Evaluation and assessment of clique arrangements for the estimation of omnipolar electrograms in high density electrode arrays: an experimental animal model study

High-density catheters combined with Orientation Independent Sensing (OIS) methods have emerged as a groundbreaking technology for cardiac substrate characterisation. In this study, we aim to assess the arrangements and constraints to reliably estimate the so-called omnipolar electrogram (oEGM). Per...

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Published in:Australasian physical & engineering sciences in medicine Vol. 46; no. 3; pp. 1193 - 1204
Main Authors: Ruipérez-Campillo, Samuel, Crespo, Marina, Tormos, Álvaro, Guill, Antonio, Cebrián, Antonio, Alberola, Antonio, Heimer, Jakob, Chorro, Francisco J., Millet, José, Castells, Francisco
Format: Journal Article
Language:English
Published: Cham Springer International Publishing 01.09.2023
Springer Nature B.V
Subjects:
Biological and Medical Physics
Biomedical and Life Sciences
Biomedical Engineering and Bioengineering
Biomedicine
Biophysics
Catheters
Distortion
Electric fields
High density
Medical and Radiation Physics
Morphology
Performance evaluation
Pulse duration
Scientific Paper
Substrates
Wave fronts
Signal processing
Cardiac catheters
Omnipolar electrograms
High density electrode arrays
Experimental animal study
Local substrate exploration
ISSN:2662-4729, 0158-9938, 2662-4737, 2662-4737, 1879-5447
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Summary:High-density catheters combined with Orientation Independent Sensing (OIS) methods have emerged as a groundbreaking technology for cardiac substrate characterisation. In this study, we aim to assess the arrangements and constraints to reliably estimate the so-called omnipolar electrogram (oEGM). Performance was evaluated using an experimental animal model. Thirty-eight recordings from nine retrospective experiments on isolated perfused rabbit hearts with an epicardial HD multielectrode were used. We estimated oEGMs according to the classic triangular clique (4 possible orientations) and a novel cross-orientation clique arrangement. Furthermore, we tested the effects of interelectrode spacing from 1 to 4 mm. Performance was evaluated by means of several parameters that measured amplitude rejection ratios, electric field loop area, activation pulse width and morphology distortion. Most reliable oEGM estimations were obtained with cross-configurations and interelectrode spacings ≤ 2 mm. Estimations from triangular cliques resulted in wider electric field loops and unreliable detection of the direction of the propagation wavefront. Moreover, increasing interelectrode distance resulted in increased pulse width and morphology distortion. The results prove that current oEGM estimation techniques are insufficiently accurate. This study opens a new standpoint for the design of new-generation HD catheters and mapping software.
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ISSN:2662-4729
0158-9938
2662-4737
2662-4737
1879-5447
DOI:10.1007/s13246-023-01287-8