Targetable Kinase-Activating Lesions in Ph-like Acute Lymphoblastic Leukemia

About 25% of young adults with ALL have Ph-like genotypes, which are associated with poor outcomes with conventional treatment. In this gene-expression study, a substantial fraction of Ph-like ALL cases were found to involve activation of kinases targeted by available agents.

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Veröffentlicht in:	The New England journal of medicine Jg. 371; H. 11; S. 1005 - 1015
Hauptverfasser:	Roberts, Kathryn G, Li, Yongjin, Payne-Turner, Debbie, Harvey, Richard C, Yang, Yung-Li, Pei, Deqing, McCastlain, Kelly, Ding, Li, Lu, Charles, Song, Guangchun, Ma, Jing, Becksfort, Jared, Rusch, Michael, Chen, Shann-Ching, Easton, John, Cheng, Jinjun, Boggs, Kristy, Santiago-Morales, Natalia, Iacobucci, Ilaria, Fulton, Robert S, Wen, Ji, Valentine, Marcus, Cheng, Cheng, Paugh, Steven W, Devidas, Meenakshi, Chen, I-Ming, Reshmi, Shalini, Smith, Amy, Hedlund, Erin, Gupta, Pankaj, Nagahawatte, Panduka, Wu, Gang, Chen, Xiang, Yergeau, Donald, Vadodaria, Bhavin, Mulder, Heather, Winick, Naomi J, Larsen, Eric C, Carroll, William L, Heerema, Nyla A, Carroll, Andrew J, Grayson, Guy, Tasian, Sarah K, Moore, Andrew S, Keller, Frank, Frei-Jones, Melissa, Whitlock, James A, Raetz, Elizabeth A, White, Deborah L, Hughes, Timothy P, Guidry Auvil, Jaime M, Smith, Malcolm A, Marcucci, Guido, Bloomfield, Clara D, Mrózek, Krzysztof, Kohlschmidt, Jessica, Stock, Wendy, Kornblau, Steven M, Konopleva, Marina, Paietta, Elisabeth, Pui, Ching-Hon, Jeha, Sima, Relling, Mary V, Evans, William E, Gerhard, Daniela S, Gastier-Foster, Julie M, Mardis, Elaine, Wilson, Richard K, Loh, Mignon L, Downing, James R, Hunger, Stephen P, Willman, Cheryl L, Zhang, Jinghui, Mullighan, Charles G
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Waltham, MA Massachusetts Medical Society 11.09.2014
Schlagworte:	Acute lymphoblastic leukemia Adolescent Adolescents Adult Age Animals Biological and medical sciences Cell activation Cell proliferation Child Child, Preschool Children Clinical trials DNA, Neoplasm - analysis Female Gene expression General aspects Genes Genome, Human Genomes Genomic analysis Hematologic and hematopoietic diseases Heterografts Humans Infant Interleukin 7 receptors Janus kinase 2 Kinases Lesions Leukemia Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphatic leukemia Lymphocytes B Male Medical sciences Mice Oligonucleotide Array Sequence Analysis Oncology Philadelphia Chromosome Polymorphism, Single Nucleotide Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - metabolism Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - mortality Protein Kinase Inhibitors - therapeutic use Protein-tyrosine kinase Protein-Tyrosine Kinases - antagonists & inhibitors Receptors, Cytokine - genetics Receptors, Cytokine - metabolism Signal Transduction - genetics Stat5 protein Survival Analysis Teenagers Thymic stromal lymphopoietin Tyk2 protein Xenografts Young Adult Young adults Medicine Enzyme Kinase Lymphoproliferative syndrome Transferases Acute leukemia pH Malignant hemopathy Lesion Acute lymphocytic leukemia Cancer
ISSN:	0028-4793, 1533-4406, 1533-4406
Online-Zugang:	Volltext
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Zusammenfassung:	About 25% of young adults with ALL have Ph-like genotypes, which are associated with poor outcomes with conventional treatment. In this gene-expression study, a substantial fraction of Ph-like ALL cases were found to involve activation of kinases targeted by available agents.
Bibliographie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Drs. Roberts and Li and Drs. Downing, Hunger, Willman, Zhang, and Mullighan contributed equally to this article.
ISSN:	0028-4793 1533-4406 1533-4406
DOI:	10.1056/NEJMoa1403088