: Intravascular beta-amyloid infusion increases blood pressure publication-title: Neurosci Lett – volume: 58 start-page: 1702 year: 1994 end-page: 1708 ident: BIB5 article-title: Jugular bulb saturation and cognitive dysfunction after cardiopulmonary bypass publication-title: Ann Thorac Surg – volume: 592 start-page: 135 year: 1992 end-page: 140 ident: BIB56 article-title: Impaired learning and memory in mature spontaneously hypertensive rats publication-title: Brain Res – volume: 826 start-page: 7 year: 1997 end-page: 24 ident: BIB2 article-title: Brain microvascular changes in Alzheimer’s disease and other dementias publication-title: Ann NY Acad Sci – volume: 21 start-page: 927 year: 1999 end-page: 935 ident: BIB23 article-title: Hypertension and dementia publication-title: Clin Exp Hypertension – volume: 245 start-page: 32 year: 1998 end-page: 39 ident: BIB55 article-title: The Dutch vascular factors in dementia study publication-title: J Neurol – volume: 4 start-page: 14 year: 1990 end-page: 23 ident: BIB11 article-title: Assessing utility of single photon emission computed tomography (SPECT) scan in Alzheimer disease publication-title: Alzheimer Dis Assoc Disord – volume: 582 start-page: 186 year: 1992 end-page: 195 ident: BIB7 article-title: Chronic cerebrovascular insufficiency induces dementia-like deficits in aged rats publication-title: Brain Res – volume: 380 start-page: 168 year: 1996 end-page: 171 ident: BIB52 article-title: beta-Amyloid mediated vasoactivity and vascular endothelial damage publication-title: Nature – volume: 47 start-page: 185 year: 1995 end-page: 194 ident: BIB18 article-title: Assessing vascular dementia publication-title: Neth J Med – start-page: 165 year: 1999 end-page: 170 ident: BIB15 article-title: Cerebral microvascular breakdown in Alzheimer’s disease and in experimental cerebral hypoperfusion publication-title: Alzheimer’s disease and related disorders – reference: Pantoni L, Garcia JH. Cerebral ischemia and cognitive impairment in the elderly. Facts and research in gerontology. Stroke 1996;(suppl.):171–82. – volume: 10 start-page: 145 year: 1992 end-page: 166 ident: BIB24 article-title: Neurologic complications related to cardiac surgery publication-title: Neurol Clin – volume: 70 start-page: S113 year: 1992 end-page: S117 ident: BIB27 article-title: Changes in the glucose transporter of brain capillaries publication-title: Can J Physiol Pharmacol – volume: 708 start-page: 50 year: 1996 end-page: 58 ident: BIB44 article-title: Chronic reduction of cerebral blood flow in the adult rat publication-title: Brain Res – volume: 347 start-page: 1141 year: 1996 end-page: 1145 ident: BIB48 article-title: A 15-year longitudinal study on blood pressure and dementia publication-title: Lancet – volume: 352 start-page: 1347 year: 1998 end-page: 1351 ident: BIB19 article-title: Prevention of dementia in randomized double-blind placebo-controlled Systolic Hypertension in Europe (Sys-Eur) trial publication-title: Lancet – volume: 14 start-page: 240 year: 1995 end-page: 257 ident: BIB26 article-title: Epidemiology of vascular dementia publication-title: Neuroepidemiology – volume: 40 start-page: 131 year: 1998 end-page: 137 ident: BIB53 article-title: Cerebral blood flow and oxygen metabolism in senile dementia of Alzheimer’s type and vascular dementia with deep white matter changes publication-title: Neuroradiology – volume: 66 start-page: 228 year: 1999 end-page: 232 ident: BIB29 article-title: Tc-99m HMPAO SPECT in the evaluation of Alzheimer’s disease publication-title: J Neurol Neurosurg Psychiatry – volume: 51 start-page: 367 year: 1997 end-page: 375 ident: BIB49 article-title: The relationship between blood pressure and dementia publication-title: Biomed Pharmacother – volume: 19 start-page: 471 year: 1997 end-page: 480 ident: BIB33 article-title: Vascular dementia, hypertension, and the brain publication-title: Neurol Res – volume: 36 start-page: 1163 year: 1995 end-page: 1169 ident: BIB41 article-title: High-resolution SPECT to assess hippocampal perfusion in neuropsychiatric diseases publication-title: J Nucl Med – volume: 826 start-page: 272 year: 1997 end-page: 281 ident: BIB36 article-title: Misery perfusion with preserved vascular reactivity in Alzheimer’s disease publication-title: Ann NY Acad Sci – volume: 15 start-page: 146 year: 1993 end-page: 153 ident: BIB8 article-title: Can disturbed brain microcirculation cause Alzheimer’s disease? publication-title: Neurol Res – volume: 653 start-page: 231 year: 1994 end-page: 236 ident: BIB38 article-title: Progressive cognitive impairment after chronic cerebral hypoperfusion induced by permanent occlusion of bilateral carotid arteries in rats publication-title: Brain Res – volume: 91 start-page: 6 year: 1996 end-page: 14 ident: BIB3 article-title: Ultrastructural features of the blood–brain barrier in biopsy tissue from Alzheimer’s disease patients publication-title: Acta Neuroptahol – volume: 91 start-page: 539 year: 1996 end-page: 550 ident: BIB12 article-title: Cerebral oxidative metabolism in hypertension publication-title: Clin Sci – volume: 21 start-page: 283 year: 1990 end-page: 290 ident: BIB21 article-title: Cerebral blood flow and metabolism in normotensive and hypertensive patients with transient neurologic deficits publication-title: Stroke – volume: 826 start-page: 498 year: 1997 end-page: 501 ident: BIB45 article-title: Chronic ischemia publication-title: Ann NY Acad Sci – volume: 26 start-page: 239 year: 1999 end-page: 245 ident: BIB46 article-title: Regional cerebral blood flow single-photon emission tomography with 99 mTc-HMPAO and the acetazolamide test in the evaluation of vascular and Alzheimer’s dementia publication-title: Eur J Nucl Med – volume: 46 start-page: 801 year: 1995 end-page: 810 ident: BIB37 article-title: Cerebral blood flow and metabolism in hypertensive patients with cerebral infarction publication-title: Angiology – volume: 26 start-page: 265 year: 1999 end-page: 271 ident: BIB4 article-title: Measurement of temporal regional cerebral pefusion with single-photon emission tomography predicts rate of decline in language function and survival in early Alzheimer’s disease publication-title: Eur J Nucl Med – volume: 21 start-page: 927 issue: 5&6 year: 1999 ident: 10.1016/S0197-4580(00)00122-6_BIB23 article-title: Hypertension and dementia publication-title: Clin Exp Hypertension doi: 10.3109/10641969909061021 – volume: 40 start-page: 131 issue: 3 year: 1998 ident: 10.1016/S0197-4580(00)00122-6_BIB53 article-title: Cerebral blood flow and oxygen metabolism in senile dementia of Alzheimer’s type and vascular dementia with deep white matter changes publication-title: Neuroradiology doi: 10.1007/s002340050553 – volume: 91 start-page: 6 year: 1996 ident: 10.1016/S0197-4580(00)00122-6_BIB3 article-title: Ultrastructural features of the blood–brain barrier in biopsy tissue from Alzheimer’s disease patients publication-title: Acta Neuroptahol doi: 10.1007/s004010050386 – volume: 582 start-page: 186 year: 1992 ident: 10.1016/S0197-4580(00)00122-6_BIB7 article-title: Chronic cerebrovascular insufficiency induces dementia-like deficits in aged rats publication-title: Brain Res doi: 10.1016/0006-8993(92)90132-S – volume: 380 start-page: 168 issue: 6570 year: 1996 ident: 10.1016/S0197-4580(00)00122-6_BIB52 article-title: beta-Amyloid mediated vasoactivity and vascular endothelial damage publication-title: Nature doi: 10.1038/380168a0 – volume: 826 start-page: 7 year: 1997 ident: 10.1016/S0197-4580(00)00122-6_BIB2 article-title: Brain microvascular changes in Alzheimer’s disease and other dementias publication-title: Ann NY Acad Sci doi: 10.1111/j.1749-6632.1997.tb48457.x – volume: 46 start-page: 801 issue: 9 year: 1995 ident: 10.1016/S0197-4580(00)00122-6_BIB37 article-title: Cerebral blood flow and metabolism in hypertensive patients with cerebral infarction publication-title: Angiology doi: 10.1177/000331979504600906 – volume: 747 start-page: 431 year: 1994 ident: 10.1016/S0197-4580(00)00122-6_BIB34 article-title: Cerebrovascular, neuronal, and behavioral effects of long-term Ca2+ channel blockade in aging normotensive and hypertensive rat strains publication-title: Ann NY Acad Sci doi: 10.1111/j.1749-6632.1994.tb44427.x – volume: 91 start-page: 203 issue: 1 year: 1999 ident: 10.1016/S0197-4580(00)00122-6_BIB6 article-title: Cerebral hypoperfusion yields capillary damage in hippocampus CA1 that correlated to spatial memory impairment publication-title: Neurosci doi: 10.1016/S0306-4522(98)00659-9 – volume: 352 start-page: 1347 issue: 9137 year: 1998 ident: 10.1016/S0197-4580(00)00122-6_BIB19 article-title: Prevention of dementia in randomized double-blind placebo-controlled Systolic Hypertension in Europe (Sys-Eur) trial publication-title: Lancet doi: 10.1016/S0140-6736(98)03086-4 – volume: 826 start-page: 498 year: 1997 ident: 10.1016/S0197-4580(00)00122-6_BIB45 article-title: Chronic ischemia publication-title: Ann NY Acad Sci doi: 10.1111/j.1749-6632.1997.tb48512.x – volume: 35 start-page: 1 issue: 1 year: 1994 ident: 10.1016/S0197-4580(00)00122-6_BIB20 article-title: Altered cerebral energy metabolism in Alzheimer’s disease publication-title: J Nucl Med – volume: 36 start-page: 1163 year: 1995 ident: 10.1016/S0197-4580(00)00122-6_BIB41 article-title: High-resolution SPECT to assess hippocampal perfusion in neuropsychiatric diseases publication-title: J Nucl Med – volume: 21 start-page: 283 issue: 2 year: 1990 ident: 10.1016/S0197-4580(00)00122-6_BIB21 article-title: Cerebral blood flow and metabolism in normotensive and hypertensive patients with transient neurologic deficits publication-title: Stroke doi: 10.1161/01.STR.21.2.283 – volume: 26 start-page: 239 issue: 3 year: 1999 ident: 10.1016/S0197-4580(00)00122-6_BIB46 article-title: Regional cerebral blood flow single-photon emission tomography with 99 mTc-HMPAO and the acetazolamide test in the evaluation of vascular and Alzheimer’s dementia publication-title: Eur J Nucl Med doi: 10.1007/s002590050383 – volume: 4 start-page: 14 issue: 1 year: 1990 ident: 10.1016/S0197-4580(00)00122-6_BIB11 article-title: Assessing utility of single photon emission computed tomography (SPECT) scan in Alzheimer disease publication-title: Alzheimer Dis Assoc Disord doi: 10.1097/00002093-199040100-00002 – volume: 66 start-page: 228 issue: 2 year: 1999 ident: 10.1016/S0197-4580(00)00122-6_BIB29 article-title: Tc-99m HMPAO SPECT in the evaluation of Alzheimer’s disease publication-title: J Neurol Neurosurg Psychiatry doi: 10.1136/jnnp.66.2.228 – volume: 233 start-page: 165 year: 1997 ident: 10.1016/S0197-4580(00)00122-6_BIB9 article-title: Reduced cytochrome oxidase and memory dysfunction after chronic brain ischemia in aged rats publication-title: Neurosci Lett doi: 10.1016/S0304-3940(97)13421-8 – volume: 55 start-page: 1182 year: 1992 ident: 10.1016/S0197-4580(00)00122-6_BIB40 article-title: A study of regional cerebral blood flow and cognitive performance in Alzheimer’s disease publication-title: J Neuro Neurosur Psych doi: 10.1136/jnnp.55.12.1182 – volume: 18 start-page: 111 issue: 2 year: 1995 ident: 10.1016/S0197-4580(00)00122-6_BIB22 article-title: Cerebral blood flow and brain function in hypertension publication-title: Hypertens Res doi: 10.1291/hypres.18.111 – volume: 138 start-page: 353 year: 1993 ident: 10.1016/S0197-4580(00)00122-6_BIB14 article-title: Untreated blood pressure level is inversely related to cognitive functioning publication-title: Am J Epidemiol doi: 10.1093/oxfordjournals.aje.a116868 – volume: 72 start-page: 193 issue: 3 year: 1996 ident: 10.1016/S0197-4580(00)00122-6_BIB30 article-title: Cerebral vessels in aging and Alzheimer’s disease publication-title: Pharmacol Ther doi: 10.1016/S0163-7258(96)00116-7 – volume: 15 start-page: 146 year: 1993 ident: 10.1016/S0197-4580(00)00122-6_BIB8 article-title: Can disturbed brain microcirculation cause Alzheimer’s disease? publication-title: Neurol Res doi: 10.1080/01616412.1993.11740127 – ident: 10.1016/S0197-4580(00)00122-6_BIB51 doi: 10.1016/S1053-0770(96)80186-8 – volume: 91 start-page: 539 year: 1996 ident: 10.1016/S0197-4580(00)00122-6_BIB12 article-title: Cerebral oxidative metabolism in hypertension publication-title: Clin Sci doi: 10.1042/cs0910539 – volume: 14 start-page: 240 issue: 5 year: 1995 ident: 10.1016/S0197-4580(00)00122-6_BIB26 article-title: Epidemiology of vascular dementia publication-title: Neuroepidemiology doi: 10.1159/000109800 – volume: 13 start-page: 483 year: 1992 ident: 10.1016/S0197-4580(00)00122-6_BIB13 article-title: Reduced temporal lobe blood flow in Alzheimer’s disease publication-title: Neurobiol Aging doi: 10.1016/0197-4580(92)90076-A – volume: 10 start-page: 145 issue: 1 year: 1992 ident: 10.1016/S0197-4580(00)00122-6_BIB24 article-title: Neurologic complications related to cardiac surgery publication-title: Neurol Clin doi: 10.1016/S0733-8619(18)30238-X – volume: 47 start-page: 185 issue: 4 year: 1995 ident: 10.1016/S0197-4580(00)00122-6_BIB18 article-title: Assessing vascular dementia publication-title: Neth J Med doi: 10.1016/0300-2977(95)00066-V – start-page: 165 year: 1999 ident: 10.1016/S0197-4580(00)00122-6_BIB15 article-title: Cerebral microvascular breakdown in Alzheimer’s disease and in experimental cerebral hypoperfusion – volume: 89 start-page: 87 issue: 1 year: 1992 ident: 10.1016/S0197-4580(00)00122-6_BIB54 article-title: Cerebral blood flow and histopathological changes after permanent bilateral carotid artery ligation in Wistar rats publication-title: Exp Brain Res doi: 10.1007/BF00229004 – volume: 58 start-page: 1702 year: 1994 ident: 10.1016/S0197-4580(00)00122-6_BIB5 article-title: Jugular bulb saturation and cognitive dysfunction after cardiopulmonary bypass publication-title: Ann Thorac Surg doi: 10.1016/0003-4975(94)91666-7 – volume: 131 start-page: 162 year: 1995 ident: 10.1016/S0197-4580(00)00122-6_BIB50 article-title: Increased incidence of neurofibrillary tangles (NFT) in non-demented individuals with hypertension publication-title: J Neurol Sci doi: 10.1016/0022-510X(95)00105-B – volume: 245 start-page: 32 issue: 1 year: 1998 ident: 10.1016/S0197-4580(00)00122-6_BIB55 article-title: The Dutch vascular factors in dementia study publication-title: J Neurol doi: 10.1007/s004150050171 – volume: 19 start-page: 471 issue: 5 year: 1997 ident: 10.1016/S0197-4580(00)00122-6_BIB33 article-title: Vascular dementia, hypertension, and the brain publication-title: Neurol Res doi: 10.1080/01616412.1997.11740844 – volume: 26 start-page: 265 issue: 3 year: 1999 ident: 10.1016/S0197-4580(00)00122-6_BIB4 article-title: Measurement of temporal regional cerebral pefusion with single-photon emission tomography predicts rate of decline in language function and survival in early Alzheimer’s disease publication-title: Eur J Nucl Med doi: 10.1007/s002590050387 – volume: 425 start-page: 69 issue: 1 year: 1994 ident: 10.1016/S0197-4580(00)00122-6_BIB28 article-title: Immunolabeling of hippocampal microvessel glucose transporter protein is reduced in Alzheimer’s disease publication-title: Virchows Arch doi: 10.1007/BF00193951 – ident: 10.1016/S0197-4580(00)00122-6_BIB17 doi: 10.1111/j.1749-6632.2000.tb06352.x – volume: 347 start-page: 1141 year: 1996 ident: 10.1016/S0197-4580(00)00122-6_BIB48 article-title: A 15-year longitudinal study on blood pressure and dementia publication-title: Lancet doi: 10.1016/S0140-6736(96)90608-X – volume: 826 start-page: 272 year: 1997 ident: 10.1016/S0197-4580(00)00122-6_BIB36 article-title: Misery perfusion with preserved vascular reactivity in Alzheimer’s disease publication-title: Ann NY Acad Sci doi: 10.1111/j.1749-6632.1997.tb48479.x – volume: 98 start-page: 1 year: 1999 ident: 10.1016/S0197-4580(00)00122-6_BIB10 article-title: Critical threshold cerebral hypoperfusion causes Alzheimer’s disease? publication-title: Acta Neuropathol doi: 10.1007/s004010051044 – volume: 268 start-page: 17 year: 1999 ident: 10.1016/S0197-4580(00)00122-6_BIB1 article-title: Intravascular beta-amyloid infusion increases blood pressure publication-title: Neurosci Lett doi: 10.1016/S0304-3940(99)00239-6 – volume: 88 start-page: 65 issue: 3 year: 1997 ident: 10.1016/S0197-4580(00)00122-6_BIB31 article-title: Decreased local cerebral blood flow in young and aged spontaneously hypertensive rats publication-title: Fukuoka Igaku Zasshi – volume: 24 start-page: 1148 issue: 8 year: 1993 ident: 10.1016/S0197-4580(00)00122-6_BIB39 article-title: Regional cerebral blood flow in chronic hypertension. A correlative study publication-title: Stroke doi: 10.1161/01.STR.24.8.1148 – volume: 24 start-page: 677 year: 1990 ident: 10.1016/S0197-4580(00)00122-6_BIB47 article-title: Microangiopathy, the vascular basement membrane and Alzheimer’s Disease publication-title: Brain Res Bull doi: 10.1016/0361-9230(90)90007-M – volume: 70 start-page: S113 issue: suppl year: 1992 ident: 10.1016/S0197-4580(00)00122-6_BIB27 article-title: Changes in the glucose transporter of brain capillaries publication-title: Can J Physiol Pharmacol doi: 10.1139/y92-252 – volume: 274 start-page: 1846 year: 1995 ident: 10.1016/S0197-4580(00)00122-6_BIB32 article-title: The association between midlife blood pressure levels and late-life cognitive function publication-title: The Honolulu-Asia Aging Study JAMA – volume: 51 start-page: 367 year: 1997 ident: 10.1016/S0197-4580(00)00122-6_BIB49 article-title: The relationship between blood pressure and dementia publication-title: Biomed Pharmacother doi: 10.1016/S0753-3322(97)89428-0 – ident: 10.1016/S0197-4580(00)00122-6_BIB43 – volume: 708 start-page: 50 year: 1996 ident: 10.1016/S0197-4580(00)00122-6_BIB44 article-title: Chronic reduction of cerebral blood flow in the adult rat publication-title: Brain Res doi: 10.1016/0006-8993(95)01267-2 – volume: 4 start-page: 12 issue: 1 year: 1998 ident: 10.1016/S0197-4580(00)00122-6_BIB25 article-title: Cerebral hypoperfusion after cardiac surgery and anesthetic strategies publication-title: Ann Thorac Cardiovasc Surg – ident: 10.1016/S0197-4580(00)00122-6_BIB16 doi: 10.1007/s004010000195 – volume: 18 start-page: 469 issue: 5 year: 1997 ident: 10.1016/S0197-4580(00)00122-6_BIB35 article-title: GLUT-1 expression in the cerebra of patients with Alzheimer’s disease publication-title: Neurobiol Aging doi: 10.1016/S0197-4580(97)00111-5 – volume: 79 start-page: 1039 issue: 4 year: 1997 ident: 10.1016/S0197-4580(00)00122-6_BIB42 article-title: Chronic cerebral hypoperfusion by permanent internal carotid ligation produces learning impairment without brain damage in rats publication-title: Neuroscience doi: 10.1016/S0306-4522(97)00037-7 – volume: 592 start-page: 135 year: 1992 ident: 10.1016/S0197-4580(00)00122-6_BIB56 article-title: Impaired learning and memory in mature spontaneously hypertensive rats publication-title: Brain Res doi: 10.1016/0006-8993(92)91668-5 – volume: 653 start-page: 231 year: 1994 ident: 10.1016/S0197-4580(00)00122-6_BIB38 article-title: Progressive cognitive impairment after chronic cerebral hypoperfusion induced by permanent occlusion of bilateral carotid arteries in rats publication-title: Brain Res doi: 10.1016/0006-8993(94)90394-8 |
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| Snippet | Alzheimer’s disease (AD) patients are often subject to vascular dysfunction besides their specific CNS pathology, which warrants further examination of the... Alzheimer's disease (AD) patients are often subject to vascular dysfunction besides their specific CNS pathology, which warrants further examination of the... |
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| SubjectTerms | Aged Alzheimer Disease - etiology Alzheimer Disease - pathology Alzheimer Disease - physiopathology Alzheimer’s disease Animals Biological and medical sciences Capillaries - pathology Carotid occlusion Cerebral capillaries Cerebral hypoperfusion Cerebrovascular Circulation - physiology Chronic hypertension Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Humans Hypertension - etiology Hypertension - pathology Hypertension - physiopathology Medical sciences Middle Aged Neurology Rats |
| Title | Are Alzheimer’s disease, hypertension, and cerebrocapillary damage related? |
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