Early intermittent hyperlipidaemia alters tissue macrophages to fuel atherosclerosis

Hyperlipidaemia is a major risk factor of atherosclerotic cardiovascular disease (ASCVD). Risk of cardiovascular events depends on cumulative lifetime exposure to low-density lipoprotein cholesterol (LDL-C) and, independently, on the time course of exposure to LDL-C, with early exposure being associ...

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Bibliographic Details
Published in:	Nature (London) Vol. 634; no. 8033; pp. 457 - 465
Main Authors:	Takaoka, Minoru, Zhao, Xiaohui, Lim, Hwee Ying, Magnussen, Costan G., Ang, Owen, Suffee, Nadine, Schrank, Patricia R., Ong, Wei Siong, Tsiantoulas, Dimitrios, Sommer, Felix, Mohanta, Sarajo K., Harrison, James, Meng, Yaxing, Laurans, Ludivine, Wu, Feitong, Lu, Yuning, Masters, Leanne, Newland, Stephen A., Denti, Laura, Hong, Mingyang, Chajadine, Mouna, Juonala, Markus, Koskinen, Juhani S., Kähönen, Mika, Pahkala, Katja, Rovio, Suvi P., Mykkänen, Juha, Thomson, Russell, Kaisho, Tsuneyasu, Habenicht, Andreas J. R., Clement, Marc, Tedgui, Alain, Ait-Oufella, Hafid, Zhao, Tian X., Nus, Meritxell, Ruhrberg, Christiana, Taleb, Soraya, Williams, Jesse W., Raitakari, Olli T., Angeli, Véronique, Mallat, Ziad
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 10.10.2024 Nature Publishing Group
Subjects:	13 13/1 13/51 14/19 631/443 631/443/592 64 Actin Adolescent Adult Animals Antibiotics Arteriosclerosis Atherosclerosis Atherosclerosis - epidemiology Atherosclerosis - etiology Atherosclerosis - genetics Atherosclerosis - metabolism Atherosclerosis - pathology Autophagy Biological effects Cardiovascular disease Cardiovascular diseases Child Child, Preschool Cholesterol Cholesterol, LDL - blood Cholesterol, LDL - metabolism Diet, Western - adverse effects Diet, Western - statistics & numerical data Experiments Exposure Female Finland - epidemiology Genes Genome-wide association studies Genome-Wide Association Study Health risks High cholesterol diet Humanities and Social Sciences Humans Hyperlipidemia Hyperlipidemias - complications Hyperlipidemias - epidemiology Hyperlipidemias - genetics Hyperlipidemias - metabolism Hyperlipidemias - pathology Incidence Low density lipoprotein Macrophages Macrophages - metabolism Macrophages - pathology Male Mice Mice, Inbred C57BL Microbiota Middle Aged multidisciplinary Optimal control Phenotype Phenotypes Plaque, Atherosclerotic - epidemiology Plaque, Atherosclerotic - etiology Plaque, Atherosclerotic - genetics Plaque, Atherosclerotic - metabolism Plaque, Atherosclerotic - pathology Plasma Risk factors Science Science (multidisciplinary) Time Factors Young Adult Finland
ISSN:	0028-0836, 1476-4687, 1476-4687
Online Access:	Get full text
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