UK Biobank: a globally important resource for cancer research

UK Biobank is a large-scale prospective study with deep phenotyping and genomic data. Its open-access policy allows researchers worldwide, from academia or industry, to perform health research in the public interest. Between 2006 and 2010, the study recruited 502,000 adults aged 40-69 years from the...

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Vydáno v:British journal of cancer Ročník 128; číslo 4; s. 519 - 527
Hlavní autoři: Conroy, Megan C, Lacey, Ben, Bešević, Jelena, Omiyale, Wemimo, Feng, Qi, Effingham, Mark, Sellers, Jonathan, Sheard, Simon, Pancholi, Mahesh, Gregory, Gareth, Busby, John, Collins, Rory, Allen, Naomi E
Médium: Journal Article
Jazyk:angličtina
Vydáno: England Nature Publishing Group 16.02.2023
Témata:
Adult
Biobanks
Biological Specimen Banks
Cancer
Cancer research
Genomics
Humans
Medical research
Neoplasms
Phenotyping
Prospective Studies
Saliva
Surveys and Questionnaires
United Kingdom - epidemiology
United Kingdom
United Kingdom > UK
ISSN:0007-0920, 1532-1827, 1532-1827
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Popis
Shrnutí:UK Biobank is a large-scale prospective study with deep phenotyping and genomic data. Its open-access policy allows researchers worldwide, from academia or industry, to perform health research in the public interest. Between 2006 and 2010, the study recruited 502,000 adults aged 40-69 years from the general population of the United Kingdom. At enrolment, participants provided information on a wide range of factors, physical measurements were taken, and biological samples (blood, urine and saliva) were collected for long-term storage. Participants have now been followed up for over a decade with more than 52,000 incident cancer cases recorded. The study continues to be enhanced with repeat assessments, web-based questionnaires, multi-modal imaging, and conversion of the stored biological samples to genomic and other '-omic' data. The study has already demonstrated its value in enabling research into the determinants of cancer, and future planned enhancements will make the resource even more valuable to cancer researchers. Over 26,000 researchers worldwide are currently using the data, performing a wide range of cancer research. UK Biobank is uniquely placed to transform our understanding of the causes of cancer development and progression, and drive improvements in cancer treatment and prevention over the coming decades.
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ISSN:0007-0920
1532-1827
1532-1827
DOI:10.1038/s41416-022-02053-5