Is it still worth pursuing the repurposing of metformin as a cancer therapeutic?

Over the past 15 years, there has been great interest in the potential to repurpose the diabetes drug, metformin, as a cancer treatment. However, despite considerable efforts being made to investigate its efficacy in a number of large randomised clinical trials in different tumour types, results hav...

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Vydané v:British journal of cancer Ročník 128; číslo 6; s. 958 - 966
Hlavní autori: Lord, Simon R, Harris, Adrian L
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: England Nature Publishing Group 06.04.2023
Predmet:
Antidiabetics
Breast cancer
Cancer
Cancer therapies
Cell growth
Chemotherapy
Clinical trials
Diabetes
Diabetes mellitus
Drug dosages
Drug Repositioning
Glucose
Humans
Hypoglycemic Agents - therapeutic use
Insulin
Kinases
Metabolism
Metabolites
Metformin
Metformin - therapeutic use
Neoplasms - drug therapy
Oncology
Pharmacodynamics
Radiation therapy
Tumors
ISSN:0007-0920, 1532-1827, 1532-1827
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Abstract Over the past 15 years, there has been great interest in the potential to repurpose the diabetes drug, metformin, as a cancer treatment. However, despite considerable efforts being made to investigate its efficacy in a number of large randomised clinical trials in different tumour types, results have been disappointing to date. This perspective article summarises how interest initially developed in the oncological potential of metformin and the diverse clinical programme of work to date including our contribution to establishing the intra-tumoral pharmacodynamic effects of metformin in the clinic. We also discuss the lessons that can be learnt from this experience and whether a further clinical investigation of metformin in cancer is warranted.
AbstractList Over the past 15 years, there has been great interest in the potential to repurpose the diabetes drug, metformin, as a cancer treatment. However, despite considerable efforts being made to investigate its efficacy in a number of large randomised clinical trials in different tumour types, results have been disappointing to date. This perspective article summarises how interest initially developed in the oncological potential of metformin and the diverse clinical programme of work to date including our contribution to establishing the intra-tumoral pharmacodynamic effects of metformin in the clinic. We also discuss the lessons that can be learnt from this experience and whether a further clinical investigation of metformin in cancer is warranted.
Over the past 15 years, there has been great interest in the potential to repurpose the diabetes drug, metformin, as a cancer treatment. However, despite considerable efforts being made to investigate its efficacy in a number of large randomised clinical trials in different tumour types, results have been disappointing to date. This perspective article summarises how interest initially developed in the oncological potential of metformin and the diverse clinical programme of work to date including our contribution to establishing the intra-tumoral pharmacodynamic effects of metformin in the clinic. We also discuss the lessons that can be learnt from this experience and whether a further clinical investigation of metformin in cancer is warranted.Over the past 15 years, there has been great interest in the potential to repurpose the diabetes drug, metformin, as a cancer treatment. However, despite considerable efforts being made to investigate its efficacy in a number of large randomised clinical trials in different tumour types, results have been disappointing to date. This perspective article summarises how interest initially developed in the oncological potential of metformin and the diverse clinical programme of work to date including our contribution to establishing the intra-tumoral pharmacodynamic effects of metformin in the clinic. We also discuss the lessons that can be learnt from this experience and whether a further clinical investigation of metformin in cancer is warranted.
Author Lord, Simon R
Harris, Adrian L
Author_xml – sequence: 1
  givenname: Simon R
  orcidid: 0000-0001-7946-5609
  surname: Lord
  fullname: Lord, Simon R
  email: simon.lord@oncology.ox.ac.uk
  organization: Department of Oncology, University of Oxford, Oxford, UK. simon.lord@oncology.ox.ac.uk
– sequence: 2
  givenname: Adrian L
  orcidid: 0000-0003-1376-8409
  surname: Harris
  fullname: Harris, Adrian L
  organization: Department of Oncology, University of Oxford, Oxford, UK
BackLink https://www.ncbi.nlm.nih.gov/pubmed/36823364$$D View this record in MEDLINE/PubMed
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StartPage 958
SubjectTerms Antidiabetics
Breast cancer
Cancer
Cancer therapies
Cell growth
Chemotherapy
Clinical trials
Diabetes
Diabetes mellitus
Drug dosages
Drug Repositioning
Glucose
Humans
Hypoglycemic Agents - therapeutic use
Insulin
Kinases
Metabolism
Metabolites
Metformin
Metformin - therapeutic use
Neoplasms - drug therapy
Oncology
Pharmacodynamics
Radiation therapy
Tumors
Title Is it still worth pursuing the repurposing of metformin as a cancer therapeutic?
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