Pharmacological modulation of Kv3.1 mitigates auditory midbrain temporal processing deficits following auditory nerve damage

Higher stages of central auditory processing compensate for a loss of cochlear nerve synapses by increasing the gain on remaining afferent inputs, thereby restoring firing rate codes for rudimentary sound features. The benefits of this compensatory plasticity are limited, as the recovery of precise...

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Bibliographic Details
Published in:	Scientific reports Vol. 7; no. 1; pp. 17496 - 15
Main Authors:	Chambers, Anna R., Pilati, Nadia, Balaram, Pooja, Large, Charles H., Kaczmarek, Leonard K., Polley, Daniel B.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 13.12.2017 Nature Publishing Group
Subjects:	631/378/2586 631/378/2619 64 64/60 9/74 Action potential Action Potentials - drug effects Aging Animals Auditory nerve Auditory Pathways - drug effects Auditory Pathways - injuries Auditory Pathways - metabolism Auditory Perception - drug effects Auditory Perception - physiology Auditory plasticity Brain stem Cochlea Cochlear Nerve - injuries Cochlear Nerve - metabolism Compulsive Behavior Cortex (auditory) Disease Models, Animal Firing pattern Hair Humanities and Social Sciences Imidazoles - pharmacology Inferior colliculus Information processing Membrane Transport Modulators - pharmacology Mesencephalon Mesencephalon - drug effects Mesencephalon - metabolism Mice Models, Biological multidisciplinary Neural coding Neurons Neurons - drug effects Neurons - metabolism Noise Ototoxicity Ouabain Potassium Potassium channels Potassium channels (voltage-gated) Pyrimidines - pharmacology Recovery of Function - drug effects Science Science (multidisciplinary) Sensory neurons Shaw Potassium Channels - metabolism Sound Synapses Synchronization Temporal lobe Temporal variations Tinnitus Tissue Culture Techniques Vestibulocochlear Nerve Diseases - drug therapy Vestibulocochlear Nerve Diseases - metabolism
ISSN:	2045-2322, 2045-2322
Online Access:	Get full text
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