A visual scale to rate amygdalar atrophy on MRI

Background Visual rating scales are routinely used in clinical radiology to assess brain atrophy on scans of patients with suspected neurodegenerative conditions. Limbic predominant age-related TDP-43 encephalopathy (LATE) has recently been described, featuring early and severe atrophy of the amygda...

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Vydané v:European radiology Ročník 35; číslo 7; s. 4246 - 4256
Hlavní autori: Pizzini, Francesca B., Ribaldi, Federica, Natale, Valerio, Scheffler, Max, Rossi, Vittoria, Frisoni, Giovanni B.
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Berlin/Heidelberg Springer Berlin Heidelberg 01.07.2025
Springer Nature B.V
Predmet:
Age
Aged
Aged, 80 and over
Alzheimer Disease - pathology
Alzheimer's disease
Amygdala
Amygdala - diagnostic imaging
Amygdala - pathology
Atrophy
Atrophy - pathology
Automation
Autopsies
Autopsy
Clinical medicine
Cognitive ability
Dementia disorders
Diagnostic Radiology
Encephalopathy
Female
Humans
Imaging
Internal Medicine
Interventional Radiology
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Male
Medical imaging
Medicine
Medicine & Public Health
Memory
Middle Aged
Morphology
Neuro
Neurodegenerative diseases
Neuroimaging
Neuropathology
Neuropsychology
Neuroradiology
Pathology
Radiology
Ratings
Reproducibility of Results
Ultrasound
Validity
Atrophy
Amygdala
MRI
Dementia
ISSN:1432-1084, 0938-7994, 1432-1084
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Abstract Background Visual rating scales are routinely used in clinical radiology to assess brain atrophy on scans of patients with suspected neurodegenerative conditions. Limbic predominant age-related TDP-43 encephalopathy (LATE) has recently been described, featuring early and severe atrophy of the amygdala. However, there is currently no scoring system specifically designed to assess amygdalar atrophy on MRI. Objectives to develop and validate a visual rating scale for amygdalar atrophy. Materials and methods Stringent criteria were developed for no, mild/moderate, and severe amygdalar atrophy based on axial and coronal volumetric T1-weighted MRI scans. Inter- and intra-rater reliabilities were estimated by three independent expert neuroradiologists in 100 randomly selected scans from the Geneva Memory Center cohort selected to be representative of the variability of medial temporal atrophy. Convergent validity was evaluated versus amygdalar volumes extracted by FreeSurfer on 1943 consecutive patients. Criterion validity versus autopsy-confirmed LATE neuropathologic changes were studied in the pathological subset of the Alzheimer’s Disease Neuroimaging Initiative (ADNI) cohort ( N  = 96). Results Intra- and inter-rater agreements of amygdalar visual ratings were between substantial and almost perfect (weighted Cohen’s Kappa 0.71 to 0.93). Visual ratings were strongly associated with amygdalar volumes ( p  ≤ 0.001 on the Kruskal–Wallis test). LATE neuropathologic changes were associated with visual ratings of amygdalar atrophy ( p  = 0.057 on a test for trend). Conclusion The proposed visual amygdalar atrophy scale is a reliable and valid tool to assess amygdalar atrophy on MRI and can be a useful adjunct in routine radiological reporting. Key Points Question Assessment of amygdalar atrophy is crucial for diagnosing neurodegenerative diseases, as the limbic predominant age-related TDP-43 encephalopathy, yet no validated visual rating scale exists. Findings The proposed amygdalar atrophy scale demonstrated high intra-rater and inter-rater reliability, strong correlation with amygdalar volumetry, and association with limbic predominant age-related TDP-43 encephalopathy (LATE). Clinical relevance The amygdalar atrophy scale provides a reliable practical assessment tool that enhances diagnostic accuracy for dementia-related conditions, particularly aiding in identifying limbic predominant age-related TDP-43 encephalopathy.
AbstractList Visual rating scales are routinely used in clinical radiology to assess brain atrophy on scans of patients with suspected neurodegenerative conditions. Limbic predominant age-related TDP-43 encephalopathy (LATE) has recently been described, featuring early and severe atrophy of the amygdala. However, there is currently no scoring system specifically designed to assess amygdalar atrophy on MRI.BACKGROUNDVisual rating scales are routinely used in clinical radiology to assess brain atrophy on scans of patients with suspected neurodegenerative conditions. Limbic predominant age-related TDP-43 encephalopathy (LATE) has recently been described, featuring early and severe atrophy of the amygdala. However, there is currently no scoring system specifically designed to assess amygdalar atrophy on MRI.to develop and validate a visual rating scale for amygdalar atrophy.OBJECTIVESto develop and validate a visual rating scale for amygdalar atrophy.Stringent criteria were developed for no, mild/moderate, and severe amygdalar atrophy based on axial and coronal volumetric T1-weighted MRI scans. Inter- and intra-rater reliabilities were estimated by three independent expert neuroradiologists in 100 randomly selected scans from the Geneva Memory Center cohort selected to be representative of the variability of medial temporal atrophy. Convergent validity was evaluated versus amygdalar volumes extracted by FreeSurfer on 1943 consecutive patients. Criterion validity versus autopsy-confirmed LATE neuropathologic changes were studied in the pathological subset of the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort (N = 96).MATERIALS AND METHODSStringent criteria were developed for no, mild/moderate, and severe amygdalar atrophy based on axial and coronal volumetric T1-weighted MRI scans. Inter- and intra-rater reliabilities were estimated by three independent expert neuroradiologists in 100 randomly selected scans from the Geneva Memory Center cohort selected to be representative of the variability of medial temporal atrophy. Convergent validity was evaluated versus amygdalar volumes extracted by FreeSurfer on 1943 consecutive patients. Criterion validity versus autopsy-confirmed LATE neuropathologic changes were studied in the pathological subset of the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort (N = 96).Intra- and inter-rater agreements of amygdalar visual ratings were between substantial and almost perfect (weighted Cohen's Kappa 0.71 to 0.93). Visual ratings were strongly associated with amygdalar volumes (p ≤ 0.001 on the Kruskal-Wallis test). LATE neuropathologic changes were associated with visual ratings of amygdalar atrophy (p = 0.057 on a test for trend).RESULTSIntra- and inter-rater agreements of amygdalar visual ratings were between substantial and almost perfect (weighted Cohen's Kappa 0.71 to 0.93). Visual ratings were strongly associated with amygdalar volumes (p ≤ 0.001 on the Kruskal-Wallis test). LATE neuropathologic changes were associated with visual ratings of amygdalar atrophy (p = 0.057 on a test for trend).The proposed visual amygdalar atrophy scale is a reliable and valid tool to assess amygdalar atrophy on MRI and can be a useful adjunct in routine radiological reporting.CONCLUSIONThe proposed visual amygdalar atrophy scale is a reliable and valid tool to assess amygdalar atrophy on MRI and can be a useful adjunct in routine radiological reporting.Question Assessment of amygdalar atrophy is crucial for diagnosing neurodegenerative diseases, as the limbic predominant age-related TDP-43 encephalopathy, yet no validated visual rating scale exists. Findings The proposed amygdalar atrophy scale demonstrated high intra-rater and inter-rater reliability, strong correlation with amygdalar volumetry, and association with limbic predominant age-related TDP-43 encephalopathy (LATE). Clinical relevance The amygdalar atrophy scale provides a reliable practical assessment tool that enhances diagnostic accuracy for dementia-related conditions, particularly aiding in identifying limbic predominant age-related TDP-43 encephalopathy.KEY POINTSQuestion Assessment of amygdalar atrophy is crucial for diagnosing neurodegenerative diseases, as the limbic predominant age-related TDP-43 encephalopathy, yet no validated visual rating scale exists. Findings The proposed amygdalar atrophy scale demonstrated high intra-rater and inter-rater reliability, strong correlation with amygdalar volumetry, and association with limbic predominant age-related TDP-43 encephalopathy (LATE). Clinical relevance The amygdalar atrophy scale provides a reliable practical assessment tool that enhances diagnostic accuracy for dementia-related conditions, particularly aiding in identifying limbic predominant age-related TDP-43 encephalopathy.
Background Visual rating scales are routinely used in clinical radiology to assess brain atrophy on scans of patients with suspected neurodegenerative conditions. Limbic predominant age-related TDP-43 encephalopathy (LATE) has recently been described, featuring early and severe atrophy of the amygdala. However, there is currently no scoring system specifically designed to assess amygdalar atrophy on MRI. Objectives to develop and validate a visual rating scale for amygdalar atrophy. Materials and methods Stringent criteria were developed for no, mild/moderate, and severe amygdalar atrophy based on axial and coronal volumetric T1-weighted MRI scans. Inter- and intra-rater reliabilities were estimated by three independent expert neuroradiologists in 100 randomly selected scans from the Geneva Memory Center cohort selected to be representative of the variability of medial temporal atrophy. Convergent validity was evaluated versus amygdalar volumes extracted by FreeSurfer on 1943 consecutive patients. Criterion validity versus autopsy-confirmed LATE neuropathologic changes were studied in the pathological subset of the Alzheimer’s Disease Neuroimaging Initiative (ADNI) cohort ( N  = 96). Results Intra- and inter-rater agreements of amygdalar visual ratings were between substantial and almost perfect (weighted Cohen’s Kappa 0.71 to 0.93). Visual ratings were strongly associated with amygdalar volumes ( p  ≤ 0.001 on the Kruskal–Wallis test). LATE neuropathologic changes were associated with visual ratings of amygdalar atrophy ( p  = 0.057 on a test for trend). Conclusion The proposed visual amygdalar atrophy scale is a reliable and valid tool to assess amygdalar atrophy on MRI and can be a useful adjunct in routine radiological reporting. Key Points Question Assessment of amygdalar atrophy is crucial for diagnosing neurodegenerative diseases, as the limbic predominant age-related TDP-43 encephalopathy, yet no validated visual rating scale exists. Findings The proposed amygdalar atrophy scale demonstrated high intra-rater and inter-rater reliability, strong correlation with amygdalar volumetry, and association with limbic predominant age-related TDP-43 encephalopathy (LATE). Clinical relevance The amygdalar atrophy scale provides a reliable practical assessment tool that enhances diagnostic accuracy for dementia-related conditions, particularly aiding in identifying limbic predominant age-related TDP-43 encephalopathy.
BackgroundVisual rating scales are routinely used in clinical radiology to assess brain atrophy on scans of patients with suspected neurodegenerative conditions. Limbic predominant age-related TDP-43 encephalopathy (LATE) has recently been described, featuring early and severe atrophy of the amygdala. However, there is currently no scoring system specifically designed to assess amygdalar atrophy on MRI.Objectivesto develop and validate a visual rating scale for amygdalar atrophy.Materials and methodsStringent criteria were developed for no, mild/moderate, and severe amygdalar atrophy based on axial and coronal volumetric T1-weighted MRI scans. Inter- and intra-rater reliabilities were estimated by three independent expert neuroradiologists in 100 randomly selected scans from the Geneva Memory Center cohort selected to be representative of the variability of medial temporal atrophy. Convergent validity was evaluated versus amygdalar volumes extracted by FreeSurfer on 1943 consecutive patients. Criterion validity versus autopsy-confirmed LATE neuropathologic changes were studied in the pathological subset of the Alzheimer’s Disease Neuroimaging Initiative (ADNI) cohort (N = 96).ResultsIntra- and inter-rater agreements of amygdalar visual ratings were between substantial and almost perfect (weighted Cohen’s Kappa 0.71 to 0.93). Visual ratings were strongly associated with amygdalar volumes (p ≤ 0.001 on the Kruskal–Wallis test). LATE neuropathologic changes were associated with visual ratings of amygdalar atrophy (p = 0.057 on a test for trend).ConclusionThe proposed visual amygdalar atrophy scale is a reliable and valid tool to assess amygdalar atrophy on MRI and can be a useful adjunct in routine radiological reporting.Key PointsQuestionAssessment of amygdalar atrophy is crucial for diagnosing neurodegenerative diseases, as the limbic predominant age-related TDP-43 encephalopathy, yet no validated visual rating scale exists.FindingsThe proposed amygdalar atrophy scale demonstrated high intra-rater and inter-rater reliability, strong correlation with amygdalar volumetry, and association with limbic predominant age-related TDP-43 encephalopathy (LATE).Clinical relevanceThe amygdalar atrophy scale provides a reliable practical assessment tool that enhances diagnostic accuracy for dementia-related conditions, particularly aiding in identifying limbic predominant age-related TDP-43 encephalopathy.
Visual rating scales are routinely used in clinical radiology to assess brain atrophy on scans of patients with suspected neurodegenerative conditions. Limbic predominant age-related TDP-43 encephalopathy (LATE) has recently been described, featuring early and severe atrophy of the amygdala. However, there is currently no scoring system specifically designed to assess amygdalar atrophy on MRI. to develop and validate a visual rating scale for amygdalar atrophy. Stringent criteria were developed for no, mild/moderate, and severe amygdalar atrophy based on axial and coronal volumetric T1-weighted MRI scans. Inter- and intra-rater reliabilities were estimated by three independent expert neuroradiologists in 100 randomly selected scans from the Geneva Memory Center cohort selected to be representative of the variability of medial temporal atrophy. Convergent validity was evaluated versus amygdalar volumes extracted by FreeSurfer on 1943 consecutive patients. Criterion validity versus autopsy-confirmed LATE neuropathologic changes were studied in the pathological subset of the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort (N = 96). Intra- and inter-rater agreements of amygdalar visual ratings were between substantial and almost perfect (weighted Cohen's Kappa 0.71 to 0.93). Visual ratings were strongly associated with amygdalar volumes (p ≤ 0.001 on the Kruskal-Wallis test). LATE neuropathologic changes were associated with visual ratings of amygdalar atrophy (p = 0.057 on a test for trend). The proposed visual amygdalar atrophy scale is a reliable and valid tool to assess amygdalar atrophy on MRI and can be a useful adjunct in routine radiological reporting. Question Assessment of amygdalar atrophy is crucial for diagnosing neurodegenerative diseases, as the limbic predominant age-related TDP-43 encephalopathy, yet no validated visual rating scale exists. Findings The proposed amygdalar atrophy scale demonstrated high intra-rater and inter-rater reliability, strong correlation with amygdalar volumetry, and association with limbic predominant age-related TDP-43 encephalopathy (LATE). Clinical relevance The amygdalar atrophy scale provides a reliable practical assessment tool that enhances diagnostic accuracy for dementia-related conditions, particularly aiding in identifying limbic predominant age-related TDP-43 encephalopathy.
Author Ribaldi, Federica
Natale, Valerio
Frisoni, Giovanni B.
Rossi, Vittoria
Scheffler, Max
Pizzini, Francesca B.
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  organization: Radiology and Department of Engineering for Innovation Medicine, Verona University
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  organization: Department of Diagnostic and Public Health, Rivoli Hospital
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  surname: Scheffler
  fullname: Scheffler, Max
  organization: Division of Radiology, Geneva University Hospitals
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  surname: Rossi
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  organization: Radiology and Department of Engineering for Innovation Medicine, Verona University
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  surname: Frisoni
  fullname: Frisoni, Giovanni B.
  organization: Geneva Memory Center, Department of Rehabilitation and Geriatrics, Geneva University Hospitals, Laboratory of Neuroimaging of Aging (LANVIE), University of Geneva
BackLink https://www.ncbi.nlm.nih.gov/pubmed/39699678$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1111/J.1468-1331.2012.03859.X
10.1002/GLIA.24096
10.1212/01.wnl.0000277459.83543.99
10.1186/s13195-021-00846-z
10.1016/j.jalz.2015.05.010
10.1136/JNNP-2014-310090
10.1093/BRAIN/AWZ099
10.1007/S11547-022-01534-0
10.1002/gps.5132
10.1016/J.NEUROBIOLAGING.2016.05.024
10.1007/BF00868807
10.1093/jnen/nlz126
10.1007/s00234-019-02188-y
10.1016/S1474-4422(17)30159-X
10.1007/s00330-021-08227-8
10.1002/hbm.24918
10.1093/cercor/bhg087
10.1093/BRAIN/AWZ184
10.1136/jnnp.55.10.967
10.3233/JAD-170850
10.1161/01.STR.0000049766.26453.E9
10.1111/j.1749-6632.2003.tb07067.x
10.1016/j.lanepe.2022.100576
10.1093/BRAIN/AWW005
10.1007/s00330-011-2205-4
10.1212/wnl.58.5.750
10.1212/wnl.58.10.1476
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GrantInformation_xml – fundername: The Centre de la mémoire is funded by the following private donors under the supervision of the Private Foundation of Geneva University Hospitals: A.P.R.A. - Association Suisse pour la Recherche sur la Maladie d’Alzheimer, Genève; Fondation Segré, Genève;
– fundername: Competitive research projects have been funded by: H2020 (projects n. 667375), Innovative Medicines Initiative (IMI contract n. 115736 and 115952), IMI2, Swiss National Science Foundation (projects n.320030_182772 and n. 320030_169876), VELUX Foundation
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Issue 7
Keywords Atrophy
Amygdala
MRI
Dementia
Language English
License 2024. The Author(s).
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References PT Nelson (11249_CR11) 2019; 142
F Barkhof (11249_CR26) 2007; 69
AJ McDonald (11249_CR20) 2003; 985
11249_CR4
11249_CR3
B Alexander (11249_CR17) 2020; 41
11249_CR2
P Scheltens (11249_CR14) 1995; 242
11249_CR21
L Harper (11249_CR8) 2015; 86
KM Gosche (11249_CR27) 2002; 58
KE Prater (11249_CR13) 2022; 70
GB Frisoni (11249_CR7) 2017; 16
GB Frisoni (11249_CR23) 2023; 26
FB Pizzini (11249_CR10) 2022; 127
WM Van Der Flier (11249_CR24) 2018; 62
B Fischl (11249_CR16) 2004; 14
M Filippi (11249_CR9) 2012; 19
AAA Gruters (11249_CR22) 2019; 34
LM Besser (11249_CR19) 2020; 79
CRJ Jack (11249_CR28) 2002; 58
L Harper (11249_CR5) 2016; 139
HY Park (11249_CR25) 2021; 31
M ten Kate (11249_CR6) 2017; 52
AJ Larner (11249_CR12) 2019; 142
P Kapeller (11249_CR1) 2003; 34
11249_CR15
EE Franklin (11249_CR18) 2015; 11
39920304 - Eur Radiol. 2025 Jul;35(7):4243-4245. doi: 10.1007/s00330-025-11424-4.
References_xml – volume: 19
  start-page: 1487
  year: 2012
  ident: 11249_CR9
  publication-title: Eur J Neurol
  doi: 10.1111/J.1468-1331.2012.03859.X
– volume: 70
  start-page: 239
  year: 2022
  ident: 11249_CR13
  publication-title: Glia
  doi: 10.1002/GLIA.24096
– volume: 69
  start-page: 1521
  year: 2007
  ident: 11249_CR26
  publication-title: Neurology
  doi: 10.1212/01.wnl.0000277459.83543.99
– ident: 11249_CR15
  doi: 10.1186/s13195-021-00846-z
– volume: 11
  start-page: 815
  year: 2015
  ident: 11249_CR18
  publication-title: Alzheimers Dement
  doi: 10.1016/j.jalz.2015.05.010
– volume: 86
  start-page: 1225
  year: 2015
  ident: 11249_CR8
  publication-title: J Neurol Neurosurg Psychiatry
  doi: 10.1136/JNNP-2014-310090
– volume: 142
  start-page: 1503
  year: 2019
  ident: 11249_CR11
  publication-title: Brain
  doi: 10.1093/BRAIN/AWZ099
– ident: 11249_CR21
– volume: 127
  start-page: 998
  year: 2022
  ident: 11249_CR10
  publication-title: Radiol Med
  doi: 10.1007/S11547-022-01534-0
– volume: 34
  start-page: 1267
  year: 2019
  ident: 11249_CR22
  publication-title: Int J Geriatr Psychiatry
  doi: 10.1002/gps.5132
– volume: 52
  start-page: 167
  year: 2017
  ident: 11249_CR6
  publication-title: Neurobiol Aging
  doi: 10.1016/J.NEUROBIOLAGING.2016.05.024
– volume: 242
  start-page: 557
  year: 1995
  ident: 11249_CR14
  publication-title: J Neurol
  doi: 10.1007/BF00868807
– volume: 79
  start-page: 305
  year: 2020
  ident: 11249_CR19
  publication-title: J Neuropathol Exp Neurol
  doi: 10.1093/jnen/nlz126
– ident: 11249_CR2
  doi: 10.1007/s00234-019-02188-y
– volume: 16
  start-page: 661
  year: 2017
  ident: 11249_CR7
  publication-title: Lancet Neurol
  doi: 10.1016/S1474-4422(17)30159-X
– volume: 31
  start-page: 9060
  year: 2021
  ident: 11249_CR25
  publication-title: Eur Radiol
  doi: 10.1007/s00330-021-08227-8
– volume: 41
  start-page: 1875
  year: 2020
  ident: 11249_CR17
  publication-title: Hum Brain Mapp
  doi: 10.1002/hbm.24918
– volume: 14
  start-page: 11
  year: 2004
  ident: 11249_CR16
  publication-title: Cereb Cortex
  doi: 10.1093/cercor/bhg087
– volume: 142
  start-page: E42
  year: 2019
  ident: 11249_CR12
  publication-title: Brain
  doi: 10.1093/BRAIN/AWZ184
– ident: 11249_CR4
  doi: 10.1136/jnnp.55.10.967
– volume: 62
  start-page: 1091
  issue: 3
  year: 2018
  ident: 11249_CR24
  publication-title: J Alzheimer’s Dis.
  doi: 10.3233/JAD-170850
– volume: 34
  start-page: 441
  year: 2003
  ident: 11249_CR1
  publication-title: Stroke
  doi: 10.1161/01.STR.0000049766.26453.E9
– volume: 985
  start-page: 1
  year: 2003
  ident: 11249_CR20
  publication-title: Ann N Y Acad Sci
  doi: 10.1111/j.1749-6632.2003.tb07067.x
– volume: 26
  start-page: 1
  year: 2023
  ident: 11249_CR23
  publication-title: Lancet Reg Health Eur
  doi: 10.1016/j.lanepe.2022.100576
– volume: 139
  start-page: 1211
  year: 2016
  ident: 11249_CR5
  publication-title: Brain
  doi: 10.1093/BRAIN/AWW005
– ident: 11249_CR3
  doi: 10.1007/s00330-011-2205-4
– volume: 58
  start-page: 750
  year: 2002
  ident: 11249_CR28
  publication-title: Neurology
  doi: 10.1212/wnl.58.5.750
– volume: 58
  start-page: 1476
  year: 2002
  ident: 11249_CR27
  publication-title: Neurology
  doi: 10.1212/wnl.58.10.1476
– reference: 39920304 - Eur Radiol. 2025 Jul;35(7):4243-4245. doi: 10.1007/s00330-025-11424-4.
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Snippet Background Visual rating scales are routinely used in clinical radiology to assess brain atrophy on scans of patients with suspected neurodegenerative...
Visual rating scales are routinely used in clinical radiology to assess brain atrophy on scans of patients with suspected neurodegenerative conditions. Limbic...
BackgroundVisual rating scales are routinely used in clinical radiology to assess brain atrophy on scans of patients with suspected neurodegenerative...
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StartPage 4246
SubjectTerms Age
Aged
Aged, 80 and over
Alzheimer Disease - pathology
Alzheimer's disease
Amygdala
Amygdala - diagnostic imaging
Amygdala - pathology
Atrophy
Atrophy - pathology
Automation
Autopsies
Autopsy
Clinical medicine
Cognitive ability
Dementia disorders
Diagnostic Radiology
Encephalopathy
Female
Humans
Imaging
Internal Medicine
Interventional Radiology
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Male
Medical imaging
Medicine
Medicine & Public Health
Memory
Middle Aged
Morphology
Neuro
Neurodegenerative diseases
Neuroimaging
Neuropathology
Neuropsychology
Neuroradiology
Pathology
Radiology
Ratings
Reproducibility of Results
Ultrasound
Validity
Title A visual scale to rate amygdalar atrophy on MRI
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