Is it still worth pursuing the repurposing of metformin as a cancer therapeutic?

Over the past 15 years, there has been great interest in the potential to repurpose the diabetes drug, metformin, as a cancer treatment. However, despite considerable efforts being made to investigate its efficacy in a number of large randomised clinical trials in different tumour types, results hav...

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Vydáno v:	British journal of cancer Ročník 128; číslo 6; s. 958 - 966
Hlavní autoři:	Lord, Simon R, Harris, Adrian L
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England Nature Publishing Group 06.04.2023
Témata:	Antidiabetics Breast cancer Cancer Cancer therapies Cell growth Chemotherapy Clinical trials Diabetes Diabetes mellitus Drug dosages Drug Repositioning Glucose Humans Hypoglycemic Agents - therapeutic use Insulin Kinases Metabolism Metabolites Metformin Metformin - therapeutic use Neoplasms - drug therapy Oncology Pharmacodynamics Radiation therapy Tumors
ISSN:	0007-0920, 1532-1827, 1532-1827
On-line přístup:	Získat plný text
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