IL-33-activated ILC2s induce tertiary lymphoid structures in pancreatic cancer
Tertiary lymphoid structures (TLSs) are de novo ectopic lymphoid aggregates that regulate immunity in chronically inflamed tissues, including tumours. Although TLSs form due to inflammation-triggered activation of the lymphotoxin (LT)–LTβ receptor (LTβR) pathway 1 , the inflammatory signals and cell...
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| Veröffentlicht in: | Nature (London) Jg. 638; H. 8052; S. 1076 - 1084 |
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| Sprache: | Englisch |
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27.02.2025
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| ISSN: | 0028-0836, 1476-4687, 1476-4687 |
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| Abstract | Tertiary lymphoid structures (TLSs) are de novo ectopic lymphoid aggregates that regulate immunity in chronically inflamed tissues, including tumours. Although TLSs form due to inflammation-triggered activation of the lymphotoxin (LT)–LTβ receptor (LTβR) pathway
1
, the inflammatory signals and cells that induce TLSs remain incompletely identified. Here we show that interleukin-33 (IL-33), the alarmin released by inflamed tissues
2
, induces TLSs. In mice,
Il33
deficiency severely attenuates inflammation- and LTβR-activation-induced TLSs in models of colitis and pancreatic ductal adenocarcinoma (PDAC). In PDAC, the alarmin domain of IL-33 activates group 2 innate lymphoid cells (ILC2s) expressing LT that engage putative LTβR
+
myeloid organizer cells to initiate tertiary lymphoneogenesis. Notably, lymphoneogenic ILC2s migrate to PDACs from the gut, can be mobilized to PDACs in different tissues and are modulated by gut microbiota. Furthermore, we detect putative lymphoneogenic ILC2s and IL-33-expressing cells within TLSs in human PDAC that correlate with improved prognosis. To harness this lymphoneogenic pathway for immunotherapy, we engineer a recombinant human IL-33 protein that expands intratumoural lymphoneogenic ILC2s and TLSs and demonstrates enhanced anti-tumour activity in PDAC mice. In summary, we identify the molecules and cells of a druggable pathway that induces inflammation-triggered TLSs. More broadly, we reveal a lymphoneogenic function for alarmins and ILC2s.
IL-33 induces tertiary lymphoid structures. |
|---|---|
| AbstractList | Tertiary lymphoid structures (TLSs) are de novo ectopic lymphoid aggregates that regulate immunity in chronically inflamed tissues, including tumours. Although TLSs form due to inflammation-triggered activation of the lymphotoxin (LT)–LTβ receptor (LTβR) pathway
1
, the inflammatory signals and cells that induce TLSs remain incompletely identified. Here we show that interleukin-33 (IL-33), the alarmin released by inflamed tissues
2
, induces TLSs. In mice,
Il33
deficiency severely attenuates inflammation- and LTβR-activation-induced TLSs in models of colitis and pancreatic ductal adenocarcinoma (PDAC). In PDAC, the alarmin domain of IL-33 activates group 2 innate lymphoid cells (ILC2s) expressing LT that engage putative LTβR
+
myeloid organizer cells to initiate tertiary lymphoneogenesis. Notably, lymphoneogenic ILC2s migrate to PDACs from the gut, can be mobilized to PDACs in different tissues and are modulated by gut microbiota. Furthermore, we detect putative lymphoneogenic ILC2s and IL-33-expressing cells within TLSs in human PDAC that correlate with improved prognosis. To harness this lymphoneogenic pathway for immunotherapy, we engineer a recombinant human IL-33 protein that expands intratumoural lymphoneogenic ILC2s and TLSs and demonstrates enhanced anti-tumour activity in PDAC mice. In summary, we identify the molecules and cells of a druggable pathway that induces inflammation-triggered TLSs. More broadly, we reveal a lymphoneogenic function for alarmins and ILC2s.
IL-33 induces tertiary lymphoid structures. Tertiary lymphoid structures (TLSs) are de novo ectopic lymphoid aggregates that regulate immunity in chronically infamed tissues, including tumours. Although TLSs form due to infammation-triggered activation of the lymphotoxin (LT)-LTβ receptor (LTβR) pathway1 , the infammatory signals and cells that induce TLSs remain incompletely identifed. Here we show that interleukin-33 (IL-33), the alarmin released by infamed tissues2 , induces TLSs. In mice, Il33 defciency severely attenuates infammation- and LTβR-activation-induced TLSs in models of colitis and pancreatic ductal adenocarcinoma (PDAC). In PDAC, the alarmin domain of IL-33 activates group 2 innate lymphoid cells (ILC2s) expressing LT that engage putative LTβR+ myeloid organizer cells to initiate tertiary lymphoneogenesis. Notably, lymphoneogenic ILC2s migrate to PDACs from the gut, can be mobilized to PDACs in diferent tissues and are modulated by gut microbiota. Furthermore, we detect putative lymphoneogenic ILC2s and IL-33-expressing cells within TLSs in human PDAC that correlate with improved prognosis. To harness this lymphoneogenic pathway for immunotherapy, we engineer a recombinant human IL-33 protein that expands intratumoural lymphoneogenic ILC2s and TLSs and demonstrates enhanced anti-tumour activity in PDAC mice. In summary, we identify the molecules and cells of a druggable pathway that induces infammationtriggered TLSs. More broadly, we reveal a lymphoneogenic function for alarmins and ILC2s. Tertiary lymphoid structures (TLSs) are de novo ectopic lymphoid aggregates that regulate immunity in chronically inflamed tissues, including tumours. Although TLSs form due to inflammation-triggered activation of the lymphotoxin (LT)-LTβ receptor (LTβR) pathway , the inflammatory signals and cells that induce TLSs remain incompletely identified. Here we show that interleukin-33 (IL-33), the alarmin released by inflamed tissues , induces TLSs. In mice, Il33 deficiency severely attenuates inflammation- and LTβR-activation-induced TLSs in models of colitis and pancreatic ductal adenocarcinoma (PDAC). In PDAC, the alarmin domain of IL-33 activates group 2 innate lymphoid cells (ILC2s) expressing LT that engage putative LTβR myeloid organizer cells to initiate tertiary lymphoneogenesis. Notably, lymphoneogenic ILC2s migrate to PDACs from the gut, can be mobilized to PDACs in different tissues and are modulated by gut microbiota. Furthermore, we detect putative lymphoneogenic ILC2s and IL-33-expressing cells within TLSs in human PDAC that correlate with improved prognosis. To harness this lymphoneogenic pathway for immunotherapy, we engineer a recombinant human IL-33 protein that expands intratumoural lymphoneogenic ILC2s and TLSs and demonstrates enhanced anti-tumour activity in PDAC mice. In summary, we identify the molecules and cells of a druggable pathway that induces inflammation-triggered TLSs. More broadly, we reveal a lymphoneogenic function for alarmins and ILC2s. Tertiary lymphoid structures (TLSs) are de novo ectopic lymphoid aggregates that regulate immunity in chronically inflamed tissues, including tumours. Although TLSs form due to inflammation-triggered activation of the lymphotoxin (LT)–LTβ receptor (LTβR) pathway1, the inflammatory signals and cells that induce TLSs remain incompletely identified. Here we show that interleukin-33 (IL-33), the alarmin released by inflamed tissues2, induces TLSs. In mice, Il33 deficiency severely attenuates inflammation- and LTβR-activation-induced TLSs in models of colitis and pancreatic ductal adenocarcinoma (PDAC). In PDAC, the alarmin domain of IL-33 activates group 2 innate lymphoid cells (ILC2s) expressing LT that engage putative LTβR+ myeloid organizer cells to initiate tertiary lymphoneogenesis. Notably, lymphoneogenic ILC2s migrate to PDACs from the gut, can be mobilized to PDACs in different tissues and are modulated by gut microbiota. Furthermore, we detect putative lymphoneogenic ILC2s and IL-33-expressing cells within TLSs in human PDAC that correlate with improved prognosis. To harness this lymphoneogenic pathway for immunotherapy, we engineer a recombinant human IL-33 protein that expands intratumoural lymphoneogenic ILC2s and TLSs and demonstrates enhanced anti-tumour activity in PDAC mice. In summary, we identify the molecules and cells of a druggable pathway that induces inflammation-triggered TLSs. More broadly, we reveal a lymphoneogenic function for alarmins and ILC2s. IL-33 induces tertiary lymphoid structures. Tertiary lymphoid structures (TLSs) are de novo ectopic lymphoid aggregates that regulate immunity in chronically inflamed tissues, including tumours. Although TLSs form due to inflammation-triggered activation of the lymphotoxin (LT)-LTβ receptor (LTβR) pathway1, the inflammatory signals and cells that induce TLSs remain incompletely identified. Here we show that interleukin-33 (IL-33), the alarmin released by inflamed tissues2, induces TLSs. In mice, Il33 deficiency severely attenuates inflammation- and LTβR-activation-induced TLSs in models of colitis and pancreatic ductal adenocarcinoma (PDAC). In PDAC, the alarmin domain of IL-33 activates group 2 innate lymphoid cells (ILC2s) expressing LT that engage putative LTβR+ myeloid organizer cells to initiate tertiary lymphoneogenesis. Notably, lymphoneogenic ILC2s migrate to PDACs from the gut, can be mobilized to PDACs in different tissues and are modulated by gut microbiota. Furthermore, we detect putative lymphoneogenic ILC2s and IL-33-expressing cells within TLSs in human PDAC that correlate with improved prognosis. To harness this lymphoneogenic pathway for immunotherapy, we engineer a recombinant human IL-33 protein that expands intratumoural lymphoneogenic ILC2s and TLSs and demonstrates enhanced anti-tumour activity in PDAC mice. In summary, we identify the molecules and cells of a druggable pathway that induces inflammation-triggered TLSs. More broadly, we reveal a lymphoneogenic function for alarmins and ILC2s.Tertiary lymphoid structures (TLSs) are de novo ectopic lymphoid aggregates that regulate immunity in chronically inflamed tissues, including tumours. Although TLSs form due to inflammation-triggered activation of the lymphotoxin (LT)-LTβ receptor (LTβR) pathway1, the inflammatory signals and cells that induce TLSs remain incompletely identified. Here we show that interleukin-33 (IL-33), the alarmin released by inflamed tissues2, induces TLSs. In mice, Il33 deficiency severely attenuates inflammation- and LTβR-activation-induced TLSs in models of colitis and pancreatic ductal adenocarcinoma (PDAC). In PDAC, the alarmin domain of IL-33 activates group 2 innate lymphoid cells (ILC2s) expressing LT that engage putative LTβR+ myeloid organizer cells to initiate tertiary lymphoneogenesis. Notably, lymphoneogenic ILC2s migrate to PDACs from the gut, can be mobilized to PDACs in different tissues and are modulated by gut microbiota. Furthermore, we detect putative lymphoneogenic ILC2s and IL-33-expressing cells within TLSs in human PDAC that correlate with improved prognosis. To harness this lymphoneogenic pathway for immunotherapy, we engineer a recombinant human IL-33 protein that expands intratumoural lymphoneogenic ILC2s and TLSs and demonstrates enhanced anti-tumour activity in PDAC mice. In summary, we identify the molecules and cells of a druggable pathway that induces inflammation-triggered TLSs. More broadly, we reveal a lymphoneogenic function for alarmins and ILC2s. |
| Author | Balachandran, Vinod P. Sethna, Zachary M. Odgerel, Zagaa Yano, Hiroshi Yu, Rebecca Gardner, Rui Patterson, Erin Ohmoto, Akihiro Bruno, Emmanuel M. Tumanov, Alexei V. Waters, Theresa Lorenz, Ivo C. Artis, David Zebboudj, Abderezak Solovyov, Alexander Doane, Ashley S. Cheng, Charlotte Chandra, Adrienne Kaya Milighetti, Martina Nyakatura, Elisabeth K. Khan, Abdul G. Baca, Manuel Greenbaum, Benjamin Moral, John Alec Gönen, Mithat Merghoub, Taha Soares, Kevin Vergnolle, Olivia Guasp, Pablo Rojas, Luis A. Reiche, Charlotte Amisaki, Masataka Payne, George Martis, Stephen Zhao, Julia N. Zhang, Siqi Linsey |
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Weill Department of Medicine, Division of Gastroenterology and Hepatology, Weill Cornell Medicine, Cornell University, Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University – sequence: 35 givenname: Taha orcidid: 0000-0002-1518-5111 surname: Merghoub fullname: Merghoub, Taha organization: Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, Weill Cornell Medical College, Parker Institute for Cancer Immunotherapy, Weill Cornell Medicine, Swim Across America and Ludwig Collaborative Laboratory, Department of Pharmacology, Weill Cornell Medicine – sequence: 36 givenname: Vinod P. orcidid: 0000-0002-2956-223X surname: Balachandran fullname: Balachandran, Vinod P. email: balachav@mskcc.org organization: Immuno-Oncology Service, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, The Olayan Center for Cancer Vaccines, Memorial Sloan Kettering Cancer Center |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/39814891$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1158/0008-5472.CAN-06-0217 10.1126/sciimmunol.abc6259 10.1016/S1074-7613(00)80588-9 10.1038/nature23469 10.1038/ncomms9327 10.4049/jimmunol.169.1.424 10.1084/jem.20191172 10.1016/j.celrep.2021.109422 10.1038/nbt.3820 10.1016/j.ccr.2009.08.021 10.1038/s41590-021-00943-z 10.4049/jimmunol.171.6.2797 10.1038/s41586-022-05297-6 10.1038/s41586-020-2015-4 10.1038/s41586-021-03531-1 10.1186/gb-2010-11-3-r25 10.1038/s41587-020-0439-x 10.12688/f1000research.8923.1 10.1084/jem.20021761 10.1038/s41586-019-1914-8 10.1038/nature12526 10.1038/s41586-019-1922-8 10.1016/j.immuni.2007.04.009 10.1016/j.ajpath.2011.03.007 10.1186/1471-213X-9-49 10.1038/nmeth.3869 10.1016/j.cell.2018.02.052 10.1016/j.bbmt.2019.05.030 10.1038/bjc.2015.145 10.1016/j.immuni.2005.02.007 10.1016/j.jhep.2018.09.003 10.1186/1471-2105-14-7 10.1084/jem.20100052 10.1038/s41467-020-19973-6 10.1371/journal.pcbi.1006701 10.1038/nature23676 10.1084/jem.185.1.99 10.3389/fmicb.2020.550420 10.1080/2162402X.2017.1378844 10.1038/ncomms3680 10.1038/nature24029 10.1084/jem.20232148 10.1038/nature16965 10.1038/nprot.2017.044 10.1038/ni.3078 10.4049/jimmunol.2001304 10.1158/0008-5472.CAN-17-1987 10.1126/science.aam5809 10.1038/s41586-022-05395-5 10.1126/science.1194597 10.1371/journal.pcbi.1012265 10.1016/j.cell.2015.05.044 10.1038/s43018-021-00232-6 10.1038/35018581 10.1093/nar/gks1219 10.1038/s41586-019-1906-8 10.1016/j.molimm.2017.05.008 10.1016/S1074-7613(00)80589-0 10.1126/science.abf9419 10.14806/ej.17.1.200 10.1093/bioinformatics/btw777 10.1038/s41586-024-07746-w 10.1038/ni.3057 10.1016/j.ccell.2018.03.014 10.1084/jem.183.4.1461 10.1172/JCI67428 10.1158/2159-8290.CD-17-1134 10.1038/nri.2016.95 10.1093/nar/gkab1049 10.1093/bioinformatics/btv359 10.1016/S1074-7613(02)00397-7 10.1038/s41568-019-0144-6 10.1016/j.immuni.2014.06.016 10.1038/35017610 10.1093/nar/gkv1507 10.1038/s41586-020-03147-x 10.1016/j.cell.2020.03.031 10.1016/j.ccell.2017.07.007 10.1038/nm.1984 10.1016/j.immuni.2011.10.015 10.1016/j.ccell.2022.01.003 10.1016/j.immuni.2005.09.015 10.1158/2326-6066.CIR-19-0775 10.1371/journal.pcbi.1007977 10.1038/s41598-018-21589-2 10.1016/j.immuni.2020.02.009 |
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| References | 8426_CR77 TN Schumacher (8426_CR15) 2022; 375 A Wallrapp (8426_CR18) 2017; 549 BJ Callahan (8426_CR62) 2016; 13 8426_CR72 BJ Raphael (8426_CR66) 2017; 32 M Arifuzzaman (8426_CR56) 2024; 221 AB Rodriguez (8426_CR71) 2021; 36 M Zhang (8426_CR49) 2020; 181 MD Robinson (8426_CR86) 2010; 11 J Schmitz (8426_CR39) 2005; 23 X Zhao (8426_CR29) 2003; 171 F Qi (8426_CR46) 2017; 87 K Kabashima (8426_CR47) 2005; 22 8426_CR35 D Alonso-Curbelo (8426_CR44) 2021; 590 AC Berger (8426_CR67) 2018; 33 M Lukashev (8426_CR12) 2006; 66 8426_CR23 L-Y Hung (8426_CR48) 2020; 5 PA Ewels (8426_CR59) 2020; 38 8426_CR61 F Petitprez (8426_CR5) 2020; 577 DJ McCarthy (8426_CR81) 2017; 33 N Nouri (8426_CR78) 2020; 16 DL Drayton (8426_CR11) 2003; 197 A Alam (8426_CR50) 2022; 40 CJ Oliphant (8426_CR24) 2014; 41 Y Huang (8426_CR31) 2015; 16 D Meier (8426_CR27) 2007; 26 J Calderaro (8426_CR74) 2019; 70 M Mounir (8426_CR85) 2019; 15 C Sautès-Fridman (8426_CR3) 2019; 19 A Colaprico (8426_CR83) 2016; 44 M Lochner (8426_CR14) 2010; 208 EY Chiang (8426_CR70) 2009; 15 AD Howard (8426_CR45) 2000; 406 P Bailey (8426_CR64) 2016; 531 TCGA Network (8426_CR68) 2015; 161 A Kratz (8426_CR1) 1996; 183 CS Carlson (8426_CR76) 2013; 4 N Hiraoka (8426_CR9) 2015; 112 J Haybaeck (8426_CR54) 2009; 16 S Hänzelmann (8426_CR80) 2013; 14 M Zhang (8426_CR30) 2020; 11 C Alt (8426_CR38) 2019; 25 8426_CR53 KM Ansel (8426_CR25) 2000; 406 S Pushalkar (8426_CR36) 2018; 8 ES Cohen (8426_CR37) 2015; 6 R Cabrita (8426_CR4) 2020; 577 JA Moral (8426_CR16) 2020; 579 8426_CR52 JK Bando (8426_CR69) 2014; 16 F Posch (8426_CR73) 2017; 7 8426_CR51 IC Scott (8426_CR2) 2018; 8 TC Silva (8426_CR84) 2016; 5 V Cardoso (8426_CR19) 2017; 549 C Gu-Trantien (8426_CR8) 2013; 123 S Sawa (8426_CR40) 2010; 330 PD Tommaso (8426_CR58) 2017; 35 Y Huang (8426_CR32) 2018; 359 D Straub (8426_CR60) 2020; 11 CSN Klose (8426_CR17) 2017; 549 L Vanhersecke (8426_CR75) 2021; 2 A Peters (8426_CR42) 2011; 35 8426_CR43 J Liu (8426_CR65) 2018; 173 D Coppola (8426_CR7) 2011; 179 MN Sarafi (8426_CR28) 1997; 185 AM Tsou (8426_CR20) 2022; 611 JC Nussbaum (8426_CR22) 2013; 502 C Quast (8426_CR63) 2013; 41 KJ Jarick (8426_CR21) 2022; 611 PD Rennert (8426_CR13) 1998; 9 Q Pu (8426_CR33) 2021; 207 F Cunningham (8426_CR82) 2021; 50 SA Luther (8426_CR26) 2002; 169 S Wirtz (8426_CR55) 2017; 12 DF Zegarra-Ruiz (8426_CR57) 2021; 594 NT Gupta (8426_CR79) 2015; 31 A Ikeda (8426_CR41) 2020; 8 BA Helmink (8426_CR6) 2020; 577 RR Ricardo-Gonzalez (8426_CR34) 2020; 217 FY Liew (8426_CR10) 2016; 16 |
| References_xml | – volume: 66 start-page: 9617 year: 2006 ident: 8426_CR12 publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-06-0217 – volume: 5 year: 2020 ident: 8426_CR48 publication-title: Sci. Immunol. doi: 10.1126/sciimmunol.abc6259 – ident: 8426_CR52 doi: 10.1016/S1074-7613(00)80588-9 – volume: 549 start-page: 277 year: 2017 ident: 8426_CR19 publication-title: Nature doi: 10.1038/nature23469 – volume: 6 start-page: 1 year: 2015 ident: 8426_CR37 publication-title: Nat. Commun. doi: 10.1038/ncomms9327 – volume: 169 start-page: 424 year: 2002 ident: 8426_CR26 publication-title: J. Immunol. doi: 10.4049/jimmunol.169.1.424 – volume: 217 start-page: 171 year: 2020 ident: 8426_CR34 publication-title: J. Exp. Med. doi: 10.1084/jem.20191172 – volume: 36 start-page: 109422 year: 2021 ident: 8426_CR71 publication-title: Cell Rep. doi: 10.1016/j.celrep.2021.109422 – volume: 35 start-page: 316 year: 2017 ident: 8426_CR58 publication-title: Nat. Biotechnol. doi: 10.1038/nbt.3820 – volume: 16 start-page: 295 year: 2009 ident: 8426_CR54 publication-title: Cancer Cell doi: 10.1016/j.ccr.2009.08.021 – ident: 8426_CR43 doi: 10.1038/s41590-021-00943-z – volume: 171 start-page: 2797 year: 2003 ident: 8426_CR29 publication-title: J. Immunol. doi: 10.4049/jimmunol.171.6.2797 – volume: 611 start-page: 787 year: 2022 ident: 8426_CR20 publication-title: Nature doi: 10.1038/s41586-022-05297-6 – volume: 579 start-page: 790 year: 2020 ident: 8426_CR16 publication-title: Nature doi: 10.1038/s41586-020-2015-4 – volume: 594 start-page: 413 year: 2021 ident: 8426_CR57 publication-title: Nature doi: 10.1038/s41586-021-03531-1 – volume: 11 year: 2010 ident: 8426_CR86 publication-title: Genome Biol. doi: 10.1186/gb-2010-11-3-r25 – volume: 38 start-page: 276 year: 2020 ident: 8426_CR59 publication-title: Nat. Biotechnol. doi: 10.1038/s41587-020-0439-x – volume: 5 start-page: 1542 year: 2016 ident: 8426_CR84 publication-title: F1000Res. doi: 10.12688/f1000research.8923.1 – volume: 197 start-page: 1153 year: 2003 ident: 8426_CR11 publication-title: J. Exp. Med. doi: 10.1084/jem.20021761 – volume: 577 start-page: 561 year: 2020 ident: 8426_CR4 publication-title: Nature doi: 10.1038/s41586-019-1914-8 – volume: 502 start-page: 245 year: 2013 ident: 8426_CR22 publication-title: Nature doi: 10.1038/nature12526 – volume: 577 start-page: 549 year: 2020 ident: 8426_CR6 publication-title: Nature doi: 10.1038/s41586-019-1922-8 – volume: 26 start-page: 643 year: 2007 ident: 8426_CR27 publication-title: Immunity doi: 10.1016/j.immuni.2007.04.009 – volume: 179 start-page: 37 year: 2011 ident: 8426_CR7 publication-title: Am. J. Pathol. doi: 10.1016/j.ajpath.2011.03.007 – ident: 8426_CR53 doi: 10.1186/1471-213X-9-49 – volume: 13 start-page: 581 year: 2016 ident: 8426_CR62 publication-title: Nat. Methods doi: 10.1038/nmeth.3869 – volume: 173 start-page: 400 year: 2018 ident: 8426_CR65 publication-title: Cell doi: 10.1016/j.cell.2018.02.052 – volume: 25 start-page: 1475 year: 2019 ident: 8426_CR38 publication-title: Biol. Blood Marrow Transplant doi: 10.1016/j.bbmt.2019.05.030 – volume: 112 start-page: 1782 year: 2015 ident: 8426_CR9 publication-title: Br. J. Cancer doi: 10.1038/bjc.2015.145 – volume: 22 start-page: 439 year: 2005 ident: 8426_CR47 publication-title: Immunity doi: 10.1016/j.immuni.2005.02.007 – volume: 70 start-page: 58 year: 2019 ident: 8426_CR74 publication-title: J. Hepatol. doi: 10.1016/j.jhep.2018.09.003 – volume: 14 start-page: 7 year: 2013 ident: 8426_CR80 publication-title: BMC Bioinform. doi: 10.1186/1471-2105-14-7 – volume: 208 start-page: 125 year: 2010 ident: 8426_CR14 publication-title: J. Exp. Med. doi: 10.1084/jem.20100052 – volume: 11 year: 2020 ident: 8426_CR30 publication-title: Nat. Commun. doi: 10.1038/s41467-020-19973-6 – volume: 15 start-page: e1006701 year: 2019 ident: 8426_CR85 publication-title: PLoS Comput. Biol. doi: 10.1371/journal.pcbi.1006701 – volume: 549 start-page: 282 year: 2017 ident: 8426_CR17 publication-title: Nature doi: 10.1038/nature23676 – volume: 185 start-page: 99 year: 1997 ident: 8426_CR28 publication-title: J. Exp. Med. doi: 10.1084/jem.185.1.99 – volume: 11 start-page: 550420 year: 2020 ident: 8426_CR60 publication-title: Front. Microbiol. doi: 10.3389/fmicb.2020.550420 – volume: 7 start-page: e1378844 year: 2017 ident: 8426_CR73 publication-title: Oncoimmunology doi: 10.1080/2162402X.2017.1378844 – volume: 4 year: 2013 ident: 8426_CR76 publication-title: Nat. Commun. doi: 10.1038/ncomms3680 – volume: 549 start-page: 351 year: 2017 ident: 8426_CR18 publication-title: Nature doi: 10.1038/nature24029 – volume: 221 start-page: e20232148 year: 2024 ident: 8426_CR56 publication-title: J. Exp. Med. doi: 10.1084/jem.20232148 – volume: 531 start-page: 47 year: 2016 ident: 8426_CR64 publication-title: Nature doi: 10.1038/nature16965 – volume: 12 start-page: 1295 year: 2017 ident: 8426_CR55 publication-title: Nat. Protoc. doi: 10.1038/nprot.2017.044 – volume: 16 start-page: 161 year: 2015 ident: 8426_CR31 publication-title: Nat. Immunol. doi: 10.1038/ni.3078 – volume: 207 start-page: 257 year: 2021 ident: 8426_CR33 publication-title: J. Immunol. doi: 10.4049/jimmunol.2001304 – ident: 8426_CR72 doi: 10.1158/0008-5472.CAN-17-1987 – volume: 359 start-page: 114 year: 2018 ident: 8426_CR32 publication-title: Science doi: 10.1126/science.aam5809 – volume: 611 start-page: 794 year: 2022 ident: 8426_CR21 publication-title: Nature doi: 10.1038/s41586-022-05395-5 – volume: 330 start-page: 665 year: 2010 ident: 8426_CR40 publication-title: Science doi: 10.1126/science.1194597 – ident: 8426_CR77 doi: 10.1371/journal.pcbi.1012265 – volume: 161 start-page: 1681 year: 2015 ident: 8426_CR68 publication-title: Cell doi: 10.1016/j.cell.2015.05.044 – volume: 2 start-page: 794 year: 2021 ident: 8426_CR75 publication-title: Nat. Cancer doi: 10.1038/s43018-021-00232-6 – volume: 406 start-page: 309 year: 2000 ident: 8426_CR25 publication-title: Nature doi: 10.1038/35018581 – volume: 41 start-page: D590 year: 2013 ident: 8426_CR63 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gks1219 – volume: 577 start-page: 556 year: 2020 ident: 8426_CR5 publication-title: Nature doi: 10.1038/s41586-019-1906-8 – volume: 87 start-page: 284 year: 2017 ident: 8426_CR46 publication-title: Mol. Immunol. doi: 10.1016/j.molimm.2017.05.008 – volume: 9 start-page: 71 year: 1998 ident: 8426_CR13 publication-title: Immunity doi: 10.1016/S1074-7613(00)80589-0 – volume: 375 start-page: eabf9419 year: 2022 ident: 8426_CR15 publication-title: Science doi: 10.1126/science.abf9419 – ident: 8426_CR61 doi: 10.14806/ej.17.1.200 – volume: 33 start-page: btw777 year: 2017 ident: 8426_CR81 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btw777 – ident: 8426_CR23 doi: 10.1038/s41586-024-07746-w – volume: 16 start-page: 153 year: 2014 ident: 8426_CR69 publication-title: Nat. Immunol. doi: 10.1038/ni.3057 – volume: 33 start-page: 690 year: 2018 ident: 8426_CR67 publication-title: Cancer Cell doi: 10.1016/j.ccell.2018.03.014 – volume: 183 start-page: 1461 year: 1996 ident: 8426_CR1 publication-title: J. Exp. Med. doi: 10.1084/jem.183.4.1461 – volume: 123 start-page: 2873 year: 2013 ident: 8426_CR8 publication-title: J. Clin. Invest. doi: 10.1172/JCI67428 – volume: 8 start-page: 403 year: 2018 ident: 8426_CR36 publication-title: Cancer Discov. doi: 10.1158/2159-8290.CD-17-1134 – volume: 16 start-page: 676 year: 2016 ident: 8426_CR10 publication-title: Nat. Rev. Immunol. doi: 10.1038/nri.2016.95 – volume: 50 start-page: D988 year: 2021 ident: 8426_CR82 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkab1049 – volume: 31 start-page: 3356 year: 2015 ident: 8426_CR79 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btv359 – ident: 8426_CR51 doi: 10.1016/S1074-7613(02)00397-7 – volume: 19 start-page: 307 year: 2019 ident: 8426_CR3 publication-title: Nat. Rev. Cancer doi: 10.1038/s41568-019-0144-6 – volume: 41 start-page: 283 year: 2014 ident: 8426_CR24 publication-title: Immunity doi: 10.1016/j.immuni.2014.06.016 – volume: 406 start-page: 70 year: 2000 ident: 8426_CR45 publication-title: Nature doi: 10.1038/35017610 – volume: 44 start-page: e71 year: 2016 ident: 8426_CR83 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkv1507 – volume: 590 start-page: 642 year: 2021 ident: 8426_CR44 publication-title: Nature doi: 10.1038/s41586-020-03147-x – volume: 181 start-page: 637 year: 2020 ident: 8426_CR49 publication-title: Cell doi: 10.1016/j.cell.2020.03.031 – volume: 32 start-page: 185 year: 2017 ident: 8426_CR66 publication-title: Cancer Cell doi: 10.1016/j.ccell.2017.07.007 – volume: 15 start-page: 766 year: 2009 ident: 8426_CR70 publication-title: Nat. Med. doi: 10.1038/nm.1984 – volume: 35 start-page: 986 year: 2011 ident: 8426_CR42 publication-title: Immunity doi: 10.1016/j.immuni.2011.10.015 – volume: 40 start-page: 153 year: 2022 ident: 8426_CR50 publication-title: Cancer Cell doi: 10.1016/j.ccell.2022.01.003 – volume: 23 start-page: 479 year: 2005 ident: 8426_CR39 publication-title: Immunity doi: 10.1016/j.immuni.2005.09.015 – volume: 8 start-page: 724 year: 2020 ident: 8426_CR41 publication-title: Cancer Immunol. Res. doi: 10.1158/2326-6066.CIR-19-0775 – volume: 16 start-page: e1007977 year: 2020 ident: 8426_CR78 publication-title: PLoS Comput. Biol. doi: 10.1371/journal.pcbi.1007977 – volume: 8 year: 2018 ident: 8426_CR2 publication-title: Sci. Rep. doi: 10.1038/s41598-018-21589-2 – ident: 8426_CR35 doi: 10.1016/j.immuni.2020.02.009 |
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| Title | IL-33-activated ILC2s induce tertiary lymphoid structures in pancreatic cancer |
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