Targetable Kinase-Activating Lesions in Ph-like Acute Lymphoblastic Leukemia
About 25% of young adults with ALL have Ph-like genotypes, which are associated with poor outcomes with conventional treatment. In this gene-expression study, a substantial fraction of Ph-like ALL cases were found to involve activation of kinases targeted by available agents.
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| Vydané v: | The New England journal of medicine Ročník 371; číslo 11; s. 1005 - 1015 |
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| Hlavní autori: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | English |
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Waltham, MA
Massachusetts Medical Society
11.09.2014
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| ISSN: | 0028-4793, 1533-4406, 1533-4406 |
| On-line prístup: | Získať plný text |
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| Abstract | About 25% of young adults with ALL have Ph-like genotypes, which are associated with poor outcomes with conventional treatment. In this gene-expression study, a substantial fraction of Ph-like ALL cases were found to involve activation of kinases targeted by available agents. |
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| AbstractList | BackgroundPhiladelphia chromosome–like acute lymphoblastic leukemia (Ph-like ALL) is characterized by a gene-expression profile similar to that of BCR–ABL1–positive ALL, alterations of lymphoid transcription factor genes, and a poor outcome. The frequency and spectrum of genetic alterations in Ph-like ALL and its responsiveness to tyrosine kinase inhibition are undefined, especially in adolescents and adults.MethodsWe performed genomic profiling of 1725 patients with precursor B-cell ALL and detailed genomic analysis of 154 patients with Ph-like ALL. We examined the functional effects of fusion proteins and the efficacy of tyrosine kinase inhibitors in mouse pre-B cells and xenografts of human Ph-like ALL.ResultsPh-like ALL increased in frequency from 10% among children with standard-risk ALL to 27% among young adults with ALL and was associated with a poor outcome. Kinase-activating alterations were identified in 91% of patients with Ph-like ALL; rearrangements involving ABL1, ABL2, CRLF2, CSF1R, EPOR, JAK2, NTRK3, PDGFRB, PTK2B, TSLP, or TYK2 and sequence mutations involving FLT3, IL7R, or SH2B3 were most common. Expression of ABL1, ABL2, CSF1R, JAK2, and PDGFRB fusions resulted in cytokine-independent proliferation and activation of phosphorylated STAT5. Cell lines and human leukemic cells expressing ABL1, ABL2, CSF1R, and PDGFRB fusions were sensitive in vitro to dasatinib, EPOR and JAK2 rearrangements were sensitive to ruxolitinib, and the ETV6–NTRK3 fusion was sensitive to crizotinib.ConclusionsPh-like ALL was found to be characterized by a range of genomic alterations that activate a limited number of signaling pathways, all of which may be amenable to inhibition with approved tyrosine kinase inhibitors. Trials identifying Ph-like ALL are needed to assess whether adding tyrosine kinase inhibitors to current therapy will improve the survival of patients with this type of leukemia. (Funded by the American Lebanese Syrian Associated Charities and others.) Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is characterized by a gene-expression profile similar to that of BCR-ABL1-positive ALL, alterations of lymphoid transcription factor genes, and a poor outcome. The frequency and spectrum of genetic alterations in Ph-like ALL and its responsiveness to tyrosine kinase inhibition are undefined, especially in adolescents and adults.BACKGROUNDPhiladelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is characterized by a gene-expression profile similar to that of BCR-ABL1-positive ALL, alterations of lymphoid transcription factor genes, and a poor outcome. The frequency and spectrum of genetic alterations in Ph-like ALL and its responsiveness to tyrosine kinase inhibition are undefined, especially in adolescents and adults.We performed genomic profiling of 1725 patients with precursor B-cell ALL and detailed genomic analysis of 154 patients with Ph-like ALL. We examined the functional effects of fusion proteins and the efficacy of tyrosine kinase inhibitors in mouse pre-B cells and xenografts of human Ph-like ALL.METHODSWe performed genomic profiling of 1725 patients with precursor B-cell ALL and detailed genomic analysis of 154 patients with Ph-like ALL. We examined the functional effects of fusion proteins and the efficacy of tyrosine kinase inhibitors in mouse pre-B cells and xenografts of human Ph-like ALL.Ph-like ALL increased in frequency from 10% among children with standard-risk ALL to 27% among young adults with ALL and was associated with a poor outcome. Kinase-activating alterations were identified in 91% of patients with Ph-like ALL; rearrangements involving ABL1, ABL2, CRLF2, CSF1R, EPOR, JAK2, NTRK3, PDGFRB, PTK2B, TSLP, or TYK2 and sequence mutations involving FLT3, IL7R, or SH2B3 were most common. Expression of ABL1, ABL2, CSF1R, JAK2, and PDGFRB fusions resulted in cytokine-independent proliferation and activation of phosphorylated STAT5. Cell lines and human leukemic cells expressing ABL1, ABL2, CSF1R, and PDGFRB fusions were sensitive in vitro to dasatinib, EPOR and JAK2 rearrangements were sensitive to ruxolitinib, and the ETV6-NTRK3 fusion was sensitive to crizotinib.RESULTSPh-like ALL increased in frequency from 10% among children with standard-risk ALL to 27% among young adults with ALL and was associated with a poor outcome. Kinase-activating alterations were identified in 91% of patients with Ph-like ALL; rearrangements involving ABL1, ABL2, CRLF2, CSF1R, EPOR, JAK2, NTRK3, PDGFRB, PTK2B, TSLP, or TYK2 and sequence mutations involving FLT3, IL7R, or SH2B3 were most common. Expression of ABL1, ABL2, CSF1R, JAK2, and PDGFRB fusions resulted in cytokine-independent proliferation and activation of phosphorylated STAT5. Cell lines and human leukemic cells expressing ABL1, ABL2, CSF1R, and PDGFRB fusions were sensitive in vitro to dasatinib, EPOR and JAK2 rearrangements were sensitive to ruxolitinib, and the ETV6-NTRK3 fusion was sensitive to crizotinib.Ph-like ALL was found to be characterized by a range of genomic alterations that activate a limited number of signaling pathways, all of which may be amenable to inhibition with approved tyrosine kinase inhibitors. Trials identifying Ph-like ALL are needed to assess whether adding tyrosine kinase inhibitors to current therapy will improve the survival of patients with this type of leukemia. (Funded by the American Lebanese Syrian Associated Charities and others.).CONCLUSIONSPh-like ALL was found to be characterized by a range of genomic alterations that activate a limited number of signaling pathways, all of which may be amenable to inhibition with approved tyrosine kinase inhibitors. Trials identifying Ph-like ALL are needed to assess whether adding tyrosine kinase inhibitors to current therapy will improve the survival of patients with this type of leukemia. (Funded by the American Lebanese Syrian Associated Charities and others.). Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is characterized by a gene-expression profile similar to that of BCR-ABL1-positive ALL, alterations of lymphoid transcription factor genes, and a poor outcome. The frequency and spectrum of genetic alterations in Ph-like ALL and its responsiveness to tyrosine kinase inhibition are undefined, especially in adolescents and adults. We performed genomic profiling of 1725 patients with precursor B-cell ALL and detailed genomic analysis of 154 patients with Ph-like ALL. We examined the functional effects of fusion proteins and the efficacy of tyrosine kinase inhibitors in mouse pre-B cells and xenografts of human Ph-like ALL. Ph-like ALL increased in frequency from 10% among children with standard-risk ALL to 27% among young adults with ALL and was associated with a poor outcome. Kinase-activating alterations were identified in 91% of patients with Ph-like ALL; rearrangements involving ABL1, ABL2, CRLF2, CSF1R, EPOR, JAK2, NTRK3, PDGFRB, PTK2B, TSLP, or TYK2 and sequence mutations involving FLT3, IL7R, or SH2B3 were most common. Expression of ABL1, ABL2, CSF1R, JAK2, and PDGFRB fusions resulted in cytokine-independent proliferation and activation of phosphorylated STAT5. Cell lines and human leukemic cells expressing ABL1, ABL2, CSF1R, and PDGFRB fusions were sensitive in vitro to dasatinib, EPOR and JAK2 rearrangements were sensitive to ruxolitinib, and the ETV6-NTRK3 fusion was sensitive to crizotinib. Ph-like ALL was found to be characterized by a range of genomic alterations that activate a limited number of signaling pathways, all of which may be amenable to inhibition with approved tyrosine kinase inhibitors. Trials identifying Ph-like ALL are needed to assess whether adding tyrosine kinase inhibitors to current therapy will improve the survival of patients with this type of leukemia. (Funded by the American Lebanese Syrian Associated Charities and others.). About 25% of young adults with ALL have Ph-like genotypes, which are associated with poor outcomes with conventional treatment. In this gene-expression study, a substantial fraction of Ph-like ALL cases were found to involve activation of kinases targeted by available agents. |
| Author | Wilson, Richard K Cheng, Cheng Keller, Frank Relling, Mary V Willman, Cheryl L McCastlain, Kelly Carroll, Andrew J Vadodaria, Bhavin Pei, Deqing Nagahawatte, Panduka Guidry Auvil, Jaime M Kornblau, Steven M Fulton, Robert S Becksfort, Jared Ding, Li Wu, Gang Grayson, Guy Winick, Naomi J Smith, Amy Downing, James R Rusch, Michael Payne-Turner, Debbie Yergeau, Donald Chen, I-Ming Konopleva, Marina Mardis, Elaine Wen, Ji Bloomfield, Clara D Tasian, Sarah K Chen, Xiang Smith, Malcolm A Kohlschmidt, Jessica Hunger, Stephen P Boggs, Kristy Whitlock, James A Santiago-Morales, Natalia Hedlund, Erin Roberts, Kathryn G Song, Guangchun Devidas, Meenakshi Mulder, Heather Lu, Charles Paugh, Steven W Yang, Yung-Li Heerema, Nyla A Chen, Shann-Ching Frei-Jones, Melissa Gastier-Foster, Julie M Hughes, Timothy P Easton, John Zhang, Jinghui Reshmi, Shalini Iacobucci, Ilaria Larsen, Eric C Paietta, Elisabeth Carroll, William L White, Deborah L Harvey, Richard C Jeha, Sima Cheng, Jinjun Moore, Andrew S Marcucci, Guido Stock, Wendy Raetz, Elizabeth A Pui, Ching-Hon Evans |
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Mrózek, J.K.) — all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) — all in Texas; Maine Children’s Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx (E.P.) — both in New York; the Department of Genetics, University of Alabama at Birmingham, Birmingham (A.J.C.); the Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia (S.K.T.); Queensland Children’s Medical Research Institute, University of Queensland and Royal Children’s Hospital Brisbane, Herston (A.S.M.), and Cancer Theme, South Australian Health and Medical Research Institute, Adelaide (D.L.W., T.P.H.) — both in Australia; Children’s Healthcare of Atlanta and Emory University School of Medicine — both in Atlanta (F.K.); the Division of Haematology–Oncology, Hospital for Sick Children, and University of Toronto — both in Toronto (J.A.W.); Hunstman Cancer Institute, University of Utah, Salt Lake City (E.A.R.); the Office of Cancer Genomics (J.M.G.A., D.S.G.) and Cancer Therapy Evaluation Program (M.A.S.), National Cancer Institute, and the Children’s Oncology Group TARGET ALL project (M.D., I-M.C., S.R., W.L.C., J.M.G.A., M.A.S., M.V.R., D.S.G., J.M.G.-F., M.L.L., J.R.D., S.P.H., C.L.W., J.Z., C.G.M.), National Institutes of Health, Bethesda, MD; Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN (J.K.); the University of Chicago Medicine, Chicago (W.S.); the Department of Pediatrics, Benioff Children’s Hospital, and the Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco (M.L.L.); and the University of Colorado School of Medicine and Children’s Hospital Colorado — both in Aurora (S.P.H.) – sequence: 5 givenname: Yung-Li surname: Yang fullname: Yang, Yung-Li organization: From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children’s Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) — all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children’s Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) — all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) — all in Texas; Maine Children’s Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx (E.P.) — both in New York; the Department of Genetics, University of Alabama at Birmingham, Birmingham (A.J.C.); the Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia (S.K.T.); Queensland Children’s Medical Research Institute, University of Queensland and Royal Children’s Hospital Brisbane, Herston (A.S.M.), and Cancer Theme, South Australian Health and Medical Research Institute, Adelaide (D.L.W., T.P.H.) — both in Australia; Children’s Healthcare of Atlanta and Emory University School of Medicine — both in Atlanta (F.K.); the Division of Haematology–Oncology, Hospital for Sick Children, and University of Toronto — both in Toronto (J.A.W.); Hunstman Cancer Institute, University of Utah, Salt Lake City (E.A.R.); the Office of Cancer Genomics (J.M.G.A., D.S.G.) and Cancer Therapy Evaluation Program (M.A.S.), National Cancer Institute, and the Children’s Oncology Group TARGET ALL project (M.D., I-M.C., S.R., W.L.C., J.M.G.A., M.A.S., M.V.R., D.S.G., J.M.G.-F., M.L.L., J.R.D., S.P.H., C.L.W., J.Z., C.G.M.), National Institutes of Health, Bethesda, MD; Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN (J.K.); the University of Chicago Medicine, Chicago (W.S.); the Department of Pediatrics, Benioff Children’s Hospital, and the Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco (M.L.L.); and the University of Colorado School of Medicine and Children’s Hospital Colorado — both in Aurora (S.P.H.) – sequence: 6 givenname: Deqing surname: Pei fullname: Pei, Deqing organization: From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children’s Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) — all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children’s Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) — all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) — all in Texas; Maine Children’s Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx (E.P.) — both in New York; the Department of Genetics, University of Alabama at Birmingham, Birmingham (A.J.C.); the Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia (S.K.T.); Queensland Children’s Medical Research Institute, University of Queensland and Royal Children’s Hospital Brisbane, Herston (A.S.M.), and Cancer Theme, South Australian Health and Medical Research Institute, Adelaide (D.L.W., T.P.H.) — both in Australia; Children’s Healthcare of Atlanta and Emory University School of Medicine — both in Atlanta (F.K.); the Division of Haematology–Oncology, Hospital for Sick Children, and University of Toronto — both in Toronto (J.A.W.); Hunstman Cancer Institute, University of Utah, Salt Lake City (E.A.R.); the Office of Cancer Genomics (J.M.G.A., D.S.G.) and Cancer Therapy Evaluation Program (M.A.S.), National Cancer Institute, and the Children’s Oncology Group TARGET ALL project (M.D., I-M.C., S.R., W.L.C., J.M.G.A., M.A.S., M.V.R., D.S.G., J.M.G.-F., M.L.L., J.R.D., S.P.H., C.L.W., J.Z., C.G.M.), National Institutes of Health, Bethesda, MD; Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN (J.K.); the University of Chicago Medicine, Chicago (W.S.); the Department of Pediatrics, Benioff Children’s Hospital, and the Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco (M.L.L.); and the University of Colorado School of Medicine and Children’s Hospital Colorado — both in Aurora (S.P.H.) – sequence: 7 givenname: Kelly surname: McCastlain fullname: McCastlain, Kelly organization: From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children’s Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) — all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children’s Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) — all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) — all in Texas; Maine Children’s Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx (E.P.) — both in New York; the Department of Genetics, University of Alabama at Birmingham, Birmingham (A.J.C.); the Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia (S.K.T.); Queensland Children’s Medical Research Institute, University of Queensland and Royal Children’s Hospital Brisbane, Herston (A.S.M.), and Cancer Theme, South Australian Health and Medical Research Institute, Adelaide (D.L.W., T.P.H.) — both in Australia; Children’s Healthcare of Atlanta and Emory University School of Medicine — both in Atlanta (F.K.); the Division of Haematology–Oncology, Hospital for Sick Children, and University of Toronto — both in Toronto (J.A.W.); Hunstman Cancer Institute, University of Utah, Salt Lake City (E.A.R.); the Office of Cancer Genomics (J.M.G.A., D.S.G.) and Cancer Therapy Evaluation Program (M.A.S.), National Cancer Institute, and the Children’s Oncology Group TARGET ALL project (M.D., I-M.C., S.R., W.L.C., J.M.G.A., M.A.S., M.V.R., D.S.G., J.M.G.-F., M.L.L., J.R.D., S.P.H., C.L.W., J.Z., C.G.M.), National Institutes of Health, Bethesda, MD; Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN (J.K.); the University of Chicago Medicine, Chicago (W.S.); the Department of Pediatrics, Benioff Children’s Hospital, and the Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco (M.L.L.); and the University of Colorado School of Medicine and Children’s Hospital Colorado — both in Aurora (S.P.H.) – sequence: 8 givenname: Li surname: Ding fullname: Ding, Li organization: From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children’s Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) — all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children’s Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) — all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) — all in Texas; Maine Children’s Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx (E.P.) — both in New York; the Department of Genetics, University of Alabama at Birmingham, Birmingham (A.J.C.); the Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia (S.K.T.); Queensland Children’s Medical Research Institute, University of Queensland and Royal Children’s Hospital Brisbane, Herston (A.S.M.), and Cancer Theme, South Australian Health and Medical Research Institute, Adelaide (D.L.W., T.P.H.) — both in Australia; Children’s Healthcare of Atlanta and Emory University School of Medicine — both in Atlanta (F.K.); the Division of Haematology–Oncology, Hospital for Sick Children, and University of Toronto — both in Toronto (J.A.W.); Hunstman Cancer Institute, University of Utah, Salt Lake City (E.A.R.); the Office of Cancer Genomics (J.M.G.A., D.S.G.) and Cancer Therapy Evaluation Program (M.A.S.), National Cancer Institute, and the Children’s Oncology Group TARGET ALL project (M.D., I-M.C., S.R., W.L.C., J.M.G.A., M.A.S., M.V.R., D.S.G., J.M.G.-F., M.L.L., J.R.D., S.P.H., C.L.W., J.Z., C.G.M.), National Institutes of Health, Bethesda, MD; Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN (J.K.); the University of Chicago Medicine, Chicago (W.S.); the Department of Pediatrics, Benioff Children’s Hospital, and the Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco (M.L.L.); and the University of Colorado School of Medicine and Children’s Hospital Colorado — both in Aurora (S.P.H.) – sequence: 9 givenname: Charles surname: Lu fullname: Lu, Charles organization: From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children’s Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) — all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children’s Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) — all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) — all in Texas; Maine Children’s Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx (E.P.) — both in New York; the Department of Genetics, University of Alabama at Birmingham, Birmingham (A.J.C.); the Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia (S.K.T.); Queensland Children’s Medical Research Institute, University of Queensland and Royal Children’s Hospital Brisbane, Herston (A.S.M.), and Cancer Theme, South Australian Health and Medical Research Institute, Adelaide (D.L.W., T.P.H.) — both in Australia; Children’s Healthcare of Atlanta and Emory University School of Medicine — both in Atlanta (F.K.); the Division of Haematology–Oncology, Hospital for Sick Children, and University of Toronto — both in Toronto (J.A.W.); Hunstman Cancer Institute, University of Utah, Salt Lake City (E.A.R.); the Office of Cancer Genomics (J.M.G.A., D.S.G.) and Cancer Therapy Evaluation Program (M.A.S.), National Cancer Institute, and the Children’s Oncology Group TARGET ALL project (M.D., I-M.C., S.R., W.L.C., J.M.G.A., M.A.S., M.V.R., D.S.G., J.M.G.-F., M.L.L., J.R.D., S.P.H., C.L.W., J.Z., C.G.M.), National Institutes of Health, Bethesda, MD; Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN (J.K.); the University of Chicago Medicine, Chicago (W.S.); the Department of Pediatrics, Benioff Children’s Hospital, and the Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco (M.L.L.); and the University of Colorado School of Medicine and Children’s Hospital Colorado — both in Aurora (S.P.H.) – sequence: 10 givenname: Guangchun surname: Song fullname: Song, Guangchun organization: From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children’s Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) — all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children’s Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) — all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) — all in Texas; Maine Children’s Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx (E.P.) — both in New York; the Department of Genetics, University of Alabama at Birmingham, Birmingham (A.J.C.); the Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia (S.K.T.); Queensland Children’s Medical Research Institute, University of Queensland and Royal Children’s Hospital Brisbane, Herston (A.S.M.), and Cancer Theme, South Australian Health and Medical Research Institute, Adelaide (D.L.W., T.P.H.) — both in Australia; Children’s Healthcare of Atlanta and Emory University School of Medicine — both in Atlanta (F.K.); the Division of Haematology–Oncology, Hospital for Sick Children, and University of Toronto — both in Toronto (J.A.W.); Hunstman Cancer Institute, University of Utah, Salt Lake City (E.A.R.); the Office of Cancer Genomics (J.M.G.A., D.S.G.) and Cancer Therapy Evaluation Program (M.A.S.), National Cancer Institute, and the Children’s Oncology Group TARGET ALL project (M.D., I-M.C., S.R., W.L.C., J.M.G.A., M.A.S., M.V.R., D.S.G., J.M.G.-F., M.L.L., J.R.D., S.P.H., C.L.W., J.Z., C.G.M.), National Institutes of Health, Bethesda, MD; Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN (J.K.); the University of Chicago Medicine, Chicago (W.S.); the Department of Pediatrics, Benioff Children’s Hospital, and the Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco (M.L.L.); and the University of Colorado School of Medicine and Children’s Hospital Colorado — both in Aurora (S.P.H.) – sequence: 11 givenname: Jing surname: Ma fullname: Ma, Jing organization: From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children’s Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) — all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children’s Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) — all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) — all in Texas; Maine Children’s Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx (E.P.) — both in New York; the Department of Genetics, University of Alabama at Birmingham, Birmingham (A.J.C.); the Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia (S.K.T.); Queensland Children’s Medical Research Institute, University of Queensland and Royal Children’s Hospital Brisbane, Herston (A.S.M.), and Cancer Theme, South Australian Health and Medical Research Institute, Adelaide (D.L.W., T.P.H.) — both in Australia; Children’s Healthcare of Atlanta and Emory University School of Medicine — both in Atlanta (F.K.); the Division of Haematology–Oncology, Hospital for Sick Children, and University of Toronto — both in Toronto (J.A.W.); Hunstman Cancer Institute, University of Utah, Salt Lake City (E.A.R.); the Office of Cancer Genomics (J.M.G.A., D.S.G.) and Cancer Therapy Evaluation Program (M.A.S.), National Cancer Institute, and the Children’s Oncology Group TARGET ALL project (M.D., I-M.C., S.R., W.L.C., J.M.G.A., M.A.S., M.V.R., D.S.G., J.M.G.-F., M.L.L., J.R.D., S.P.H., C.L.W., J.Z., C.G.M.), National Institutes of Health, Bethesda, MD; Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN (J.K.); the University of Chicago Medicine, Chicago (W.S.); the Department of Pediatrics, Benioff Children’s Hospital, and the Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco (M.L.L.); and the University of Colorado School of Medicine and Children’s Hospital Colorado — both in Aurora (S.P.H.) – sequence: 12 givenname: Jared surname: Becksfort fullname: Becksfort, Jared organization: From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children’s Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) — all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children’s Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) — all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) — all in Texas; Maine Children’s Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx (E.P.) — both in New York; the Department of Genetics, University of Alabama at Birmingham, Birmingham (A.J.C.); the Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia (S.K.T.); Queensland Children’s Medical Research Institute, University of Queensland and Royal Children’s Hospital Brisbane, Herston (A.S.M.), and Cancer Theme, South Australian Health and Medical Research Institute, Adelaide (D.L.W., T.P.H.) — both in Australia; Children’s Healthcare of Atlanta and Emory University School of Medicine — both in Atlanta (F.K.); the Division of Haematology–Oncology, Hospital for Sick Children, and University of Toronto — both in Toronto (J.A.W.); Hunstman Cancer Institute, University of Utah, Salt Lake City (E.A.R.); the Office of Cancer Genomics (J.M.G.A., D.S.G.) and Cancer Therapy Evaluation Program (M.A.S.), National Cancer Institute, and the Children’s Oncology Group TARGET ALL project (M.D., I-M.C., S.R., W.L.C., J.M.G.A., M.A.S., M.V.R., D.S.G., J.M.G.-F., M.L.L., J.R.D., S.P.H., C.L.W., J.Z., C.G.M.), National Institutes of Health, Bethesda, MD; Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN (J.K.); the University of Chicago Medicine, Chicago (W.S.); the Department of Pediatrics, Benioff Children’s Hospital, and the Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco (M.L.L.); and the University of Colorado School of Medicine and Children’s Hospital Colorado — both in Aurora (S.P.H.) – sequence: 13 givenname: Michael surname: Rusch fullname: Rusch, Michael organization: From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children’s Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) — all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children’s Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) — all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) — all in Texas; Maine Children’s Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx (E.P.) — both in New York; the Department of Genetics, University of Alabama at Birmingham, Birmingham (A.J.C.); the Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia (S.K.T.); Queensland Children’s Medical Research Institute, University of Queensland and Royal Children’s Hospital Brisbane, Herston (A.S.M.), and Cancer Theme, South Australian Health and Medical Research Institute, Adelaide (D.L.W., T.P.H.) — both in Australia; Children’s Healthcare of Atlanta and Emory University School of Medicine — both in Atlanta (F.K.); the Division of Haematology–Oncology, Hospital for Sick Children, and University of Toronto — both in Toronto (J.A.W.); Hunstman Cancer Institute, University of Utah, Salt Lake City (E.A.R.); the Office of Cancer Genomics (J.M.G.A., D.S.G.) and Cancer Therapy Evaluation Program (M.A.S.), National Cancer Institute, and the Children’s Oncology Group TARGET ALL project (M.D., I-M.C., S.R., W.L.C., J.M.G.A., M.A.S., M.V.R., D.S.G., J.M.G.-F., M.L.L., J.R.D., S.P.H., C.L.W., J.Z., C.G.M.), National Institutes of Health, Bethesda, MD; Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN (J.K.); the University of Chicago Medicine, Chicago (W.S.); the Department of Pediatrics, Benioff Children’s Hospital, and the Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco (M.L.L.); and the University of Colorado School of Medicine and Children’s Hospital Colorado — both in Aurora (S.P.H.) – sequence: 14 givenname: Shann-Ching surname: Chen fullname: Chen, Shann-Ching organization: From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children’s Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) — all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children’s Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) — all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) — all in Texas; Maine Children’s Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx (E.P.) — both in New York; the Department of Genetics, University of Alabama at Birmingham, Birmingham (A.J.C.); the Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia (S.K.T.); Queensland Children’s Medical Research Institute, University of Queensland and Royal Children’s Hospital Brisbane, Herston (A.S.M.), and Cancer Theme, South Australian Health and Medical Research Institute, Adelaide (D.L.W., T.P.H.) — both in Australia; Children’s Healthcare of Atlanta and Emory University School of Medicine — both in Atlanta (F.K.); the Division of Haematology–Oncology, Hospital for Sick Children, and University of Toronto — both in Toronto (J.A.W.); Hunstman Cancer Institute, University of Utah, Salt Lake City (E.A.R.); the Office of Cancer Genomics (J.M.G.A., D.S.G.) and Cancer Therapy Evaluation Program (M.A.S.), National Cancer Institute, and the Children’s Oncology Group TARGET ALL project (M.D., I-M.C., S.R., W.L.C., J.M.G.A., M.A.S., M.V.R., D.S.G., J.M.G.-F., M.L.L., J.R.D., S.P.H., C.L.W., J.Z., C.G.M.), National Institutes of Health, Bethesda, MD; Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN (J.K.); the University of Chicago Medicine, Chicago (W.S.); the Department of Pediatrics, Benioff Children’s Hospital, and the Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco (M.L.L.); and the University of Colorado School of Medicine and Children’s Hospital Colorado — both in Aurora (S.P.H.) – sequence: 15 givenname: John surname: Easton fullname: Easton, John organization: From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children’s Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) — all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children’s Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) — all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) — all in Texas; Maine Children’s Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx (E.P.) — both in New York; the Department of Genetics, University of Alabama at Birmingham, Birmingham (A.J.C.); the Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia (S.K.T.); Queensland Children’s Medical Research Institute, University of Queensland and Royal Children’s Hospital Brisbane, Herston (A.S.M.), and Cancer Theme, South Australian Health and Medical Research Institute, Adelaide (D.L.W., T.P.H.) — both in Australia; Children’s Healthcare of Atlanta and Emory University School of Medicine — both in Atlanta (F.K.); the Division of Haematology–Oncology, Hospital for Sick Children, and University of Toronto — both in Toronto (J.A.W.); Hunstman Cancer Institute, University of Utah, Salt Lake City (E.A.R.); the Office of Cancer Genomics (J.M.G.A., D.S.G.) and Cancer Therapy Evaluation Program (M.A.S.), National Cancer Institute, and the Children’s Oncology Group TARGET ALL project (M.D., I-M.C., S.R., W.L.C., J.M.G.A., M.A.S., M.V.R., D.S.G., J.M.G.-F., M.L.L., J.R.D., S.P.H., C.L.W., J.Z., C.G.M.), National Institutes of Health, Bethesda, MD; Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN (J.K.); the University of Chicago Medicine, Chicago (W.S.); the Department of Pediatrics, Benioff Children’s Hospital, and the Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco (M.L.L.); and the University of Colorado School of Medicine and Children’s Hospital Colorado — both in Aurora (S.P.H.) – sequence: 16 givenname: Jinjun surname: Cheng fullname: Cheng, Jinjun organization: From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children’s Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) — all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children’s Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) — all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) — all in Texas; Maine Children’s Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx (E.P.) — both in New York; the Department of Genetics, University of Alabama at Birmingham, Birmingham (A.J.C.); the Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia (S.K.T.); Queensland Children’s Medical Research Institute, University of Queensland and Royal Children’s Hospital Brisbane, Herston (A.S.M.), and Cancer Theme, South Australian Health and Medical Research Institute, Adelaide (D.L.W., T.P.H.) — both in Australia; Children’s Healthcare of Atlanta and Emory University School of Medicine — both in Atlanta (F.K.); the Division of Haematology–Oncology, Hospital for Sick Children, and University of Toronto — both in Toronto (J.A.W.); Hunstman Cancer Institute, University of Utah, Salt Lake City (E.A.R.); the Office of Cancer Genomics (J.M.G.A., D.S.G.) and Cancer Therapy Evaluation Program (M.A.S.), National Cancer Institute, and the Children’s Oncology Group TARGET ALL project (M.D., I-M.C., S.R., W.L.C., J.M.G.A., M.A.S., M.V.R., D.S.G., J.M.G.-F., M.L.L., J.R.D., S.P.H., C.L.W., J.Z., C.G.M.), National Institutes of Health, Bethesda, MD; Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN (J.K.); the University of Chicago Medicine, Chicago (W.S.); the Department of Pediatrics, Benioff Children’s Hospital, and the Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco (M.L.L.); and the University of Colorado School of Medicine and Children’s Hospital Colorado — both in Aurora (S.P.H.) – sequence: 17 givenname: Kristy surname: Boggs fullname: Boggs, Kristy organization: From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children’s Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) — all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children’s Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) — all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) — all in Texas; Maine Children’s Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx (E.P.) — both in New York; the Department of Genetics, University of Alabama at Birmingham, Birmingham (A.J.C.); the Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia (S.K.T.); Queensland Children’s Medical Research Institute, University of Queensland and Royal Children’s Hospital Brisbane, Herston (A.S.M.), and Cancer Theme, South Australian Health and Medical Research Institute, Adelaide (D.L.W., T.P.H.) — both in Australia; Children’s Healthcare of Atlanta and Emory University School of Medicine — both in Atlanta (F.K.); the Division of Haematology–Oncology, Hospital for Sick Children, and University of Toronto — both in Toronto (J.A.W.); Hunstman Cancer Institute, University of Utah, Salt Lake City (E.A.R.); the Office of Cancer Genomics (J.M.G.A., D.S.G.) and Cancer Therapy Evaluation Program (M.A.S.), National Cancer Institute, and the Children’s Oncology Group TARGET ALL project (M.D., I-M.C., S.R., W.L.C., J.M.G.A., M.A.S., M.V.R., D.S.G., J.M.G.-F., M.L.L., J.R.D., S.P.H., C.L.W., J.Z., C.G.M.), National Institutes of Health, Bethesda, MD; Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN (J.K.); the University of Chicago Medicine, Chicago (W.S.); the Department of Pediatrics, Benioff Children’s Hospital, and the Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco (M.L.L.); and the University of Colorado School of Medicine and Children’s Hospital Colorado — both in Aurora (S.P.H.) – sequence: 18 givenname: Natalia surname: Santiago-Morales fullname: Santiago-Morales, Natalia organization: From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children’s Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) — all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children’s Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) — all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) — all in Texas; Maine Children’s Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx (E.P.) — both in New York; the Department of Genetics, University of Alabama at Birmingham, Birmingham (A.J.C.); the Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia (S.K.T.); Queensland Children’s Medical Research Institute, University of Queensland and Royal Children’s Hospital Brisbane, Herston (A.S.M.), and Cancer Theme, South Australian Health and Medical Research Institute, Adelaide (D.L.W., T.P.H.) — both in Australia; Children’s Healthcare of Atlanta and Emory University School of Medicine — both in Atlanta (F.K.); the Division of Haematology–Oncology, Hospital for Sick Children, and University of Toronto — both in Toronto (J.A.W.); Hunstman Cancer Institute, University of Utah, Salt Lake City (E.A.R.); the Office of Cancer Genomics (J.M.G.A., D.S.G.) and Cancer Therapy Evaluation Program (M.A.S.), National Cancer Institute, and the Children’s Oncology Group TARGET ALL project (M.D., I-M.C., S.R., W.L.C., J.M.G.A., M.A.S., M.V.R., D.S.G., J.M.G.-F., M.L.L., J.R.D., S.P.H., C.L.W., J.Z., C.G.M.), National Institutes of Health, Bethesda, MD; Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN (J.K.); the University of Chicago Medicine, Chicago (W.S.); the Department of Pediatrics, Benioff Children’s Hospital, and the Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco (M.L.L.); and the University of Colorado School of Medicine and Children’s Hospital Colorado — both in Aurora (S.P.H.) – sequence: 19 givenname: Ilaria surname: Iacobucci fullname: Iacobucci, Ilaria organization: From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children’s Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) — all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children’s Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) — all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) — all in Texas; Maine Children’s Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx (E.P.) — both in New York; the Department of Genetics, University of Alabama at Birmingham, Birmingham (A.J.C.); the Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia (S.K.T.); Queensland Children’s Medical Research Institute, University of Queensland and Royal Children’s Hospital Brisbane, Herston (A.S.M.), and Cancer Theme, South Australian Health and Medical Research Institute, Adelaide (D.L.W., T.P.H.) — both in Australia; Children’s Healthcare of Atlanta and Emory University School of Medicine — both in Atlanta (F.K.); the Division of Haematology–Oncology, Hospital for Sick Children, and University of Toronto — both in Toronto (J.A.W.); Hunstman Cancer Institute, University of Utah, Salt Lake City (E.A.R.); the Office of Cancer Genomics (J.M.G.A., D.S.G.) and Cancer Therapy Evaluation Program (M.A.S.), National Cancer Institute, and the Children’s Oncology Group TARGET ALL project (M.D., I-M.C., S.R., W.L.C., J.M.G.A., M.A.S., M.V.R., D.S.G., J.M.G.-F., M.L.L., J.R.D., S.P.H., C.L.W., J.Z., C.G.M.), National Institutes of Health, Bethesda, MD; Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN (J.K.); the University of Chicago Medicine, Chicago (W.S.); the Department of Pediatrics, Benioff Children’s Hospital, and the Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco (M.L.L.); and the University of Colorado School of Medicine and Children’s Hospital Colorado — both in Aurora (S.P.H.) – sequence: 20 givenname: Robert S surname: Fulton fullname: Fulton, Robert S organization: From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children’s Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) — all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children’s Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) — all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) — all in Texas; Maine Children’s Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx (E.P.) — both in New York; the Department of Genetics, University of Alabama at Birmingham, Birmingham (A.J.C.); the Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia (S.K.T.); Queensland Children’s Medical Research Institute, University of Queensland and Royal Children’s Hospital Brisbane, Herston (A.S.M.), and Cancer Theme, South Australian Health and Medical Research Institute, Adelaide (D.L.W., T.P.H.) — both in Australia; Children’s Healthcare of Atlanta and Emory University School of Medicine — both in Atlanta (F.K.); the Division of Haematology–Oncology, Hospital for Sick Children, and University of Toronto — both in Toronto (J.A.W.); Hunstman Cancer Institute, University of Utah, Salt Lake City (E.A.R.); the Office of Cancer Genomics (J.M.G.A., D.S.G.) and Cancer Therapy Evaluation Program (M.A.S.), National Cancer Institute, and the Children’s Oncology Group TARGET ALL project (M.D., I-M.C., S.R., W.L.C., J.M.G.A., M.A.S., M.V.R., D.S.G., J.M.G.-F., M.L.L., J.R.D., S.P.H., C.L.W., J.Z., C.G.M.), National Institutes of Health, Bethesda, MD; Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN (J.K.); the University of Chicago Medicine, Chicago (W.S.); the Department of Pediatrics, Benioff Children’s Hospital, and the Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco (M.L.L.); and the University of Colorado School of Medicine and Children’s Hospital Colorado — both in Aurora (S.P.H.) – sequence: 21 givenname: Ji surname: Wen fullname: Wen, Ji organization: From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children’s Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) — all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children’s Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) — all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) — all in Texas; Maine Children’s Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx (E.P.) — both in New York; the Department of Genetics, University of Alabama at Birmingham, Birmingham (A.J.C.); the Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia (S.K.T.); Queensland Children’s Medical Research Institute, University of Queensland and Royal Children’s Hospital Brisbane, Herston (A.S.M.), and Cancer Theme, South Australian Health and Medical Research Institute, Adelaide (D.L.W., T.P.H.) — both in Australia; Children’s Healthcare of Atlanta and Emory University School of Medicine — both in Atlanta (F.K.); the Division of Haematology–Oncology, Hospital for Sick Children, and University of Toronto — both in Toronto (J.A.W.); Hunstman Cancer Institute, University of Utah, Salt Lake City (E.A.R.); the Office of Cancer Genomics (J.M.G.A., D.S.G.) and Cancer Therapy Evaluation Program (M.A.S.), National Cancer Institute, and the Children’s Oncology Group TARGET ALL project (M.D., I-M.C., S.R., W.L.C., J.M.G.A., M.A.S., M.V.R., D.S.G., J.M.G.-F., M.L.L., J.R.D., S.P.H., C.L.W., J.Z., C.G.M.), National Institutes of Health, Bethesda, MD; Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN (J.K.); the University of Chicago Medicine, Chicago (W.S.); the Department of Pediatrics, Benioff Children’s Hospital, and the Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco (M.L.L.); and the University of Colorado School of Medicine and Children’s Hospital Colorado — both in Aurora (S.P.H.) – sequence: 22 givenname: Marcus surname: Valentine fullname: Valentine, Marcus organization: From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children’s Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) — all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children’s Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) — all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) — all in Texas; Maine Children’s Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx (E.P.) — both in New York; the Department of Genetics, University of Alabama at Birmingham, Birmingham (A.J.C.); the Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia (S.K.T.); Queensland Children’s Medical Research Institute, University of Queensland and Royal Children’s Hospital Brisbane, Herston (A.S.M.), and Cancer Theme, South Australian Health and Medical Research Institute, Adelaide (D.L.W., T.P.H.) — both in Australia; Children’s Healthcare of Atlanta and Emory University School of Medicine — both in Atlanta (F.K.); the Division of Haematology–Oncology, Hospital for Sick Children, and University of Toronto — both in Toronto (J.A.W.); Hunstman Cancer Institute, University of Utah, Salt Lake City (E.A.R.); the Office of Cancer Genomics (J.M.G.A., D.S.G.) and Cancer Therapy Evaluation Program (M.A.S.), National Cancer Institute, and the Children’s Oncology Group TARGET ALL project (M.D., I-M.C., S.R., W.L.C., J.M.G.A., M.A.S., M.V.R., D.S.G., J.M.G.-F., M.L.L., J.R.D., S.P.H., C.L.W., J.Z., C.G.M.), National Institutes of Health, Bethesda, MD; Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN (J.K.); the University of Chicago Medicine, Chicago (W.S.); the Department of Pediatrics, Benioff Children’s Hospital, and the Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco (M.L.L.); and the University of Colorado School of Medicine and Children’s Hospital Colorado — both in Aurora (S.P.H.) – sequence: 23 givenname: Cheng surname: Cheng fullname: Cheng, Cheng organization: From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children’s Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) — all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children’s Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) — all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) — all in Texas; Maine Children’s Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx (E.P.) — both in New York; the Department of Genetics, University of Alabama at Birmingham, Birmingham (A.J.C.); the Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia (S.K.T.); Queensland Children’s Medical Research Institute, University of Queensland and Royal Children’s Hospital Brisbane, Herston (A.S.M.), and Cancer Theme, South Australian Health and Medical Research Institute, Adelaide (D.L.W., T.P.H.) — both in Australia; Children’s Healthcare of Atlanta and Emory University School of Medicine — both in Atlanta (F.K.); the Division of Haematology–Oncology, Hospital for Sick Children, and University of Toronto — both in Toronto (J.A.W.); Hunstman Cancer Institute, University of Utah, Salt Lake City (E.A.R.); the Office of Cancer Genomics (J.M.G.A., D.S.G.) and Cancer Therapy Evaluation Program (M.A.S.), National Cancer Institute, and the Children’s Oncology Group TARGET ALL project (M.D., I-M.C., S.R., W.L.C., J.M.G.A., M.A.S., M.V.R., D.S.G., J.M.G.-F., M.L.L., J.R.D., S.P.H., C.L.W., J.Z., C.G.M.), National Institutes of Health, Bethesda, MD; Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN (J.K.); the University of Chicago Medicine, Chicago (W.S.); the Department of Pediatrics, Benioff Children’s Hospital, and the Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco (M.L.L.); and the University of Colorado School of Medicine and Children’s Hospital Colorado — both in Aurora (S.P.H.) – sequence: 24 givenname: Steven W surname: Paugh fullname: Paugh, Steven W organization: From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children’s Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) — all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children’s Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) — all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) — all in Texas; Maine Children’s Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx (E.P.) — both in New York; the Department of Genetics, University of Alabama at Birmingham, Birmingham (A.J.C.); the Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia (S.K.T.); Queensland Children’s Medical Research Institute, University of Queensland and Royal Children’s Hospital Brisbane, Herston (A.S.M.), and Cancer Theme, South Australian Health and Medical Research Institute, Adelaide (D.L.W., T.P.H.) — both in Australia; Children’s Healthcare of Atlanta and Emory University School of Medicine — both in Atlanta (F.K.); the Division of Haematology–Oncology, Hospital for Sick Children, and University of Toronto — both in Toronto (J.A.W.); Hunstman Cancer Institute, University of Utah, Salt Lake City (E.A.R.); the Office of Cancer Genomics (J.M.G.A., D.S.G.) and Cancer Therapy Evaluation Program (M.A.S.), National Cancer Institute, and the Children’s Oncology Group TARGET ALL project (M.D., I-M.C., S.R., W.L.C., J.M.G.A., M.A.S., M.V.R., D.S.G., J.M.G.-F., M.L.L., J.R.D., S.P.H., C.L.W., J.Z., C.G.M.), National Institutes of Health, Bethesda, MD; Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN (J.K.); the University of Chicago Medicine, Chicago (W.S.); the Department of Pediatrics, Benioff Children’s Hospital, and the Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco (M.L.L.); and the University of Colorado School of Medicine and Children’s Hospital Colorado — both in Aurora (S.P.H.) – sequence: 25 givenname: Meenakshi surname: Devidas fullname: Devidas, Meenakshi organization: From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children’s Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) — all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children’s Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) — all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) — all in Texas; Maine Children’s Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx (E.P.) — both in New York; the Department of Genetics, University of Alabama at Birmingham, Birmingham (A.J.C.); the Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia (S.K.T.); Queensland Children’s Medical Research Institute, University of Queensland and Royal Children’s Hospital Brisbane, Herston (A.S.M.), and Cancer Theme, South Australian Health and Medical Research Institute, Adelaide (D.L.W., T.P.H.) — both in Australia; Children’s Healthcare of Atlanta and Emory University School of Medicine — both in Atlanta (F.K.); the Division of Haematology–Oncology, Hospital for Sick Children, and University of Toronto — both in Toronto (J.A.W.); Hunstman Cancer Institute, University of Utah, Salt Lake City (E.A.R.); the Office of Cancer Genomics (J.M.G.A., D.S.G.) and Cancer Therapy Evaluation Program (M.A.S.), National Cancer Institute, and the Children’s Oncology Group TARGET ALL project (M.D., I-M.C., S.R., W.L.C., J.M.G.A., M.A.S., M.V.R., D.S.G., J.M.G.-F., M.L.L., J.R.D., S.P.H., C.L.W., J.Z., C.G.M.), National Institutes of Health, Bethesda, MD; Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN (J.K.); the University of Chicago Medicine, Chicago (W.S.); the Department of Pediatrics, Benioff Children’s Hospital, and the Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco (M.L.L.); and the University of Colorado School of Medicine and Children’s Hospital Colorado — both in Aurora (S.P.H.) – sequence: 26 givenname: I-Ming surname: Chen fullname: Chen, I-Ming organization: From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children’s Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) — all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children’s Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) — all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) — all in Texas; Maine Children’s Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx (E.P.) — both in New York; the Department of Genetics, University of Alabama at Birmingham, Birmingham (A.J.C.); the Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia (S.K.T.); Queensland Children’s Medical Research Institute, University of Queensland and Royal Children’s Hospital Brisbane, Herston (A.S.M.), and Cancer Theme, South Australian Health and Medical Research Institute, Adelaide (D.L.W., T.P.H.) — both in Australia; Children’s Healthcare of Atlanta and Emory University School of Medicine — both in Atlanta (F.K.); the Division of Haematology–Oncology, Hospital for Sick Children, and University of Toronto — both in Toronto (J.A.W.); Hunstman Cancer Institute, University of Utah, Salt Lake City (E.A.R.); the Office of Cancer Genomics (J.M.G.A., D.S.G.) and Cancer Therapy Evaluation Program (M.A.S.), National Cancer Institute, and the Children’s Oncology Group TARGET ALL project (M.D., I-M.C., S.R., W.L.C., J.M.G.A., M.A.S., M.V.R., D.S.G., J.M.G.-F., M.L.L., J.R.D., S.P.H., C.L.W., J.Z., C.G.M.), National Institutes of Health, Bethesda, MD; Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN (J.K.); the University of Chicago Medicine, Chicago (W.S.); the Department of Pediatrics, Benioff Children’s Hospital, and the Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco (M.L.L.); and the University of Colorado School of Medicine and Children’s Hospital Colorado — both in Aurora (S.P.H.) – sequence: 27 givenname: Shalini surname: Reshmi fullname: Reshmi, Shalini organization: From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children’s Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) — all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children’s Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) — all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) — all in Texas; Maine Children’s Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx (E.P.) — both in New York; the Department of Genetics, University of Alabama at Birmingham, Birmingham (A.J.C.); the Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia (S.K.T.); Queensland Children’s Medical Research Institute, University of Queensland and Royal Children’s Hospital Brisbane, Herston (A.S.M.), and Cancer Theme, South Australian Health and Medical Research Institute, Adelaide (D.L.W., T.P.H.) — both in Australia; Children’s Healthcare of Atlanta and Emory University School of Medicine — both in Atlanta (F.K.); the Division of Haematology–Oncology, Hospital for Sick Children, and University of Toronto — both in Toronto (J.A.W.); Hunstman Cancer Institute, University of Utah, Salt Lake City (E.A.R.); the Office of Cancer Genomics (J.M.G.A., D.S.G.) and Cancer Therapy Evaluation Program (M.A.S.), National Cancer Institute, and the Children’s Oncology Group TARGET ALL project (M.D., I-M.C., S.R., W.L.C., J.M.G.A., M.A.S., M.V.R., D.S.G., J.M.G.-F., M.L.L., J.R.D., S.P.H., C.L.W., J.Z., C.G.M.), National Institutes of Health, Bethesda, MD; Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN (J.K.); the University of Chicago Medicine, Chicago (W.S.); the Department of Pediatrics, Benioff Children’s Hospital, and the Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco (M.L.L.); and the University of Colorado School of Medicine and Children’s Hospital Colorado — both in Aurora (S.P.H.) – sequence: 28 givenname: Amy surname: Smith fullname: Smith, Amy organization: From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children’s Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) — all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children’s Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) — all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) — all in Texas; Maine Children’s Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx (E.P.) — both in New York; the Department of Genetics, University of Alabama at Birmingham, Birmingham (A.J.C.); the Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia (S.K.T.); Queensland Children’s Medical Research Institute, University of Queensland and Royal Children’s Hospital Brisbane, Herston (A.S.M.), and Cancer Theme, South Australian Health and Medical Research Institute, Adelaide (D.L.W., T.P.H.) — both in Australia; Children’s Healthcare of Atlanta and Emory University School of Medicine — both in Atlanta (F.K.); the Division of Haematology–Oncology, Hospital for Sick Children, and University of Toronto — both in Toronto (J.A.W.); Hunstman Cancer Institute, University of Utah, Salt Lake City (E.A.R.); the Office of Cancer Genomics (J.M.G.A., D.S.G.) and Cancer Therapy Evaluation Program (M.A.S.), National Cancer Institute, and the Children’s Oncology Group TARGET ALL project (M.D., I-M.C., S.R., W.L.C., J.M.G.A., M.A.S., M.V.R., D.S.G., J.M.G.-F., M.L.L., J.R.D., S.P.H., C.L.W., J.Z., C.G.M.), National Institutes of Health, Bethesda, MD; Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN (J.K.); the University of Chicago Medicine, Chicago (W.S.); the Department of Pediatrics, Benioff Children’s Hospital, and the Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco (M.L.L.); and the University of Colorado School of Medicine and Children’s Hospital Colorado — both in Aurora (S.P.H.) – sequence: 29 givenname: Erin surname: Hedlund fullname: Hedlund, Erin organization: From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children’s Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) — all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children’s Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) — all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) — all in Texas; Maine Children’s Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx (E.P.) — both in New York; the Department of Genetics, University of Alabama at Birmingham, Birmingham (A.J.C.); the Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia (S.K.T.); Queensland Children’s Medical Research Institute, University of Queensland and Royal Children’s Hospital Brisbane, Herston (A.S.M.), and Cancer Theme, South Australian Health and Medical Research Institute, Adelaide (D.L.W., T.P.H.) — both in Australia; Children’s Healthcare of Atlanta and Emory University School of Medicine — both in Atlanta (F.K.); the Division of Haematology–Oncology, Hospital for Sick Children, and University of Toronto — both in Toronto (J.A.W.); Hunstman Cancer Institute, University of Utah, Salt Lake City (E.A.R.); the Office of Cancer Genomics (J.M.G.A., D.S.G.) and Cancer Therapy Evaluation Program (M.A.S.), National Cancer Institute, and the Children’s Oncology Group TARGET ALL project (M.D., I-M.C., S.R., W.L.C., J.M.G.A., M.A.S., M.V.R., D.S.G., J.M.G.-F., M.L.L., J.R.D., S.P.H., C.L.W., J.Z., C.G.M.), National Institutes of Health, Bethesda, MD; Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN (J.K.); the University of Chicago Medicine, Chicago (W.S.); the Department of Pediatrics, Benioff Children’s Hospital, and the Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco (M.L.L.); and the University of Colorado School of Medicine and Children’s Hospital Colorado — both in Aurora (S.P.H.) – sequence: 30 givenname: Pankaj surname: Gupta fullname: Gupta, Pankaj organization: From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children’s Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) — all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children’s Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) — all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) — all in Texas; Maine Children’s Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx (E.P.) — both in New York; the Department of Genetics, University of Alabama at Birmingham, Birmingham (A.J.C.); the Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia (S.K.T.); Queensland Children’s Medical Research Institute, University of Queensland and Royal Children’s Hospital Brisbane, Herston (A.S.M.), and Cancer Theme, South Australian Health and Medical Research Institute, Adelaide (D.L.W., T.P.H.) — both in Australia; Children’s Healthcare of Atlanta and Emory University School of Medicine — both in Atlanta (F.K.); the Division of Haematology–Oncology, Hospital for Sick Children, and University of Toronto — both in Toronto (J.A.W.); Hunstman Cancer Institute, University of Utah, Salt Lake City (E.A.R.); the Office of Cancer Genomics (J.M.G.A., D.S.G.) and Cancer Therapy Evaluation Program (M.A.S.), National Cancer Institute, and the Children’s Oncology Group TARGET ALL project (M.D., I-M.C., S.R., W.L.C., J.M.G.A., M.A.S., M.V.R., D.S.G., J.M.G.-F., M.L.L., J.R.D., S.P.H., C.L.W., J.Z., C.G.M.), National Institutes of Health, Bethesda, MD; Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN (J.K.); the University of Chicago Medicine, Chicago (W.S.); the Department of Pediatrics, Benioff Children’s Hospital, and the Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco (M.L.L.); and the University of Colorado School of Medicine and Children’s Hospital Colorado — both in Aurora (S.P.H.) – sequence: 31 givenname: Panduka surname: Nagahawatte fullname: Nagahawatte, Panduka organization: From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children’s Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) — all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children’s Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) — all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) — all in Texas; Maine Children’s Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx (E.P.) — both in New York; the Department of Genetics, University of Alabama at Birmingham, Birmingham (A.J.C.); the Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia (S.K.T.); Queensland Children’s Medical Research Institute, University of Queensland and Royal Children’s Hospital Brisbane, Herston (A.S.M.), and Cancer Theme, South Australian Health and Medical Research Institute, Adelaide (D.L.W., T.P.H.) — both in Australia; Children’s Healthcare of Atlanta and Emory University School of Medicine — both in Atlanta (F.K.); the Division of Haematology–Oncology, Hospital for Sick Children, and University of Toronto — both in Toronto (J.A.W.); Hunstman Cancer Institute, University of Utah, Salt Lake City (E.A.R.); the Office of Cancer Genomics (J.M.G.A., D.S.G.) and Cancer Therapy Evaluation Program (M.A.S.), National Cancer Institute, and the Children’s Oncology Group TARGET ALL project (M.D., I-M.C., S.R., W.L.C., J.M.G.A., M.A.S., M.V.R., D.S.G., J.M.G.-F., M.L.L., J.R.D., S.P.H., C.L.W., J.Z., C.G.M.), National Institutes of Health, Bethesda, MD; Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN (J.K.); the University of Chicago Medicine, Chicago (W.S.); the Department of Pediatrics, Benioff Children’s Hospital, and the Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco (M.L.L.); and the University of Colorado School of Medicine and Children’s Hospital Colorado — both in Aurora (S.P.H.) – sequence: 32 givenname: Gang surname: Wu fullname: Wu, Gang organization: From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children’s Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) — all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children’s Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) — all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) — all in Texas; Maine Children’s Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx (E.P.) — both in New York; the Department of Genetics, University of Alabama at Birmingham, Birmingham (A.J.C.); the Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia (S.K.T.); Queensland Children’s Medical Research Institute, University of Queensland and Royal Children’s Hospital Brisbane, Herston (A.S.M.), and Cancer Theme, South Australian Health and Medical Research Institute, Adelaide (D.L.W., T.P.H.) — both in Australia; Children’s Healthcare of Atlanta and Emory University School of Medicine — both in Atlanta (F.K.); the Division of Haematology–Oncology, Hospital for Sick Children, and University of Toronto — both in Toronto (J.A.W.); Hunstman Cancer Institute, University of Utah, Salt Lake City (E.A.R.); the Office of Cancer Genomics (J.M.G.A., D.S.G.) and Cancer Therapy Evaluation Program (M.A.S.), National Cancer Institute, and the Children’s Oncology Group TARGET ALL project (M.D., I-M.C., S.R., W.L.C., J.M.G.A., M.A.S., M.V.R., D.S.G., J.M.G.-F., M.L.L., J.R.D., S.P.H., C.L.W., J.Z., C.G.M.), National Institutes of Health, Bethesda, MD; Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN (J.K.); the University of Chicago Medicine, Chicago (W.S.); the Department of Pediatrics, Benioff Children’s Hospital, and the Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco (M.L.L.); and the University of Colorado School of Medicine and Children’s Hospital Colorado — both in Aurora (S.P.H.) – sequence: 33 givenname: Xiang surname: Chen fullname: Chen, Xiang organization: From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children’s Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) — all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children’s Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) — all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) — all in Texas; Maine Children’s Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx (E.P.) — both in New York; the Department of Genetics, University of Alabama at Birmingham, Birmingham (A.J.C.); the Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia (S.K.T.); Queensland Children’s Medical Research Institute, University of Queensland and Royal Children’s Hospital Brisbane, Herston (A.S.M.), and Cancer Theme, South Australian Health and Medical Research Institute, Adelaide (D.L.W., T.P.H.) — both in Australia; Children’s Healthcare of Atlanta and Emory University School of Medicine — both in Atlanta (F.K.); the Division of Haematology–Oncology, Hospital for Sick Children, and University of Toronto — both in Toronto (J.A.W.); Hunstman Cancer Institute, University of Utah, Salt Lake City (E.A.R.); the Office of Cancer Genomics (J.M.G.A., D.S.G.) and Cancer Therapy Evaluation Program (M.A.S.), National Cancer Institute, and the Children’s Oncology Group TARGET ALL project (M.D., I-M.C., S.R., W.L.C., J.M.G.A., M.A.S., M.V.R., D.S.G., J.M.G.-F., M.L.L., J.R.D., S.P.H., C.L.W., J.Z., C.G.M.), National Institutes of Health, Bethesda, MD; Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN (J.K.); the University of Chicago Medicine, Chicago (W.S.); the Department of Pediatrics, Benioff Children’s Hospital, and the Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco (M.L.L.); and the University of Colorado School of Medicine and Children’s Hospital Colorado — both in Aurora (S.P.H.) – sequence: 34 givenname: Donald surname: Yergeau fullname: Yergeau, Donald organization: From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children’s Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) — all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children’s Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) — all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) — all in Texas; Maine Children’s Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx (E.P.) — both in New York; the Department of Genetics, University of Alabama at Birmingham, Birmingham (A.J.C.); the Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia (S.K.T.); Queensland Children’s Medical Research Institute, University of Queensland and Royal Children’s Hospital Brisbane, Herston (A.S.M.), and Cancer Theme, South Australian Health and Medical Research Institute, Adelaide (D.L.W., T.P.H.) — both in Australia; Children’s Healthcare of Atlanta and Emory University School of Medicine — both in Atlanta (F.K.); the Division of Haematology–Oncology, Hospital for Sick Children, and University of Toronto — both in Toronto (J.A.W.); Hunstman Cancer Institute, University of Utah, Salt Lake City (E.A.R.); the Office of Cancer Genomics (J.M.G.A., D.S.G.) and Cancer Therapy Evaluation Program (M.A.S.), National Cancer Institute, and the Children’s Oncology Group TARGET ALL project (M.D., I-M.C., S.R., W.L.C., J.M.G.A., M.A.S., M.V.R., D.S.G., J.M.G.-F., M.L.L., J.R.D., S.P.H., C.L.W., J.Z., C.G.M.), National Institutes of Health, Bethesda, MD; Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN (J.K.); the University of Chicago Medicine, Chicago (W.S.); the Department of Pediatrics, Benioff Children’s Hospital, and the Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco (M.L.L.); and the University of Colorado School of Medicine and Children’s Hospital Colorado — both in Aurora (S.P.H.) – sequence: 35 givenname: Bhavin surname: Vadodaria fullname: Vadodaria, Bhavin organization: From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children’s Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) — all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children’s Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) — all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) — all in Texas; Maine Children’s Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx (E.P.) — both in New York; the Department of Genetics, University of Alabama at Birmingham, Birmingham (A.J.C.); the Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia (S.K.T.); Queensland Children’s Medical Research Institute, University of Queensland and Royal Children’s Hospital Brisbane, Herston (A.S.M.), and Cancer Theme, South Australian Health and Medical Research Institute, Adelaide (D.L.W., T.P.H.) — both in Australia; Children’s Healthcare of Atlanta and Emory University School of Medicine — both in Atlanta (F.K.); the Division of Haematology–Oncology, Hospital for Sick Children, and University of Toronto — both in Toronto (J.A.W.); Hunstman Cancer Institute, University of Utah, Salt Lake City (E.A.R.); the Office of Cancer Genomics (J.M.G.A., D.S.G.) and Cancer Therapy Evaluation Program (M.A.S.), National Cancer Institute, and the Children’s Oncology Group TARGET ALL project (M.D., I-M.C., S.R., W.L.C., J.M.G.A., M.A.S., M.V.R., D.S.G., J.M.G.-F., M.L.L., J.R.D., S.P.H., C.L.W., J.Z., C.G.M.), National Institutes of Health, Bethesda, MD; Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN (J.K.); the University of Chicago Medicine, Chicago (W.S.); the Department of Pediatrics, Benioff Children’s Hospital, and the Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco (M.L.L.); and the University of Colorado School of Medicine and Children’s Hospital Colorado — both in Aurora (S.P.H.) – sequence: 36 givenname: Heather surname: Mulder fullname: Mulder, Heather organization: From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children’s Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) — all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children’s Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) — all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) — all in Texas; Maine Children’s Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx (E.P.) — both in New York; the Department of Genetics, University of Alabama at Birmingham, Birmingham (A.J.C.); the Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia (S.K.T.); Queensland Children’s Medical Research Institute, University of Queensland and Royal Children’s Hospital Brisbane, Herston (A.S.M.), and Cancer Theme, South Australian Health and Medical Research Institute, Adelaide (D.L.W., T.P.H.) — both in Australia; Children’s Healthcare of Atlanta and Emory University School of Medicine — both in Atlanta (F.K.); the Division of Haematology–Oncology, Hospital for Sick Children, and University of Toronto — both in Toronto (J.A.W.); Hunstman Cancer Institute, University of Utah, Salt Lake City (E.A.R.); the Office of Cancer Genomics (J.M.G.A., D.S.G.) and Cancer Therapy Evaluation Program (M.A.S.), National Cancer Institute, and the Children’s Oncology Group TARGET ALL project (M.D., I-M.C., S.R., W.L.C., J.M.G.A., M.A.S., M.V.R., D.S.G., J.M.G.-F., M.L.L., J.R.D., S.P.H., C.L.W., J.Z., C.G.M.), National Institutes of Health, Bethesda, MD; Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN (J.K.); the University of Chicago Medicine, Chicago (W.S.); the Department of Pediatrics, Benioff Children’s Hospital, and the Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco (M.L.L.); and the University of Colorado School of Medicine and Children’s Hospital Colorado — both in Aurora (S.P.H.) – sequence: 37 givenname: Naomi J surname: Winick fullname: Winick, Naomi J organization: From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children’s Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) — all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children’s Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) — all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) — all in Texas; Maine Children’s Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx (E.P.) — both in New York; the Department of Genetics, University of Alabama at Birmingham, Birmingham (A.J.C.); the Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia (S.K.T.); Queensland Children’s Medical Research Institute, University of Queensland and Royal Children’s Hospital Brisbane, Herston (A.S.M.), and Cancer Theme, South Australian Health and Medical Research Institute, Adelaide (D.L.W., T.P.H.) — both in Australia; Children’s Healthcare of Atlanta and Emory University School of Medicine — both in Atlanta (F.K.); the Division of Haematology–Oncology, Hospital for Sick Children, and University of Toronto — both in Toronto (J.A.W.); Hunstman Cancer Institute, University of Utah, Salt Lake City (E.A.R.); the Office of Cancer Genomics (J.M.G.A., D.S.G.) and Cancer Therapy Evaluation Program (M.A.S.), National Cancer Institute, and the Children’s Oncology Group TARGET ALL project (M.D., I-M.C., S.R., W.L.C., J.M.G.A., M.A.S., M.V.R., D.S.G., J.M.G.-F., M.L.L., J.R.D., S.P.H., C.L.W., J.Z., C.G.M.), National Institutes of Health, Bethesda, MD; Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN (J.K.); the University of Chicago Medicine, Chicago (W.S.); the Department of Pediatrics, Benioff Children’s Hospital, and the Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco (M.L.L.); and the University of Colorado School of Medicine and Children’s Hospital Colorado — both in Aurora (S.P.H.) – sequence: 38 givenname: Eric C surname: Larsen fullname: Larsen, Eric C organization: From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children’s Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) — all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children’s Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) — all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) — all in Texas; Maine Children’s Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx (E.P.) — both in New York; the Department of Genetics, University of Alabama at Birmingham, Birmingham (A.J.C.); the Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia (S.K.T.); Queensland Children’s Medical Research Institute, University of Queensland and Royal Children’s Hospital Brisbane, Herston (A.S.M.), and Cancer Theme, South Australian Health and Medical Research Institute, Adelaide (D.L.W., T.P.H.) — both in Australia; Children’s Healthcare of Atlanta and Emory University School of Medicine — both in Atlanta (F.K.); the Division of Haematology–Oncology, Hospital for Sick Children, and University of Toronto — both in Toronto (J.A.W.); Hunstman Cancer Institute, University of Utah, Salt Lake City (E.A.R.); the Office of Cancer Genomics (J.M.G.A., D.S.G.) and Cancer Therapy Evaluation Program (M.A.S.), National Cancer Institute, and the Children’s Oncology Group TARGET ALL project (M.D., I-M.C., S.R., W.L.C., J.M.G.A., M.A.S., M.V.R., D.S.G., J.M.G.-F., M.L.L., J.R.D., S.P.H., C.L.W., J.Z., C.G.M.), National Institutes of Health, Bethesda, MD; Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN (J.K.); the University of Chicago Medicine, Chicago (W.S.); the Department of Pediatrics, Benioff Children’s Hospital, and the Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco (M.L.L.); and the University of Colorado School of Medicine and Children’s Hospital Colorado — both in Aurora (S.P.H.) – sequence: 39 givenname: William L surname: Carroll fullname: Carroll, William L organization: From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children’s Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) — all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children’s Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) — all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) — all in Texas; Maine Children’s Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx (E.P.) — both in New York; the Department of Genetics, University of Alabama at Birmingham, Birmingham (A.J.C.); the Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia (S.K.T.); Queensland Children’s Medical Research Institute, University of Queensland and Royal Children’s Hospital Brisbane, Herston (A.S.M.), and Cancer Theme, South Australian Health and Medical Research Institute, Adelaide (D.L.W., T.P.H.) — both in Australia; Children’s Healthcare of Atlanta and Emory University School of Medicine — both in Atlanta (F.K.); the Division of Haematology–Oncology, Hospital for Sick Children, and University of Toronto — both in Toronto (J.A.W.); Hunstman Cancer Institute, University of Utah, Salt Lake City (E.A.R.); the Office of Cancer Genomics (J.M.G.A., D.S.G.) and Cancer Therapy Evaluation Program (M.A.S.), National Cancer Institute, and the Children’s Oncology Group TARGET ALL project (M.D., I-M.C., S.R., W.L.C., J.M.G.A., M.A.S., M.V.R., D.S.G., J.M.G.-F., M.L.L., J.R.D., S.P.H., C.L.W., J.Z., C.G.M.), National Institutes of Health, Bethesda, MD; Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN (J.K.); the University of Chicago Medicine, Chicago (W.S.); the Department of Pediatrics, Benioff Children’s Hospital, and the Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco (M.L.L.); and the University of Colorado School of Medicine and Children’s Hospital Colorado — both in Aurora (S.P.H.) – sequence: 40 givenname: Nyla A surname: Heerema fullname: Heerema, Nyla A organization: From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children’s Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) — all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children’s Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) — all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) — all in Texas; Maine Children’s Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx (E.P.) — both in New York; the Department of Genetics, University of Alabama at Birmingham, Birmingham (A.J.C.); the Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia (S.K.T.); Queensland Children’s Medical Research Institute, University of Queensland and Royal Children’s Hospital Brisbane, Herston (A.S.M.), and Cancer Theme, South Australian Health and Medical Research Institute, Adelaide (D.L.W., T.P.H.) — both in Australia; Children’s Healthcare of Atlanta and Emory University School of Medicine — both in Atlanta (F.K.); the Division of Haematology–Oncology, Hospital for Sick Children, and University of Toronto — both in Toronto (J.A.W.); Hunstman Cancer Institute, University of Utah, Salt Lake City (E.A.R.); the Office of Cancer Genomics (J.M.G.A., D.S.G.) and Cancer Therapy Evaluation Program (M.A.S.), National Cancer Institute, and the Children’s Oncology Group TARGET ALL project (M.D., I-M.C., S.R., W.L.C., J.M.G.A., M.A.S., M.V.R., D.S.G., J.M.G.-F., M.L.L., J.R.D., S.P.H., C.L.W., J.Z., C.G.M.), National Institutes of Health, Bethesda, MD; Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN (J.K.); the University of Chicago Medicine, Chicago (W.S.); the Department of Pediatrics, Benioff Children’s Hospital, and the Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco (M.L.L.); and the University of Colorado School of Medicine and Children’s Hospital Colorado — both in Aurora (S.P.H.) – sequence: 41 givenname: Andrew J surname: Carroll fullname: Carroll, Andrew J organization: From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children’s Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) — all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children’s Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) — all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) — all in Texas; Maine Children’s Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx (E.P.) — both in New York; the Department of Genetics, University of Alabama at Birmingham, Birmingham (A.J.C.); the Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia (S.K.T.); Queensland Children’s Medical Research Institute, University of Queensland and Royal Children’s Hospital Brisbane, Herston (A.S.M.), and Cancer Theme, South Australian Health and Medical Research Institute, Adelaide (D.L.W., T.P.H.) — both in Australia; Children’s Healthcare of Atlanta and Emory University School of Medicine — both in Atlanta (F.K.); the Division of Haematology–Oncology, Hospital for Sick Children, and University of Toronto — both in Toronto (J.A.W.); Hunstman Cancer Institute, University of Utah, Salt Lake City (E.A.R.); the Office of Cancer Genomics (J.M.G.A., D.S.G.) and Cancer Therapy Evaluation Program (M.A.S.), National Cancer Institute, and the Children’s Oncology Group TARGET ALL project (M.D., I-M.C., S.R., W.L.C., J.M.G.A., M.A.S., M.V.R., D.S.G., J.M.G.-F., M.L.L., J.R.D., S.P.H., C.L.W., J.Z., C.G.M.), National Institutes of Health, Bethesda, MD; Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN (J.K.); the University of Chicago Medicine, Chicago (W.S.); the Department of Pediatrics, Benioff Children’s Hospital, and the Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco (M.L.L.); and the University of Colorado School of Medicine and Children’s Hospital Colorado — both in Aurora (S.P.H.) – sequence: 42 givenname: Guy surname: Grayson fullname: Grayson, Guy organization: From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children’s Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) — all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children’s Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) — all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) — all in Texas; Maine Children’s Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx (E.P.) — both in New York; the Department of Genetics, University of Alabama at Birmingham, Birmingham (A.J.C.); the Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia (S.K.T.); Queensland Children’s Medical Research Institute, University of Queensland and Royal Children’s Hospital Brisbane, Herston (A.S.M.), and Cancer Theme, South Australian Health and Medical Research Institute, Adelaide (D.L.W., T.P.H.) — both in Australia; Children’s Healthcare of Atlanta and Emory University School of Medicine — both in Atlanta (F.K.); the Division of Haematology–Oncology, Hospital for Sick Children, and University of Toronto — both in Toronto (J.A.W.); Hunstman Cancer Institute, University of Utah, Salt Lake City (E.A.R.); the Office of Cancer Genomics (J.M.G.A., D.S.G.) and Cancer Therapy Evaluation Program (M.A.S.), National Cancer Institute, and the Children’s Oncology Group TARGET ALL project (M.D., I-M.C., S.R., W.L.C., J.M.G.A., M.A.S., M.V.R., D.S.G., J.M.G.-F., M.L.L., J.R.D., S.P.H., C.L.W., J.Z., C.G.M.), National Institutes of Health, Bethesda, MD; Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN (J.K.); the University of Chicago Medicine, Chicago (W.S.); the Department of Pediatrics, Benioff Children’s Hospital, and the Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco (M.L.L.); and the University of Colorado School of Medicine and Children’s Hospital Colorado — both in Aurora (S.P.H.) – sequence: 43 givenname: Sarah K surname: Tasian fullname: Tasian, Sarah K organization: From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children’s Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) — all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children’s Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) — all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) — all in Texas; Maine Children’s Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx (E.P.) — both in New York; the Department of Genetics, University of Alabama at Birmingham, Birmingham (A.J.C.); the Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia (S.K.T.); Queensland Children’s Medical Research Institute, University of Queensland and Royal Children’s Hospital Brisbane, Herston (A.S.M.), and Cancer Theme, South Australian Health and Medical Research Institute, Adelaide (D.L.W., T.P.H.) — both in Australia; Children’s Healthcare of Atlanta and Emory University School of Medicine — both in Atlanta (F.K.); the Division of Haematology–Oncology, Hospital for Sick Children, and University of Toronto — both in Toronto (J.A.W.); Hunstman Cancer Institute, University of Utah, Salt Lake City (E.A.R.); the Office of Cancer Genomics (J.M.G.A., D.S.G.) and Cancer Therapy Evaluation Program (M.A.S.), National Cancer Institute, and the Children’s Oncology Group TARGET ALL project (M.D., I-M.C., S.R., W.L.C., J.M.G.A., M.A.S., M.V.R., D.S.G., J.M.G.-F., M.L.L., J.R.D., S.P.H., C.L.W., J.Z., C.G.M.), National Institutes of Health, Bethesda, MD; Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN (J.K.); the University of Chicago Medicine, Chicago (W.S.); the Department of Pediatrics, Benioff Children’s Hospital, and the Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco (M.L.L.); and the University of Colorado School of Medicine and Children’s Hospital Colorado — both in Aurora (S.P.H.) – sequence: 44 givenname: Andrew S surname: Moore fullname: Moore, Andrew S organization: From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children’s Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) — all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children’s Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) — all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) — all in Texas; Maine Children’s Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx (E.P.) — both in New York; the Department of Genetics, University of Alabama at Birmingham, Birmingham (A.J.C.); the Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia (S.K.T.); Queensland Children’s Medical Research Institute, University of Queensland and Royal Children’s Hospital Brisbane, Herston (A.S.M.), and Cancer Theme, South Australian Health and Medical Research Institute, Adelaide (D.L.W., T.P.H.) — both in Australia; Children’s Healthcare of Atlanta and Emory University School of Medicine — both in Atlanta (F.K.); the Division of Haematology–Oncology, Hospital for Sick Children, and University of Toronto — both in Toronto (J.A.W.); Hunstman Cancer Institute, University of Utah, Salt Lake City (E.A.R.); the Office of Cancer Genomics (J.M.G.A., D.S.G.) and Cancer Therapy Evaluation Program (M.A.S.), National Cancer Institute, and the Children’s Oncology Group TARGET ALL project (M.D., I-M.C., S.R., W.L.C., J.M.G.A., M.A.S., M.V.R., D.S.G., J.M.G.-F., M.L.L., J.R.D., S.P.H., C.L.W., J.Z., C.G.M.), National Institutes of Health, Bethesda, MD; Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN (J.K.); the University of Chicago Medicine, Chicago (W.S.); the Department of Pediatrics, Benioff Children’s Hospital, and the Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco (M.L.L.); and the University of Colorado School of Medicine and Children’s Hospital Colorado — both in Aurora (S.P.H.) – sequence: 45 givenname: Frank surname: Keller fullname: Keller, Frank organization: From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children’s Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) — all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children’s Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) — all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) — all in Texas; Maine Children’s Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx (E.P.) — both in New York; the Department of Genetics, University of Alabama at Birmingham, Birmingham (A.J.C.); the Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia (S.K.T.); Queensland Children’s Medical Research Institute, University of Queensland and Royal Children’s Hospital Brisbane, Herston (A.S.M.), and Cancer Theme, South Australian Health and Medical Research Institute, Adelaide (D.L.W., T.P.H.) — both in Australia; Children’s Healthcare of Atlanta and Emory University School of Medicine — both in Atlanta (F.K.); the Division of Haematology–Oncology, Hospital for Sick Children, and University of Toronto — both in Toronto (J.A.W.); Hunstman Cancer Institute, University of Utah, Salt Lake City (E.A.R.); the Office of Cancer Genomics (J.M.G.A., D.S.G.) and Cancer Therapy Evaluation Program (M.A.S.), National Cancer Institute, and the Children’s Oncology Group TARGET ALL project (M.D., I-M.C., S.R., W.L.C., J.M.G.A., M.A.S., M.V.R., D.S.G., J.M.G.-F., M.L.L., J.R.D., S.P.H., C.L.W., J.Z., C.G.M.), National Institutes of Health, Bethesda, MD; Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN (J.K.); the University of Chicago Medicine, Chicago (W.S.); the Department of Pediatrics, Benioff Children’s Hospital, and the Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco (M.L.L.); and the University of Colorado School of Medicine and Children’s Hospital Colorado — both in Aurora (S.P.H.) – sequence: 46 givenname: Melissa surname: Frei-Jones fullname: Frei-Jones, Melissa organization: From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children’s Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) — all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children’s Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) — all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) — all in Texas; Maine Children’s Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx (E.P.) — both in New York; the Department of Genetics, University of Alabama at Birmingham, Birmingham (A.J.C.); the Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia (S.K.T.); Queensland Children’s Medical Research Institute, University of Queensland and Royal Children’s Hospital Brisbane, Herston (A.S.M.), and Cancer Theme, South Australian Health and Medical Research Institute, Adelaide (D.L.W., T.P.H.) — both in Australia; Children’s Healthcare of Atlanta and Emory University School of Medicine — both in Atlanta (F.K.); the Division of Haematology–Oncology, Hospital for Sick Children, and University of Toronto — both in Toronto (J.A.W.); Hunstman Cancer Institute, University of Utah, Salt Lake City (E.A.R.); the Office of Cancer Genomics (J.M.G.A., D.S.G.) and Cancer Therapy Evaluation Program (M.A.S.), National Cancer Institute, and the Children’s Oncology Group TARGET ALL project (M.D., I-M.C., S.R., W.L.C., J.M.G.A., M.A.S., M.V.R., D.S.G., J.M.G.-F., M.L.L., J.R.D., S.P.H., C.L.W., J.Z., C.G.M.), National Institutes of Health, Bethesda, MD; Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN (J.K.); the University of Chicago Medicine, Chicago (W.S.); the Department of Pediatrics, Benioff Children’s Hospital, and the Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco (M.L.L.); and the University of Colorado School of Medicine and Children’s Hospital Colorado — both in Aurora (S.P.H.) – sequence: 47 givenname: James A surname: Whitlock fullname: Whitlock, James A organization: From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children’s Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) — all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children’s Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) — all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) — all in Texas; Maine Children’s Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx (E.P.) — both in New York; the Department of Genetics, University of Alabama at Birmingham, Birmingham (A.J.C.); the Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia (S.K.T.); Queensland Children’s Medical Research Institute, University of Queensland and Royal Children’s Hospital Brisbane, Herston (A.S.M.), and Cancer Theme, South Australian Health and Medical Research Institute, Adelaide (D.L.W., T.P.H.) — both in Australia; Children’s Healthcare of Atlanta and Emory University School of Medicine — both in Atlanta (F.K.); the Division of Haematology–Oncology, Hospital for Sick Children, and University of Toronto — both in Toronto (J.A.W.); Hunstman Cancer Institute, University of Utah, Salt Lake City (E.A.R.); the Office of Cancer Genomics (J.M.G.A., D.S.G.) and Cancer Therapy Evaluation Program (M.A.S.), National Cancer Institute, and the Children’s Oncology Group TARGET ALL project (M.D., I-M.C., S.R., W.L.C., J.M.G.A., M.A.S., M.V.R., D.S.G., J.M.G.-F., M.L.L., J.R.D., S.P.H., C.L.W., J.Z., C.G.M.), National Institutes of Health, Bethesda, MD; Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN (J.K.); the University of Chicago Medicine, Chicago (W.S.); the Department of Pediatrics, Benioff Children’s Hospital, and the Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco (M.L.L.); and the University of Colorado School of Medicine and Children’s Hospital Colorado — both in Aurora (S.P.H.) – sequence: 48 givenname: Elizabeth A surname: Raetz fullname: Raetz, Elizabeth A organization: From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children’s Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) — all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children’s Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) — all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) — all in Texas; Maine Children’s Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx (E.P.) — both in New York; the Department of Genetics, University of Alabama at Birmingham, Birmingham (A.J.C.); the Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia (S.K.T.); Queensland Children’s Medical Research Institute, University of Queensland and Royal Children’s Hospital Brisbane, Herston (A.S.M.), and Cancer Theme, South Australian Health and Medical Research Institute, Adelaide (D.L.W., T.P.H.) — both in Australia; Children’s Healthcare of Atlanta and Emory University School of Medicine — both in Atlanta (F.K.); the Division of Haematology–Oncology, Hospital for Sick Children, and University of Toronto — both in Toronto (J.A.W.); Hunstman Cancer Institute, University of Utah, Salt Lake City (E.A.R.); the Office of Cancer Genomics (J.M.G.A., D.S.G.) and Cancer Therapy Evaluation Program (M.A.S.), National Cancer Institute, and the Children’s Oncology Group TARGET ALL project (M.D., I-M.C., S.R., W.L.C., J.M.G.A., M.A.S., M.V.R., D.S.G., J.M.G.-F., M.L.L., J.R.D., S.P.H., C.L.W., J.Z., C.G.M.), National Institutes of Health, Bethesda, MD; Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN (J.K.); the University of Chicago Medicine, Chicago (W.S.); the Department of Pediatrics, Benioff Children’s Hospital, and the Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco (M.L.L.); and the University of Colorado School of Medicine and Children’s Hospital Colorado — both in Aurora (S.P.H.) – sequence: 49 givenname: Deborah L surname: White fullname: White, Deborah L organization: From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children’s Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) — all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children’s Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) — all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) — all in Texas; Maine Children’s Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx (E.P.) — both in New York; the Department of Genetics, University of Alabama at Birmingham, Birmingham (A.J.C.); the Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia (S.K.T.); Queensland Children’s Medical Research Institute, University of Queensland and Royal Children’s Hospital Brisbane, Herston (A.S.M.), and Cancer Theme, South Australian Health and Medical Research Institute, Adelaide (D.L.W., T.P.H.) — both in Australia; Children’s Healthcare of Atlanta and Emory University School of Medicine — both in Atlanta (F.K.); the Division of Haematology–Oncology, Hospital for Sick Children, and University of Toronto — both in Toronto (J.A.W.); Hunstman Cancer Institute, University of Utah, Salt Lake City (E.A.R.); the Office of Cancer Genomics (J.M.G.A., D.S.G.) and Cancer Therapy Evaluation Program (M.A.S.), National Cancer Institute, and the Children’s Oncology Group TARGET ALL project (M.D., I-M.C., S.R., W.L.C., J.M.G.A., M.A.S., M.V.R., D.S.G., J.M.G.-F., M.L.L., J.R.D., S.P.H., C.L.W., J.Z., C.G.M.), National Institutes of Health, Bethesda, MD; Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN (J.K.); the University of Chicago Medicine, Chicago (W.S.); the Department of Pediatrics, Benioff Children’s Hospital, and the Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco (M.L.L.); and the University of Colorado School of Medicine and Children’s Hospital Colorado — both in Aurora (S.P.H.) – sequence: 50 givenname: Timothy P surname: Hughes fullname: Hughes, Timothy P organization: From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children’s Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) — all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children’s Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) — all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) — all in Texas; Maine Children’s Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx (E.P.) — both in New York; the Department of Genetics, University of Alabama at Birmingham, Birmingham (A.J.C.); the Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia (S.K.T.); Queensland Children’s Medical Research Institute, University of Queensland and Royal Children’s Hospital Brisbane, Herston (A.S.M.), and Cancer Theme, South Australian Health and Medical Research Institute, Adelaide (D.L.W., T.P.H.) — both in Australia; Children’s Healthcare of Atlanta and Emory University School of Medicine — both in Atlanta (F.K.); the Division of Haematology–Oncology, Hospital for Sick Children, and University of Toronto — both in Toronto (J.A.W.); Hunstman Cancer Institute, University of Utah, Salt Lake City (E.A.R.); the Office of Cancer Genomics (J.M.G.A., D.S.G.) and Cancer Therapy Evaluation Program (M.A.S.), National Cancer Institute, and the Children’s Oncology Group TARGET ALL project (M.D., I-M.C., S.R., W.L.C., J.M.G.A., M.A.S., M.V.R., D.S.G., J.M.G.-F., M.L.L., J.R.D., S.P.H., C.L.W., J.Z., C.G.M.), National Institutes of Health, Bethesda, MD; Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN (J.K.); the University of Chicago Medicine, Chicago (W.S.); the Department of Pediatrics, Benioff Children’s Hospital, and the Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco (M.L.L.); and the University of Colorado School of Medicine and Children’s Hospital Colorado — both in Aurora (S.P.H.) – sequence: 51 givenname: Jaime M surname: Guidry Auvil fullname: Guidry Auvil, Jaime M organization: From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children’s Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) — all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children’s Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) — all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) — all in Texas; Maine Children’s Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx (E.P.) — both in New York; the Department of Genetics, University of Alabama at Birmingham, Birmingham (A.J.C.); the Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia (S.K.T.); Queensland Children’s Medical Research Institute, University of Queensland and Royal Children’s Hospital Brisbane, Herston (A.S.M.), and Cancer Theme, South Australian Health and Medical Research Institute, Adelaide (D.L.W., T.P.H.) — both in Australia; Children’s Healthcare of Atlanta and Emory University School of Medicine — both in Atlanta (F.K.); the Division of Haematology–Oncology, Hospital for Sick Children, and University of Toronto — both in Toronto (J.A.W.); Hunstman Cancer Institute, University of Utah, Salt Lake City (E.A.R.); the Office of Cancer Genomics (J.M.G.A., D.S.G.) and Cancer Therapy Evaluation Program (M.A.S.), National Cancer Institute, and the Children’s Oncology Group TARGET ALL project (M.D., I-M.C., S.R., W.L.C., J.M.G.A., M.A.S., M.V.R., D.S.G., J.M.G.-F., M.L.L., J.R.D., S.P.H., C.L.W., J.Z., C.G.M.), National Institutes of Health, Bethesda, MD; Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN (J.K.); the University of Chicago Medicine, Chicago (W.S.); the Department of Pediatrics, Benioff Children’s Hospital, and the Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco (M.L.L.); and the University of Colorado School of Medicine and Children’s Hospital Colorado — both in Aurora (S.P.H.) – sequence: 52 givenname: Malcolm A surname: Smith fullname: Smith, Malcolm A organization: From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children’s Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) — all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children’s Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) — all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) — all in Texas; Maine Children’s Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx (E.P.) — both in New York; the Department of Genetics, University of Alabama at Birmingham, Birmingham (A.J.C.); the Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia (S.K.T.); Queensland Children’s Medical Research Institute, University of Queensland and Royal Children’s Hospital Brisbane, Herston (A.S.M.), and Cancer Theme, South Australian Health and Medical Research Institute, Adelaide (D.L.W., T.P.H.) — both in Australia; Children’s Healthcare of Atlanta and Emory University School of Medicine — both in Atlanta (F.K.); the Division of Haematology–Oncology, Hospital for Sick Children, and University of Toronto — both in Toronto (J.A.W.); Hunstman Cancer Institute, University of Utah, Salt Lake City (E.A.R.); the Office of Cancer Genomics (J.M.G.A., D.S.G.) and Cancer Therapy Evaluation Program (M.A.S.), National Cancer Institute, and the Children’s Oncology Group TARGET ALL project (M.D., I-M.C., S.R., W.L.C., J.M.G.A., M.A.S., M.V.R., D.S.G., J.M.G.-F., M.L.L., J.R.D., S.P.H., C.L.W., J.Z., C.G.M.), National Institutes of Health, Bethesda, MD; Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN (J.K.); the University of Chicago Medicine, Chicago (W.S.); the Department of Pediatrics, Benioff Children’s Hospital, and the Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco (M.L.L.); and the University of Colorado School of Medicine and Children’s Hospital Colorado — both in Aurora (S.P.H.) – sequence: 53 givenname: Guido surname: Marcucci fullname: Marcucci, Guido organization: From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children’s Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) — all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children’s Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) — all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) — all in Texas; Maine Children’s Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx (E.P.) — both in New York; the Department of Genetics, University of Alabama at Birmingham, Birmingham (A.J.C.); the Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia (S.K.T.); Queensland Children’s Medical Research Institute, University of Queensland and Royal Children’s Hospital Brisbane, Herston (A.S.M.), and Cancer Theme, South Australian Health and Medical Research Institute, Adelaide (D.L.W., T.P.H.) — both in Australia; Children’s Healthcare of Atlanta and Emory University School of Medicine — both in Atlanta (F.K.); the Division of Haematology–Oncology, Hospital for Sick Children, and University of Toronto — both in Toronto (J.A.W.); Hunstman Cancer Institute, University of Utah, Salt Lake City (E.A.R.); the Office of Cancer Genomics (J.M.G.A., D.S.G.) and Cancer Therapy Evaluation Program (M.A.S.), National Cancer Institute, and the Children’s Oncology Group TARGET ALL project (M.D., I-M.C., S.R., W.L.C., J.M.G.A., M.A.S., M.V.R., D.S.G., J.M.G.-F., M.L.L., J.R.D., S.P.H., C.L.W., J.Z., C.G.M.), National Institutes of Health, Bethesda, MD; Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN (J.K.); the University of Chicago Medicine, Chicago (W.S.); the Department of Pediatrics, Benioff Children’s Hospital, and the Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco (M.L.L.); and the University of Colorado School of Medicine and Children’s Hospital Colorado — both in Aurora (S.P.H.) – sequence: 54 givenname: Clara D surname: Bloomfield fullname: Bloomfield, Clara D organization: From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children’s Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) — all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children’s Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) — all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) — all in Texas; Maine Children’s Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx (E.P.) — both in New York; the Department of Genetics, University of Alabama at Birmingham, Birmingham (A.J.C.); the Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia (S.K.T.); Queensland Children’s Medical Research Institute, University of Queensland and Royal Children’s Hospital Brisbane, Herston (A.S.M.), and Cancer Theme, South Australian Health and Medical Research Institute, Adelaide (D.L.W., T.P.H.) — both in Australia; Children’s Healthcare of Atlanta and Emory University School of Medicine — both in Atlanta (F.K.); the Division of Haematology–Oncology, Hospital for Sick Children, and University of Toronto — both in Toronto (J.A.W.); Hunstman Cancer Institute, University of Utah, Salt Lake City (E.A.R.); the Office of Cancer Genomics (J.M.G.A., D.S.G.) and Cancer Therapy Evaluation Program (M.A.S.), National Cancer Institute, and the Children’s Oncology Group TARGET ALL project (M.D., I-M.C., S.R., W.L.C., J.M.G.A., M.A.S., M.V.R., D.S.G., J.M.G.-F., M.L.L., J.R.D., S.P.H., C.L.W., J.Z., C.G.M.), National Institutes of Health, Bethesda, MD; Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN (J.K.); the University of Chicago Medicine, Chicago (W.S.); the Department of Pediatrics, Benioff Children’s Hospital, and the Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco (M.L.L.); and the University of Colorado School of Medicine and Children’s Hospital Colorado — both in Aurora (S.P.H.) – sequence: 55 givenname: Krzysztof surname: Mrózek fullname: Mrózek, Krzysztof organization: From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children’s Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) — all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children’s Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) — all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) — all in Texas; Maine Children’s Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx (E.P.) — both in New York; the Department of Genetics, University of Alabama at Birmingham, Birmingham (A.J.C.); the Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia (S.K.T.); Queensland Children’s Medical Research Institute, University of Queensland and Royal Children’s Hospital Brisbane, Herston (A.S.M.), and Cancer Theme, South Australian Health and Medical Research Institute, Adelaide (D.L.W., T.P.H.) — both in Australia; Children’s Healthcare of Atlanta and Emory University School of Medicine — both in Atlanta (F.K.); the Division of Haematology–Oncology, Hospital for Sick Children, and University of Toronto — both in Toronto (J.A.W.); Hunstman Cancer Institute, University of Utah, Salt Lake City (E.A.R.); the Office of Cancer Genomics (J.M.G.A., D.S.G.) and Cancer Therapy Evaluation Program (M.A.S.), National Cancer Institute, and the Children’s Oncology Group TARGET ALL project (M.D., I-M.C., S.R., W.L.C., J.M.G.A., M.A.S., M.V.R., D.S.G., J.M.G.-F., M.L.L., J.R.D., S.P.H., C.L.W., J.Z., C.G.M.), National Institutes of Health, Bethesda, MD; Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN (J.K.); the University of Chicago Medicine, Chicago (W.S.); the Department of Pediatrics, Benioff Children’s Hospital, and the Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco (M.L.L.); and the University of Colorado School of Medicine and Children’s Hospital Colorado — both in Aurora (S.P.H.) – sequence: 56 givenname: Jessica surname: Kohlschmidt fullname: Kohlschmidt, Jessica organization: From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children’s Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) — all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children’s Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) — all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) — all in Texas; Maine Children’s Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx (E.P.) — both in New York; the Department of Genetics, University of Alabama at Birmingham, Birmingham (A.J.C.); the Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia (S.K.T.); Queensland Children’s Medical Research Institute, University of Queensland and Royal Children’s Hospital Brisbane, Herston (A.S.M.), and Cancer Theme, South Australian Health and Medical Research Institute, Adelaide (D.L.W., T.P.H.) — both in Australia; Children’s Healthcare of Atlanta and Emory University School of Medicine — both in Atlanta (F.K.); the Division of Haematology–Oncology, Hospital for Sick Children, and University of Toronto — both in Toronto (J.A.W.); Hunstman Cancer Institute, University of Utah, Salt Lake City (E.A.R.); the Office of Cancer Genomics (J.M.G.A., D.S.G.) and Cancer Therapy Evaluation Program (M.A.S.), National Cancer Institute, and the Children’s Oncology Group TARGET ALL project (M.D., I-M.C., S.R., W.L.C., J.M.G.A., M.A.S., M.V.R., D.S.G., J.M.G.-F., M.L.L., J.R.D., S.P.H., C.L.W., J.Z., C.G.M.), National Institutes of Health, Bethesda, MD; Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN (J.K.); the University of Chicago Medicine, Chicago (W.S.); the Department of Pediatrics, Benioff Children’s Hospital, and the Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco (M.L.L.); and the University of Colorado School of Medicine and Children’s Hospital Colorado — both in Aurora (S.P.H.) – sequence: 57 givenname: Wendy surname: Stock fullname: Stock, Wendy organization: From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children’s Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) — all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children’s Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) — all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) — all in Texas; Maine Children’s Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx (E.P.) — both in New York; the Department of Genetics, University of Alabama at Birmingham, Birmingham (A.J.C.); the Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia (S.K.T.); Queensland Children’s Medical Research Institute, University of Queensland and Royal Children’s Hospital Brisbane, Herston (A.S.M.), and Cancer Theme, South Australian Health and Medical Research Institute, Adelaide (D.L.W., T.P.H.) — both in Australia; Children’s Healthcare of Atlanta and Emory University School of Medicine — both in Atlanta (F.K.); the Division of Haematology–Oncology, Hospital for Sick Children, and University of Toronto — both in Toronto (J.A.W.); Hunstman Cancer Institute, University of Utah, Salt Lake City (E.A.R.); the Office of Cancer Genomics (J.M.G.A., D.S.G.) and Cancer Therapy Evaluation Program (M.A.S.), National Cancer Institute, and the Children’s Oncology Group TARGET ALL project (M.D., I-M.C., S.R., W.L.C., J.M.G.A., M.A.S., M.V.R., D.S.G., J.M.G.-F., M.L.L., J.R.D., S.P.H., C.L.W., J.Z., C.G.M.), National Institutes of Health, Bethesda, MD; Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN (J.K.); the University of Chicago Medicine, Chicago (W.S.); the Department of Pediatrics, Benioff Children’s Hospital, and the Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco (M.L.L.); and the University of Colorado School of Medicine and Children’s Hospital Colorado — both in Aurora (S.P.H.) – sequence: 58 givenname: Steven M surname: Kornblau fullname: Kornblau, Steven M organization: From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children’s Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) — all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children’s Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) — all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) — all in Texas; Maine Children’s Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx (E.P.) — both in New York; the Department of Genetics, University of Alabama at Birmingham, Birmingham (A.J.C.); the Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia (S.K.T.); Queensland Children’s Medical Research Institute, University of Queensland and Royal Children’s Hospital Brisbane, Herston (A.S.M.), and Cancer Theme, South Australian Health and Medical Research Institute, Adelaide (D.L.W., T.P.H.) — both in Australia; Children’s Healthcare of Atlanta and Emory University School of Medicine — both in Atlanta (F.K.); the Division of Haematology–Oncology, Hospital for Sick Children, and University of Toronto — both in Toronto (J.A.W.); Hunstman Cancer Institute, University of Utah, Salt Lake City (E.A.R.); the Office of Cancer Genomics (J.M.G.A., D.S.G.) and Cancer Therapy Evaluation Program (M.A.S.), National Cancer Institute, and the Children’s Oncology Group TARGET ALL project (M.D., I-M.C., S.R., W.L.C., J.M.G.A., M.A.S., M.V.R., D.S.G., J.M.G.-F., M.L.L., J.R.D., S.P.H., C.L.W., J.Z., C.G.M.), National Institutes of Health, Bethesda, MD; Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN (J.K.); the University of Chicago Medicine, Chicago (W.S.); the Department of Pediatrics, Benioff Children’s Hospital, and the Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco (M.L.L.); and the University of Colorado School of Medicine and Children’s Hospital Colorado — both in Aurora (S.P.H.) – sequence: 59 givenname: Marina surname: Konopleva fullname: Konopleva, Marina organization: From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children’s Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) — all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children’s Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) — all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) — all in Texas; Maine Children’s Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx (E.P.) — both in New York; the Department of Genetics, University of Alabama at Birmingham, Birmingham (A.J.C.); the Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia (S.K.T.); Queensland Children’s Medical Research Institute, University of Queensland and Royal Children’s Hospital Brisbane, Herston (A.S.M.), and Cancer Theme, South Australian Health and Medical Research Institute, Adelaide (D.L.W., T.P.H.) — both in Australia; Children’s Healthcare of Atlanta and Emory University School of Medicine — both in Atlanta (F.K.); the Division of Haematology–Oncology, Hospital for Sick Children, and University of Toronto — both in Toronto (J.A.W.); Hunstman Cancer Institute, University of Utah, Salt Lake City (E.A.R.); the Office of Cancer Genomics (J.M.G.A., D.S.G.) and Cancer Therapy Evaluation Program (M.A.S.), National Cancer Institute, and the Children’s Oncology Group TARGET ALL project (M.D., I-M.C., S.R., W.L.C., J.M.G.A., M.A.S., M.V.R., D.S.G., J.M.G.-F., M.L.L., J.R.D., S.P.H., C.L.W., J.Z., C.G.M.), National Institutes of Health, Bethesda, MD; Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN (J.K.); the University of Chicago Medicine, Chicago (W.S.); the Department of Pediatrics, Benioff Children’s Hospital, and the Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco (M.L.L.); and the University of Colorado School of Medicine and Children’s Hospital Colorado — both in Aurora (S.P.H.) – sequence: 60 givenname: Elisabeth surname: Paietta fullname: Paietta, Elisabeth organization: From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children’s Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) — all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children’s Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) — all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) — all in Texas; Maine Children’s Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx (E.P.) — both in New York; the Department of Genetics, University of Alabama at Birmingham, Birmingham (A.J.C.); the Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia (S.K.T.); Queensland Children’s Medical Research Institute, University of Queensland and Royal Children’s Hospital Brisbane, Herston (A.S.M.), and Cancer Theme, South Australian Health and Medical Research Institute, Adelaide (D.L.W., T.P.H.) — both in Australia; Children’s Healthcare of Atlanta and Emory University School of Medicine — both in Atlanta (F.K.); the Division of Haematology–Oncology, Hospital for Sick Children, and University of Toronto — both in Toronto (J.A.W.); Hunstman Cancer Institute, University of Utah, Salt Lake City (E.A.R.); the Office of Cancer Genomics (J.M.G.A., D.S.G.) and Cancer Therapy Evaluation Program (M.A.S.), National Cancer Institute, and the Children’s Oncology Group TARGET ALL project (M.D., I-M.C., S.R., W.L.C., J.M.G.A., M.A.S., M.V.R., D.S.G., J.M.G.-F., M.L.L., J.R.D., S.P.H., C.L.W., J.Z., C.G.M.), National Institutes of Health, Bethesda, MD; Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN (J.K.); the University of Chicago Medicine, Chicago (W.S.); the Department of Pediatrics, Benioff Children’s Hospital, and the Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco (M.L.L.); and the University of Colorado School of Medicine and Children’s Hospital Colorado — both in Aurora (S.P.H.) – sequence: 61 givenname: Ching-Hon surname: Pui fullname: Pui, Ching-Hon organization: From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children’s Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) — all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children’s Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) — all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) — all in Texas; Maine Children’s Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx (E.P.) — both in New York; the Department of Genetics, University of Alabama at Birmingham, Birmingham (A.J.C.); the Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia (S.K.T.); Queensland Children’s Medical Research Institute, University of Queensland and Royal Children’s Hospital Brisbane, Herston (A.S.M.), and Cancer Theme, South Australian Health and Medical Research Institute, Adelaide (D.L.W., T.P.H.) — both in Australia; Children’s Healthcare of Atlanta and Emory University School of Medicine — both in Atlanta (F.K.); the Division of Haematology–Oncology, Hospital for Sick Children, and University of Toronto — both in Toronto (J.A.W.); Hunstman Cancer Institute, University of Utah, Salt Lake City (E.A.R.); the Office of Cancer Genomics (J.M.G.A., D.S.G.) and Cancer Therapy Evaluation Program (M.A.S.), National Cancer Institute, and the Children’s Oncology Group TARGET ALL project (M.D., I-M.C., S.R., W.L.C., J.M.G.A., M.A.S., M.V.R., D.S.G., J.M.G.-F., M.L.L., J.R.D., S.P.H., C.L.W., J.Z., C.G.M.), National Institutes of Health, Bethesda, MD; Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN (J.K.); the University of Chicago Medicine, Chicago (W.S.); the Department of Pediatrics, Benioff Children’s Hospital, and the Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco (M.L.L.); and the University of Colorado School of Medicine and Children’s Hospital Colorado — both in Aurora (S.P.H.) – sequence: 62 givenname: Sima surname: Jeha fullname: Jeha, Sima organization: From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children’s Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) — all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children’s Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) — all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) — all in Texas; Maine Children’s Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx (E.P.) — both in New York; the Department of Genetics, University of Alabama at Birmingham, Birmingham (A.J.C.); the Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia (S.K.T.); Queensland Children’s Medical Research Institute, University of Queensland and Royal Children’s Hospital Brisbane, Herston (A.S.M.), and Cancer Theme, South Australian Health and Medical Research Institute, Adelaide (D.L.W., T.P.H.) — both in Australia; Children’s Healthcare of Atlanta and Emory University School of Medicine — both in Atlanta (F.K.); the Division of Haematology–Oncology, Hospital for Sick Children, and University of Toronto — both in Toronto (J.A.W.); Hunstman Cancer Institute, University of Utah, Salt Lake City (E.A.R.); the Office of Cancer Genomics (J.M.G.A., D.S.G.) and Cancer Therapy Evaluation Program (M.A.S.), National Cancer Institute, and the Children’s Oncology Group TARGET ALL project (M.D., I-M.C., S.R., W.L.C., J.M.G.A., M.A.S., M.V.R., D.S.G., J.M.G.-F., M.L.L., J.R.D., S.P.H., C.L.W., J.Z., C.G.M.), National Institutes of Health, Bethesda, MD; Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN (J.K.); the University of Chicago Medicine, Chicago (W.S.); the Department of Pediatrics, Benioff Children’s Hospital, and the Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco (M.L.L.); and the University of Colorado School of Medicine and Children’s Hospital Colorado — both in Aurora (S.P.H.) – sequence: 63 givenname: Mary V surname: Relling fullname: Relling, Mary V organization: From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children’s Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) — all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children’s Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) — all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) — all in Texas; Maine Children’s Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx (E.P.) — both in New York; the Department of Genetics, University of Alabama at Birmingham, Birmingham (A.J.C.); the Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia (S.K.T.); Queensland Children’s Medical Research Institute, University of Queensland and Royal Children’s Hospital Brisbane, Herston (A.S.M.), and Cancer Theme, South Australian Health and Medical Research Institute, Adelaide (D.L.W., T.P.H.) — both in Australia; Children’s Healthcare of Atlanta and Emory University School of Medicine — both in Atlanta (F.K.); the Division of Haematology–Oncology, Hospital for Sick Children, and University of Toronto — both in Toronto (J.A.W.); Hunstman Cancer Institute, University of Utah, Salt Lake City (E.A.R.); the Office of Cancer Genomics (J.M.G.A., D.S.G.) and Cancer Therapy Evaluation Program (M.A.S.), National Cancer Institute, and the Children’s Oncology Group TARGET ALL project (M.D., I-M.C., S.R., W.L.C., J.M.G.A., M.A.S., M.V.R., D.S.G., J.M.G.-F., M.L.L., J.R.D., S.P.H., C.L.W., J.Z., C.G.M.), National Institutes of Health, Bethesda, MD; Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN (J.K.); the University of Chicago Medicine, Chicago (W.S.); the Department of Pediatrics, Benioff Children’s Hospital, and the Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco (M.L.L.); and the University of Colorado School of Medicine and Children’s Hospital Colorado — both in Aurora (S.P.H.) – sequence: 64 givenname: William E surname: Evans fullname: Evans, William E organization: From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children’s Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) — all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children’s Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) — all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) — all in Texas; Maine Children’s Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx (E.P.) — both in New York; the Department of Genetics, University of Alabama at Birmingham, Birmingham (A.J.C.); the Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia (S.K.T.); Queensland Children’s Medical Research Institute, University of Queensland and Royal Children’s Hospital Brisbane, Herston (A.S.M.), and Cancer Theme, South Australian Health and Medical Research Institute, Adelaide (D.L.W., T.P.H.) — both in Australia; Children’s Healthcare of Atlanta and Emory University School of Medicine — both in Atlanta (F.K.); the Division of Haematology–Oncology, Hospital for Sick Children, and University of Toronto — both in Toronto (J.A.W.); Hunstman Cancer Institute, University of Utah, Salt Lake City (E.A.R.); the Office of Cancer Genomics (J.M.G.A., D.S.G.) and Cancer Therapy Evaluation Program (M.A.S.), National Cancer Institute, and the Children’s Oncology Group TARGET ALL project (M.D., I-M.C., S.R., W.L.C., J.M.G.A., M.A.S., M.V.R., D.S.G., J.M.G.-F., M.L.L., J.R.D., S.P.H., C.L.W., J.Z., C.G.M.), National Institutes of Health, Bethesda, MD; Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN (J.K.); the University of Chicago Medicine, Chicago (W.S.); the Department of Pediatrics, Benioff Children’s Hospital, and the Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco (M.L.L.); and the University of Colorado School of Medicine and Children’s Hospital Colorado — both in Aurora (S.P.H.) – sequence: 65 givenname: Daniela S surname: Gerhard fullname: Gerhard, Daniela S organization: From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children’s Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) — all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children’s Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) — all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) — all in Texas; Maine Children’s Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx (E.P.) — both in New York; the Department of Genetics, University of Alabama at Birmingham, Birmingham (A.J.C.); the Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia (S.K.T.); Queensland Children’s Medical Research Institute, University of Queensland and Royal Children’s Hospital Brisbane, Herston (A.S.M.), and Cancer Theme, South Australian Health and Medical Research Institute, Adelaide (D.L.W., T.P.H.) — both in Australia; Children’s Healthcare of Atlanta and Emory University School of Medicine — both in Atlanta (F.K.); the Division of Haematology–Oncology, Hospital for Sick Children, and University of Toronto — both in Toronto (J.A.W.); Hunstman Cancer Institute, University of Utah, Salt Lake City (E.A.R.); the Office of Cancer Genomics (J.M.G.A., D.S.G.) and Cancer Therapy Evaluation Program (M.A.S.), National Cancer Institute, and the Children’s Oncology Group TARGET ALL project (M.D., I-M.C., S.R., W.L.C., J.M.G.A., M.A.S., M.V.R., D.S.G., J.M.G.-F., M.L.L., J.R.D., S.P.H., C.L.W., J.Z., C.G.M.), National Institutes of Health, Bethesda, MD; Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN (J.K.); the University of Chicago Medicine, Chicago (W.S.); the Department of Pediatrics, Benioff Children’s Hospital, and the Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco (M.L.L.); and the University of Colorado School of Medicine and Children’s Hospital Colorado — both in Aurora (S.P.H.) – sequence: 66 givenname: Julie M surname: Gastier-Foster fullname: Gastier-Foster, Julie M organization: From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children’s Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) — all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children’s Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) — all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) — all in Texas; Maine Children’s Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx (E.P.) — both in New York; the Department of Genetics, University of Alabama at Birmingham, Birmingham (A.J.C.); the Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia (S.K.T.); Queensland Children’s Medical Research Institute, University of Queensland and Royal Children’s Hospital Brisbane, Herston (A.S.M.), and Cancer Theme, South Australian Health and Medical Research Institute, Adelaide (D.L.W., T.P.H.) — both in Australia; Children’s Healthcare of Atlanta and Emory University School of Medicine — both in Atlanta (F.K.); the Division of Haematology–Oncology, Hospital for Sick Children, and University of Toronto — both in Toronto (J.A.W.); Hunstman Cancer Institute, University of Utah, Salt Lake City (E.A.R.); the Office of Cancer Genomics (J.M.G.A., D.S.G.) and Cancer Therapy Evaluation Program (M.A.S.), National Cancer Institute, and the Children’s Oncology Group TARGET ALL project (M.D., I-M.C., S.R., W.L.C., J.M.G.A., M.A.S., M.V.R., D.S.G., J.M.G.-F., M.L.L., J.R.D., S.P.H., C.L.W., J.Z., C.G.M.), National Institutes of Health, Bethesda, MD; Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN (J.K.); the University of Chicago Medicine, Chicago (W.S.); the Department of Pediatrics, Benioff Children’s Hospital, and the Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco (M.L.L.); and the University of Colorado School of Medicine and Children’s Hospital Colorado — both in Aurora (S.P.H.) – sequence: 67 givenname: Elaine surname: Mardis fullname: Mardis, Elaine organization: From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children’s Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) — all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children’s Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) — all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) — all in Texas; Maine Children’s Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx (E.P.) — both in New York; the Department of Genetics, University of Alabama at Birmingham, Birmingham (A.J.C.); the Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia (S.K.T.); Queensland Children’s Medical Research Institute, University of Queensland and Royal Children’s Hospital Brisbane, Herston (A.S.M.), and Cancer Theme, South Australian Health and Medical Research Institute, Adelaide (D.L.W., T.P.H.) — both in Australia; Children’s Healthcare of Atlanta and Emory University School of Medicine — both in Atlanta (F.K.); the Division of Haematology–Oncology, Hospital for Sick Children, and University of Toronto — both in Toronto (J.A.W.); Hunstman Cancer Institute, University of Utah, Salt Lake City (E.A.R.); the Office of Cancer Genomics (J.M.G.A., D.S.G.) and Cancer Therapy Evaluation Program (M.A.S.), National Cancer Institute, and the Children’s Oncology Group TARGET ALL project (M.D., I-M.C., S.R., W.L.C., J.M.G.A., M.A.S., M.V.R., D.S.G., J.M.G.-F., M.L.L., J.R.D., S.P.H., C.L.W., J.Z., C.G.M.), National Institutes of Health, Bethesda, MD; Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN (J.K.); the University of Chicago Medicine, Chicago (W.S.); the Department of Pediatrics, Benioff Children’s Hospital, and the Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco (M.L.L.); and the University of Colorado School of Medicine and Children’s Hospital Colorado — both in Aurora (S.P.H.) – sequence: 68 givenname: Richard K surname: Wilson fullname: Wilson, Richard K organization: From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children’s Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) — all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children’s Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) — all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) — all in Texas; Maine Children’s Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx (E.P.) — both in New York; the Department of Genetics, University of Alabama at Birmingham, Birmingham (A.J.C.); the Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia (S.K.T.); Queensland Children’s Medical Research Institute, University of Queensland and Royal Children’s Hospital Brisbane, Herston (A.S.M.), and Cancer Theme, South Australian Health and Medical Research Institute, Adelaide (D.L.W., T.P.H.) — both in Australia; Children’s Healthcare of Atlanta and Emory University School of Medicine — both in Atlanta (F.K.); the Division of Haematology–Oncology, Hospital for Sick Children, and University of Toronto — both in Toronto (J.A.W.); Hunstman Cancer Institute, University of Utah, Salt Lake City (E.A.R.); the Office of Cancer Genomics (J.M.G.A., D.S.G.) and Cancer Therapy Evaluation Program (M.A.S.), National Cancer Institute, and the Children’s Oncology Group TARGET ALL project (M.D., I-M.C., S.R., W.L.C., J.M.G.A., M.A.S., M.V.R., D.S.G., J.M.G.-F., M.L.L., J.R.D., S.P.H., C.L.W., J.Z., C.G.M.), National Institutes of Health, Bethesda, MD; Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN (J.K.); the University of Chicago Medicine, Chicago (W.S.); the Department of Pediatrics, Benioff Children’s Hospital, and the Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco (M.L.L.); and the University of Colorado School of Medicine and Children’s Hospital Colorado — both in Aurora (S.P.H.) – sequence: 69 givenname: Mignon L surname: Loh fullname: Loh, Mignon L organization: From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children’s Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) — all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children’s Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) — all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) — all in Texas; Maine Children’s Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx (E.P.) — both in New York; the Department of Genetics, University of Alabama at Birmingham, Birmingham (A.J.C.); the Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia (S.K.T.); Queensland Children’s Medical Research Institute, University of Queensland and Royal Children’s Hospital Brisbane, Herston (A.S.M.), and Cancer Theme, South Australian Health and Medical Research Institute, Adelaide (D.L.W., T.P.H.) — both in Australia; Children’s Healthcare of Atlanta and Emory University School of Medicine — both in Atlanta (F.K.); the Division of Haematology–Oncology, Hospital for Sick Children, and University of Toronto — both in Toronto (J.A.W.); Hunstman Cancer Institute, University of Utah, Salt Lake City (E.A.R.); the Office of Cancer Genomics (J.M.G.A., D.S.G.) and Cancer Therapy Evaluation Program (M.A.S.), National Cancer Institute, and the Children’s Oncology Group TARGET ALL project (M.D., I-M.C., S.R., W.L.C., J.M.G.A., M.A.S., M.V.R., D.S.G., J.M.G.-F., M.L.L., J.R.D., S.P.H., C.L.W., J.Z., C.G.M.), National Institutes of Health, Bethesda, MD; Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN (J.K.); the University of Chicago Medicine, Chicago (W.S.); the Department of Pediatrics, Benioff Children’s Hospital, and the Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco (M.L.L.); and the University of Colorado School of Medicine and Children’s Hospital Colorado — both in Aurora (S.P.H.) – sequence: 70 givenname: James R surname: Downing fullname: Downing, James R organization: From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children’s Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) — all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children’s Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) — all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) — all in Texas; Maine Children’s Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx (E.P.) — both in New York; the Department of Genetics, University of Alabama at Birmingham, Birmingham (A.J.C.); the Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia (S.K.T.); Queensland Children’s Medical Research Institute, University of Queensland and Royal Children’s Hospital Brisbane, Herston (A.S.M.), and Cancer Theme, South Australian Health and Medical Research Institute, Adelaide (D.L.W., T.P.H.) — both in Australia; Children’s Healthcare of Atlanta and Emory University School of Medicine — both in Atlanta (F.K.); the Division of Haematology–Oncology, Hospital for Sick Children, and University of Toronto — both in Toronto (J.A.W.); Hunstman Cancer Institute, University of Utah, Salt Lake City (E.A.R.); the Office of Cancer Genomics (J.M.G.A., D.S.G.) and Cancer Therapy Evaluation Program (M.A.S.), National Cancer Institute, and the Children’s Oncology Group TARGET ALL project (M.D., I-M.C., S.R., W.L.C., J.M.G.A., M.A.S., M.V.R., D.S.G., J.M.G.-F., M.L.L., J.R.D., S.P.H., C.L.W., J.Z., C.G.M.), National Institutes of Health, Bethesda, MD; Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN (J.K.); the University of Chicago Medicine, Chicago (W.S.); the Department of Pediatrics, Benioff Children’s Hospital, and the Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco (M.L.L.); and the University of Colorado School of Medicine and Children’s Hospital Colorado — both in Aurora (S.P.H.) – sequence: 71 givenname: Stephen P surname: Hunger fullname: Hunger, Stephen P organization: From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children’s Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) — all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children’s Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) — all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) — all in Texas; Maine Children’s Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx (E.P.) — both in New York; the Department of Genetics, University of Alabama at Birmingham, Birmingham (A.J.C.); the Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia (S.K.T.); Queensland Children’s Medical Research Institute, University of Queensland and Royal Children’s Hospital Brisbane, Herston (A.S.M.), and Cancer Theme, South Australian Health and Medical Research Institute, Adelaide (D.L.W., T.P.H.) — both in Australia; Children’s Healthcare of Atlanta and Emory University School of Medicine — both in Atlanta (F.K.); the Division of Haematology–Oncology, Hospital for Sick Children, and University of Toronto — both in Toronto (J.A.W.); Hunstman Cancer Institute, University of Utah, Salt Lake City (E.A.R.); the Office of Cancer Genomics (J.M.G.A., D.S.G.) and Cancer Therapy Evaluation Program (M.A.S.), National Cancer Institute, and the Children’s Oncology Group TARGET ALL project (M.D., I-M.C., S.R., W.L.C., J.M.G.A., M.A.S., M.V.R., D.S.G., J.M.G.-F., M.L.L., J.R.D., S.P.H., C.L.W., J.Z., C.G.M.), National Institutes of Health, Bethesda, MD; Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN (J.K.); the University of Chicago Medicine, Chicago (W.S.); the Department of Pediatrics, Benioff Children’s Hospital, and the Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco (M.L.L.); and the University of Colorado School of Medicine and Children’s Hospital Colorado — both in Aurora (S.P.H.) – sequence: 72 givenname: Cheryl L surname: Willman fullname: Willman, Cheryl L organization: From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children’s Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) — all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children’s Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) — all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) — all in Texas; Maine Children’s Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx (E.P.) — both in New York; the Department of Genetics, University of Alabama at Birmingham, Birmingham (A.J.C.); the Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia (S.K.T.); Queensland Children’s Medical Research Institute, University of Queensland and Royal Children’s Hospital Brisbane, Herston (A.S.M.), and Cancer Theme, South Australian Health and Medical Research Institute, Adelaide (D.L.W., T.P.H.) — both in Australia; Children’s Healthcare of Atlanta and Emory University School of Medicine — both in Atlanta (F.K.); the Division of Haematology–Oncology, Hospital for Sick Children, and University of Toronto — both in Toronto (J.A.W.); Hunstman Cancer Institute, University of Utah, Salt Lake City (E.A.R.); the Office of Cancer Genomics (J.M.G.A., D.S.G.) and Cancer Therapy Evaluation Program (M.A.S.), National Cancer Institute, and the Children’s Oncology Group TARGET ALL project (M.D., I-M.C., S.R., W.L.C., J.M.G.A., M.A.S., M.V.R., D.S.G., J.M.G.-F., M.L.L., J.R.D., S.P.H., C.L.W., J.Z., C.G.M.), National Institutes of Health, Bethesda, MD; Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN (J.K.); the University of Chicago Medicine, Chicago (W.S.); the Department of Pediatrics, Benioff Children’s Hospital, and the Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco (M.L.L.); and the University of Colorado School of Medicine and Children’s Hospital Colorado — both in Aurora (S.P.H.) – sequence: 73 givenname: Jinghui surname: Zhang fullname: Zhang, Jinghui organization: From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children’s Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) — all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children’s Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) — all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) — all in Texas; Maine Children’s Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx (E.P.) — both in New York; the Department of Genetics, University of Alabama at Birmingham, Birmingham (A.J.C.); the Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia (S.K.T.); Queensland Children’s Medical Research Institute, University of Queensland and Royal Children’s Hospital Brisbane, Herston (A.S.M.), and Cancer Theme, South Australian Health and Medical Research Institute, Adelaide (D.L.W., T.P.H.) — both in Australia; Children’s Healthcare of Atlanta and Emory University School of Medicine — both in Atlanta (F.K.); the Division of Haematology–Oncology, Hospital for Sick Children, and University of Toronto — both in Toronto (J.A.W.); Hunstman Cancer Institute, University of Utah, Salt Lake City (E.A.R.); the Office of Cancer Genomics (J.M.G.A., D.S.G.) and Cancer Therapy Evaluation Program (M.A.S.), National Cancer Institute, and the Children’s Oncology Group TARGET ALL project (M.D., I-M.C., S.R., W.L.C., J.M.G.A., M.A.S., M.V.R., D.S.G., J.M.G.-F., M.L.L., J.R.D., S.P.H., C.L.W., J.Z., C.G.M.), National Institutes of Health, Bethesda, MD; Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN (J.K.); the University of Chicago Medicine, Chicago (W.S.); the Department of Pediatrics, Benioff Children’s Hospital, and the Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco (M.L.L.); and the University of Colorado School of Medicine and Children’s Hospital Colorado — both in Aurora (S.P.H.) – sequence: 74 givenname: Charles G surname: Mullighan fullname: Mullighan, Charles G organization: From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children’s Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) — all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children’s Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) — all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) — all in Texas; Maine Children’s Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx (E.P.) — both in New York; the Department of Genetics, University of Alabama at Birmingham, Birmingham (A.J.C.); the Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia (S.K.T.); Queensland Children’s Medical Research Institute, University of Queensland and Royal Children’s Hospital Brisbane, Herston (A.S.M.), and Cancer Theme, South Australian Health and Medical Research Institute, Adelaide (D.L.W., T.P.H.) — both in Australia; Children’s Healthcare of Atlanta and Emory University School of Medicine — both in Atlanta (F.K.); the Division of Haematology–Oncology, Hospital for Sick Children, and University of Toronto — both in Toronto (J.A.W.); Hunstman Cancer Institute, University of Utah, Salt Lake City (E.A.R.); the Office of Cancer Genomics (J.M.G.A., D.S.G.) and Cancer Therapy Evaluation Program (M.A.S.), National Cancer Institute, and the Children’s Oncology Group TARGET ALL project (M.D., I-M.C., S.R., W.L.C., J.M.G.A., M.A.S., M.V.R., D.S.G., J.M.G.-F., M.L.L., J.R.D., S.P.H., C.L.W., J.Z., C.G.M.), National Institutes of Health, Bethesda, MD; Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN (J.K.); the University of Chicago Medicine, Chicago (W.S.); the Department of Pediatrics, Benioff Children’s Hospital, and the Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco (M.L.L.); and the University of Colorado School of Medicine and Children’s Hospital Colorado — both in Aurora (S.P.H.) |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=29054076$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/25207766$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1038/nbt.2620 10.1038/ng.2754 10.1200/JCO.2008.21.2514 10.1182/blood-2011-12-389932 10.1111/j.2517-6161.1972.tb00899.x 10.1002/gcc.20585 10.3324/haematol.2013.095372 10.1038/sj.leu.2405033 10.1002/mpo.1222 10.1182/asheducation-2010.1.21 10.1016/j.ccr.2012.06.005 10.1053/j.seminhematol.2013.10.001 10.2307/2670170 10.1182/blood.V122.21.826.826 10.1182/blood-2009-09-245944 10.1182/blood-2009-03-208397 10.1002/mpo.1223 10.1101/gad.1588607 10.1126/science.278.5341.1309 10.1038/nrc3563 10.1182/blood-2012-03-415448 10.1182/blood-2012-10-462358 10.1111/j.1365-2141.2010.08457.x 10.1056/NEJMoa0808253 10.1182/blood-2012-04-422691 10.1038/ng0298-184 10.1016/S1535-6108(02)00180-0 10.1200/JCO.2012.47.6770 10.1038/ng.469 10.1016/S1470-2045(08)70339-5 10.1038/nature06866 10.1073/pnas.0602030103 10.1016/S0140-6736(12)62187-4 10.1182/blood-2004-10-3967 |
| ContentType | Journal Article |
| Copyright | Copyright © 2014 Massachusetts Medical Society. All rights reserved. 2015 INIST-CNRS Copyright © 2014 Massachusetts Medical Society. 2014 |
| Copyright_xml | – notice: Copyright © 2014 Massachusetts Medical Society. All rights reserved. – notice: 2015 INIST-CNRS – notice: Copyright © 2014 Massachusetts Medical Society. 2014 |
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| Keywords | Medicine Enzyme Kinase Lymphoproliferative syndrome Transferases Acute leukemia pH Malignant hemopathy Lesion Acute lymphocytic leukemia Cancer |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Drs. Roberts and Li and Drs. Downing, Hunger, Willman, Zhang, and Mullighan contributed equally to this article. |
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| References | Mullighan, CG, Collins-Underwood, JR, Phillips, LA (r022) 2009; 41 Mullighan, CG (r002) 2013; 50 Knezevich, SR, Garnett, MJ, Pysher, TJ, Beckwith, JB, Grundy, PE, Sorensen, PH (r025) 1998; 58 Weston, BW, Hayden, MA, Roberts, KG (r012) 2013; 31 Cox, DR (r017) 1972; 34 Alessandri, AJ, Knezevich, SR, Mathers, JA, Schultz, KR, Sorensen, PH (r028) 2001; 37 Lacronique, V, Boureux, A, Valle, VD (r023) 1997; 278 Shah, S, Schrader, KA, Waanders, E (r014) 2013; 45 Harvey, RC, Mullighan, CG, Chen, IM (r035) 2010; 115 Inaba, H, Greaves, M, Mullighan, CG (r001) 2013; 381 r018 Tognon, C, Knezevich, SR, Huntsman, D (r027) 2002; 2 Loh, ML, Zhang, J, Harvey, RC (r008) 2013; 121 Tasian, SK, Doral, MY, Borowitz, MJ (r037) 2012; 120 Stock, W (r003) 2010; 2010 Roberts, KG, Morin, RD, Zhang, J (r011) 2012; 22 Eguchi, M, Eguchi-Ishimae, M (r029) 2001; 37 Soler, G, Radford-Weiss, I, Ben-Abdelali, R (r020) 2008; 22 Russell, LJ, Capasso, M, Vater, I (r021) 2009; 114 Dewar, AL, Cambareri, AC, Zannettino, AC (r039) 2005; 105 Mantel, N (r015) 1966; 50 Fine, JP, Gray, RJ (r016) 1999; 94 Poitras, JL, Dal Cin, P, Aster, JC, Deangelo, DJ, Morton, CC (r024) 2008; 47 Knezevich, SR, McFadden, DE, Tao, W, Lim, JF, Sorensen, PH (r026) 1998; 18 van der Veer, A, Waanders, E, Pieters, R (r007) 2013; 122 r010 Ernst, T, Score, J, Deininger, M (r019) 2011; 153 Mullighan, CG, Miller, CB, Radtke, I (r006) 2008; 453 Mullighan, CG, Su, X, Zhang, J (r004) 2009; 360 r009 Greuber, EK, Smith-Pearson, P, Wang, J, Pendergast, AM (r038) 2013; 13 Schultz, KR, Bowman, WP, Aledo, A (r033) 2009; 27 Lengline, E, Beldjord, K, Dombret, H, Soulier, J, Boissel, N, Clappier, E (r013) 2013; 98 Den Boer, ML, van Slegtenhorst, M, De Menezes, RX (r005) 2009; 10 Williams, RT, Roussel, MF, Sherr, CJ (r030) 2006; 103 Taipale, M, Krykbaeva, I, Whitesell, L (r032) 2013; 31 Harvey, RC, Kang, H, Roberts, KG (r034) 2013; 122 Maude, SL, Tasian, SK, Vincent, T (r036) 2012; 120 Williams, RT, den Besten, W, Sherr, CJ (r031) 2007; 21 Mantel N (r015) 1966; 50 r020 r021 r022 r001 r023 r039 r019 r013 r035 r014 r036 r037 r016 r038 Harvey RC (r034) 2013; 122 r031 r032 r011 Cox DR (r017) 1972; 34 r033 r012 r030 r006 r028 r007 r029 r008 r002 r024 r003 r004 r026 r005 r027 Knezevich SR (r025) 1998; 58 24246699 - Semin Hematol. 2013 Oct;50(4):314-24 22955920 - Blood. 2012 Oct 25;120(17):3510-8 25470705 - N Engl J Med. 2014 Dec 4;371(23):2235 19641190 - Blood. 2009 Sep 24;114(13):2688-98 19805687 - J Clin Oncol. 2009 Nov 1;27(31):5175-81 5910392 - Cancer Chemother Rep. 1966 Mar;50(3):163-70 17761812 - Genes Dev. 2007 Sep 15;21(18):2283-7 19838194 - Nat Genet. 2009 Nov;41(11):1243-6 18618714 - Genes Chromosomes Cancer. 2008 Oct;47(10):884-9 9360930 - Science. 1997 Nov 14;278(5341):1309-12 22897847 - Cancer Cell. 2012 Aug 14;22(2):153-66 25207770 - N Engl J Med. 2014 Sep 11;371(11):1064-6 19129520 - N Engl J Med. 2009 Jan 29;360(5):470-80 21391972 - Br J Haematol. 2011 Apr;153(1):43-6 23842646 - Nat Rev Cancer. 2013 Aug;13(8):559-71 24186319 - Haematologica. 2013 Nov;98(11):e146-8 23212523 - Blood. 2013 Jan 17;121(3):485-8 12450792 - Cancer Cell. 2002 Nov;2(5):367-76 11568911 - Med Pediatr Oncol. 2001 Oct;37(4):415-6 22685175 - Blood. 2012 Jul 26;120(4):833-42 16618932 - Proc Natl Acad Sci U S A. 2006 Apr 25;103(17):6688-93 9462753 - Nat Genet. 1998 Feb;18(2):184-7 19138562 - Lancet Oncol. 2009 Feb;10(2):125-34 23811600 - Nat Biotechnol. 2013 Jul;31(7):630-7 11568912 - Med Pediatr Oncol. 2001 Oct;37(4):417 9823307 - Cancer Res. 1998 Nov 15;58(22):5046-8 24013638 - Nat Genet. 2013 Oct;45(10):1226-31 15637141 - Blood. 2005 Apr 15;105(8):3127-32 23835704 - J Clin Oncol. 2013 Sep 1;31(25):e413-6 21239766 - Hematology Am Soc Hematol Educ Program. 2010;2010:21-9 18007576 - Leukemia. 2008 Jun;22(6):1278-80 23974192 - Blood. 2013 Oct 10;122(15):2622-9 20139093 - Blood. 2010 Jul 1;115(26):5312-21 18408710 - Nature. 2008 May 1;453(7191):110-4 23523389 - Lancet. 2013 Jun 1;381(9881):1943-55 |
| References_xml | – volume: 120 start-page: 833 year: 2012 end-page: 842 ident: r037 article-title: Aberrant STAT5 and PI3K/mTOR pathway signaling occurs in human CRLF2-rearranged B-precursor acute lymphoblastic leukemia. publication-title: Blood – volume: 10 start-page: 125 year: 2009 end-page: 134 ident: r005 article-title: A subtype of childhood acute lymphoblastic leukaemia with poor treatment outcome: a genome-wide classification study. publication-title: Lancet Oncol – volume: 50 start-page: 314 year: 2013 end-page: 324 ident: r002 article-title: Genomic characterization of childhood acute lymphoblastic leukemia. publication-title: Semin Hematol – ident: r010 article-title: Te Kronnie G , Silvestri D , Vendramini E , Philadelphia-like signature in childhood acute lymphoblastic leukemia: the AEIOP experience. Presented at the American Society of Hematology Annual Meeting, New Orleans, December 7–10, 2013. abstract 353. – volume: 50 start-page: 163 year: 1966 end-page: 170 ident: r015 article-title: Evaluation of survival data and two new rank order statistics arising in its consideration. publication-title: Cancer Chemother Rep – volume: 114 start-page: 2688 year: 2009 end-page: 2698 ident: r021 article-title: Deregulated expression of cytokine receptor gene, CRLF2, is involved in lymphoid transformation in B-cell precursor acute lymphoblastic leukemia. publication-title: Blood – volume: 58 start-page: 5046 year: 1998 end-page: 5048 ident: r025 article-title: ETV6-NTRK3 gene fusions and trisomy 11 establish a histogenetic link between mesoblastic nephroma and congenital fibrosarcoma. publication-title: Cancer Res – volume: 13 start-page: 559 year: 2013 end-page: 571 ident: r038 article-title: Role of ABL family kinases in cancer: from leukaemia to solid tumours. publication-title: Nat Rev Cancer – volume: 360 start-page: 470 year: 2009 end-page: 480 ident: r004 article-title: Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia. publication-title: N Engl J Med – volume: 34 start-page: 187 year: 1972 end-page: 220 ident: r017 article-title: Regression models and life-tables. publication-title: J R Stat Soc Series B Stat Methodol – volume: 41 start-page: 1243 year: 2009 end-page: 1246 ident: r022 article-title: Rearrangement of CRLF2 in B-progenitor- and Down syndrome-associated acute lymphoblastic leukemia. publication-title: Nat Genet – volume: 122 start-page: 2622 year: 2013 end-page: 2629 ident: r007 article-title: Independent prognostic value of BCR-ABL1-like signature and IKZF1 deletion, but not high CRLF2 expression, in children with B-cell precursor ALL. publication-title: Blood – volume: 45 start-page: 1226 year: 2013 end-page: 1231 ident: r014 article-title: A recurrent germline PAX5 mutation confers susceptibility to pre-B cell acute lymphoblastic leukemia. publication-title: Nat Genet – volume: 2010 start-page: 21 year: 2010 end-page: 29 ident: r003 article-title: Adolescents and young adults with acute lymphoblastic leukemia. publication-title: Hematology Am Soc Hematol Educ Program – volume: 27 start-page: 5175 year: 2009 end-page: 5181 ident: r033 article-title: Improved early event-free survival with imatinib in Philadelphia chromosome-positive acute lymphoblastic leukemia: a children’s oncology group study. publication-title: J Clin Oncol – volume: 381 start-page: 1943 year: 2013 end-page: 1955 ident: r001 article-title: Acute lymphoblastic leukaemia. publication-title: Lancet – volume: 21 start-page: 2283 year: 2007 end-page: 2287 ident: r031 article-title: Cytokine-dependent imatinib resistance in mouse BCR-ABL+, Arf-null lymphoblastic leukemia. publication-title: Genes Dev – volume: 47 start-page: 884 year: 2008 end-page: 889 ident: r024 article-title: Novel SSBP2-JAK2 fusion gene resulting from a t(5;9)(q14.1;p24.1) in pre-B acute lymphocytic leukemia. publication-title: Genes Chromosomes Cancer – volume: 31 start-page: 630 year: 2013 end-page: 637 ident: r032 article-title: Chaperones as thermodynamic sensors of drug-target interactions reveal kinase inhibitor specificities in living cells. publication-title: Nat Biotechnol – volume: 453 start-page: 110 year: 2008 end-page: 114 ident: r006 article-title: BCR-ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros. publication-title: Nature – volume: 2 start-page: 367 year: 2002 end-page: 376 ident: r027 article-title: Expression of the ETV6-NTRK3 gene fusion as a primary event in human secretory breast carcinoma. publication-title: Cancer Cell – volume: 121 start-page: 485 year: 2013 end-page: 488 ident: r008 article-title: Tyrosine kinome sequencing of pediatric acute lymphoblastic leukemia: a report from the Children’s Oncology Group TARGET Project. publication-title: Blood – volume: 98 start-page: e146 year: 2013 end-page: e148 ident: r013 article-title: Successful tyrosine kinase inhibitor therapy in a refractory B-cell precursor acute lymphoblastic leukemia with EBF1-PDGFRB fusion. publication-title: Haematologica – volume: 122 start-page: 826 year: 2013 end-page: 826 ident: r034 article-title: Development and validation of a highly sensitive and specific gene expression classifier to prospectively screen and identify B-precursor acute lymphoblastic leukemia (ALL) patients with a Philadelphia chromosome-Like (“Ph-like” or “BCR-ABL1-Like”) signature for therapeutic targeting and clinical intervention. publication-title: Blood – ident: r009 article-title: Kiyokawa N , Iijima K , Yoshihara H , An analysis of Ph-like ALL in Japanese patients. Presented at the American Society of Hematology Annual Meeting, New Orleans, December 7–10, 2013. abstract 352. – volume: 22 start-page: 1278 year: 2008 end-page: 1280 ident: r020 article-title: Fusion of ZMIZ1 to ABL1 in a B-cell acute lymphoblastic leukaemia with a t(9;10)(q34;q22.3) translocation. publication-title: Leukemia – volume: 105 start-page: 3127 year: 2005 end-page: 3132 ident: r039 article-title: Macrophage colony-stimulating factor receptor c-fms is a novel target of imatinib. publication-title: Blood – volume: 120 start-page: 3510 year: 2012 end-page: 3518 ident: r036 article-title: Targeting JAK1/2 and mTOR in murine xenograft models of Ph-like acute lymphoblastic leukemia. publication-title: Blood – ident: r018 article-title: R Development Core Team. R: A language and environment for statistical computing. 2009 ( http://www.R-project.org ). – volume: 37 start-page: 415 year: 2001 end-page: 416 ident: r028 article-title: Absence of t(12;15) associated ETV6-NTRK3 fusion transcripts in pediatric acute leukemias. publication-title: Med Pediatr Oncol – volume: 115 start-page: 5312 year: 2010 end-page: 5321 ident: r035 article-title: Rearrangement of CRLF2 is associated with mutation of JAK kinases, alteration of IKZF1, Hispanic/Latino ethnicity, and a poor outcome in pediatric B-progenitor acute lymphoblastic leukemia. publication-title: Blood – volume: 278 start-page: 1309 year: 1997 end-page: 1312 ident: r023 article-title: A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia. publication-title: Science – volume: 18 start-page: 184 year: 1998 end-page: 187 ident: r026 article-title: A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma. publication-title: Nat Genet – volume: 103 start-page: 6688 year: 2006 end-page: 6693 ident: r030 article-title: Arf gene loss enhances oncogenicity and limits imatinib response in mouse models of Bcr-Abl-induced acute lymphoblastic leukemia. publication-title: Proc Natl Acad Sci U S A – volume: 22 start-page: 153 year: 2012 end-page: 166 ident: r011 article-title: Genetic alterations activating kinase and cytokine receptor signaling in high-risk acute lymphoblastic leukemia. publication-title: Cancer Cell – volume: 31 start-page: e413 year: 2013 end-page: e416 ident: r012 article-title: Tyrosine kinase inhibitor therapy induces remission in a patient with refractory EBF1-PDGFRB-positive acute lymphoblastic leukemia. publication-title: J Clin Oncol – volume: 94 start-page: 496 year: 1999 end-page: 509 ident: r016 article-title: A proportional hazards model for the subdistribution of a competing risk. publication-title: J Am Stat Assoc – volume: 153 start-page: 43 year: 2011 end-page: 46 ident: r019 article-title: Identification of FOXP1 and SNX2 as novel ABL1 fusion partners in acute lymphoblastic leukaemia. publication-title: Br J Haematol – volume: 37 start-page: 417 year: 2001 end-page: 417 ident: r029 article-title: Absence of t(12;15) associated ETV6-NTRK3 fusion transcripts in pediatric acute leukemias. publication-title: Med Pediatr Oncol – ident: r032 doi: 10.1038/nbt.2620 – ident: r014 doi: 10.1038/ng.2754 – ident: r033 doi: 10.1200/JCO.2008.21.2514 – ident: r037 doi: 10.1182/blood-2011-12-389932 – volume: 34 start-page: 187 year: 1972 ident: r017 publication-title: J R Stat Soc Series B Stat Methodol doi: 10.1111/j.2517-6161.1972.tb00899.x – ident: r024 doi: 10.1002/gcc.20585 – ident: r013 doi: 10.3324/haematol.2013.095372 – ident: r020 doi: 10.1038/sj.leu.2405033 – ident: r028 doi: 10.1002/mpo.1222 – ident: r003 doi: 10.1182/asheducation-2010.1.21 – ident: r011 doi: 10.1016/j.ccr.2012.06.005 – ident: r002 doi: 10.1053/j.seminhematol.2013.10.001 – volume: 50 start-page: 163 year: 1966 ident: r015 publication-title: Cancer Chemother Rep – ident: r016 doi: 10.2307/2670170 – volume: 122 start-page: 826 year: 2013 ident: r034 publication-title: Blood doi: 10.1182/blood.V122.21.826.826 – ident: r035 doi: 10.1182/blood-2009-09-245944 – ident: r021 doi: 10.1182/blood-2009-03-208397 – ident: r029 doi: 10.1002/mpo.1223 – ident: r031 doi: 10.1101/gad.1588607 – ident: r023 doi: 10.1126/science.278.5341.1309 – ident: r038 doi: 10.1038/nrc3563 – volume: 58 start-page: 5046 year: 1998 ident: r025 publication-title: Cancer Res – ident: r036 doi: 10.1182/blood-2012-03-415448 – ident: r007 doi: 10.1182/blood-2012-10-462358 – ident: r019 doi: 10.1111/j.1365-2141.2010.08457.x – ident: r004 doi: 10.1056/NEJMoa0808253 – ident: r008 doi: 10.1182/blood-2012-04-422691 – ident: r026 doi: 10.1038/ng0298-184 – ident: r027 doi: 10.1016/S1535-6108(02)00180-0 – ident: r012 doi: 10.1200/JCO.2012.47.6770 – ident: r022 doi: 10.1038/ng.469 – ident: r005 doi: 10.1016/S1470-2045(08)70339-5 – ident: r006 doi: 10.1038/nature06866 – ident: r030 doi: 10.1073/pnas.0602030103 – ident: r001 doi: 10.1016/S0140-6736(12)62187-4 – ident: r039 doi: 10.1182/blood-2004-10-3967 – reference: 22897847 - Cancer Cell. 2012 Aug 14;22(2):153-66 – reference: 11568911 - Med Pediatr Oncol. 2001 Oct;37(4):415-6 – reference: 24186319 - Haematologica. 2013 Nov;98(11):e146-8 – reference: 19641190 - Blood. 2009 Sep 24;114(13):2688-98 – reference: 18408710 - Nature. 2008 May 1;453(7191):110-4 – reference: 11568912 - Med Pediatr Oncol. 2001 Oct;37(4):417 – reference: 20139093 - Blood. 2010 Jul 1;115(26):5312-21 – reference: 25207770 - N Engl J Med. 2014 Sep 11;371(11):1064-6 – reference: 22685175 - Blood. 2012 Jul 26;120(4):833-42 – reference: 9462753 - Nat Genet. 1998 Feb;18(2):184-7 – reference: 19129520 - N Engl J Med. 2009 Jan 29;360(5):470-80 – reference: 21239766 - Hematology Am Soc Hematol Educ Program. 2010;2010:21-9 – reference: 9360930 - Science. 1997 Nov 14;278(5341):1309-12 – reference: 18618714 - Genes Chromosomes Cancer. 2008 Oct;47(10):884-9 – reference: 19838194 - Nat Genet. 2009 Nov;41(11):1243-6 – reference: 22955920 - Blood. 2012 Oct 25;120(17):3510-8 – reference: 23811600 - Nat Biotechnol. 2013 Jul;31(7):630-7 – reference: 5910392 - Cancer Chemother Rep. 1966 Mar;50(3):163-70 – reference: 23835704 - J Clin Oncol. 2013 Sep 1;31(25):e413-6 – reference: 24246699 - Semin Hematol. 2013 Oct;50(4):314-24 – reference: 25470705 - N Engl J Med. 2014 Dec 4;371(23):2235 – reference: 19805687 - J Clin Oncol. 2009 Nov 1;27(31):5175-81 – reference: 15637141 - Blood. 2005 Apr 15;105(8):3127-32 – reference: 17761812 - Genes Dev. 2007 Sep 15;21(18):2283-7 – reference: 24013638 - Nat Genet. 2013 Oct;45(10):1226-31 – reference: 16618932 - Proc Natl Acad Sci U S A. 2006 Apr 25;103(17):6688-93 – reference: 23523389 - Lancet. 2013 Jun 1;381(9881):1943-55 – reference: 21391972 - Br J Haematol. 2011 Apr;153(1):43-6 – reference: 19138562 - Lancet Oncol. 2009 Feb;10(2):125-34 – reference: 12450792 - Cancer Cell. 2002 Nov;2(5):367-76 – reference: 18007576 - Leukemia. 2008 Jun;22(6):1278-80 – reference: 23974192 - Blood. 2013 Oct 10;122(15):2622-9 – reference: 23212523 - Blood. 2013 Jan 17;121(3):485-8 – reference: 9823307 - Cancer Res. 1998 Nov 15;58(22):5046-8 – reference: 23842646 - Nat Rev Cancer. 2013 Aug;13(8):559-71 |
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| Snippet | About 25% of young adults with ALL have Ph-like genotypes, which are associated with poor outcomes with conventional treatment. In this gene-expression study,... Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is characterized by a gene-expression profile similar to that of BCR-ABL1-positive ALL,... BackgroundPhiladelphia chromosome–like acute lymphoblastic leukemia (Ph-like ALL) is characterized by a gene-expression profile similar to that of... |
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| SubjectTerms | Acute lymphoblastic leukemia Adolescent Adolescents Adult Age Animals Biological and medical sciences Cell activation Cell proliferation Child Child, Preschool Children Clinical trials DNA, Neoplasm - analysis Female Gene expression General aspects Genes Genome, Human Genomes Genomic analysis Hematologic and hematopoietic diseases Heterografts Humans Infant Interleukin 7 receptors Janus kinase 2 Kinases Lesions Leukemia Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphatic leukemia Lymphocytes B Male Medical sciences Mice Oligonucleotide Array Sequence Analysis Oncology Philadelphia Chromosome Polymorphism, Single Nucleotide Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - metabolism Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - mortality Protein Kinase Inhibitors - therapeutic use Protein-tyrosine kinase Protein-Tyrosine Kinases - antagonists & inhibitors Receptors, Cytokine - genetics Receptors, Cytokine - metabolism Signal Transduction - genetics Stat5 protein Survival Analysis Teenagers Thymic stromal lymphopoietin Tyk2 protein Xenografts Young Adult Young adults |
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| Title | Targetable Kinase-Activating Lesions in Ph-like Acute Lymphoblastic Leukemia |
| URI | https://nejm.org/doi/full/10.1056/NEJMoa1403088 https://www.ncbi.nlm.nih.gov/pubmed/25207766 https://www.proquest.com/docview/1561513837 https://www.proquest.com/docview/1561972745 https://pubmed.ncbi.nlm.nih.gov/PMC4191900 |
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