The genomic basis of childhood T-lineage acute lymphoblastic leukaemia

T-lineage acute lymphoblastic leukaemia (T-ALL) is a high-risk tumour 1 that has eluded comprehensive genomic characterization, which is partly due to the high frequency of noncoding genomic alterations that result in oncogene deregulation 2 , 3 . Here we report an integrated analysis of genome and...

Full description

Saved in:

Bibliographic Details
Published in:	Nature (London) Vol. 632; no. 8027; pp. 1082 - 1091
Main Authors:	Pölönen, Petri, Di Giacomo, Danika, Seffernick, Anna Eames, Elsayed, Abdelrahman, Kimura, Shunsuke, Benini, Francesca, Montefiori, Lindsey E., Wood, Brent L., Xu, Jason, Chen, Changya, Cheng, Zhongshan, Newman, Haley, Myers, Jason, Iacobucci, Ilaria, Li, Elizabeth, Sussman, Jonathan, Hedges, Dale, Hui, Yawei, Diorio, Caroline, Uppuluri, Lahari, Frank, David, Fan, Yiping, Chang, Yunchao, Meshinchi, Soheil, Ries, Rhonda, Shraim, Rawan, Li, Alexander, Bernt, Kathrin M., Devidas, Meenakshi, Winter, Stuart S., Dunsmore, Kimberly P., Inaba, Hiroto, Carroll, William L., Ramirez, Nilsa C., Phillips, Aaron H., Kriwacki, Richard W., Yang, Jun J., Vincent, Tiffaney L., Zhao, Yaqi, Ghate, Pankaj S., Wang, Jian, Reilly, Colleen, Zhou, Xin, Sanders, Mathijs A., Takita, Junko, Kato, Motohiro, Takasugi, Nao, Chang, Bill H., Press, Richard D., Loh, Mignon, Rampersaud, Evadnie, Raetz, Elizabeth, Hunger, Stephen P., Tan, Kai, Chang, Ti-Cheng, Wu, Gang, Pounds, Stanley B., Mullighan, Charles G., Teachey, David T.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 29.08.2024 Nature Publishing Group
Subjects:	38 38/91 45 631/114/2401 631/67/1990/283/2125 631/67/68 631/67/69 Acute lymphoblastic leukemia Cell culture Child Childhood Children Chromatin Chromatin - genetics Chromatin - metabolism Deregulation Enhancer Elements, Genetic - genetics Enhancers Epigenomics Female Gene expression Gene Expression Regulation, Leukemic Gene sequencing Genes Genetic diversity Genome, Human - genetics Genomes Genomic analysis Genomics Hematopoietic stem cells Humanities and Social Sciences Humans Leukemia Lymphocytes Lymphocytes T Male Medical prognosis multidisciplinary Mutation Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - pathology Precursors Remission Science Science (multidisciplinary) Single-Cell Analysis Stem cells T cell receptors T-Lymphocytes - cytology T-Lymphocytes - pathology Topology Transcriptome - genetics Transcriptomes
ISSN:	0028-0836, 1476-4687, 1476-4687
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Abstract	T-lineage acute lymphoblastic leukaemia (T-ALL) is a high-risk tumour 1 that has eluded comprehensive genomic characterization, which is partly due to the high frequency of noncoding genomic alterations that result in oncogene deregulation 2 , 3 . Here we report an integrated analysis of genome and transcriptome sequencing of tumour and remission samples from more than 1,300 uniformly treated children with T-ALL, coupled with epigenomic and single-cell analyses of malignant and normal T cell precursors. This approach identified 15 subtypes with distinct genomic drivers, gene expression patterns, developmental states and outcomes. Analyses of chromatin topology revealed multiple mechanisms of enhancer deregulation that involve enhancers and genes in a subtype-specific manner, thereby demonstrating widespread involvement of the noncoding genome. We show that the immunophenotypically described, high-risk entity of early T cell precursor ALL is superseded by a broader category of ‘early T cell precursor-like’ leukaemia. This category has a variable immunophenotype and diverse genomic alterations of a core set of genes that encode regulators of hematopoietic stem cell development. Using multivariable outcome models, we show that genetic subtypes, driver and concomitant genetic alterations independently predict treatment failure and survival. These findings provide a roadmap for the classification, risk stratification and mechanistic understanding of this disease. Comprehensive genomic and transcriptomics analyses of more than 1,300 cases of childhood T-lineage acute lymphoblastic leukaemia identify 15 distinct subtypes that are associated with specific outcomes.
AbstractList	T-lineage acute lymphoblastic leukemia (T-ALL) is a high-risk tumor1 that has eluded comprehensive genomic characterization, in part due to the high frequency of non-coding genomic alterations resulting in oncogene deregulation2,3. Here we report integrated analysis of genome and transcriptome sequencing of tumor and remission samples from over 1300 uniformly treated children with T-ALL, coupled with epigenomic and single cell analysis of malignant and normal T cell precursors. This identified 15 subtypes with distinct genomic drivers, gene expression, developmental state and outcome. Analysis of chromatin topology elucidated multiple mechanisms of enhancer deregulation that involve enhancers and genes in a subtype-specific fashion, demonstrating widespread involvement of the noncoding genome. We show that the immunophenotypically-described, high-risk entity of early T-cell precursor ALL is superseded by a broader category of “ETP-like” leukemia with variable immunophenotype and diverse genomic alterations of a core set of genes encoding regulators of hematopoietic stem cell development. Using multivariable outcome models, we show that genetic subtypes, driver and concomitant genetic alterations independently predict treatment failure and survival. These findings provide a roadmap for the classification, risk stratification and mechanistic understanding of this disease. T-lineage acute lymphoblastic leukaemia (T-ALL) is a high-risk tumour that has eluded comprehensive genomic characterization, which is partly due to the high frequency of noncoding genomic alterations that result in oncogene deregulation . Here we report an integrated analysis of genome and transcriptome sequencing of tumour and remission samples from more than 1,300 uniformly treated children with T-ALL, coupled with epigenomic and single-cell analyses of malignant and normal T cell precursors. This approach identified 15 subtypes with distinct genomic drivers, gene expression patterns, developmental states and outcomes. Analyses of chromatin topology revealed multiple mechanisms of enhancer deregulation that involve enhancers and genes in a subtype-specific manner, thereby demonstrating widespread involvement of the noncoding genome. We show that the immunophenotypically described, high-risk entity of early T cell precursor ALL is superseded by a broader category of 'early T cell precursor-like' leukaemia. This category has a variable immunophenotype and diverse genomic alterations of a core set of genes that encode regulators of hematopoietic stem cell development. Using multivariable outcome models, we show that genetic subtypes, driver and concomitant genetic alterations independently predict treatment failure and survival. These findings provide a roadmap for the classification, risk stratification and mechanistic understanding of this disease. T-lineage acute lymphoblastic leukaemia (T-ALL) is a high-risk tumour 1 that has eluded comprehensive genomic characterization, which is partly due to the high frequency of noncoding genomic alterations that result in oncogene deregulation 2 , 3 . Here we report an integrated analysis of genome and transcriptome sequencing of tumour and remission samples from more than 1,300 uniformly treated children with T-ALL, coupled with epigenomic and single-cell analyses of malignant and normal T cell precursors. This approach identified 15 subtypes with distinct genomic drivers, gene expression patterns, developmental states and outcomes. Analyses of chromatin topology revealed multiple mechanisms of enhancer deregulation that involve enhancers and genes in a subtype-specific manner, thereby demonstrating widespread involvement of the noncoding genome. We show that the immunophenotypically described, high-risk entity of early T cell precursor ALL is superseded by a broader category of ‘early T cell precursor-like’ leukaemia. This category has a variable immunophenotype and diverse genomic alterations of a core set of genes that encode regulators of hematopoietic stem cell development. Using multivariable outcome models, we show that genetic subtypes, driver and concomitant genetic alterations independently predict treatment failure and survival. These findings provide a roadmap for the classification, risk stratification and mechanistic understanding of this disease. Comprehensive genomic and transcriptomics analyses of more than 1,300 cases of childhood T-lineage acute lymphoblastic leukaemia identify 15 distinct subtypes that are associated with specific outcomes. T-lineage acute lymphoblastic leukaemia (T-ALL) is a high-risk tumour1 that has eluded comprehensive genomic characterization, which is partly due to the high frequency of noncoding genomic alterations that result in oncogene deregulation2,3. Here we report an integrated analysis of genome and transcriptome sequencing of tumour and remission samples from more than 1,300 uniformly treated children with T-ALL, coupled with epigenomic and single-cell analyses of malignant and normal T cell precursors. This approach identified 15 subtypes with distinct genomic drivers, gene expression patterns, developmental states and outcomes. Analyses of chromatin topology revealed multiple mechanisms of enhancer deregulation that involve enhancers and genes in a subtype-specific manner, thereby demonstrating widespread involvement of the noncoding genome. We show that the immunophenotypically described, high-risk entity of early T cell precursor ALL is superseded by a broader category of 'early T cell precursor-like' leukaemia. This category has a variable immunophenotype and diverse genomic alterations of a core set of genes that encode regulators of hematopoietic stem cell development. Using multivariable outcome models, we show that genetic subtypes, driver and concomitant genetic alterations independently predict treatment failure and survival. These findings provide a roadmap for the classification, risk stratification and mechanistic understanding of this disease.T-lineage acute lymphoblastic leukaemia (T-ALL) is a high-risk tumour1 that has eluded comprehensive genomic characterization, which is partly due to the high frequency of noncoding genomic alterations that result in oncogene deregulation2,3. Here we report an integrated analysis of genome and transcriptome sequencing of tumour and remission samples from more than 1,300 uniformly treated children with T-ALL, coupled with epigenomic and single-cell analyses of malignant and normal T cell precursors. This approach identified 15 subtypes with distinct genomic drivers, gene expression patterns, developmental states and outcomes. Analyses of chromatin topology revealed multiple mechanisms of enhancer deregulation that involve enhancers and genes in a subtype-specific manner, thereby demonstrating widespread involvement of the noncoding genome. We show that the immunophenotypically described, high-risk entity of early T cell precursor ALL is superseded by a broader category of 'early T cell precursor-like' leukaemia. This category has a variable immunophenotype and diverse genomic alterations of a core set of genes that encode regulators of hematopoietic stem cell development. Using multivariable outcome models, we show that genetic subtypes, driver and concomitant genetic alterations independently predict treatment failure and survival. These findings provide a roadmap for the classification, risk stratification and mechanistic understanding of this disease. T-lineage acute lymphoblastic leukaemia (T-ALL) is a high-risk tumour1 that has eluded comprehensive genomic characterization, which is partly due to the high frequency of noncoding genomic alterations that result in oncogene deregulation2,3. Here we report an integrated analysis of genome and transcriptome sequencing of tumour and remission samples from more than 1,300 uniformly treated children with T-ALL, coupled with epigenomic and single-cell analyses of malignant and normal T cell precursors. This approach identified 15 subtypes with distinct genomic drivers, gene expression patterns, developmental states and outcomes. Analyses of chromatin topology revealed multiple mechanisms of enhancer deregulation that involve enhancers and genes in a subtype-specific manner, thereby demonstrating widespread involvement of the noncoding genome. We show that the immunophenotypically described, high-risk entity of early T cell precursor ALL is superseded by a broader category of'early T cell precursor-like' leukaemia. This category has a variable immunophenotype and diverse genomic alterations of a core set of genes that encode regulators of hematopoietic stem cell development. Using multivariable outcome models, we show that genetic subtypes, driver and concomitant genetic alterations independently predict treatment failure and survival. These findings provide a roadmap for the classification, risk stratification and mechanistic understanding of this disease.
Author	Myers, Jason Teachey, David T. Benini, Francesca Reilly, Colleen Press, Richard D. Sussman, Jonathan Chang, Bill H. Tan, Kai Fan, Yiping Shraim, Rawan Wu, Gang Montefiori, Lindsey E. Ramirez, Nilsa C. Bernt, Kathrin M. Winter, Stuart S. Mullighan, Charles G. Kato, Motohiro Phillips, Aaron H. Zhou, Xin Takasugi, Nao Rampersaud, Evadnie Chen, Changya Yang, Jun J. Inaba, Hiroto Hunger, Stephen P. Loh, Mignon Pölönen, Petri Li, Elizabeth Uppuluri, Lahari Wood, Brent L. Sanders, Mathijs A. Chang, Yunchao Devidas, Meenakshi Raetz, Elizabeth Chang, Ti-Cheng Cheng, Zhongshan Carroll, William L. Seffernick, Anna Eames Newman, Haley Li, Alexander Iacobucci, Ilaria Vincent, Tiffaney L. Wang, Jian Elsayed, Abdelrahman Kimura, Shunsuke Dunsmore, Kimberly P. Pounds, Stanley B. Diorio, Caroline Meshinchi, Soheil Di Giacomo, Danika Hui, Yawei Ries, Rhonda Ghate, Pankaj S. Frank, David Takita, Junko Zhao, Yaqi Xu, Jason Kriwacki, Richard W. Hedges, Dale
AuthorAffiliation	16 Department of Oncology, St. Jude Children’s Research Hospital, Memphis, TN, USA 6 Children’s Hospital Los Angeles, Laboratory Medicine, Los Angeles, CA, USA 20 Department of Structural Biology, St. Jude Children’s Research Hospital, Memphis, TN, USA 7 Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA 18 Department of Pediatrics and Pathology, Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA 21 Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Sciences Center, Memphis, TN, USA 1 Department of Pathology, St. Jude Children’s Research Hospital, Memphis, TN, USA 3 Department of Biostatistics, St. Jude Children’s Research Hospital, Memphis, TN, USA 22 Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, TN, USA 23 Department of Computational Biology, St. Jude Children’s Research Hospital, Memphis, TN, USA 12 Fred Hutchinson Cancer Research Center, Clinical Research Division, Seattle,
AuthorAffiliation_xml	– name: 19 Department of Pathology and Laboratory Medicine, Nationwide Children’s Hospital, Columbus, OH, USA – name: 13 Global Pediatric Medicine, St. Jude Children’s Research Hospital, Memphis, TN, USA – name: 1 Department of Pathology, St. Jude Children’s Research Hospital, Memphis, TN, USA – name: 12 Fred Hutchinson Cancer Research Center, Clinical Research Division, Seattle, WA, USA – name: 6 Children’s Hospital Los Angeles, Laboratory Medicine, Los Angeles, CA, USA – name: 14 Research Institute and Cancer and Blood Disorders Program, Children’s Minnesota, Minneapolis, MN, USA – name: 27 Department of Pediatrics, Tokyo University, Tokyo, Japan – name: 5 Department of Pediatric Hematology and Oncology, Bambino Gesù Children’s Research Hospital, Rome, Italy – name: 26 Department of Pediatrics, Graduate School of Medicine Kyoto University, Kyoto, Japan – name: 18 Department of Pediatrics and Pathology, Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA – name: 25 Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK – name: 17 Division of Pediatric Hematology Oncology, Department of Pediatrics, NYU Langone Health, New York, NY, USA – name: 21 Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Sciences Center, Memphis, TN, USA – name: 2 Department of Chemistry, Biology and Biotechnology, University of Perugia, Perugia, Italy – name: 7 Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA – name: 10 Center for Applied Bioinformatics, St. Jude Children’s Research Hospital, Memphis, TN, USA – name: 23 Department of Computational Biology, St. Jude Children’s Research Hospital, Memphis, TN, USA – name: 24 Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands – name: 8 Division of Oncology and Center for Childhood Cancer Research, Children’s Hospital of Philadelphia, Philadelphia, PA, USA – name: 4 Department of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Rome, Italy – name: 30 Department of Pediatrics and the Ben Towne Center for Childhood Cancer Research, Seattle Children’s Hospital, University of Washington, Seattle, WA, USA – name: 31 Center for Single Cell Biology, Children’s Hospital of Philadelphia, Philadelphia, PA, USA – name: 28 Department of Pediatrics, Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA – name: 16 Department of Oncology, St. Jude Children’s Research Hospital, Memphis, TN, USA – name: 20 Department of Structural Biology, St. Jude Children’s Research Hospital, Memphis, TN, USA – name: 9 Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia, Philadelphia, PA, USA – name: 15 Division of Oncology, University of Virginia Children’s Hospital, Charlottesville, VA, USA – name: 29 Department of Pathology, Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA – name: 3 Department of Biostatistics, St. Jude Children’s Research Hospital, Memphis, TN, USA – name: 22 Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, TN, USA – name: 11 Department of Pediatrics and the Center for Childhood Cancer Research, Children’s Hospital of Philadelphia, Philadelphia, PA, USA
Author_xml	– sequence: 1 givenname: Petri orcidid: 0000-0001-6128-9985 surname: Pölönen fullname: Pölönen, Petri organization: Department of Pathology, St Jude Children’s Research Hospital – sequence: 2 givenname: Danika orcidid: 0000-0002-5558-7967 surname: Di Giacomo fullname: Di Giacomo, Danika organization: Department of Pathology, St Jude Children’s Research Hospital, Department of Chemistry, Biology and Biotechnology, University of Perugia – sequence: 3 givenname: Anna Eames orcidid: 0000-0003-0848-4604 surname: Seffernick fullname: Seffernick, Anna Eames organization: Department of Biostatistics, St Jude Children’s Research Hospital – sequence: 4 givenname: Abdelrahman surname: Elsayed fullname: Elsayed, Abdelrahman organization: Department of Pathology, St Jude Children’s Research Hospital, Department of Biostatistics, St Jude Children’s Research Hospital – sequence: 5 givenname: Shunsuke orcidid: 0000-0002-2158-467X surname: Kimura fullname: Kimura, Shunsuke organization: Department of Pathology, St Jude Children’s Research Hospital – sequence: 6 givenname: Francesca orcidid: 0000-0003-2900-6636 surname: Benini fullname: Benini, Francesca organization: Department of Pathology, St Jude Children’s Research Hospital, Department of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Department of Pediatric Hematology and Oncology, Bambino Gesù Children’s Research Hospital – sequence: 7 givenname: Lindsey E. orcidid: 0000-0003-2342-6349 surname: Montefiori fullname: Montefiori, Lindsey E. organization: Department of Pathology, St Jude Children’s Research Hospital – sequence: 8 givenname: Brent L. surname: Wood fullname: Wood, Brent L. organization: Children’s Hospital Los Angeles, Laboratory Medicine – sequence: 9 givenname: Jason surname: Xu fullname: Xu, Jason organization: Perelman School of Medicine, University of Pennsylvania – sequence: 10 givenname: Changya surname: Chen fullname: Chen, Changya organization: Division of Oncology and Center for Childhood Cancer Research, Children’s Hospital of Philadelphia, Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia – sequence: 11 givenname: Zhongshan surname: Cheng fullname: Cheng, Zhongshan organization: Center for Applied Bioinformatics, St Jude Children’s Research Hospital – sequence: 12 givenname: Haley surname: Newman fullname: Newman, Haley organization: Department of Pediatrics and the Center for Childhood Cancer Research, Children’s Hospital of Philadelphia – sequence: 13 givenname: Jason orcidid: 0000-0002-0341-0860 surname: Myers fullname: Myers, Jason organization: Center for Applied Bioinformatics, St Jude Children’s Research Hospital – sequence: 14 givenname: Ilaria orcidid: 0000-0003-2008-1365 surname: Iacobucci fullname: Iacobucci, Ilaria organization: Department of Pathology, St Jude Children’s Research Hospital – sequence: 15 givenname: Elizabeth surname: Li fullname: Li, Elizabeth organization: Division of Oncology and Center for Childhood Cancer Research, Children’s Hospital of Philadelphia – sequence: 16 givenname: Jonathan orcidid: 0000-0002-3057-3550 surname: Sussman fullname: Sussman, Jonathan organization: Perelman School of Medicine, University of Pennsylvania – sequence: 17 givenname: Dale surname: Hedges fullname: Hedges, Dale organization: Center for Applied Bioinformatics, St Jude Children’s Research Hospital – sequence: 18 givenname: Yawei surname: Hui fullname: Hui, Yawei organization: Center for Applied Bioinformatics, St Jude Children’s Research Hospital – sequence: 19 givenname: Caroline surname: Diorio fullname: Diorio, Caroline organization: Perelman School of Medicine, University of Pennsylvania, Division of Oncology and Center for Childhood Cancer Research, Children’s Hospital of Philadelphia, Department of Pediatrics and the Center for Childhood Cancer Research, Children’s Hospital of Philadelphia – sequence: 20 givenname: Lahari orcidid: 0000-0002-7217-892X surname: Uppuluri fullname: Uppuluri, Lahari organization: Division of Oncology and Center for Childhood Cancer Research, Children’s Hospital of Philadelphia – sequence: 21 givenname: David surname: Frank fullname: Frank, David organization: Perelman School of Medicine, University of Pennsylvania – sequence: 22 givenname: Yiping surname: Fan fullname: Fan, Yiping organization: Center for Applied Bioinformatics, St Jude Children’s Research Hospital – sequence: 23 givenname: Yunchao orcidid: 0009-0005-3906-5543 surname: Chang fullname: Chang, Yunchao organization: Department of Pathology, St Jude Children’s Research Hospital – sequence: 24 givenname: Soheil surname: Meshinchi fullname: Meshinchi, Soheil organization: Fred Hutchinson Cancer Research Center, Clinical Research Division – sequence: 25 givenname: Rhonda orcidid: 0000-0002-3702-7923 surname: Ries fullname: Ries, Rhonda organization: Fred Hutchinson Cancer Research Center, Clinical Research Division – sequence: 26 givenname: Rawan surname: Shraim fullname: Shraim, Rawan organization: Department of Pediatrics and the Center for Childhood Cancer Research, Children’s Hospital of Philadelphia – sequence: 27 givenname: Alexander surname: Li fullname: Li, Alexander organization: Division of Oncology and Center for Childhood Cancer Research, Children’s Hospital of Philadelphia – sequence: 28 givenname: Kathrin M. orcidid: 0000-0002-0691-356X surname: Bernt fullname: Bernt, Kathrin M. organization: Perelman School of Medicine, University of Pennsylvania, Division of Oncology and Center for Childhood Cancer Research, Children’s Hospital of Philadelphia, Department of Pediatrics and the Center for Childhood Cancer Research, Children’s Hospital of Philadelphia – sequence: 29 givenname: Meenakshi orcidid: 0000-0002-1099-3478 surname: Devidas fullname: Devidas, Meenakshi organization: Global Pediatric Medicine, St Jude Children’s Research Hospital – sequence: 30 givenname: Stuart S. orcidid: 0000-0003-3583-7727 surname: Winter fullname: Winter, Stuart S. organization: Research Institute and Cancer and Blood Disorders Program, Children’s Minnesota – sequence: 31 givenname: Kimberly P. surname: Dunsmore fullname: Dunsmore, Kimberly P. organization: Division of Oncology, University of Virginia Children’s Hospital – sequence: 32 givenname: Hiroto orcidid: 0000-0003-0605-7342 surname: Inaba fullname: Inaba, Hiroto organization: Department of Oncology, St Jude Children’s Research Hospital – sequence: 33 givenname: William L. surname: Carroll fullname: Carroll, William L. organization: Division of Pediatric Hematology Oncology, Department of Pediatrics, NYU Langone Health, Department of Pediatrics and Pathology, Perlmutter Cancer Center, NYU Langone Health – sequence: 34 givenname: Nilsa C. surname: Ramirez fullname: Ramirez, Nilsa C. organization: Department of Pathology and Laboratory Medicine, Nationwide Children’s Hospital – sequence: 35 givenname: Aaron H. surname: Phillips fullname: Phillips, Aaron H. organization: Department of Structural Biology, St Jude Children’s Research Hospital – sequence: 36 givenname: Richard W. orcidid: 0000-0002-9798-6018 surname: Kriwacki fullname: Kriwacki, Richard W. organization: Department of Structural Biology, St Jude Children’s Research Hospital, Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Sciences Center – sequence: 37 givenname: Jun J. orcidid: 0000-0002-0770-9659 surname: Yang fullname: Yang, Jun J. organization: Department of Pharmaceutical Sciences, St Jude Children’s Research Hospital – sequence: 38 givenname: Tiffaney L. surname: Vincent fullname: Vincent, Tiffaney L. organization: Division of Oncology and Center for Childhood Cancer Research, Children’s Hospital of Philadelphia – sequence: 39 givenname: Yaqi orcidid: 0000-0002-8230-5312 surname: Zhao fullname: Zhao, Yaqi organization: Department of Pathology, St Jude Children’s Research Hospital – sequence: 40 givenname: Pankaj S. orcidid: 0000-0001-6678-781X surname: Ghate fullname: Ghate, Pankaj S. organization: Department of Pathology, St Jude Children’s Research Hospital – sequence: 41 givenname: Jian surname: Wang fullname: Wang, Jian organization: Department of Computational Biology, St Jude Children’s Research Hospital – sequence: 42 givenname: Colleen orcidid: 0000-0003-3119-9940 surname: Reilly fullname: Reilly, Colleen organization: Department of Computational Biology, St Jude Children’s Research Hospital – sequence: 43 givenname: Xin orcidid: 0000-0003-3979-8200 surname: Zhou fullname: Zhou, Xin organization: Department of Computational Biology, St Jude Children’s Research Hospital – sequence: 44 givenname: Mathijs A. surname: Sanders fullname: Sanders, Mathijs A. organization: Department of Hematology, Erasmus MC Cancer Institute, Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute – sequence: 45 givenname: Junko surname: Takita fullname: Takita, Junko organization: Department of Pediatrics, Graduate School of Medicine Kyoto University – sequence: 46 givenname: Motohiro surname: Kato fullname: Kato, Motohiro organization: Department of Pediatrics, Tokyo University – sequence: 47 givenname: Nao surname: Takasugi fullname: Takasugi, Nao organization: Department of Pediatrics, Tokyo University – sequence: 48 givenname: Bill H. orcidid: 0000-0003-3783-1820 surname: Chang fullname: Chang, Bill H. organization: Department of Pediatrics, Knight Cancer Institute, Oregon Health and Science University – sequence: 49 givenname: Richard D. orcidid: 0000-0002-2103-5144 surname: Press fullname: Press, Richard D. organization: Department of Pathology, Knight Cancer Institute, Oregon Health and Science University – sequence: 50 givenname: Mignon orcidid: 0000-0003-4099-4700 surname: Loh fullname: Loh, Mignon organization: Department of Pediatrics and the Ben Towne Center for Childhood Cancer Research, Seattle Children’s Hospital, University of Washington – sequence: 51 givenname: Evadnie surname: Rampersaud fullname: Rampersaud, Evadnie organization: Center for Applied Bioinformatics, St Jude Children’s Research Hospital – sequence: 52 givenname: Elizabeth surname: Raetz fullname: Raetz, Elizabeth organization: Division of Pediatric Hematology Oncology, Department of Pediatrics, NYU Langone Health, Department of Pediatrics and Pathology, Perlmutter Cancer Center, NYU Langone Health – sequence: 53 givenname: Stephen P. surname: Hunger fullname: Hunger, Stephen P. organization: Perelman School of Medicine, University of Pennsylvania, Division of Oncology and Center for Childhood Cancer Research, Children’s Hospital of Philadelphia, Department of Pediatrics and the Center for Childhood Cancer Research, Children’s Hospital of Philadelphia – sequence: 54 givenname: Kai surname: Tan fullname: Tan, Kai organization: Perelman School of Medicine, University of Pennsylvania, Division of Oncology and Center for Childhood Cancer Research, Children’s Hospital of Philadelphia, Center for Single Cell Biology, Children’s Hospital of Philadelphia – sequence: 55 givenname: Ti-Cheng orcidid: 0000-0001-5302-9147 surname: Chang fullname: Chang, Ti-Cheng organization: Center for Applied Bioinformatics, St Jude Children’s Research Hospital – sequence: 56 givenname: Gang orcidid: 0000-0002-1678-5864 surname: Wu fullname: Wu, Gang organization: Center for Applied Bioinformatics, St Jude Children’s Research Hospital – sequence: 57 givenname: Stanley B. orcidid: 0000-0002-9167-2114 surname: Pounds fullname: Pounds, Stanley B. organization: Department of Biostatistics, St Jude Children’s Research Hospital – sequence: 58 givenname: Charles G. orcidid: 0000-0002-1871-1850 surname: Mullighan fullname: Mullighan, Charles G. email: charles.mullighan@stjude.org organization: Department of Pathology, St Jude Children’s Research Hospital – sequence: 59 givenname: David T. orcidid: 0000-0001-7373-8987 surname: Teachey fullname: Teachey, David T. email: teacheyd@chop.edu organization: Perelman School of Medicine, University of Pennsylvania, Division of Oncology and Center for Childhood Cancer Research, Children’s Hospital of Philadelphia, Department of Pediatrics and the Center for Childhood Cancer Research, Children’s Hospital of Philadelphia
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/39143224$$D View this record in MEDLINE/PubMed
BookMark	eNp9kUtv1DAYRS1URKePP8ACRWLDxvTz214hVFFaqVI3w9ryOM7ExYmHOEHqv8fDtDy66MoLn3N17XuCjsY8BoTeEvhIgOmLwonQEgPlGJQGheEVWhGuJOZSqyO0AqAag2byGJ2Ucg8Agij-Bh0zQzijlK_Q1boPzTaMeYi-2bgSS5O7xvcxtX3ObbPGKY7BbUPj_DKHJj0Muz5vkitzFVJYvrswRHeGXnculXD-eJ6ib1df1pfX-Pbu683l51vsuRIzFsrJjaeGCMqNFopI6ERHZEuZ4KzlVErjtPOtV8qAM9p00mkKgSnTBdqxU_TpkLtbNkNofRjnySW7m-LgpgebXbT_34yxt9v80xIiCQGpasKHx4Qp_1hCme0Qiw8puTHkpVgGhhFFhd6j75-h93mZxvo-ywjUzwfBWKXe_VvpT5enP66APgB-yqVMobM-zm6Oed8wJkvA7ue0hzltndP-ntNCVekz9Sn9RYkdpFLhcRumv7VfsH4BA2Wwvw
CitedBy_id	crossref_primary_10_1016_j_jbc_2025_108233 crossref_primary_10_1158_2643_3230_BCD_25_0049 crossref_primary_10_1111_bjh_70118 crossref_primary_10_1200_CCI_24_00324 crossref_primary_10_1002_pbc_31689 crossref_primary_10_3390_ijms26157117 crossref_primary_10_1038_s41375_025_02529_2 crossref_primary_10_1016_S2152_2650_25_00331_3 crossref_primary_10_1182_blood_2023022920 crossref_primary_10_1002_hem3_70154 crossref_primary_10_1182_blood_2024027982 crossref_primary_10_1371_journal_pone_0324443 crossref_primary_10_1038_d41586_024_02613_0 crossref_primary_10_1016_j_ejcped_2024_100204 crossref_primary_10_1016_j_bneo_2025_100069 crossref_primary_10_1159_000547659 crossref_primary_10_1111_cas_70010 crossref_primary_10_1159_000547135 crossref_primary_10_1182_bloodadvances_2024014209 crossref_primary_10_1002_hem3_70206 crossref_primary_10_1038_s41375_025_02723_2 crossref_primary_10_1182_blood_2024026642 crossref_primary_10_3390_cancers16244241 crossref_primary_10_1002_pbc_31679 crossref_primary_10_1182_blood_2025029096 crossref_primary_10_1016_S1773_035X_25_76375_3 crossref_primary_10_1016_j_ncrna_2025_08_003 crossref_primary_10_1126_scitranslmed_adr2012 crossref_primary_10_1182_blood_2025028566 crossref_primary_10_1038_s41375_025_02599_2 crossref_primary_10_1038_s41590_025_02096_9 crossref_primary_10_1038_s41590_025_02265_w crossref_primary_10_1038_s41408_024_01180_x crossref_primary_10_1016_j_ejca_2025_115629 crossref_primary_10_1007_s00277_025_06535_3 crossref_primary_10_1038_s43018_024_00864_4 crossref_primary_10_1158_2643_3230_BCD_25_0221 crossref_primary_10_1084_jem_20231349 crossref_primary_10_1016_j_bneo_2024_100041 crossref_primary_10_1016_j_jmoldx_2025_01_006 crossref_primary_10_1182_blood_2024028016 crossref_primary_10_1016_j_molmed_2025_04_005 crossref_primary_10_1111_bjh_70053 crossref_primary_10_1093_ajcp_aqaf035 crossref_primary_10_1016_S0140_6736_25_00864_5 crossref_primary_10_1002_pbc_31394 crossref_primary_10_1016_j_exphem_2025_104712 crossref_primary_10_1038_s41467_025_61222_1 crossref_primary_10_1146_annurev_genom_120823_010156 crossref_primary_10_1002_hem3_70027 crossref_primary_10_1182_blood_2024026027 crossref_primary_10_1182_blood_2024026381 crossref_primary_10_1111_bjh_20065 crossref_primary_10_1182_blood_2024027270 crossref_primary_10_1016_j_modpat_2025_100741 crossref_primary_10_1038_s43018_024_00863_5
Cites_doi	10.1038/nm.3665 10.1038/ng.2532 10.1182/blood-2004-10-3900 10.1002/cncy.20147 10.1074/jbc.273.13.7709 10.1111/bjh.13841 10.1200/JCO.2012.48.5292 10.1016/j.cell.2017.09.001 10.1128/MCB.21.22.7761-7774.2001 10.1038/ng.3900 10.1038/s41598-019-41695-z 10.1182/blood-2007-12-130096 10.1016/j.ccell.2020.12.011 10.1126/science.1259037 10.1038/ng.3466 10.1158/2159-8290.CD-21-0145 10.1038/s41586-021-03819-2 10.1200/JCO.20.00256 10.1200/JCO.22.02734 10.1038/s41588-022-01159-z 10.1182/blood.2023020678 10.1016/S1470-2045(08)70314-0 10.1038/nature10725 10.1242/jcs.035683 10.1016/j.clml.2022.07.010 10.1182/blood-2016-09-742148 10.1056/NEJMoa1403088 10.1186/gb-2011-12-4-r41 10.1016/j.immuni.2021.08.012 10.1016/j.cell.2017.09.042 10.1016/j.pharmthera.2017.05.009 10.1038/leu.2011.119 10.1200/JCO.2018.77.7250 10.1038/nbt.4314 10.1002/(SICI)1097-0258(19960229)15:4<361::AID-SIM168>3.0.CO;2-4 10.1038/ng.3909 10.1073/pnas.1407079111 10.1007/978-1-0716-2986-4_16 10.1038/s41588-020-0659-5 10.1158/2159-8290.CD-23-1452 10.1182/blood-2021-150841
ContentType	Journal Article
Copyright	The Author(s), under exclusive licence to Springer Nature Limited 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. 2024. The Author(s), under exclusive licence to Springer Nature Limited. Copyright Nature Publishing Group Aug 29, 2024
Copyright_xml	– notice: The Author(s), under exclusive licence to Springer Nature Limited 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. – notice: 2024. The Author(s), under exclusive licence to Springer Nature Limited. – notice: Copyright Nature Publishing Group Aug 29, 2024
DBID	AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7QG 7QL 7QP 7QR 7RV 7SN 7SS 7ST 7T5 7TG 7TK 7TM 7TO 7U9 7X2 7X7 7XB 88A 88E 88G 88I 8AF 8AO 8C1 8FD 8FE 8FG 8FH 8FI 8FJ 8FK 8G5 ABJCF ABUWG AEUYN AFKRA ARAPS ATCPS AZQEC BBNVY BEC BENPR BGLVJ BHPHI BKSAR C1K CCPQU D1I DWQXO FR3 FYUFA GHDGH GNUQQ GUQSH H94 HCIFZ K9. KB. KB0 KL. L6V LK8 M0K M0S M1P M2M M2O M2P M7N M7P M7S MBDVC NAPCQ P5Z P62 P64 PATMY PCBAR PDBOC PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS PSYQQ PTHSS PYCSY Q9U R05 RC3 S0X SOI 7X8 5PM
DOI	10.1038/s41586-024-07807-0
DatabaseName	CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Calcium & Calcified Tissue Abstracts Chemoreception Abstracts Nursing & Allied Health Database Ecology Abstracts Entomology Abstracts (Full archive) Environment Abstracts Immunology Abstracts Meteorological & Geoastrophysical Abstracts Neurosciences Abstracts Nucleic Acids Abstracts Oncogenes and Growth Factors Abstracts Virology and AIDS Abstracts Agricultural Science Collection Proquest Health & Medical Complete ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) Psychology Database (Alumni) Science Database (Alumni Edition) STEM Database ProQuest Pharma Collection Public Health Database Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Research Library (Alumni) ProQuest Materials Science & Engineering ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland Advanced Technologies & Computer Science Collection Agricultural & Environmental Science Collection ProQuest Central Essentials Biological Science Collection eLibrary ProQuest Central Technology collection Natural Science Collection Earth, Atmospheric & Aquatic Science Collection Environmental Sciences and Pollution Management ProQuest One ProQuest Materials Science Collection ProQuest Central Engineering Research Database Proquest Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student ProQuest Research Library AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Materials Science Database Nursing & Allied Health Database (Alumni Edition) Meteorological & Geoastrophysical Abstracts - Academic ProQuest Engineering Collection Biological Sciences Agricultural Science Database ProQuest Health & Medical Collection Medical Database Psychology Database Research Library Science Database Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Engineering Database Research Library (Corporate) Nursing & Allied Health Premium Advanced Technologies & Aerospace Database ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts Environmental Science Database Earth, Atmospheric & Aquatic Science Database Materials Science Collection Proquest Central Premium ProQuest One Academic ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China One Psychology Engineering Collection Environmental Science Collection ProQuest Central Basic University of Michigan Genetics Abstracts SIRS Editorial Environment Abstracts MEDLINE - Academic PubMed Central (Full Participant titles)
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Agricultural Science Database ProQuest One Psychology Research Library Prep ProQuest Central Student Oncogenes and Growth Factors Abstracts ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts elibrary ProQuest AP Science SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Meteorological & Geoastrophysical Abstracts Natural Science Collection Health & Medical Research Collection Biological Science Collection Chemoreception Abstracts ProQuest Central (New) ProQuest Medical Library (Alumni) Engineering Collection Advanced Technologies & Aerospace Collection Engineering Database Virology and AIDS Abstracts ProQuest Science Journals (Alumni Edition) ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Earth, Atmospheric & Aquatic Science Database Agricultural Science Collection ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts Neurosciences Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Environmental Science Collection Entomology Abstracts Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Environmental Science Database ProQuest Nursing & Allied Health Source (Alumni) Engineering Research Database ProQuest One Academic Calcium & Calcified Tissue Abstracts Meteorological & Geoastrophysical Abstracts - Academic ProQuest One Academic (New) University of Michigan Technology Collection Technology Research Database ProQuest One Academic Middle East (New) SIRS Editorial Materials Science Collection ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing Research Library (Alumni Edition) ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Biology Journals (Alumni Edition) ProQuest Central Earth, Atmospheric & Aquatic Science Collection ProQuest Health & Medical Research Collection Genetics Abstracts ProQuest Engineering Collection Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) Agricultural & Environmental Science Collection AIDS and Cancer Research Abstracts Materials Science Database ProQuest Research Library ProQuest Materials Science Collection ProQuest Public Health ProQuest Central Basic ProQuest Science Journals ProQuest Nursing & Allied Health Source ProQuest Psychology Journals (Alumni) ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library ProQuest Psychology Journals Animal Behavior Abstracts Materials Science & Engineering Collection Immunology Abstracts Environment Abstracts ProQuest Central (Alumni) MEDLINE - Academic
DatabaseTitleList	MEDLINE MEDLINE - Academic Agricultural Science Database
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: PATMY name: Environmental Science Database url: http://search.proquest.com/environmentalscience sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Sciences (General) Physics
EISSN	1476-4687
EndPage	1091
ExternalDocumentID	PMC11611067 39143224 10_1038_s41586_024_07807_0
Genre	Journal Article
GrantInformation_xml	– fundername: NCI NIH HHS grantid: U10 CA180886 – fundername: NCI NIH HHS grantid: R35 CA197695 – fundername: NIGMS NIH HHS grantid: R01 GM115634 – fundername: NCI NIH HHS grantid: U54 CA243124 – fundername: NCI NIH HHS grantid: U24 CA196173 – fundername: NCI NIH HHS grantid: R01 CA264837 – fundername: NCI NIH HHS grantid: T32 CA236748 – fundername: NCI NIH HHS grantid: F32 CA254140 – fundername: NCI NIH HHS grantid: U24 CA114766 – fundername: NCI NIH HHS grantid: K08 CA286762
GroupedDBID	--- --Z -DZ -ET -~X .55 .CO .XZ 07C 0R~ 123 186 1OL 29M 2KS 39C 53G 5RE 6TJ 70F 7RV 85S 8WZ 97F A6W A7Z AAEEF AAHBH AAHTB AAIKC AAKAB AAMNW AASDW AAYEP AAYZH AAZLF ABDQB ABFSI ABIVO ABJNI ABLJU ABOCM ABPEJ ABPPZ ABWJO ABZEH ACBEA ACBWK ACGFO ACGFS ACGOD ACIWK ACKOT ACMJI ACNCT ACPRK ACWUS ADBBV ADFRT ADUKH AENEX AFBBN AFFNX AFLOW AFRAH AFSHS AGAYW AGHSJ AGHTU AGOIJ AGSOS AHMBA AHSBF AIDUJ ALFFA ALIPV ALMA_UNASSIGNED_HOLDINGS AMTXH ARAPS ARMCB ASPBG ATCPS ATWCN AVWKF AXYYD AZFZN BENPR BHPHI BIN BKKNO CJ0 CS3 DU5 E.- E.L EAP EBS EE. EPS EXGXG F5P FAC FEDTE FQGFK FSGXE HCIFZ HG6 HVGLF HZ~ IAO ICQ IEA IEP IGS IH2 IHR INH IOF IPY KOO L7B LGEZI LOTEE LSO M0K M2O M7P N9A NADUK NEPJS NXXTH O9- OBC ODYON OES OHH OMK OVD P2P PKN PV9 RND RNS RNT RNTTT RXW SC5 SHXYY SIXXV SJN SNYQT SOJ TAE TAOOD TBHMF TDRGL TEORI TN5 TSG TWZ U5U UIG UKR UMD UQL VQA VVN WH7 X7M XIH XKW XZL Y6R YAE YCJ YFH YIF YIN YJ6 YNT YOC YQT YR2 YR5 YXB YZZ Z5M ZCA ~02 ~88 ~KM 0WA 1VR 2XV 41X 7X2 7X7 7XC 88E 88I 8AF 8AO 8C1 8CJ 8FE 8FG 8FH 8FI 8FJ 8G5 8R4 8R5 97L AARCD AAYXX ABFSG ABJCF ABUFD ABUWG ACSTC AEUYN AEZWR AFANA AFFHD AFHIU AFKRA AFKWF AGSTI AHWEU AIXLP ALPWD ATHPR AZQEC BBNVY BCU BEC BGLVJ BKEYQ BKSAR BPHCQ BVXVI CCPQU CITATION D1I D1J D1K DWQXO EMH EX3 FYUFA GNUQQ GUQSH HMCUK INR ISR K6- KB. L6V LK5 LK8 M1P M2M M2P M7R M7S NAPCQ NFIDA P62 PATMY PCBAR PDBOC PHGZM PHGZT PJZUB PPXIY PQGLB PQQKQ PROAC PSQYO PSYQQ PTHSS PYCSY Q2X R05 S0X SJFOW TUS UKHRP WOW ~7V .-4 .GJ .HR 00M 08P 1CY 1VW 354 3EH 3O- 4.4 41~ 42X 4R4 663 79B 9M8 A8Z AAJYS AAKAS AAVBQ ABAWZ ABDBF ABDPE ABEFU ABNNU ACBNA ACBTR ACRPL ACTDY ACUHS ADGHP ADNMO ADRHT ADXHL ADYSU ADZCM AETEA AFFDN AFHKK AGCDD AGGDT AGNAY AGQPQ AIDAL AIYXT AJUXI APEBS ARTTT B0M BCR BDKGC BES BKOMP BLC CGR CUY CVF DB5 DO4 EAD EAS EAZ EBC EBD EBO ECC ECM EIF EJD EMB EMF EMK EMOBN EPL ESE ESN ESX FA8 I-F ITC J5H L-9 MVM N4W NEJ NPM OHT P-O PEA PM3 QS- R4F RHI SKT SV3 TH9 TUD UBY UHB USG VOH X7L XOL YQI YQJ YV5 YXA YYP YYQ ZCG ZE2 ZGI ZHY ZKB ZY4 ~8M ~G0 3V. 7QG 7QL 7QP 7QR 7SN 7SS 7ST 7T5 7TG 7TK 7TM 7TO 7U9 7XB 88A 8FD 8FK C1K FR3 H94 K9. KL. M7N MBDVC P64 PKEHL PQEST PQUKI PRINS Q9U RC3 SOI 7X8 PUEGO 5PM
ID	FETCH-LOGICAL-c475t-57a6bc2915249857160f5f16d23543d42669a8acdc7790a989f6a820e379fe2f3
IEDL.DBID	P5Z
ISICitedReferencesCount	67
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=001300534300004&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	0028-0836 1476-4687
IngestDate	Tue Nov 04 02:06:25 EST 2025 Sat Sep 27 23:23:37 EDT 2025 Tue Oct 07 07:45:27 EDT 2025 Tue Jul 22 01:42:04 EDT 2025 Sat Nov 29 04:19:15 EST 2025 Tue Nov 18 22:18:31 EST 2025 Fri Feb 21 02:37:47 EST 2025
IsDoiOpenAccess	false
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	8027
Language	English
License	2024. The Author(s), under exclusive licence to Springer Nature Limited. Reprints and permissions information is available at http://www.nature.com/reprints.
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c475t-57a6bc2915249857160f5f16d23543d42669a8acdc7790a989f6a820e379fe2f3
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Equal contribution M.L., E.R., S.P.H., J.J.Y., M.D., H.I., S.W., K.D., W.L.C, N.C.R, K.B., C.D., L.U., D.F., S.M., R.R., A.L., T.L.V., P.S.G., M.A.S., J.T., M.K., N.T., B.H.C., R.D.P., Y.Z., provided patient samples and collected data. P.P., Z.C., J.M, Y.H., Y.F., D.H., E.R, preprocessed data. P.P., T.C.C, G.W., H.N., R.S., analyzed genomic data. P.P., A.E.S., A.E, S.B.P. performed statistical analysis. P.P., J.X., C.C., E.L., J.S., A.L., K.T analyzed single cell RNA data. P.P., J.W., C.R., X.Z., generated cloud-based visualizations. R.R., S.M., T.V isolated DNA/RNA, J.X., C.C, performed single cell library preparation and sequencing, D.D.G. and L.E.M. performed HiCHIP and ATACseq, R.D.P. performed targeted amplicon sequencing, F.B., S.K., performed long read sequencing, S.K. engineered MED12 knock-out cells, Y.C. performed western blotting, F.B., I.I., S.K., performed luciferase report assays. B.L.W analyzed flow cytometry data. P.P., C.G.M., D.T.T. designed the study and wrote the manuscript. Author Contributions
ORCID	0000-0003-3583-7727 0000-0002-1871-1850 0000-0002-2158-467X 0000-0002-1099-3478 0000-0002-3702-7923 0000-0002-8230-5312 0000-0003-2342-6349 0000-0003-2008-1365 0000-0002-0691-356X 0000-0001-6128-9985 0000-0002-3057-3550 0000-0002-0341-0860 0000-0001-7373-8987 0000-0003-3783-1820 0000-0002-9167-2114 0000-0002-1678-5864 0000-0002-9798-6018 0000-0002-5558-7967 0000-0001-5302-9147 0000-0003-0848-4604 0000-0002-7217-892X 0000-0003-3119-9940 0000-0002-0770-9659 0000-0003-0605-7342 0000-0001-6678-781X 0009-0005-3906-5543 0000-0003-3979-8200 0000-0002-2103-5144 0000-0003-2900-6636 0000-0003-4099-4700
OpenAccessLink	https://www.ncbi.nlm.nih.gov/pmc/articles/11611067
PMID	39143224
PQID	3104150533
PQPubID	40569
PageCount	10
ParticipantIDs	pubmedcentral_primary_oai_pubmedcentral_nih_gov_11611067 proquest_miscellaneous_3093172587 proquest_journals_3104150533 pubmed_primary_39143224 crossref_citationtrail_10_1038_s41586_024_07807_0 crossref_primary_10_1038_s41586_024_07807_0 springer_journals_10_1038_s41586_024_07807_0
PublicationCentury	2000
PublicationDate	2024-08-29
PublicationDateYYYYMMDD	2024-08-29
PublicationDate_xml	– month: 08 year: 2024 text: 2024-08-29 day: 29
PublicationDecade	2020
PublicationPlace	London
PublicationPlace_xml	– name: London – name: England
PublicationSubtitle	International weekly journal of science
PublicationTitle	Nature (London)
PublicationTitleAbbrev	Nature
PublicationTitleAlternate	Nature
PublicationYear	2024
Publisher	Nature Publishing Group UK Nature Publishing Group
Publisher_xml	– name: Nature Publishing Group UK – name: Nature Publishing Group
References	Gordon, Arnett, Blacklow (CR41) 2008; 121 Di Giacomo (CR19) 2021; 138 Cao, Elsayed, Pounds (CR24) 2023; 2629 Kato (CR32) 2016; 175 Winter (CR35) 2018; 36 Zhang (CR8) 2012; 481 Montefiori (CR20) 2021; 11 Liu (CR34) 2021; 54 CR33 O’Connor (CR25) 2023; 41 Traag, Waltman, Van Eck (CR12) 2019; 9 Zhou (CR39) 2016; 48 Liu (CR29) 2020; 52 Jumper (CR27) 2021; 596 Harrell, Lee, Mark (CR37) 1996; 15 Liu (CR3) 2017; 49 Wood (CR9) 2023; 142 Nagel, Kaufmann, Drexler, MacLeod (CR16) 2003; 63 Isoda (CR13) 2017; 171 Mansour (CR2) 2014; 346 Coustan-Smith (CR7) 2009; 10 Chen (CR21) 2011; 25 Brady (CR5) 2022; 54 Becht (CR11) 2019; 37 Herranz (CR14) 2014; 20 Yashiro-Ohtani (CR15) 2014; 111 Goffin (CR31) 2017; 179 Dunsmore (CR10) 2020; 38 Martincorena (CR22) 2017; 171 Roberts (CR4) 2014; 371 Sulis (CR28) 2008; 112 Ali, Ali (CR30) 1998; 273 Trinquand (CR42) 2013; 31 Seki (CR18) 2017; 49 Zhou (CR40) 2021; 39 Summers, Teachey (CR1) 2022; 22 Holmfeldt (CR6) 2013; 45 Oswald (CR38) 2001; 21 Rahman (CR26) 2017; 129 Soulier (CR17) 2005; 106 Moore (CR36) 2011; 119 Mermel (CR23) 2011; 12 X Zhou (7807_CR39) 2016; 48 I Martincorena (7807_CR22) 2017; 171 D O’Connor (7807_CR25) 2023; 41 J Jumper (7807_CR27) 2021; 596 S Ali (7807_CR30) 1998; 273 J Zhang (7807_CR8) 2012; 481 SS Winter (7807_CR35) 2018; 36 F Oswald (7807_CR38) 2001; 21 VA Traag (7807_CR12) 2019; 9 J Soulier (7807_CR17) 2005; 106 SW Brady (7807_CR5) 2022; 54 S Nagel (7807_CR16) 2003; 63 7807_CR33 M Seki (7807_CR18) 2017; 49 L Holmfeldt (7807_CR6) 2013; 45 HM Moore (7807_CR36) 2011; 119 Y Liu (7807_CR3) 2017; 49 WR Gordon (7807_CR41) 2008; 121 X Liu (7807_CR34) 2021; 54 KG Roberts (7807_CR4) 2014; 371 E Coustan-Smith (7807_CR7) 2009; 10 CH Mermel (7807_CR23) 2011; 12 KP Dunsmore (7807_CR10) 2020; 38 LE Montefiori (7807_CR20) 2021; 11 S Rahman (7807_CR26) 2017; 129 MR Mansour (7807_CR2) 2014; 346 FE Harrell Jr. (7807_CR37) 1996; 15 D Herranz (7807_CR14) 2014; 20 Y Liu (7807_CR29) 2020; 52 A Trinquand (7807_CR42) 2013; 31 BL Wood (7807_CR9) 2023; 142 ML Sulis (7807_CR28) 2008; 112 D Di Giacomo (7807_CR19) 2021; 138 V Goffin (7807_CR31) 2017; 179 M Kato (7807_CR32) 2016; 175 S Chen (7807_CR21) 2011; 25 Y Yashiro-Ohtani (7807_CR15) 2014; 111 RJ Summers (7807_CR1) 2022; 22 E Becht (7807_CR11) 2019; 37 X Zhou (7807_CR40) 2021; 39 T Isoda (7807_CR13) 2017; 171 X Cao (7807_CR24) 2023; 2629
References_xml	– volume: 20 start-page: 1130 year: 2014 end-page: 1137 ident: CR14 article-title: A NOTCH1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia publication-title: Nat. Med. doi: 10.1038/nm.3665 – volume: 45 start-page: 242 year: 2013 end-page: 252 ident: CR6 article-title: The genomic landscape of hypodiploid acute lymphoblastic leukemia publication-title: Nat. Genet. doi: 10.1038/ng.2532 – volume: 106 start-page: 274 year: 2005 end-page: 286 ident: CR17 article-title: genes are included in genetic and biologic networks defining human acute T-cell leukemia (T-ALL) publication-title: Blood doi: 10.1182/blood-2004-10-3900 – volume: 119 start-page: 92 year: 2011 end-page: 101 ident: CR36 article-title: Biospecimen reporting for improved study quality (BRISQ) publication-title: Cancer Cytopathol. doi: 10.1002/cncy.20147 – volume: 273 start-page: 7709 year: 1998 end-page: 7716 ident: CR30 article-title: Prolactin receptor regulates Stat5 tyrosine phosphorylation and nuclear translocation by two separate pathways publication-title: J. Biol. Chem. doi: 10.1074/jbc.273.13.7709 – volume: 175 start-page: 169 year: 2016 end-page: 172 ident: CR32 article-title: Genomic analysis of clonal origin of Langerhans cell histiocytosis following acute lymphoblastic leukaemia publication-title: Br. J. Haematol. doi: 10.1111/bjh.13841 – volume: 31 start-page: 4333 year: 2013 end-page: 4342 ident: CR42 article-title: Toward a NOTCH1/FBXW7/RAS/PTEN-based oncogenetic risk classification of adult T-cell acute lymphoblastic leukemia: a group for research in adult acute lymphoblastic leukemia study publication-title: J. Clin. Oncol. doi: 10.1200/JCO.2012.48.5292 – volume: 171 start-page: 103 year: 2017 end-page: 119.e18 ident: CR13 article-title: Non-coding transcription instructs chromatin folding and compartmentalization to dictate enhancer–promoter communication and T cell fate publication-title: Cell doi: 10.1016/j.cell.2017.09.001 – volume: 21 start-page: 7761 year: 2001 end-page: 7774 ident: CR38 article-title: p300 acts as a transcriptional coactivator for mammalian Notch-1 publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.21.22.7761-7774.2001 – volume: 49 start-page: 1274 year: 2017 end-page: 1281 ident: CR18 article-title: Recurrent SPI1 (PU.1) fusions in high-risk pediatric T cell acute lymphoblastic leukemia publication-title: Nat. Genet. doi: 10.1038/ng.3900 – volume: 9 year: 2019 ident: CR12 article-title: From Louvain to Leiden: guaranteeing well-connected communities publication-title: Sci. Rep. doi: 10.1038/s41598-019-41695-z – volume: 112 start-page: 733 year: 2008 end-page: 740 ident: CR28 article-title: NOTCH1 extracellular juxtamembrane expansion mutations in T-ALL publication-title: Blood doi: 10.1182/blood-2007-12-130096 – volume: 39 start-page: 83 year: 2021 end-page: 95.e4 ident: CR40 article-title: Exploration of coding and non-coding variants in cancer using GenomePaint publication-title: Cancer Cell doi: 10.1016/j.ccell.2020.12.011 – ident: CR33 – volume: 346 start-page: 1373 year: 2014 end-page: 1377 ident: CR2 article-title: Oncogene regulation. An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element publication-title: Science doi: 10.1126/science.1259037 – volume: 48 start-page: 4 year: 2016 end-page: 6 ident: CR39 article-title: Exploring genomic alteration in pediatric cancer using ProteinPaint publication-title: Nat. Genet. doi: 10.1038/ng.3466 – volume: 11 start-page: 2846 year: 2021 end-page: 2867 ident: CR20 article-title: Enhancer hijacking drives oncogenic expression in lineage-ambiguous stem cell leukemia publication-title: Cancer Discov. doi: 10.1158/2159-8290.CD-21-0145 – volume: 596 start-page: 583 year: 2021 end-page: 589 ident: CR27 article-title: Highly accurate protein structure prediction with AlphaFold publication-title: Nature doi: 10.1038/s41586-021-03819-2 – volume: 38 start-page: 3282 year: 2020 end-page: 3293 ident: CR10 article-title: Children’s Oncology Group AALL0434: a Phase III randomized clinical trial testing nelarabine in newly diagnosed T-cell acute lymphoblastic leukemia publication-title: J. Clin. Oncol. doi: 10.1200/JCO.20.00256 – volume: 41 start-page: 3545 year: 2023 end-page: 3556 ident: CR25 article-title: The clinicogenomic landscape of induction failure in childhood and young adult T-cell acute lymphoblastic leukemia publication-title: J. Clin. Oncol. doi: 10.1200/JCO.22.02734 – volume: 54 start-page: 1376 year: 2022 end-page: 1389 ident: CR5 article-title: The genomic landscape of pediatric acute lymphoblastic leukemia publication-title: Nat. Genet. doi: 10.1038/s41588-022-01159-z – volume: 142 start-page: 2069 year: 2023 end-page: 2078 ident: CR9 article-title: Prognostic significance of ETP phenotype and minimal residual disease in T-ALL: a Children’s Oncology Group study publication-title: Blood doi: 10.1182/blood.2023020678 – volume: 10 start-page: 147 year: 2009 end-page: 156 ident: CR7 article-title: Early T-cell precursor leukaemia: a subtype of very high-risk acute lymphoblastic leukaemia publication-title: Lancet Oncol. doi: 10.1016/S1470-2045(08)70314-0 – volume: 138 start-page: 773 year: 2021 end-page: 784 ident: CR19 article-title: 14q32 rearrangements deregulating BCL11B mark a distinct subgroup of T-lymphoid and myeloid immature acute leukemia publication-title: Blood – volume: 481 start-page: 157 year: 2012 end-page: 163 ident: CR8 article-title: The genetic basis of early T-cell precursor acute lymphoblastic leukaemia publication-title: Nature doi: 10.1038/nature10725 – volume: 121 start-page: 3109 year: 2008 end-page: 3119 ident: CR41 article-title: The molecular logic of Notch signaling—a structural and biochemical perspective publication-title: J. Cell Sci. doi: 10.1242/jcs.035683 – volume: 22 start-page: 718 year: 2022 end-page: 725 ident: CR1 article-title: SOHO state of the art updates and next questions \| novel approaches to pediatric T-cell ALL and T-lymphoblastic lymphoma publication-title: Clin. Lymphoma Myeloma Leuk. doi: 10.1016/j.clml.2022.07.010 – volume: 129 start-page: 3221 year: 2017 end-page: 3226 ident: CR26 article-title: Activation of the oncogene through a somatically acquired neomorphic promoter in T-cell acute lymphoblastic leukemia publication-title: Blood doi: 10.1182/blood-2016-09-742148 – volume: 371 start-page: 1005 year: 2014 end-page: 1015 ident: CR4 article-title: Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa1403088 – volume: 12 year: 2011 ident: CR23 article-title: GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers publication-title: Genome Biol. doi: 10.1186/gb-2011-12-4-r41 – volume: 54 start-page: 2305 year: 2021 end-page: 2320.e11 ident: CR34 article-title: Distinct human Langerhans cell subsets orchestrate reciprocal functions and require different developmental regulation publication-title: Immunity doi: 10.1016/j.immuni.2021.08.012 – volume: 171 start-page: 1029 year: 2017 end-page: 1041.e21 ident: CR22 article-title: Universal patterns of selection in cancer and somatic tissues publication-title: Cell doi: 10.1016/j.cell.2017.09.042 – volume: 179 start-page: 111 year: 2017 end-page: 126 ident: CR31 article-title: Prolactin receptor targeting in breast and prostate cancers: new insights into an old challenge publication-title: Pharmacol. Ther. doi: 10.1016/j.pharmthera.2017.05.009 – volume: 25 start-page: 1632 year: 2011 end-page: 1635 ident: CR21 article-title: Novel non-TCR chromosome translocations t(3;11)(q25;p13) and t(X;11)(q25;p13) activating LMO2 by juxtaposition with and publication-title: Leukemia doi: 10.1038/leu.2011.119 – volume: 36 start-page: 2926 year: 2018 end-page: 2934 ident: CR35 article-title: Improved survival for children and young adults with T-lineage acute lymphoblastic leukemia: results from the Children’s Oncology Group AALL0434 methotrexate randomization publication-title: J. Clin. Oncol. doi: 10.1200/JCO.2018.77.7250 – volume: 63 start-page: 5329 year: 2003 end-page: 5334 ident: CR16 article-title: The cardiac homeobox gene is deregulated by juxtaposition with BCL11B in pediatric T-ALL cell lines via a novel t(5;14)(q35.1;q32.2) publication-title: Cancer Res. – volume: 37 start-page: 38 year: 2019 end-page: 44 ident: CR11 article-title: Dimensionality reduction for visualizing single-cell data using UMAP publication-title: Nat. Biotechnol. doi: 10.1038/nbt.4314 – volume: 15 start-page: 361 year: 1996 end-page: 387 ident: CR37 article-title: Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors publication-title: Stat. Med. doi: 10.1002/(SICI)1097-0258(19960229)15:4<361::AID-SIM168>3.0.CO;2-4 – volume: 49 start-page: 1211 year: 2017 end-page: 1218 ident: CR3 article-title: The genomic landscape of pediatric and young adult T-lineage acute lymphoblastic leukemia publication-title: Nat. Genet. doi: 10.1038/ng.3909 – volume: 111 start-page: E4946 year: 2014 end-page: E4953 ident: CR15 article-title: Long-range enhancer activity determines Myc sensitivity to Notch inhibitors in T cell leukemia publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1407079111 – volume: 2629 start-page: 349 year: 2023 end-page: 373 ident: CR24 article-title: Statistical methods inspired by challenges in pediatric cancer multi-omics publication-title: Methods Mol. Biol. doi: 10.1007/978-1-0716-2986-4_16 – volume: 52 start-page: 811 year: 2020 end-page: 818 ident: CR29 article-title: Discovery of regulatory noncoding variants in individual cancer genomes by using cis-X publication-title: Nat. Genet. doi: 10.1038/s41588-020-0659-5 – volume: 10 start-page: 147 year: 2009 ident: 7807_CR7 publication-title: Lancet Oncol. doi: 10.1016/S1470-2045(08)70314-0 – volume: 20 start-page: 1130 year: 2014 ident: 7807_CR14 publication-title: Nat. Med. doi: 10.1038/nm.3665 – volume: 49 start-page: 1211 year: 2017 ident: 7807_CR3 publication-title: Nat. Genet. doi: 10.1038/ng.3909 – volume: 54 start-page: 1376 year: 2022 ident: 7807_CR5 publication-title: Nat. Genet. doi: 10.1038/s41588-022-01159-z – volume: 63 start-page: 5329 year: 2003 ident: 7807_CR16 publication-title: Cancer Res. – volume: 371 start-page: 1005 year: 2014 ident: 7807_CR4 publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa1403088 – volume: 36 start-page: 2926 year: 2018 ident: 7807_CR35 publication-title: J. Clin. Oncol. doi: 10.1200/JCO.2018.77.7250 – volume: 37 start-page: 38 year: 2019 ident: 7807_CR11 publication-title: Nat. Biotechnol. doi: 10.1038/nbt.4314 – volume: 112 start-page: 733 year: 2008 ident: 7807_CR28 publication-title: Blood doi: 10.1182/blood-2007-12-130096 – volume: 179 start-page: 111 year: 2017 ident: 7807_CR31 publication-title: Pharmacol. Ther. doi: 10.1016/j.pharmthera.2017.05.009 – volume: 175 start-page: 169 year: 2016 ident: 7807_CR32 publication-title: Br. J. Haematol. doi: 10.1111/bjh.13841 – volume: 38 start-page: 3282 year: 2020 ident: 7807_CR10 publication-title: J. Clin. Oncol. doi: 10.1200/JCO.20.00256 – volume: 111 start-page: E4946 year: 2014 ident: 7807_CR15 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1407079111 – volume: 39 start-page: 83 year: 2021 ident: 7807_CR40 publication-title: Cancer Cell doi: 10.1016/j.ccell.2020.12.011 – volume: 346 start-page: 1373 year: 2014 ident: 7807_CR2 publication-title: Science doi: 10.1126/science.1259037 – volume: 21 start-page: 7761 year: 2001 ident: 7807_CR38 publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.21.22.7761-7774.2001 – volume: 596 start-page: 583 year: 2021 ident: 7807_CR27 publication-title: Nature doi: 10.1038/s41586-021-03819-2 – ident: 7807_CR33 doi: 10.1158/2159-8290.CD-23-1452 – volume: 171 start-page: 103 year: 2017 ident: 7807_CR13 publication-title: Cell doi: 10.1016/j.cell.2017.09.001 – volume: 2629 start-page: 349 year: 2023 ident: 7807_CR24 publication-title: Methods Mol. Biol. doi: 10.1007/978-1-0716-2986-4_16 – volume: 171 start-page: 1029 year: 2017 ident: 7807_CR22 publication-title: Cell doi: 10.1016/j.cell.2017.09.042 – volume: 273 start-page: 7709 year: 1998 ident: 7807_CR30 publication-title: J. Biol. Chem. doi: 10.1074/jbc.273.13.7709 – volume: 54 start-page: 2305 year: 2021 ident: 7807_CR34 publication-title: Immunity doi: 10.1016/j.immuni.2021.08.012 – volume: 142 start-page: 2069 year: 2023 ident: 7807_CR9 publication-title: Blood doi: 10.1182/blood.2023020678 – volume: 45 start-page: 242 year: 2013 ident: 7807_CR6 publication-title: Nat. Genet. doi: 10.1038/ng.2532 – volume: 106 start-page: 274 year: 2005 ident: 7807_CR17 publication-title: Blood doi: 10.1182/blood-2004-10-3900 – volume: 41 start-page: 3545 year: 2023 ident: 7807_CR25 publication-title: J. Clin. Oncol. doi: 10.1200/JCO.22.02734 – volume: 48 start-page: 4 year: 2016 ident: 7807_CR39 publication-title: Nat. Genet. doi: 10.1038/ng.3466 – volume: 9 year: 2019 ident: 7807_CR12 publication-title: Sci. Rep. doi: 10.1038/s41598-019-41695-z – volume: 138 start-page: 773 year: 2021 ident: 7807_CR19 publication-title: Blood doi: 10.1182/blood-2021-150841 – volume: 25 start-page: 1632 year: 2011 ident: 7807_CR21 publication-title: Leukemia doi: 10.1038/leu.2011.119 – volume: 121 start-page: 3109 year: 2008 ident: 7807_CR41 publication-title: J. Cell Sci. doi: 10.1242/jcs.035683 – volume: 119 start-page: 92 year: 2011 ident: 7807_CR36 publication-title: Cancer Cytopathol. doi: 10.1002/cncy.20147 – volume: 12 year: 2011 ident: 7807_CR23 publication-title: Genome Biol. doi: 10.1186/gb-2011-12-4-r41 – volume: 15 start-page: 361 year: 1996 ident: 7807_CR37 publication-title: Stat. Med. doi: 10.1002/(SICI)1097-0258(19960229)15:4<361::AID-SIM168>3.0.CO;2-4 – volume: 31 start-page: 4333 year: 2013 ident: 7807_CR42 publication-title: J. Clin. Oncol. doi: 10.1200/JCO.2012.48.5292 – volume: 11 start-page: 2846 year: 2021 ident: 7807_CR20 publication-title: Cancer Discov. doi: 10.1158/2159-8290.CD-21-0145 – volume: 52 start-page: 811 year: 2020 ident: 7807_CR29 publication-title: Nat. Genet. doi: 10.1038/s41588-020-0659-5 – volume: 22 start-page: 718 year: 2022 ident: 7807_CR1 publication-title: Clin. Lymphoma Myeloma Leuk. doi: 10.1016/j.clml.2022.07.010 – volume: 129 start-page: 3221 year: 2017 ident: 7807_CR26 publication-title: Blood doi: 10.1182/blood-2016-09-742148 – volume: 481 start-page: 157 year: 2012 ident: 7807_CR8 publication-title: Nature doi: 10.1038/nature10725 – volume: 49 start-page: 1274 year: 2017 ident: 7807_CR18 publication-title: Nat. Genet. doi: 10.1038/ng.3900
SSID	ssj0005174
Score	2.6464956
Snippet	T-lineage acute lymphoblastic leukaemia (T-ALL) is a high-risk tumour 1 that has eluded comprehensive genomic characterization, which is partly due to the high... T-lineage acute lymphoblastic leukaemia (T-ALL) is a high-risk tumour that has eluded comprehensive genomic characterization, which is partly due to the high... T-lineage acute lymphoblastic leukaemia (T-ALL) is a high-risk tumour1 that has eluded comprehensive genomic characterization, which is partly due to the high... T-lineage acute lymphoblastic leukemia (T-ALL) is a high-risk tumor1 that has eluded comprehensive genomic characterization, in part due to the high frequency...
SourceID	pubmedcentral proquest pubmed crossref springer
SourceType	Open Access Repository Aggregation Database Index Database Enrichment Source Publisher
StartPage	1082
SubjectTerms	38 38/91 45 631/114/2401 631/67/1990/283/2125 631/67/68 631/67/69 Acute lymphoblastic leukemia Cell culture Child Childhood Children Chromatin Chromatin - genetics Chromatin - metabolism Deregulation Enhancer Elements, Genetic - genetics Enhancers Epigenomics Female Gene expression Gene Expression Regulation, Leukemic Gene sequencing Genes Genetic diversity Genome, Human - genetics Genomes Genomic analysis Genomics Hematopoietic stem cells Humanities and Social Sciences Humans Leukemia Lymphocytes Lymphocytes T Male Medical prognosis multidisciplinary Mutation Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - pathology Precursors Remission Science Science (multidisciplinary) Single-Cell Analysis Stem cells T cell receptors T-Lymphocytes - cytology T-Lymphocytes - pathology Topology Transcriptome - genetics Transcriptomes
Title	The genomic basis of childhood T-lineage acute lymphoblastic leukaemia
URI	https://link.springer.com/article/10.1038/s41586-024-07807-0 https://www.ncbi.nlm.nih.gov/pubmed/39143224 https://www.proquest.com/docview/3104150533 https://www.proquest.com/docview/3093172587 https://pubmed.ncbi.nlm.nih.gov/PMC11611067
Volume	632
WOSCitedRecordID	wos001300534300004&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVAQT databaseName: Nature customDbUrl: eissn: 1476-4687 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: RNT dateStart: 19970101 isFulltext: true titleUrlDefault: https://www.nature.com providerName: Nature Publishing – providerCode: PRVPQU databaseName: Advanced Technologies & Aerospace Database customDbUrl: eissn: 1476-4687 dateEnd: 20241207 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: P5Z dateStart: 19880107 isFulltext: true titleUrlDefault: https://search.proquest.com/hightechjournals providerName: ProQuest – providerCode: PRVPQU databaseName: Agricultural Science Database customDbUrl: eissn: 1476-4687 dateEnd: 20241207 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: M0K dateStart: 19880107 isFulltext: true titleUrlDefault: https://search.proquest.com/agriculturejournals providerName: ProQuest – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 1476-4687 dateEnd: 20241207 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: M7P dateStart: 19880107 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Earth, Atmospheric & Aquatic Science Database customDbUrl: eissn: 1476-4687 dateEnd: 20241207 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: PCBAR dateStart: 19880107 isFulltext: true titleUrlDefault: https://search.proquest.com/eaasdb providerName: ProQuest – providerCode: PRVPQU databaseName: Engineering Database customDbUrl: eissn: 1476-4687 dateEnd: 20241207 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: M7S dateStart: 19880107 isFulltext: true titleUrlDefault: http://search.proquest.com providerName: ProQuest – providerCode: PRVPQU databaseName: Environmental Science Database customDbUrl: eissn: 1476-4687 dateEnd: 20241207 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: PATMY dateStart: 19880107 isFulltext: true titleUrlDefault: http://search.proquest.com/environmentalscience providerName: ProQuest – providerCode: PRVPQU databaseName: Materials Science Database customDbUrl: eissn: 1476-4687 dateEnd: 20241207 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: KB. dateStart: 19880107 isFulltext: true titleUrlDefault: http://search.proquest.com/materialsscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Nursing & allied health premium. customDbUrl: eissn: 1476-4687 dateEnd: 20241207 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: 7RV dateStart: 19880107 isFulltext: true titleUrlDefault: https://search.proquest.com/nahs providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1476-4687 dateEnd: 20241207 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: BENPR dateStart: 19880107 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Health & Medical Collection customDbUrl: eissn: 1476-4687 dateEnd: 20241207 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: 7X7 dateStart: 19880107 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: Psychology Database customDbUrl: eissn: 1476-4687 dateEnd: 20241207 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: M2M dateStart: 19880107 isFulltext: true titleUrlDefault: https://www.proquest.com/psychology providerName: ProQuest – providerCode: PRVPQU databaseName: Public Health Database customDbUrl: eissn: 1476-4687 dateEnd: 20241207 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: 8C1 dateStart: 19880107 isFulltext: true titleUrlDefault: https://search.proquest.com/publichealth providerName: ProQuest – providerCode: PRVPQU databaseName: Research Library customDbUrl: eissn: 1476-4687 dateEnd: 20241207 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: M2O dateStart: 19880107 isFulltext: true titleUrlDefault: https://search.proquest.com/pqrl providerName: ProQuest – providerCode: PRVPQU databaseName: Science Database customDbUrl: eissn: 1476-4687 dateEnd: 20241207 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: M2P dateStart: 19880107 isFulltext: true titleUrlDefault: https://search.proquest.com/sciencejournals providerName: ProQuest
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3db9MwED-xDSRegI2vwKiMxAMIwlLnw_YT2qZVSFNLNAoqvESu44iILh1Li8R_z52TtOom9sLLSVGcD-vufD_b598BvJKGT0URW1_wqfJx_pX7iuvc59rG2oTTRJnCFZsQo5GcTFTaLrjVbVplNya6gTqfG1ojP0AYgrGGTo5-uPjlU9Uo2l1tS2hswQ6xJJBjpvH3dYrHFRbm9tBMEMqDGl8mKf028jFI0nLdZmC6hjavJ01e2Tl1AWlw_3-78gDutVCUHTa2swu3bLUHd1xKqKn3YLd1-5q9brmp3zyEAZoVI17X89IwjIBlzeYFMx0_Mhv7BFtxjGLaLBeWzf6gtcynCNHxI2xmlz-1PS_1I_gyOBkff_TbUgy-iUS88GOhk6nhCqN9pGSMk6ygiIt-kvMwjsKcwrzSUpvcEH-hVlIViUZwYUOhCsuL8DFsV_PKPgVGUx4R2SSSiAwCXigRmNBqdNY8l1HMPeh3eshMy1NO5TJmmdsvD2XW6C5D3WVOd1ngwdvVMxcNS8eNrfc7vWStx9bZWikevFzdRl-jDRRd2fkS2wQK4RaPpfDgSWMNq8-FCpEn4iEP5IadrBoQj_fmnar84fi8-4i6icnPg3edSa3_69_deHZzN57DXe7Mm07Z7MP24nJpX8Bt83tR1pc92BJnX0lOhJMSpTzu92Dn6GSUnuHV6dF7lMPglCQfOvnJyZSkaOTnnnM5fC49HA-__QU5tiNv
linkProvider	ProQuest
linkToHtml	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwEB6VAioXoIVCoICRQAKB1awdx_YBIQSsWrWsOCzS3lLHcUTENinNLqh_it_IOI9dbSt664FznNiOv3nZ428AXijLUpkLRyVLNcX4K6OamYwy44SxPI21zZtiE3I0UpOJ_roGf_q7MD6tsteJjaLOKuv3yHfRDUFb42-Ovj_5SX3VKH-62pfQaGFx4M5-Y8hWv9v_hOv7krHh5_HHPdpVFaA2kmJGhTRxaplGwxVpJTBeCHORD-KMcRHxzFssbZSxmfVUfEYrnccG7aTjUueO5Ry_ew2uox6XPoVMTuQypeQc63N3SSfkarfGwSuf7htRNMp-e3DVEF7wbi8maZ47qW0M4PDO__br7sLtztUmH1rZ2IQ1V27BzSbl1dZbsNmptZq86ri3X9-DIYoN8by1x4UlaOGLmlQ5sT3_MxlT75ajDibGzmeOTM9QGqoUQxDshEzd_Idxx4W5D9-uZGbbsF5WpXsIxId0MnJxpNDzCVmuZWi5M6iMskxFggUw6Nc9sR0Puy8HMk2afACukhYrCWIlabCShAG8Wbxz0rKQXNp6p8dB0mmkOlmCIIDni8eoS_wBkSldNcc2oUZ3kgklA3jQom_RHdfoWaO_F4BaweWigecpX31SFt8bvvIBRhWeqTCAtz2El-P69zQeXT6NZ7CxN_5ymBzujw4ewy3WiJa_UbQD67PTuXsCN-yvWVGfPm2ElMDRVUP7L1ODcCo
linkToPdf	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwEB6VAhUXoIVCoICRQAKBtVknju0DQoiyoipa7aFIFZfUcWwRsU1KswvqX-PXMc5jV9uK3nrgHCfOJN-87PE3AC-kYZlw3FLBMkUx_8qpYjqnTFuuTZQlyrim2YQYj-XhoZqswZ_-LIwvq-xtYmOo88r4NfIBhiHoa_zJ0YHryiImu6P3Jz-p7yDld1r7dhotRPbt2W9M3-p3e7v4r18yNvp08PEz7ToMUBMLPqNc6CQzTKETi5XkmDuEjrthkrOIx1HuvZfSUpvceFo-raRyiUafaSOhnGUuwudeg-sCZfSJ34R_W5aXnGOA7g7shJEc1CiI9KW_MUUH7ZcKV53ihUj3YsHmuV3bxhmO7vzPn_Eu3O5CcPKh1ZlNWLPlFtxsSmFNvQWbnbmryauOk_v1PRihOhHPZ3tcGIKev6hJ5YjpeaHJAfXhOtpmos18Zsn0DLWkyjA1wUnI1M5_aHtc6Pvw9Uok24b1sirtQyA-1ROxTWKJEVHInBKhiaxGI5XnMuYsgGGPgdR0_Oy-Tcg0beoEIpm2uEkRN2mDmzQM4M3inpOWneTS0Ts9JtLOUtXpEhABPF9cRhvjN450aas5jgkVhpmMSxHAgxaJi-kihRE3xoEByBWMLgZ4_vLVK2XxveExH2K24RkMA3jbw3n5Xv8W49HlYjyDDUR0-mVvvP8YbrFGy_xBox1Yn53O7RO4YX7Nivr0aaOvBI6uGtl_AaWjeR0
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+genomic+basis+of+childhood+T-lineage+acute+lymphoblastic+leukaemia&rft.jtitle=Nature+%28London%29&rft.au=P%C3%B6l%C3%B6nen%2C+Petri&rft.au=Di+Giacomo%2C+Danika&rft.au=Seffernick%2C+Anna+Eames&rft.au=Elsayed%2C+Abdelrahman&rft.date=2024-08-29&rft.eissn=1476-4687&rft.volume=632&rft.issue=8027&rft.spage=1082&rft_id=info:doi/10.1038%2Fs41586-024-07807-0&rft_id=info%3Apmid%2F39143224&rft.externalDocID=39143224
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0028-0836&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0028-0836&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0028-0836&client=summon