Inhibition of RORγT Skews TCRα Gene Rearrangement and Limits T Cell Repertoire Diversity

Recent studies have elucidated the molecular mechanism of RORγT transcriptional regulation of Th17 differentiation and function. RORγT was initially identified as a transcription factor required for thymopoiesis by maintaining survival of CD4+CD8+ (DP) thymocytes. While RORγ antagonists are currentl...

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Bibliographic Details
Published in:	Cell reports (Cambridge) Vol. 17; no. 12; pp. 3206 - 3218
Main Authors:	Guo, Yanxia, MacIsaac, Kenzie D., Chen, Yi, Miller, Richard J., Jain, Renu, Joyce-Shaikh, Barbara, Ferguson, Heidi, Wang, I-Ming, Cristescu, Razvan, Mudgett, John, Engstrom, Laura, Piers, Kyle J., Baltus, Gretchen A., Barr, Kenneth, Zhang, Hongjun, Mehmet, Huseyin, Hegde, Laxminarayan G., Hu, Xiao, Carter, Laura L., Aicher, Thomas D., Glick, Gary, Zaller, Dennis, Hawwari, Abbas, Correll, Craig C., Jones, Dallas C., Cua, Daniel J.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 20.12.2016 Elsevier
Subjects:	Animals Antigens - immunology autoimmunity CD4-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - immunology Cell Differentiation - genetics Encephalomyelitis, Autoimmune, Experimental - genetics Encephalomyelitis, Autoimmune, Experimental - immunology Encephalomyelitis, Autoimmune, Experimental - therapy experimental autoimmune encephalomyelitis experimental psoriasis Gene Expression Regulation - immunology Gene Rearrangement - genetics Humans Mice Nuclear Receptor Subfamily 1, Group F, Member 3 - genetics Nuclear Receptor Subfamily 1, Group F, Member 3 - immunology Receptors, Antigen, T-Cell, alpha-beta - antagonists & inhibitors Receptors, Antigen, T-Cell, alpha-beta - genetics Receptors, Antigen, T-Cell, alpha-beta - immunology RORγT small-molecule antagonist T cell repertoire Th17 Cells - drug effects Th17 Cells - immunology Thymocytes - immunology thymopoiesis experimental autoimmune encephalomyelitis autoimmunity thymopoiesis T cell repertoire experimental psoriasis RORγT small-molecule antagonist
ISSN:	2211-1247, 2211-1247
Online Access:	Get full text
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