Direct visualization of transcription-replication conflicts reveals post-replicative DNA:RNA hybrids

Transcription-replication collisions (TRCs) are crucial determinants of genome instability. R-loops were linked to head-on TRCs and proposed to obstruct replication fork progression. The underlying mechanisms, however, remained elusive due to the lack of direct visualization and of non-ambiguous res...

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Veröffentlicht in:	Nature structural & molecular biology Jg. 30; H. 3; S. 348 - 359
Hauptverfasser:	Stoy, Henriette, Zwicky, Katharina, Kuster, Danina, Lang, Kevin S, Krietsch, Jana, Crossley, Magdalena P., Schmid, Jonas A., Cimprich, Karlene A., Merrikh, Houra, Lopes, Massimo
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	New York Nature Publishing Group US 01.03.2023 Nature Publishing Group
Schlagworte:	101/28 631/1647/328/1259 631/337/1427 631/337/151/1431 631/337/151/2356 631/337/572 Accumulation Bacteria Bioassays Biochemistry Biological Microscopy Biomedical and Life Sciences Chromosomes - metabolism Deoxyribonucleic acid DNA DNA - chemistry DNA biosynthesis DNA Replication DNA-Binding Proteins - metabolism Electron microscopy Estrogens Genomes Genomic Instability Humans Hybrids Life Sciences Membrane Biology Okazaki fragments Protein Structure R-loops Replication Replication forks Ribonucleic acid RNA Transcription Visualization
ISSN:	1545-9993, 1545-9985, 1545-9985
Online-Zugang:	Volltext
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