Multiomic analysis of familial adenomatous polyposis reveals molecular pathways associated with early tumorigenesis

Familial adenomatous polyposis (FAP) is a genetic disease causing hundreds of premalignant polyps in affected persons and is an ideal model to study transitions of early precancer states to colorectal cancer (CRC). We performed deep multiomic profiling of 93 samples, including normal mucosa, benign...

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Veröffentlicht in:	Nature cancer Jg. 5; H. 11; S. 1737 - 1753
Hauptverfasser:	Esplin, Edward D., Hanson, Casey, Wu, Si, Horning, Aaron M., Barapour, Nasim, Nevins, Stephanie A., Jiang, Lihua, Contrepois, Kévin, Lee, Hayan, Guha, Tuhin K., Hu, Zheng, Laquindanum, Rozelle, Mills, Meredith A., Chaib, Hassan, Chiu, Roxanne, Jian, Ruiqi, Chan, Joanne, Ellenberger, Mathew, Becker, Winston R., Bahmani, Bahareh, Khan, Aziz, Michael, Basil, Weimer, Annika K., Esplin, D. Glen, Shen, Jeanne, Lancaster, Samuel, Monte, Emma, Karathanos, Thomas V., Ladabaum, Uri, Longacre, Teri A., Kundaje, Anshul, Curtis, Christina, Greenleaf, William J., Ford, James M., Snyder, Michael P.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	New York Nature Publishing Group US 01.11.2024 Nature Publishing Group
Schlagworte:	631/114 631/67 631/67/1504/1885/1393 Adenomatous Polyposis Coli - genetics Adenomatous Polyposis Coli - pathology Biomedical and Life Sciences Cancer Carcinogenesis - genetics Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Colon Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Female Females Gene Expression Profiling - methods Gene Expression Regulation, Neoplastic Hispanic Americans Humans Life Sciences Lipids Male Metabolites Mutation Polyps Precancerous Conditions - genetics Precancerous Conditions - metabolism Precancerous Conditions - pathology Proteins Proteomics Proteomics - methods Resource Transcriptome Tumorigenesis
ISSN:	2662-1347, 2662-1347
Online-Zugang:	Volltext
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