Aging exacerbates impairments of cerebral blood flow autoregulation and cognition in diabetic rats

Diabetes mellitus (DM) is a leading risk factor for aging-related dementia; however, the underlying mechanisms are not well understood. The present study, utilizing a non-obese T2DN diabetic model, demonstrates that the myogenic response of the middle cerebral artery (MCA) and parenchymal arteriole...

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Bibliographic Details
Published in:	GeroScience Vol. 42; no. 5; pp. 1387 - 1410
Main Authors:	Wang, Shaoxun, Lv, Wenshan, Zhang, Huawei, Liu, Yedan, Li, Longyang, Jefferson, Joshua R., Guo, Ya, Li, Man, Gao, Wenjun, Fang, Xing, Paul, Ian A., Rajkowska, Grazyna, Shaffery, James P., Mosley, Thomas H., Hu, Xinlin, Liu, Ruen, Wang, Yangang, Yu, Hongwei, Roman, Richard J., Fan, Fan
Format:	Journal Article
Language:	English
Published:	Cham Springer International Publishing 01.10.2020 Springer Nature B.V
Subjects:	Aging Animals Antidiabetics Biomedical and Life Sciences Blood flow Blood-brain barrier Brain Capillaries Cell Biology Cerebral blood flow Cerebrovascular Circulation Cognition Cortex Dementia Dementia disorders Diabetes Diabetes mellitus Diabetes Mellitus, Experimental - complications Geriatrics Geriatrics/Gerontology Hippocampus Homeostasis Hyperemia Life Sciences Long term memory Memory Molecular Medicine Neurodegeneration Obesity Older people Original Original Article Perfusion Rats Risk factors Rodents Short term memory Spatial discrimination learning Spatial memory Autoregulation Cognitive impairments Myogenic response Blood-brain barrier Diabetes mellitus
ISSN:	2509-2715, 2509-2723, 2509-2723
Online Access:	Get full text
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