Targeted Knockdown of Overexpressed VEGFA or VEGF164 in Müller cells maintains retinal function by triggering different signaling mechanisms

Oxygen-induced retinopathy (OIR) upregulates Müller cell vascular endothelial growth factor A (VEGFA) that causes intravitreal neovascularization similar to severe retinopathy of prematurity (ROP). Safety concerns exist with anti-VEGF treatment for ROP. We evaluated long-term knockdown of Müller cel...

Celý popis

Uložené v:

Podrobná bibliografia
Vydané v:	Scientific reports Ročník 8; číslo 1; s. 2003 - 13
Hlavní autori:	Becker, Silke, Wang, Haibo, Simmons, Aaron B., Suwanmanee, Thipparat, Stoddard, Gregory J., Kafri, Tal, Hartnett, M. Elizabeth
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	London Nature Publishing Group UK 31.01.2018 Nature Publishing Group
Predmet:	13/106 13/51 14/19 38/77 38/89 42/41 692/308 692/617 Animals Astrocytes - metabolism Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - metabolism Cells, Cultured Electroretinograms Erythropoietin Erythropoietin - metabolism Gene Knockdown Techniques Gene Silencing Glial Cell Line-Derived Neurotrophic Factor - metabolism Humanities and Social Sciences multidisciplinary Nerve growth factor Nerve Growth Factor - metabolism Neuronal-glial interactions Neuroprotection Neurotrophin 3 Neurotrophin 3 - metabolism Rats Rats, Sprague-Dawley Retina Retina - metabolism Retina - pathology Retinopathy Retinopathy of Prematurity - metabolism Rodents Science Science (multidisciplinary) Signal Transduction Structure-function relationships Vascular endothelial growth factor Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism Vascularization
ISSN:	2045-2322, 2045-2322
On-line prístup:	Získať plný text
Tagy:	Pridať tag Žiadne tagy, Buďte prvý, kto otaguje tento záznam!

Buďte prvý, kto okomentuje tento záznam!