Clonal populations of a human TNBC model display significant functional heterogeneity and divergent growth dynamics in distinct contexts

Intratumoral heterogeneity has been described for various tumor types and models of human cancer, and can have profound effects on tumor progression and drug resistance. This study describes an in-depth analysis of molecular and functional heterogeneity among subclonal populations (SCPs) derived fro...

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Veröffentlicht in:	Oncogene Jg. 41; H. 1; S. 112 - 124
Hauptverfasser:	Kuiken, Hendrik J., Dhakal, Sabin, Selfors, Laura M., Friend, Chandler M., Zhang, Tian, Callari, Maurizio, Schackmann, Ron C. J., Gray, G. Kenneth, Crowdis, Jett, Bhang, Hyo-eun C., Baslan, Timour, Stegmeier, Frank, Gygi, Steven P., Caldas, Carlos, Brugge, Joan S.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 03.01.2022 Nature Publishing Group
Schlagworte:	13/106 38/22 38/23 38/77 38/90 38/91 42/44 631/67/1347 631/67/2329 64/60 82/58 Animals Apoptosis Breast cancer Cancer Cell Biology Cell culture Copy number Divergence Drug resistance Genetic Heterogeneity Human Genetics Humans Interferon Internal Medicine Medicine Medicine & Public Health Mice Microenvironments Mutation Oncology Propagation Proteomes Triple Negative Breast Neoplasms - genetics Triple Negative Breast Neoplasms - pathology Tumor cell lines Tumor Microenvironment - genetics Tumor suppressor genes Tumors Xenografts
ISSN:	0950-9232, 1476-5594, 1476-5594
Online-Zugang:	Volltext
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