HNRNPM controls circRNA biogenesis and splicing fidelity to sustain cancer cell fitness

High spliceosome activity is a dependency for cancer cells, making them more vulnerable to perturbation of the splicing machinery compared to normal cells. To identify splicing factors important for prostate cancer (PCa) fitness, we performed pooled shRNA screens in vitro and in vivo. Our screens id...

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Bibliographic Details
Published in:	eLife Vol. 10
Main Authors:	Ho, Jessica SY, Di Tullio, Federico, Schwarz, Megan, Low, Diana, Incarnato, Danny, Gay, Florence, Tabaglio, Tommaso, Zhang, JingXian, Wollmann, Heike, Chen, Leilei, An, Omer, Chan, Tim Hon Man, Hall Hickman, Alexander, Zheng, Simin, Roudko, Vladimir, Chen, Sujun, Karz, Alcida, Ahmed, Musaddeque, He, Housheng Hansen, Greenbaum, Benjamin D, Oliviero, Salvatore, Serresi, Michela, Gargiulo, Gaetano, Mann, Karen M, Hernando, Eva, Mulholland, David, Marazzi, Ivan, Wee, Dave Keng Boon, Guccione, Ernesto
Format:	Journal Article
Language:	English
Published:	England eLife Sciences Publications Ltd 02.06.2021 eLife Sciences Publications, Ltd
Subjects:	Adenocarcinoma - genetics Adenocarcinoma - metabolism Adenocarcinoma - pathology Animals Antisense oligonucleotides Biosynthesis Cell growth Cell Proliferation circular RNA Fitness Gene expression Gene Expression Regulation, Neoplastic Genetics and Genomics Genomes Hep G2 Cells Heterogeneous-Nuclear Ribonucleoprotein Group M - genetics Heterogeneous-Nuclear Ribonucleoprotein Group M - metabolism Humans Introns Male Mice Mice, SCID Mimicry Mutation Oligonucleotides PC-3 Cells Prostate cancer Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology RNA Splicing RNA, Circular - biosynthesis RNA, Circular - genetics Solid tumors splicing Splicing factors Tumor Burden Tumor Cells, Cultured Tumors genomics genetics splicing human circular RNA antisense oligonucleotides
ISSN:	2050-084X, 2050-084X
Online Access:	Get full text
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